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Esthesioneuroblastoma

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Chemotherapy in Esthesioneuroblastoma/Olfactory Neuroblastoma: An Analysis of the Surveillance Epidemiology and End Results (SEER) 1973-2015 Database.

Lee D Cranmer, Bonny Chau, Jason K Rockhill, Manuel Ferreira, Jay J Liao,

OBJECTIVE:Chemotherapy has been proposed as an adjunct to primary local therapy in esthesioneuroblastoma (ENB)/olfactory neuroblastoma (ON), but its role has not been precisely defined. Here, we evaluated its role in ENB treatment. MATERIALS AND METHODS:The Surveillance Epidemiology and End Results (SEER) database was queried for ENB/ON (International Classification of Diseases-3 ... Read more >>

Am. J. Clin. Oncol. (American journal of clinical oncology)
[2020, 43(3):203-209]

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Adrenocorticotropic Hormone-Secreting Esthesioneuroblastoma with Ectopic Cushing's Syndrome.

Young Soo Chung, Minkyun Na, Cheol Ryong Ku, Se Hoon Kim, Eui Hyun Kim,

Esthesioneuroblastoma as a source of ectopic Cushing's syndrome is rare, and to the best of our knowledge, only 20 cases have been reported worldwide. A 46-year-old healthy man visited a local clinic for general weakness and hyposmia, and underwent examination with serial endocrinological workup and brain imaging. 68Gallium-DOTA-TOC positron emission ... Read more >>

Yonsei Med. J. (Yonsei medical journal)
[2020, 61(3):257-261]

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Correction to: advanced olfactory neuroblastoma in a teenager: a clinical case and short review of literature.

Gino Amleto Pacino, Salvatore Cocuzza, Antonino Maniaci, Maria Cristina Da Mosto, Piero Pavone, Giacomo Spinato,

The original version of this article unfortunately contained an error. The author apologizes for having communicated an interchanged author's first and family names. Given in this article are the correct author names. ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Prognostic factors and outcomes of multimodality treatment in olfactory neuroblastoma.

Xinmao Song, Jie Wang, Shengzi Wang, Li Yan, Yi Li,

OBJECTIVE:The clinical data on olfactory neuroblastomas (ONBs) are scarce owing to their rarity. This study aimed to assess the potential prognostic factors, outcomes, and optimal treatment strategies in patients with ONB. METHODS AND MATERIALS:The data of 217 patients with ONB between 1991 and 2019 were retrospectively reviewed. Long-term survival, potential ... Read more >>

Oral Oncol. (Oral oncology)
[2020, 103:104618]

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Extensive tumor calcification in response to pre-operative reductive chemotherapy in pediatric esthesioneuroblastoma: a case report.

Michael M McDowell, Souvik Roy, Ezequiel Goldschmidt, Paul A Gardner, Elizabeth Tyler-Kabara, Carl H Snyderman,

Esthesioneuroblastomas are uncommon tumors in pediatric patients and are typically treated with multimodal therapy. Changes in gross tumor quality and character in response to adjuvant treatment have not been clearly reported. We report the case of a 15-year-old female with a diagnosis of Kadish stage C esthesioneuroblastoma who was treated ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Advanced olfactory neuroblastoma in a teenager: a clinical case and short review of literature.

Gino Amleto Pacino, Cocuzza Salvatore, Maniaci Antonino, Da Mosto Maria Cristina, Pavone Piero, Spinato Giacomo,

BACKGROUND:Olfactory neuroblastoma, also called esthesioneuroblastoma (ONB), is a rare neuroectodermal neoplasm that originates from the olfactory epithelium of the nose-sinus tract. It generally occurs with epistaxis, nasal obstruction, diplopia, and anosmia. METHODS:A 16-year-old female was admitted to our Unit with a complaint of nasal obstruction, recurrent epistaxis, anosmia, and intermittent ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, 36(3):485-489]

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Efficacy of Peptide Receptor Radionuclide Therapy for Esthesioneuroblastoma.

