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Ethanol Toxicity

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In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Ashok Aspatwar, Milka Hammaren, Mataleena Parikka, Seppo Parkkila, Fabrizio Carta, Murat Bozdag, Daniela Vullo, Claudiu T Supuran,

We investigated a panel of 14 compounds belonging to the monothiocarbamate (MTC) and dithiocarbamate (DTC) series against the β-carbonic anhydrase 3 (β-CA3) of Mycobacterium tuberculosis (Mtb). We also evaluated all compounds for toxicity using 1-5-day post fertilisation zebrafish embryos. 11 out of the 14 investigated derivatives showed effective nanomolar or ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):65-71]

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Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum,

With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against human CA I, CA II and CA IX. We also evaluated the toxicity of ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):109-117]

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Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents.

Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin, Fuliang Cao,

Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):216-227]

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Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent.

Fabrice Pagniez, Nicolas Lebouvier, Young Min Na, Isabelle Ourliac-Garnier, Carine Picot, Marc Le Borgne, Patrice Le Pape,

(2-(2,4-Dichlorophenyl)-3-(1H-indol-1-yl)-1-(1,2,4-1H-triazol-1-yl)propan-2-ol (8 g), a new 1,2,4-triazole-indole hybrid molecule, showed a broad-spectrum activity against Candida, particularly against low fluconazole-susceptible species. Its activity was higher than fluconazole and similar to voriconazole on C. glabrata (MIC90 = 0.25, 64 and 1 µg/mL, respectively), C. krusei (MIC90 = 0.125, 64 and 0.125 µg/mL, respectively) and C. albicans ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):398-403]

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Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control.

Xin Wang, Kaiyuan Deng, Cheng Wang, Yao Li, Tianqi Wang, Zhi Huang, Yakun Ma, Peiqing Sun, Yi Shi, Shengyong Yang, Yan Fan, Rong Xiang,

A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identification of compound X22 with a nanomolar potency against CDK4 and CDK9 and potent antiproliferative ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):414-423]

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Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin.

Yili Ding, Yuchang Pang, Chamakura V N S Vara Prasad, Bingyun Wang,

Enrofloxacin, a third-generation fluoroquinolone, is a broad-spectrum antimicrobial drug against a lot of veterinary bacterial diseases. However, bactericidal activity of enrofloxacin is concentration-dependent and its poor aqueous solubility and bitter taste limit its development and application. Meanwhile, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used cyclodextrin analog, is a safe and an effective ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):334-343]

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Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling.

Guohua Zhu, Qun Shen, Hong Jiang, Ou Ji, Lingling Zhu, Linyang Zhang,

Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Materials and methods: The SHI-1 cells (1 × 106 cells ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):25-34]

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Genome-wide transcriptional analysis of Aristolochia manshuriensis induced gastric carcinoma.

Lianmei Wang, Chunying Li, Jingzhuo Tian, Jing Liu, Yong Zhao, Yan Yi, Yushi Zhang, Jiayin Han, Chen Pan, Suyan Liu, Nuo Deng, Zhong Xian, Guiqin Li, Xin Zhang, Aihua Liang,

Context: Aristolochia manshuriensis Kom (Aristolochiaceae) (AMK) is known for toxicity and mutagenicity.Objective: The tumorigenic role of AMK has yet to be understood.Materials and methods: AMK extracts were extracted from root crude drug. SD (Sprague Dawley) rats underwent gavage with AMK (0.92 g/kg) every other day for 10 (AMK-10) or 20 (AMK-20) ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):98-106]

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Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.

Hang Pong Ng, Scott Jennings, Steve Nelson, Guoshun Wang,

Alcohol differentially affects human health, depending on the pattern of exposure. Moderate intake provides beneficial mood modulation and an anti-inflammatory effect, while excessive consumption leads to immunosuppression and various alcohol use disorders. The mechanism underlying this bi-phasic action mode of alcohol has not been clearly defined. Our previous publication demonstrated ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:53]

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Sub-chronic toxicity study of ethanol stem-bark extract of Blighia sapida (Sapindaceae) in wistar rats.

M B Adekola, J O Areola, N O Omisore, F T Asaolu, S G Ogunleye, O E Apalowo, O O Babalola,

Blighia sapida has been used in the treatment of different pathologies. The study aimed at evaluating the acute and sub-chronic toxicity of ethanol stem-bark extract of B. sapida. The acute toxicity was evaluated by gavage administration at single dose and the extract was also administered at doses of 250, 500 and ... Read more >>

Heliyon (Heliyon)
[2020, 6(2):e02801]

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Toxicological assessments of an ethanol extract complex of Descurainia sophia and Peucedanum praeruptorum: Subacute oral toxicity and genotoxicity studies.

