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Failure to Thrive in Elderly Adults

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The diagnosis "failure to thrive" and its impact on the care of hospitalized older adults: a matched case-control study.

Clara Tsui, Kristine Kim, Martha Spencer,

BACKGROUND:"Failure to thrive" and associated diagnoses are non-specific terms applied to older adults when there is lack of diagnostic clarity and imply an absence of medical acuity. We investigated the effect of such admission diagnoses on delivery of patient care in a cohort of older adults admitted to a tertiary ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):62]

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Anomalous Left Coronary Artery From The Pulmonary Artery (ALCAPA) as a Cause of Heart Failure.

Daniel Sadoma, Christopher Valente, Adam Sigal,

BACKGROUND Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare anomaly. When present it can result in failure to thrive and congestive heart failure. CASE REPORT We present the case of a 6-month old female whose presentation was one of failure to thrive. Point of care ultrasound ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1797-1800]

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Geriatric Events Among Older Adults Undergoing Nonelective Surgery Are Associated with Poor Outcomes.

Jill Q Dworsky, Christopher P Childers, Timothy Copeland, Melinda Maggard-Gibbons, Hung-Jui Tan, Debra Saliba, Marcia M Russell,

Older adults undergoing nonelective surgery are at risk for geriatric events (GEs: delirium, dehydration, falls/fractures, failure to thrive, and pressure ulcers), but the impact of GEs on postoperative outcomes is unclear. Using the 2013 to 2014 National Inpatient Sample, we analyzed nonelective hospital admissions for five common operations (laparoscopic cholecystectomy, ... Read more >>

Am Surg (The American surgeon)
[2019, 85(10):1089-1093]

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Diagnosing coeliac disease in the elderly: a United Kingdom cohort study.

Mohamed G Shiha, Lauren J Marks, David S Sanders,

Aim:To assess the outcomes for an elderly population with coeliac disease and to compare with younger adults with CD. Background:Coeliac disease in the elderly has been underdiagnosed due to the heterogeneity of presentation as well as lack of physicians' awareness of CD in this population. However, the benefits of diagnosing ... Read more >>

Gastroenterol Hepatol Bed Bench (Gastroenterology and hepatology from bed to bench)
[2020, 13(1):37-43]

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Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.

Sampada Chande, Daniel Caballero, Bryan B Ho, Jonathan Fetene, Juan Serna, Dominik Pesta, Ali Nasiri, Michael Jurczak, Nicholas W Chavkin, Nati Hernando, Cecilia M Giachelli, Carsten A Wagner, Caroline Zeiss, Gerald I Shulman, Clemens Bergwitz,

Low blood phosphate (Pi) reduces muscle function in hypophosphatemic disorders. Which Pi transporters are required and whether hormonal changes due to hypophosphatemia contribute to muscle function is unknown. To address these questions we generated a series of conditional knockout mice lacking one or both house-keeping Pi transporters Pit1 and Pit2 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3069]

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Impact on Isoleucine and Valine Supplementation When Decreasing Use of Medical Food in the Nutritional Management of Methylmalonic Acidemia.

Laurie E Bernstein, Casey Burns, Morgan Drumm, Sommer Gaughan, Melissa Sailer, Peter R Baker,

BACKGROUND:Methylmalonic acidemia (MMA) is an autosomal recessive disorder treated with precursor-free medical food while limiting natural protein. This retrospective chart review was to determine if there was a relationship between medical food, valine (VAL) and/or isoleucine (ILE) supplementation, total protein intake, and plasma amino acid profiles. Methods: A chart review, ... Read more >>

Nutrients (Nutrients)
[2020, 12(2):]

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Fibrogenesis in LAMA2-Related Muscular Dystrophy Is a Central Tenet of Disease Etiology.

