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The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming.

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun,

We recently identified FAcilitates Chromatin Transcription (FACT) as a reprogramming barrier of transcription factor (TF) mediated conversion of germ cells into neurons in <i>C. elegans</i>. FACT is a conserved heterodimer consisting of SPT16 and SSRP1 in mammals. Duplication events during evolution in <i>C. elegans</i> generated two SSRP1 homologs named HMG-3 ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Saul-Wilson Syndrome Missense Allele Does Not Show Obvious Golgi Defects in a C. elegans Model.

Isabella Zafra, Benjamin Nebenfuehr, Andy Golden,

Saul-Wilson Syndrome is an ultra-rare skeletal syndrome caused by a mutation in the COG4 gene resulting in a glycine-to-arginine substitution at amino acid position 516. The COG4 gene encodes one of 8 subunits of the conserved oligomeric Golgi complex. Using CRISPR-Cas9, our lab generated a <i>C. elegans</i> model for Saul-Wilson ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.

Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Caenorhabditis elegans larvae undergo early developmental arrest on a diet of Gram-positive bacterium Enterococcus faecalis.

Madhumanti Dasgupta, Nagagireesh Bojanala, Meghana Shashikanth, Varsha Singh,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway.

Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang, Zhen-Yu Chen,

The successful treatment of keloids is a great challenge in the plastic surgery field. Activating transcription factor 3 (ATF3) is discovered as an adaptive responsive gene, which plays a critical role in fibroblast activation. This study aimed to investigate the expression and biological role of ATF3 in the pathogenesis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):117-126]

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Acute effects of dietary phosphorus intake on markers of mineral metabolism in hemodialysis patients: post hoc analysis of a randomized crossover trial.

Wan-Chuan Tsai, Hon-Yen Wu, Yen-Ling Chiu, Ju-Yeh Yang, Mei-Fen Pai, Yong-Ru Wu, Wan-Yu Lin, Kuan-Yu Hung, Kuo-Liong Chien, Shih-Ping Hsu, Yu-Sen Peng,

<h4>Background</h4>Long-term dietary phosphorus excess influences disturbances in mineral metabolism, but it is unclear how rapidly the mineral metabolism responds to short-term dietary change in dialysis populations.<h4>Methods</h4>This was a post hoc analysis of a randomized crossover trial that evaluated the short-term effects of low-phosphorus diets on mineral parameters in hemodialysis patients. ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):141-148]

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Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.

Mercedes A Hernandez-Sapiens, Edwin E Reza-Zaldívar, Ana L Márquez-Aguirre, Ulises Gómez-Pinedo, Jorge Matias-Guiu, Ricardo R Cevallos, Juan C Mateos-Díaz, Víctor J Sánchez-González, Alejandro A Canales-Aguirre,

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex that conducts the intramembranous proteolytic excision of multiple ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):31-37]

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Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.

Hao Xu, Chen Xiong, Yuan Chen, Chi Zhang, Dousheng Bai,

Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its link with immune infiltration in liver cancer still unknown. Therefore, more research into the roles and activities of Rad51 in hepatocellular carcinoma (HCC) is required. The International Cancer Genome Consortium (ICGC) was used to identify ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2664-2675]

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Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.

Shengming Huang, Zhanguo Tan, Jirui Cai, Zhiping Wang, Yuejun Tian,

<h4>Context</h4>Cerebral ischaemia/reperfusion (I/R) injury has a high disability and fatality worldwide. Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects.<h4>Objective</h4>This study investigated the effect of myrtenol on cerebral ischaemia/reperfusion (I/R) injury and the underlying mechanism.<h4>Materials and methods</h4>Cerebral I/R injury was induced in adult Sprague-Dawley rats by ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):584-593]

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis.

Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz, Ali Sonboli,

<h4>Context</h4><i>Zataria multiflora</i> Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.<h4>Objective</h4>This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds.<h4>Materials and methods</h4>A full-thickness excisional skin wound was surgically created in each mouse and inoculated ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1-10]

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Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis.

Zixuan Cheng, Jialin Zhang, Wanying Deng, Shaojian Lin, Donghai Li, Ke Zhu, Qing Qi,

Systemic sclerosis (SSc) refers to a group of autoimmune rheumatic diseases. Bushen Yijing decoction (BSYJ) is used for treating SSc. However, its underlying mechanism remains unknown. The present study aims to investigate potential roles of Friend leukemia integration factor 1 (FLI1) and microRNA in the beneficial effects of BSYJ on ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1212-1225]

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Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase.

Di Liu, Juan Du, Jing Sun, Minqi Li,

Massive production of reactive oxygen species (ROS) in human periodontal ligament fibroblasts (HPdLFs) by nitrogen-containing bisphosphonates (BPs) is the main factor causing BP-related osteonecrosis of the jaw. Further, oxidative stress and apoptosis of fibroblasts induced by ROS are closely associated with the activation of MAPK. Parathyroid hormone-related protein (PTHrP) can ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1997-2006]

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Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway.

Guoqiang Wang, Hong Wu, Peng Liang, Xiaojiao He, Dong Liu,

The Angiotensin II/transforming growth factor-β1 (AngII/TGF-β1) signal axis is an important regulatory pathway for atrial fibrosis, which can contribute to atrial fibrillation (AF). Fused in sarcoma (FUS) was recently found to regulate cardiac diseases. This study aimed to investigate whether FUS could regulate AngII induced fibrosis and uncover the possible ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1415-1425]

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Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis.