Eun-Sang Cho, Sarah Shin, You Jin Lee, No Soo Kim, Jinhee Kim, Seok-Jong Lee, Hwa-Young Son, Woo-Joo Lee, Ok-Sun Bang,

An ethanol extract complex of Descurainia sophia seeds and Peucedanum praeruptorum roots, called BP10A, has antitumor potential against colorectal cancer. In the present study, we evaluated the 28-day oral toxicity and the genotoxicity of BP10A. The subacute toxicity test was done through oral administration to mice. ICR mice (n = ... Read more >>

J Appl Toxicol (Journal of applied toxicology : JAT)
[2020, :]

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Ethanol introduced synthesis of ultrastable 1T-MoS2 for removal of Cr(VI).

Zeyang Li, Ruoyu Fan, Zhi Hu, Wenchao Li, Hongjian Zhou, Shenghong Kang, Yunxia Zhang, Haimin Zhang, Guozhong Wang,

Metallic 1T phase of MoS2 (1T-MoS2) has aroused great concern for decontamination of heavy metal ions from water. Herein, ultrastable 1T-MoS2 was successfully achieved via a gentle two-stage solvothermal strategy utilizing water and ethanol as solvent for efficient removal of Cr(VI). Notably, nearly 100 % 1T-MoS2 was obtained, and it ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2020, 394:122525]

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Data on the relationship between acetone, ethylene glycol, isopropanol, methanol, and propylene glycol serum/plasma concentrations and osmolal gaps in patients at an academic medical center.

Heather R Greene, Matthew D Krasowski,

Ingestion of toxic alcohols other than ethanol (ethylene glycol, methanol, isopropanol, and propylene glycol) can cause life-threatening complications including altered level of consciousness, respiratory depression, and organ damage from metabolites. Many hospitals lack the ability to specifically analyze these compounds using gas chromatography, gas chromatography/mass spectrometry, or by enzymatic assays ... Read more >>

Data Brief (Data in brief)
[2020, 29:105189]

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Hexanol biosynthesis from syngas by Clostridium carboxidivorans P7 is enhanced by in‑line extraction with a biocompatible solvent to avoid product toxicity

Stefan Jennewein, Patrick Kottenhahn, Gabriele Philipps,

<title>Abstract</title> <p> <bold>Background</bold> <italic>Clostridium carboxidivorans</italic> P7 has the rare ability to metabolize syngas – a mixture of H<sub>2</sub>, CO and CO<sub>2</sub> – by converting it directly into industrially relevant alcohols (hexanol, butanol and ethanol) and the corresponding acids (caproate, butyrate and acetate). The product titers and ratios are ... Read more >>

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Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane.

Angela Cirigliano, Antonia Amelina, Beatrice Biferali, Alberto Macone, Chiara Mozzetta, Michele Maria Bianchi, Mattia Mori, Bruno Botta, Elah Pick, Rodolfo Negri, Teresa Rinaldi,

The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in a wide medical use, yet statins treatment could induce side effects as hepatotoxicity and myopathy in ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):129-137]

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6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes.

Tomoya Kitakaze, Sihao Yuan, Masako Inoue, Yasukiyo Yoshioka, Yoko Yamashita, Hitoshi Ashida,

In the body, alcohol dehydrogenase rapidly converts ethanol to its toxic metabolite, acetaldehyde, which is further metabolized to non-toxic acetic acid by aldehyde dehydrogenase (ALDH). 6-(methylsulfinyl)hexyl isothiocyanate (6-MSITC), a major bioactive compound in Wasabi (Wasabia japonica) has various physiological effects such as anti-oxidative, anti-inflammatory and anti-cancer effects. However, the effect ... Read more >>

Arch. Biochem. Biophys. (Archives of biochemistry and biophysics)
[2020, :108329]

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Causes and possibilities to circumvent cyclophosphamide toxicity.

Georg Voelcker,

Cyclophosphamide is an inert prodrug converted into 4-hydroxycyclophosphamide (OHCP) by hepatic hydroxylation. OHCP is in equilibrium with its tautomeric aldophosphamide (ALDO). From ALDO, the cytotoxic active metabolites are formed enzymatically by phosphodiesterases; these are the alkylating metabolite phosphoramide mustard (PAM) and the proapoptotic aldehyde 3-hydroxypropanal (HPA). PAM damages the DNA ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2020, :]

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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats.

