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Fibrosis

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Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression.

Changqing Yu, Ning Yang, Weidong Wang, Xiangning Du, Qingzhu Tang, Hongli Lin, Longkai Li,

<h4>Objective</h4>Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it. Core fucosylation, which is catalyzed by α1,6-fucosyltransferase (Fut8) in mammals, may play a crucial role in PF development. This study aims to assess the effects of inhibiting core fucosylation of ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):869-877]

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All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats.

Zhiqing Zhong, Hong-Yan Li, Hongzhen Zhong, Wenshan Lin, Shujun Lin, Tianbiao Zhou,

All-trans retinoic acid (ATRA) is one of essentially active metabolite of vitamin A, and plays an important role in diverse physiological processes, such as cellular growth and function. Renal interstitial fibrosis (RIF) is a common pathological characteristic of chronic renal disease causing end-stage renal disease currently lacking effective treatment. Low ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):658-663]

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Fibrosis as a common trait in amyotrophic lateral sclerosis tissues.

Savina Apolloni, Nadia D'Ambrosi,

Neural Regen Res (Neural regeneration research)
[2022, 17(1):97-98]

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Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from Amygdalus mongolica.

Chen Gao, Wan-Fu Bai, Hong-Bing Zhou, Hai-Mei Hao, Ying-Chun Bai, Quan-Li Liu, Hong Chang, Song-Li Shi,

<h4>Context</h4>The petroleum ether extract (PET) of <i>Amygdalus mongolica</i> (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF).<h4>Objective</h4>To evaluate the antifibrotic effects of <i>A. mongolica</i> seeds PET on RF by serum metabolomics, biochemical and histopathological analyses.<h4>Materials and methods</h4>Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, RF model, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):565-574]

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Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.

Quanwei Wang, Wenwen Fu, Xiaofeng Yu, Huali Xu, Dayun Sui, Yeling Wang,

<h4>Context</h4><i>Panax ginseng</i> C.A. Meyer (Araliaceae) has cardioprotective effects. Ginsenosides are responsible for most of the pharmacological activities of ginseng.<h4>Objective</h4>This study investigates the effect of ginsenoside Rg2 on myocardial fibrosis in myocardial ischaemia rats.<h4>Materials and methods</h4>Male Wistar rats were divided into control, isoproterenol, ginsenoside Rg2 (5, 20 mg/kg) groups (<i>n</i> = 8). The rats ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):106-113]

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Blood alcohol levels in Finnish victims of non-ischaemic sudden cardiac death.

Janna P Kauppila, Lasse Pakanen, Katja Porvari, Juha Vähätalo, Lauri Holmström, Juha S Perkiömäki, Heikki V Huikuri, M Juhani Junttila,

<h4>Introduction</h4>Non-ischaemic heart disease (NIHD) is the underlying pathology in∼20% of all sudden cardiac deaths (SCDs). Heavy drinking is known to be associated with SCD due to ischaemic heart disease, but studies on association of recent alcohol consumption and SCD in patients with NIHD are scarce. We evaluated the blood alcohol ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):413-419]

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The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model.

Yuya Sannomiya, Shota Kaseda, Misato Kamura, Hiroshi Yamamoto, Hiroyuki Yamada, Masataka Inamoto, Jun Kuwazuru, Saki Niino, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai,

Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glomerular basement membrane, and end-stage renal disease. Previous reports have suggested ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):510-519]

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High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study.

Yong Xiao, Dongwen Wu, Xiao Shi, Shuzhong Liu, Xudong Hu, Chenliang Zhou, Xia Tian, Huimin Liu, Hui Long, Zhihong Li, Ji Wang, Tao Tan, Ying Xu, Bitao Chen, Ting Liu, Heng Zhang, Shihua Zheng, Shunlin Hu, Jun Song, Jie Tang, Jichun Song, Zhengwei Cheng, Weitian Xu, Yongxiang Shen, Wenhu Yu, Yong Xu, Jiao Li, Jing Zhou, Fen Wang, Mingkai Chen,

<b>Background</b>: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear.<b>Methods</b>: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using ... Read more >>

Virulence (Virulence)
[2021, 12(1):1199-1208]

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Retrospective analysis on incidence and risk factors of early onset acute kidney injury after lung transplantation and its association with mortality.