Olfat Kamel Hasan, Aravind S Ravi Kumar, Grace Kong, Kira Oleinikov, Simona Ben-Haim, Simona Grozinsky-Glasberg, Rodney J Hicks,

Objectives: Esthesioneuroblastoma (ENB) is rare with limited therapeutic options when unresectable or metastatic; however, expression of somatostatin receptors qualifies it for peptide receptor radionuclide therapy (PRRT). We report outcomes of PRRT in ENB from two referral centers. Methods: Using PRRT databases at two European Neuroendocrine Tumour Society Centers of Excellence, ... Read more >>

J. Nucl. Med. (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2020, :]

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Rare neural crest tumor in teleost species: olfactory neuroblastoma in a spotted pike-characin Boulengerella maculata.

Amelia C Gould, Martin Haulena, Michael Pawlik, Véronique LePage, Augustin Mareschal, Michael R M Manalang, Heindrich Snyman,

One spotted pike-characin Boulengerella maculata, managed in a public display aquarium for 7 yr, developed a small unilateral pink growth associated with the right nare. The growth eventually extended through both nares after 5 mo. B. maculata is a species of piscivorous fish that relies on visual acuity when hunting ... Read more >>

Dis. Aquat. Org. (Diseases of aquatic organisms)
[2020, 138:29-33]

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[Analysis of the effect of endoscopic surgery combined with conventional surgery in Neuroblastoma].

Wei Gao, Yinfeng Wang, Yalin Wang, Tao Guo, Xianguang Li, Fei Yin, Chunchen Pan, Jingwu Sun,

Objective:The aim of this study is to evaluate the efficacy of endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma. Method:Forty-three patients with olfactory neuroblastoma undergoing surgery combined with radiotherapy were retrospectively analyzed. The patients were divided into endoscopic surgery and conventional surgery. All patients received ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2020, 34(2):128-130]

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Olfactory neuroblastoma pulmonary metastasis presenting as a solitary pulmonary mass in an adult: A case report with pathologic correlation.

Thangavijayan Bosemani, Dimitri G Trembath,

Pulmonary metastasis of an esthesioneuroblastoma is uncommon. In this report, we present a case of an esthesioneuroblastoma pulmonary metastasis in an adult. A 39-year-old man treated with surgical resection of olfactory neuroblastoma was found to have a solitary pulmonary mass on a surveillance computed tomography scan performed 5 years after ... Read more >>

Radiol Case Rep (Radiology case reports)
[2020, 15(4):330-333]

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Pattern of loco-regional relapses and treatment in pediatric esthesioneuroblastoma: The French very rare tumors group (Fracture) contribution.

Benoît Dumont, Brice Fresneau, Line Claude, Anne-Sophie Defachelles, Vincent Couloigner, Stéphanie Puget, Hervé J Brisse, Paul Fréneaux, Brigitte Lacour, Daniel Orbach,

BACKGROUND:Esthesioneuroblastoma (ENB) is a rare neuroectodermal tumor that seldom occurs during childhood. Multimodal treatments are currently proposed, but the place of each therapy is still in debate. Our objective is to describe clinical evolution, especially the pattern of relapses and determine contributors to tumor progression. PROCEDURE:Medical charts of all children ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(4):e28154]

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Fibroblast Growth Factor 23-Producing Phosphaturic Mesenchymal Tumor with Extraordinary Morphology Causing Oncogenic Osteomalacia.

Cornelia Then, Evelyn Asbach, Harald Bartsch, Niklas Thon, Christian Betz, Martin Reincke, Ralf Schmidmaier,

A possible cause of hypophosphatemia is paraneoplastic secretion of fibroblast growth factor 23 (FGF-23). Tumors secreting FGF-23 are rare, mostly of mesenchymal origin, usually benign, and may be located anywhere in the body, including hands and feet, which are often not represented in conventional imaging. A 50-year-old woman presented with ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(1):]

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Multimodal strategy for the management of sphenoid osteoradionecrosis: Preliminary results.