Anthony Accorsi, Megan L Cramer, Mahasweta Girgenrath,

LAMA2-related congenital muscular dystrophy, also known as MDC1A, is caused by loss-of-function mutations in the alpha2 chain of Laminin-211. Loss of this protein interrupts the connection between the muscle cell and its extracellular environment and results in an aggressive, congenital-onset muscular dystrophy characterized by severe hypotonia, lack of independent ambulation, ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2020, 13:3]

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Metabolic Dysfunction in Hutchinson-Gilford Progeria Syndrome.

Ray Kreienkamp, Susana Gonzalo,

Hutchinson-Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction. Although HGPS does not totally recapitulate normal aging, it does harbor many similarities to the normal aging process, with patients also developing cardiovascular disease, alopecia, bone and joint abnormalities, and ... Read more >>

Cells (Cells)
[2020, 9(2):]

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Familial Russell-Silver Syndrome like Phenotype in the PCNA Domain of the CDKN1C Gene, a Further Case.

A H Sabir, G Ryan, Z Mohammed, J Kirk, N Kiely, M Thyagarajan, T Cole,

We present two half siblings with significant short stature who proved a diagnostic challenge for several years. Radiological findings included subtle epiphyseal changes. The diagnosis was made through whole genome sequencing via the 100,000 genome project. A maternally inherited pathogenic heterozygous CDKN1C variant was found in the PCNA (proliferating cell ... Read more >>

Case Rep Genet (Case reports in genetics)
[2019, 2019:1398250]

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Type 5 Familial Hemophagocytic Lymphohistiocytosis in a Seven-year-old Girl Post Second Bone Marrow Transplantation with Failure to Thrive: STXBP2 Novel Mutation.

Abdullah Baothman, Hani Almalki, Khalid Abumelha, Abobaker Alshegifi, Abdulrahman Baashar,

Familial hemophagocytic lymphohistiocytosis (HLH) is a fatal autosomal recessive disorder resulting in an exaggerated and ineffective immune response. Genetic defects in familial HLH can lead to the impaired function of the secretory lysosome-dependent exocytosis pathway. We report an STXBP2 homozygous missense mutation c.1139A>G, p.(Gln380Arg) consistent with a genetic diagnosis of ... Read more >>

Cureus (Cureus)
[2019, 11(11):e6246]

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Awareness of feeding, growth and development among mothers of infants with cleft lip and/or palate.

Parakrama Wijekoon, Thanuja Herath, Rahini Mahendran,

Background:Awareness of feeding among mothers plays an important role in the growth and development of children with cleft lip and palate. Mothers' increased awareness provides the right care and nutrition to these children in order to grow and achieve their developmental milestones. Objectives:This study aimed at (1) assessing mothers' awareness ... Read more >>

Heliyon (Heliyon)
[2019, 5(12):e02900]

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Allogeneic transplantation in elderly patients ≥65 years with non-Hodgkin lymphoma: a time-trend analysis.

Nirav N Shah, Kwang Woo Ahn, Carlos Litovich, Anna Sureda, Mohamed A Kharfan-Dabaja, Farrukh T Awan, Siddhartha Ganguly, Usama Gergis, David Inwards, Reem Karmali, Alexsandr Lazaryan, Lazaros Lekakis, Pashna Munshi, Sunita Nathan, Ayman A Saad, Melhem Solh, Amir Steinberg, Ravi Vij, William A Wood, Timothy S Fenske, Sonali Smith, Mehdi Hamadani,

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for relapsed/refractory and high-risk non-Hodgkin lymphoma (NHL). However, no large studies have evaluated allo-HCT utilization in elderly NHL patients (≥65 years). Using the CIBMTR registry, we report a time-trend analysis of 727 NHL patients (≥65 years) undergoing the first allo-HCT from ... Read more >>

Blood Cancer J (Blood cancer journal)
[2019, 9(12):97]

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Nonspecific complaints in the emergency department - a systematic review.