Wen-Wen Du, Xiao-Xing Wang, Dan Zhang, Wen-Qian Chen, Xiang-Lin Zhang, Peng-Mei Li,

<h4>Objectives</h4>Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which is closely related to the poor prognosis of patients. We aimed to explore potential risk factors and outcomes associated with early post-operative AKI after LTx.<h4>Methods</h4>A retrospective study was conducted in 136 patients who underwent LTx at our ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):535-542]

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Effects of pirfenidone on renal function in patients with interstitial pneumonia.

Jun Matsumoto, Keisuke Sunohara, Yoshiko Mori, Hiroshi Nagaya, Shinichiro Inaba,

Ren Fail (Renal failure)
[2021, 43(1):879-881]

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Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans.

Hajar Yaakoub, Cindy Staerck, Sara Mina, Charlotte Godon, Maxime Fleury, Jean-Philippe Bouchara, Alphonse Calenda,

The slowing-down <i>de novo</i> drug-discovery emphasized the importance of repurposing old drugs. This is particularly true when combating infections caused by therapy-refractory microorganisms, such as <i>Scedosporium</i> species and <i>Lomentospora prolificans</i>. Recent studies on <i>Scedosporium</i> responses to oxidative stress underscored the importance of targeting the underlying mechanisms. Auranofin, ebselen, PX-12, honokiol, ... Read more >>

Virulence (Virulence)
[2021, 12(1):1076-1090]

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Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria.

Ritika Chatterjee, Atish Roy Chowdhury, Debapriya Mukherjee, Dipshikha Chakravortty,

Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (<i>Staphylococcus sp., Listeria monocytogenes, etc</i>.) and Gram-negative bacteria (<i>Chlamydia sp., Salmonella sp., E. coli</i>, etc.) ... Read more >>

Virulence (Virulence)
[2021, 12(1):195-216]

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Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru, Yuzhi Bai,

The study was designed to explore the effects of Withaferin A (WFA) on hyperuricemia-induced kidney injury and its action mechanism. Potassium oxonate (PO) was employed to establish the hyperuricemic mouse model. The pathological changes of renal tissue were evaluated by hematoxylin-eosin and masson trichrome staining. The levels of creatinine, blood ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):589-600]

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Pinocembrin ameliorates arrhythmias in rats with chronic ischaemic heart failure.

Yan Guo, Cui Zhang, Tianxin Ye, Xiuhuan Chen, Xin Liu, Xiaoli Chen, Yazhou Sun, Chuan Qu, Jinjun Liang, Shaobo Shi, Bo Yang,

<h4>Objective</h4>Ventricular arrhythmias (VAs) are a common complication of chronic ischaemic heart failure (CIHF). The purpose of this study is to investigate the efficacy of pinocembrin in a rat model of VAs induced by CIHF and further examine the possible mechanism.<h4>Methods</h4>Rats were subjected to ligation of left anterior descending coronary artery ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):830-840]

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Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model.

Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan, Weixin Zhu,

<h4>Context</h4>Cryptotanshinone (CT), a lipophilic compound extracted from roots of <i>Salvia miltiorrhiza</i> Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis. Our previous findings suggest that CT plays a protective role in cerebral stroke. However, the molecular mechanisms underlying CT protection in ischaemic stroke ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):465-471]

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Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade.

Shaydee J Budel, Marloes M Penning, Louis C Penning,

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):172-180]

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Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease - a fifteen year single center experience.

Zafirah Zahir, Asif Sadiq Wani, Narayan Prasad, Manoj Jain,

<h4>Introduction</h4>Anti-glomerular basement membrane (anti-GBM) disease is a small vessel vasculitis affecting the renal and lung capillary beds. We aim to study the clinicopathological characteristics and predictors of poor outcome of this disease in our population.<h4>Materials and methods</h4>This is a 15 year retrospective, single center observational study of Indian cohort. Patients with ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):79-89]

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Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway.