Jeong-Hyun Yoo, Eun-Jung Park, So Hyeun Kim, Hae-Jeung Lee,

Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity.

Qi-Yuan Shan, Xia-Nan Sang, Hui Hui, Qi-Yang Shou, Hui-Ying Fu, Min Hao, Kao-Hua Liu, Qiao-Yan Zhang, Gang Cao, Lu-Ping Qin,

Herbal medicine is a major part of traditional Chinese medicine (TCM), which is evolved as a system of medical practice from ancient China. The use of herbal medicine is mainly based on practice and theories and concepts rooted in ancient philosophy. In the era of evidence-based medicine, it is essential ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:133]

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Rethinking the role of lipids in lager yeast cell during beer fermentation from a transcriptome and systems biology perspective

Diego Bonatto,

Abstract Brewing lager yeasts ( Saccharomyces pastorianus ) should deal with stressful conditions during beer fermentation, including ethanol toxicity. In response to ethanol toxicity, different biological mechanisms are modulated, including lipid biosynthesis. It is well known that during beer fermentation, the composition of yeast membranes change in response to ethanol ... Read more >>

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Immunohistochemical and histological evaluations of cyclophosphamide-induced acute cardiotoxicity in wistar rats: The role of turmeric extract (curcuma).

O A Komolafe, B E Arayombo, A A Abiodun, O S Saka, A Z Abijo, S K Ojo, O O Fakunle,

Chemotherapy-induced cardiac derangement is a major concern in health sector. Cyclophosphamide as a chemotherapeutic agent induces acute cardiotoxicity through its toxic metabolite, acrolein. This study evaluated the effect of ethanol extract of turmeric on cyclophosphamide-induced acute cardiotoxicity in Wistar rats. Thirty-five healthy Wistar rats, weighing 200-250g were randomly assigned into ... Read more >>

Morphologie (Morphologie : bulletin de l'Association des anatomistes)
[2020, :]

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Sequestration and Elimination of Toxic Aldehydes.

Herbert T Nagasawa, Robert J Valentekovich, Scott G Nagasawa, Richard H Nagasawa,

It is well-known that aldehydes resulting from the in vivo oxidation of primary alcohols are toxic. Here, we experimentally demonstrate in rat models that the dipeptide cysteinylglycine (CG), formed in vivo from its oxidized product, cystinyl-bis-glycine (CbG), will sequester acetaldehyde and isoamyl aldehyde, two model aldehydes resulting from the oxidation ... Read more >>

Chem. Res. Toxicol. (Chemical research in toxicology)
[2020, 33(3):764-768]

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Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: possible role of nitric oxide isoforms and inflammatory cytokines.

Swati Chaturvedi, Mohd Yaseen Malik, Mamunur Rashid, Sandeep Singh, Virendra Tiwari, Parul Gupta, Shubha Shukla, Sarika Singh, Muhammad Wahajuddin,

AIM:Metronidazole, a nitroimidazole derived antibiotic used to treat many bacterial infections, is reported to penetrate the blood brain barrier after long term administration resulting into neuronal toxicity. Further, quercetin, a polyphenol flavonoid is reported to exhibit neuroprotective activity but its pharmacodynamics interaction against metronidazole induced neurotoxicity. Therefore, the present study ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.

Giulia Costa, Maria Antonietta De Luca, Gessica Piras, Jacopo Marongiu, Liana Fattore, Nicola Simola,

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):802-816]

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Preparation and surface engineering of CM-β-CD functionalized [email protected] nanoparticles for photocatalytic degradation of polychlorinated biphenyls (PCBs) from transformer oil.

Sanaz Khammar, Nader Bahramifar, Habibollah Younesi,

The aim of the present research is to investigate the efficiency of surface-modified magnetic nanoparticles for photocatalytic degradation of PCBs from transformer oil. Therefore, [email protected] was successfully produced via grafting of carboxymethyl-β-cyclodextrin (CM-β-CD) onto the core-shell titania magnetic nanoparticles surface. The photocatalytic efficiency of [email protected] for degradation of PCBs was ... Read more >>

J. Hazard. Mater. (Journal of hazardous materials)
[2020, 394:122422]

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