Kirsi Kemp, Reija Mertanen, Mitja Lääperi, Leila Niemi-Murola, Lasse Lehtonen, Maaret Castren,

BACKGROUND:Nonspecific complaint (NSC) is a common presenting complaint in the emergency setting, especially in the elderly population. Individual studies have shown that it is associated with significant morbidity and mortality. This prognostic systematic review draws a synthesis of reported outcomes for patients presenting with NSC and compares them with outcomes ... Read more >>

Scand J Trauma Resusc Emerg Med (Scandinavian journal of trauma, resuscitation and emergency medicine)
[2020, 28(1):6]

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Current Trends in Tolerance Induction in Cow's Milk Allergy: From Passive to Proactive Strategies.

Cansin Sackesen, Derya Ufuk Altintas, Aysen Bingol, Gulbin Bingol, Betul Buyuktiryaki, Esen Demir, Aydan Kansu, Zarife Kuloglu, Zeynep Tamay, Bulent Enis Sekerel,

This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to support the efficacy of food allergen avoidance in infancy and the concept of the ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:372]

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Interventions Addressing Food Insecurity in Health Care Settings: A Systematic Review.

Emilia H De Marchis, Jacqueline M Torres, Tara Benesch, Caroline Fichtenberg, Isabel Elaine Allen, Evans M Whitaker, Laura M Gottlieb,

PURPOSE:Based on the recognition that food insecurity (FI) is associated with poor health across the life course, many US health systems are actively exploring ways to help patients access food resources. This review synthesizes findings from studies examining the effects of health care-based interventions designed to reduce FI. METHODS:We conducted ... Read more >>

Ann Fam Med (Annals of family medicine)
[2019, 17(5):436-447]

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Recent Advances in Neonatal Diabetes.

Amanda Dahl, Seema Kumar,

Neonatal diabetes mellitus (DM) is defined by the onset of persistent hyperglycemia within the first six months of life but may present up to 12 months of life. A gene mutation affecting pancreatic beta cells or synthesis/secretion of insulin is present in more than 80% of the children with neonatal ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2020, 13:355-364]

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Tuberculosis treatment outcomes among people living with HIV diagnosed using Xpert MTB/RIF versus sputum-smear microscopy in Botswana: a stepped-wedge cluster randomised trial.

Tefera Agizew, Violet Chihota, Sambayawo Nyirenda, Zegabriel Tedla, Andrew F Auld, Unami Mathebula, Anikie Mathoma, Rosanna Boyd, Anand Date, Sherri L Pals, Phenyo Lekone, Alyssa Finlay,

BACKGROUND:Xpert® MTB/RIF (Xpert) has high sensitivity for diagnosing tuberculosis (TB) compared to sputum-smear microscopy (smear) and can reduce time-to-diagnosis, time-to-treatment and potentially unfavorable patient-level treatment outcome. METHODS:People living with HIV (PLHIV) initiating antiretroviral therapy at 22 HIV clinics were enrolled and underwent systematic screening for TB (August 2012-November 2014). GeneXpert ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):1058]

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Growth of young HIV-infected and HIV-exposed children in western Kenya: A retrospective chart review.

Megan S McHenry, Edith Apondi, Samuel O Ayaya, Ziyi Yang, Wenfang Li, Wanzhu Tu, Guanying Bi, Edwin Sang, Rachel C Vreeman,

INTRODUCTION:The objective of this study was to determine the growth patterns, rates of malnutrition, and factors associated with malnutrition in children born to HIV-infected mothers in western Kenya using data from an electronic medical record system. METHODS:This study was a retrospective chart review of HIV-infected (HIV+) and-exposed (HEU) children (<5 ... Read more >>

PLoS ONE (PloS one)
[2019, 14(12):e0224295]

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Breastfeeding Difficulties and Risk for Early Breastfeeding Cessation.