Hannah Daoudi, Marc A Labeyrie, Sophie Guillerm, Sylvie Delanian, Jean-Pierre Guichard, Clément Jourdaine, Sandrine Faivre, Helene Gauthier, François-Régis Ferrand, Benjamin Verillaud, Philippe Herman,

Objective:Osteoradionecrosis (ORN) of the sphenoid is a rare but potentially lethal complication that can occur after irradiation of nasopharyngeal and clival malignancies. The objective of this study was to describe a multimodal treatment strategy tailored to the clinical signs and to the radiological extent of the disease, and to report ... Read more >>

Laryngoscope Investig Otolaryngol (Laryngoscope Investigative Otolaryngology)
[2020, 5(1):19-23]

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[Treatment of primary craniofacial (sinonasal) malignant tumors affecting the anterior and middle skull base].

D S Spirin, I V Chernov, V A Cherekaev, P L Kalinin, V V Nazarov, I A Muzyshev, O V Absalyamova, G L Kobyakov, E R Vetlova,

Sinonasal malignant tumors are characterized by high histological variability and complexity of the differential diagnosis. Currently, there are classifications of these tumors, which are based on their localization and involvement of various anatomical structures. However, generally accepted algorithms for treatment of this pathology have not yet been developed. This review ... Read more >>

Zh Vopr Neirokhir Im N N Burdenko (Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko)
[2020, 84(1):101-108]

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Neck management in patients with olfactory neuroblastoma.

Xinmao Song, Chuang Huang, Shengzi Wang, Li Yan, Jie Wang, Yi Li,

OBJECTIVE:Optimal neck management in patients with olfactory neuroblastoma (ONB), a rare malignancy, remains uncertain. This study aimed to analyse patterns of cervical lymph node metastases and corresponding clinical outcomes and to investigate the value of elective neck irradiation (ENI) in this population. METHODS AND MATERIALS:This study retrospectively reviewed clinical records, ... Read more >>

Oral Oncol. (Oral oncology)
[2020, 101:104505]

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[Spectrum analysis of pathological classification in 463 cases with nasal and paranasal sinuses malignant tumors].

J Li, H Yuan, Y Li, X Q Zhao, L Chen, M K Han, C Q Liu, Q Liu, H T Wang, Q Zhong, B Feng,

Objective:The characteristics of pathological histological classification of nasal and paranasal sinuses malignant tumors in the past 10 years were analyzed, so as to provide possible basis, direction and ideas for the development of relevant effective treatment measures for nasal and paranasal sinuses malignant tumors in clinical practice. Method:The clinical data ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2019, 33(12):1176-1180]

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Expression of Programmed Cell Death Ligand 1 and Associated Lymphocyte Infiltration in Olfactory Neuroblastoma.

Nyall R London, Lisa M Rooper, Justin A Bishop, Haiying Xu, Lydia J Bernhardt, Masaru Ishii, Christine L Hann, Janis M Taube, Evgeny Izumchenko, Daria A Gaykalova, Gary L Gallia,

BACKGROUND:Programmed cell death ligand 1 (PD-L1) is a transmembrane glycoprotein that interacts with the receptor programmed cell death 1 (PD-1) to suppress T-cell activation, reduce adjacent tissue damage, and promote tolerance to self-antigens. Tumors may express PD-L1 as a mechanism to evade immune detection. Recent clinical trials have demonstrated the ... Read more >>

World Neurosurg (World neurosurgery)
[2020, 135:e187-e193]

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Cranio-Orbital and Orbitocranial Approaches to Orbital and Intracranial Disease: Eye-Opening Approaches for Neurosurgeons.

Hussam Abou-Al-Shaar, Khaled M Krisht, Michael A Cohen, Abdullah M Abunimer, Jayson A Neil, Michael Karsy, Gmaan Alzhrani, William T Couldwell,

Orbital approaches for targeting intracranial, orbital, and infratemporal disease have evolved over the years in an effort to discover safe, reliable, effective, and cosmetically satisfying surgical corridors. The surgical goals of these approaches balance important factors such as proximity of the lesion to the optic nerve, the degree of anticipated ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:1]

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Remote Leptomeningeal Dissemination in Olfactory Neuroblastoma Mimicking Multiple Parasagittal Meningiomas: Diagnostic and Therapeutic Challenge.