Sonoo Mizuiri, Yoshiko Nishizawa, Toshiki Doi, Kazuomi Yamashita, Kenichiro Shigemoto, Koji Usui, Michiko Arita, Takayuki Naito, Shigehiro Doi, Takao Masaki,

<h4>Objective</h4>A high coronary artery calcification score (CACS) may be associated with high mortality in patients undergoing hemodialysis (HD). Recently, effects of iron on vascular smooth muscle cell calcification have been described. We aimed to investigate the relationships between iron, CACS, and mortality in HD patients.<h4>Methods</h4>We studied 173 consecutive patients who ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):371-380]

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Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus.

Long Cheng, Jingkang Wang, Hongyu Dai, Yuhui Duan, Yongcheng An, Lu Shi, Yinglan Lv, Huimin Li, Chen Wang, Quantao Ma, Yaqi Li, Pengfei Li, Haifeng Du, Baosheng Zhao,

Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):48-65]

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Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing.

Zhimin Li, Yu Sun, Maolin He, Jianwei Liu,

The underlying molecular mechanisms of intervertebral disc degeneration (IDD) remain unclear. This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected three samples each from an IDD and a spinal cord injury group (control) for RNA-sequencing. We ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1026-1039]

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Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.

Meiyu Chen, Kai Wang, Xiaohui Cai, Xiuwen Zhang, Hongying Chao, Suning Chen, Hongjie Shen, Qian Wang, Ri Zhang,

<b>Objectives:</b> The 8p11 myeloproliferative syndrome (EMS) is an extremely rare, generally aggressive haematologic malignancies. This study provided the clinical outcomes and therapeutic strategies for EMS patients confirmed with CEP110-FGFR1 fusion. <b>Methods:</b> We report here a case of translocation (8;9) (p12;q33)/CEP110-FGFR1 who received allo-HSCT and achieved molecular remission. We searched the ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):153-159]

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Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis.

Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang, Birong Dong,

Long noncoding RNAs (lncRNAs) play vital roles in the progression of hypertrophic scar (HS). We aimed to explore the effect of lncRNA INHBA Antisense RNA1 (INHBA-AS1) in the formation of HS and identify the potential mechanisms. INHBA-AS1 and microRNA (miR)-141-3p expression in human HS fibroblasts (hHSFs) was determined using RT-qPCR. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1663-1675]

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Weighted gene co-expression network analysis (WGCNA) to explore genes responsive to Streptococcus oralis biofilm and immune infiltration analysis in human gingival fibroblasts cells.

Xia Chen, Jianfeng Ma,

The correlation between oral bacteria and dental implants failure has been reported. However, the effect and mechanism of bacteria during dental implants is unclear. In this study, we explored key genes and candidate gene clusters in human gingival fibroblasts (HGF) cells in response to <i>Streptococcus oralis</i> biofilm through weighted gene ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1054-1065]

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Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.

Zhiyong Dong, Xinyi Lei, Stacy A Kujawa, NaciEmre Bolu, Hong Zhao, Cunchuan Wang,

<b>Objectives</b> Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis.<b>Methods</b> The GSE27951 gene expression ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):310-321]

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Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling.

Yixuan Qiu, Jiaming Yu, Yi Li, Fan Yang, Huiyuan Yu, Mengjuan Xue, Fan Zhang, Xin Jiang, Xueying Ji, Zhijun Bao,

<b>Background:</b> Recent evidence indicates that host-gut microbiota crosstalk has nonnegligible effects on host skeletal muscle, yet gut microbiota-regulating mechanisms remain obscure.<b>Methods:</b> C57BL/6 mice were treated with a cocktail of antibiotics (Abx) to depress gut microbiota for 4 weeks. The profiles of gut microbiota and microbial bile acids were measured by ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):508-522]

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Facile green synthesis of silver nanoparticles using Mangifera indica seed aqueous extract and its antimicrobial, antioxidant and cytotoxic potential (3-in-1 system).

Savan Donga, Sumitra Chanda,

A novel approach for the utilisation of fruit waste is attempted in the present investigation. <i>Mangifera indica</i> seed aqueous extract was utilised for green synthesis of silver nanoparticles (AgNPs). The phytoconstituents in the seed acted as reducing and stabilising agent for AgNP formation. UV-Vis, Zeta potential, FT-IR, XRD, TEM, SAED, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):292-302]

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Effects of hormone replacement therapy on lens opacity, serum inflammatory cytokines, and antioxidant levels.

Donghyun Jee, Sang Hee Park, Ho Sik Hwang, Hyun Seung Kim, Man Soo Kim, Eun Chul Kim,

<h4>Purpose</h4>To evaluate the effect of hormone replacement therapy (HRT) on lens opacity as measured by Scheimpflug densitometry, serum inflammatory cytokines, and antioxidant levels.<h4>Methods</h4>A total of 264 women who were at least five years beyond menopause were included. The control group of 128 patients (Group 1) did not use HRT at ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):707-714]

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Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.

Patrycja Sosińska-Zawierucha, Andrzej Bręborowicz,

<h4>Background</h4>Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree.<h4>Methods</h4>The effect of uremic serum obtained from patients with end stage renal failure on the gene expression and secretory activity of ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):401-405]

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Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells.

Wagdy M Eldehna, Mahmoud F Abo-Ashour, Tarfah Al-Warhi, Sara T Al-Rashood, Amal Alharbi, Rezk R Ayyad, Khayal Al-Khayal, Maha Abdulla, Hatem A Abdel-Aziz, Rehan Ahmad, Radwan El-Haggar,

Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):319-328]

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