Maria Lorella Gianni, Maria Enrica Bettinelli, Priscilla Manfra, Gabriele Sorrentino, Elena Bezze, Laura Plevani, Giacomo Cavallaro, Genny Raffaeli, Beatrice Letizia Crippa, Lorenzo Colombo, Daniela Morniroli, Nadia Liotto, Paola Roggero, Eduardo Villamor, Paola Marchisio, Fabio Mosca,

Although breast milk is the normative feeding for infants, breastfeeding rates are lower than recommended. We investigated breastfeeding difficulties experienced by mothers in the first months after delivery and their association with early breastfeeding discontinuation. We conducted a prospective observational study. Mothers breastfeeding singleton healthy term newborns at hospital discharge ... Read more >>

Nutrients (Nutrients)
[2019, 11(10):]

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Improving measurement of child abuse and neglect: A systematic review and analysis of national prevalence studies.

Ben Mathews, Rosana Pacella, Michael P Dunne, Marko Simunovic, Cicely Marston,

OBJECTIVES:Child maltreatment through physical abuse, sexual abuse, emotional abuse, neglect, and exposure to domestic violence, causes substantial adverse health, educational and behavioural consequences through the lifespan. The generation of reliable data on the prevalence and characteristics of child maltreatment in nationwide populations is essential to plan and evaluate public health ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227884]

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Oral status of HIV-infected children aged 12 years or younger who attended a Paediatric Infectious Diseases Clinic in Cape Town.

Nadia Mohamed, Olorato Patience Mathiba, Riaan Mulder,

BACKGROUND:Children continue to suffer from the impact of the human immunodeficiency virus-acquired immunodeficiency syndrome (HIV/AIDS) pandemic. In Cape Town, these children receive medical care including antiretroviral therapy from facilities like Tygerberg Hospital's Paediatric Infectious Diseases Clinic. HIV-infected children may experience an increased caries experience when compared with their healthy peers. ... Read more >>

Clin Exp Dent Res (Clinical and experimental dental research)
[2020, 6(1):75-81]

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Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants.

Maria Elisabetta Baldassarre, Antonio Di Mauro, Maria Cristina Pignatelli, Margherita Fanelli, Silvia Salvatore, Giovanni Di Nardo, Andrea Chiaro, Licia Pensabene, Nicola Laforgia,

The aims of this study were to evaluate the efficacy of magnesium alginate in decreasing functional regurgitation symptoms in infants, and to assess the cost-benefit ratio of magnesium alginate compared to a thickened formula. A multicenter perspective cross-over study was conducted in formula-fed infants with persisting regurgitation, randomly assigned to ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 17(1):]

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Hyperinsulinaemic hypoglycaemia: A rare association of vanishing white matter disease.

Carolyn Bursle, Eppie M Yiu, Alison Yeung, Jeremy L Freeman, Chloe Stutterd, Richard J Leventer, Adeline Vanderver, Joy Yaplito-Lee,

We report two unrelated patients with infantile onset leukoencephalopathy with vanishing white matter (VWM) and hyperinsulinaemic hypoglycaemia. To our knowledge, this association has not been described previously. Both patients had compound heterozygous pathogenic variants in EIF2B4 detected on exome sequencing and absence of other variants which might explain the hyperinsulinism. ... Read more >>

JIMD Rep (JIMD reports)
[2020, 51(1):11-16]

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Healthy ageing in the far North: perspectives and prescriptions.

Jennifer R Peterson, Didar A Baumgartner, Sabrina L Austin,

Objectives: This study captured factors integral to healthy ageing in central Alaska. To date, conceptual models fail to meaningfully address how healthy ageing is impacted by location and context, particularly in remote or sparsely populated areas. The way "healthy", or "successful", ageing is defined in an extreme environment, and how ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1735036]

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Genetic Disorders Associated with Metal Metabolism.

Muhammad Umair, Majid Alfadhel,

Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some disorders have moderate to severe ... Read more >>

Cells (Cells)
[2019, 8(12):]

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