Rafael Martinez-Perez, Douglas A Hardesty, Joshua Palmer, Marcus Zachariah, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello,

BACKGROUND:Olfactory neuroblastoma (ON) is a highly aggressive and locally recurrent neoplasm. Distant systemic metastases are not uncommon, but remote leptomeningeal dissemination is extremely rare. CASE DESCRIPTION:We report 2 cases of ON previously treated with endoscopic endonasal radical surgical resection and radiotherapy. After a relatively long period of disease-free survival, multiple ... Read more >>

World Neurosurg (World neurosurgery)
[2020, 134:361-364]

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Electronic tumor board presentations as the basis for the development of a head and neck cancer database.

Mahalakshmi Rangabashyam, Hide E Wee, Weining Wang, Stefan Mueller, Khairul A B A Karim, Thakshayeni Skanthakumar, Bhuvaneshwari Hariraman, Kiattisa Sommat, Yoke-Lim Soong, Melvin L K Chua, Gerald Tay, Ngian-Chye Tan, Hiang Khoon- Tan, N Gopalakrishna Iyer,

Background:Multidisciplinary team meetings or tumor boards (TBs) form a pivotal component of oncology practice. The crux of a TB revolves around making treatment decisions based on succinct head and neck cancer (HNC) patient data presentations, which can be challenging and complex. Apart from meticulous TB presentations, discussions and treatment plan ... Read more >>

Laryngoscope Investig Otolaryngol (Laryngoscope Investigative Otolaryngology)
[2020, 5(1):46-54]

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Olfactory neuroblastoma (esthesioneuroblastoma) presenting as ectopic ACTH syndrome: always follow your nose.

Karen Decaestecker, Veerle Wijtvliet, Peter Coremans, Nike Van Doninck,

Summary:ACTH-dependent hypercortisolism is caused by an ectopic ACTH syndrome (EAS) in 20% of cases. We report a rare cause of EAS in a 41-year-old woman, presenting with clinical features of Cushing's syndrome which developed over several months. Biochemical tests revealed hypokalemic metabolic alkalosis and high morning cortisol and ACTH levels. ... Read more >>

Endocrinol Diabetes Metab Case Rep (Endocrinology, diabetes & metabolism case reports)
[2019, 2019:]

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Evaluating the prognostic potential of the Ki67 proliferation index and tumour-infiltrating lymphocytes in olfactory neuroblastoma.

Marion Classe, Alice Burgess, Sophie El Zein, Michel Wassef, Philippe Herman, Geoffrey Mortuaire, Xavier Leroy, Gabriel G Malouf, Benjamin Verillaud,

AIMS:Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, the Hyams grade remains the only widely used histological grading system. However, it is based only on morphological criteria, and has not been updated since 1988. The objective of this study was to explore the ... Read more >>

Histopathology (Histopathology)
[2019, 75(6):853-864]

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What is your diagnosis? Maxillary sinus mass in a young Lowline Angus bull.

Jessica K Wong, Meaghan V Eren, Ashley L Hanna, Ashley R Bredenberg, Kyle R Taylor,

Vet Clin Pathol (Veterinary clinical pathology)
[2019, :]

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Use of 68Ga DOTATATE, a new molecular imaging agent, for neuroendocrine tumors.

Raymond Andrew LeBlanc, Umesh D Oza, Ryan Hayden, Hanna Fanous,

Neuroendocrine tumors (NET), such as insulinomas and carcinoid tumors, can be challenging to diagnose since patients often present with vague symptoms. Adding to the challenge, these tumors are often occult on typical cross-sectional imaging modalities. Because of these challenges, there has been an increase in the utilization of radiopharmaceuticals that ... Read more >>

Proc (Bayl Univ Med Cent) (Proceedings (Baylor University. Medical Center))
[2020, 33(1):51-52]

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Radiotherapy in Leptomeningeal Disease: A Systematic Review of Randomized and Non-randomized Trials.

Samantha M Buszek, Caroline Chung,

Background: Leptomeningeal disease (LMD), also known as neoplastic meningitis, leptomeningeal carcinomatosis, or carcinomatous meningitis, is a rare cancer complication occurring in ~5% of cases and ultimately leads to significant morbidity and mortality. In the modern era, incidence of this condition continues to rise with longer survival of patients with advanced ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1224]

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