Guoqiang Wang, Hong Wu, Peng Liang, Xiaojiao He, Dong Liu,

The Angiotensin II/transforming growth factor-β1 (AngII/TGF-β1) signal axis is an important regulatory pathway for atrial fibrosis, which can contribute to atrial fibrillation (AF). Fused in sarcoma (FUS) was recently found to regulate cardiac diseases. This study aimed to investigate whether FUS could regulate AngII induced fibrosis and uncover the possible ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1415-1425]

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Accelerated cardiovascular risk after viral clearance in hepatitis C patients with the NAMPT-rs61330082 TT genotype: An 8-year prospective cohort study.

Ming-Ling Chang, Yu-Sheng Lin, Ming-Yu Chang, Chia-Lin Hsu, Rong-Nan Chien, Cathy Sj Fann,

Involvement of extracellular nicotinamide phosphoribosyltransferase (eNAMPT, i.e., visfatin or pre-B-cell colony-enhancing factor), a cancer metabokine, in chronically hepatitis C virus (HCV)-infected (CHC) patients with sustained virological responses (SVRs) remains elusive. This 8-year prospective cohort study evaluated eNAMPT profiles of 842 consecutive CHC patients, including 519 who had completed an anti-HCV ... Read more >>

Virulence (Virulence)
[2021, 12(1):270-280]

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Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis.

Zixuan Cheng, Jialin Zhang, Wanying Deng, Shaojian Lin, Donghai Li, Ke Zhu, Qing Qi,

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. The present study aims to investigate potential roles of Friend leukemia integration factor 1 (FLI1) and microRNA in the beneficial effects of BSYJ on ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1212-1225]

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Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma.

Fucheng Meng, Yafei Xiao, Longxiang Xie, Qiao Liu, Keli Qian,

As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there are no specific molecular-targeted drugs for ccRCC at present. Human ATP-binding cassette (ABC) transporter family plays an important role in homeostasis maintenance. This study aimed to ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):375-385]

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Correlation analysis between expression of histone deacetylase 6 and clinical parameters in IgA nephropathy patients.

Yan Hu, Minghua Shang, Yingfeng Shi, Min Tao, Weijie Yuan, Lunxian Tang, Xiaoyan Ma, Binbin Cui, Hui Chen, Xun Zhou, Shougang Zhuang, Na Liu,

<h4>Background</h4>It has been demonstrated that histone deacetylase 6 (HDAC6) is involved in various kidney diseases in experimental study. However, correlation between HDAC6 and clinical parameters in IgA nephropathy (IgAN) patients is still unknown.<h4>Methods</h4>A total of 46 human kidney biopsy specimens with IgAN were selected as observation group, specimens of normal ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):684-697]

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Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus.

Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E Cooper, Fang Liu,

<h4>Aims</h4>Chronic kidney disease (CKD) and diabetes mellitus increase atherosclerotic cardiovascular diseases (ASCVD) risk. However, the association between renal outcome of diabetic kidney disease (DKD) and ASCVD risk is unclear.<h4>Methods</h4>This retrospective study enrolled 218 type 2 diabetic patients with biopsy-proven DKD, and without known cardiovascular diseases. Baseline characteristics were obtained and ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):477-487]

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Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung.

Leonor de Braganca, G John Ferguson, Jose Luis Santos, Jeremy P Derrick,

There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease at the DNA/RNA level. Despite recent innovations in non-viral gene therapy delivery for chronic respiratory diseases, unwanted ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):61-73]

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Human umbilical cord-derived mesenchymal stem cells improve chronic pancreatitis in rats via the AKT-mTOR-S6K1 signaling pathway.

Lijun Kong, Xiangxiang Xu, Hewei Zhang, Yi Zhou, Hongjian Huang, Bicheng Chen, Zhenxu Zhou,

Chronic pancreatitis (CP) is a progressive inflammatory disease. In clinical treatment, many patients cannot get a timely diagnosis and effective treatment due to the lack of early diagnosis indicators. Mesenchymal stem cells have immunomodulatory and anti-inflammatory effects, and have broad application prospects in treating auto-immune diseases and inflammatory diseases. This ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1986-1996]

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