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MicroRNA-155 acts as a diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma.

Ying-Juan Zheng, Tian-Song Liang, Juan Wang, Jing-Yi Zhao, Su-Nan Zhai, Dao-Ke Yang, Li-Dong Wang,

MicroRNA-155 is over-expressed in many human cancers, but researches on its association with malignant oesophageal squamous cell carcinoma (ESCC) are limited. The aim of the present study was to evaluate the potential value of miR-155 as a biomarker for ESCC diagnosis and prognosis. In this study, we found that miR-155 ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):977-982]

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Dexmedetomidine suppresses the progression of esophageal cancer via miR-143-3p/epidermal growth factor receptor pathway substrate 8 axis.

Peisen Zhang, Hefan He, Yuyan Bai, Weifeng Liu, Lirong Huang,

Esophageal cancer is one of the fatal cancers around the world. Dexmedetomidine (DEX) is widely used during anesthesia of esophageal cancer surgery. Nevertheless, the role of DEX in the progression of esophageal cancer remains barely known. The proliferation, apoptosis and metastasis of esophageal cancer cells were detected by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2020, 31(7):693-701]

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[Chinese expert consensus on multiple primary cancers of hypopharynx and esophagus].

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Hypopharyngeal cancer and esophageal cancer often occur synchronously or metachronously. Timely screening, diagnosis and individual treatment are important to improve the prognosis of patients. At present, there is no clinical guideline or consensus in this cross-cutting area in China, and there is a need of consistent diagnosis and treatment recommendation ... Read more >>

Zhonghua Wai Ke Za Zhi (Zhonghua wai ke za zhi [Chinese journal of surgery])
[2020, 58(8):589-595]

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The Nissen-Sleeve (N-Sleeve): Results of a Cohort Study.

Imed Ben Amor, Vincent Casanova, Geoffroy Vanbiervliet, Jean Marc Bereder, Richard Habitan, Radwan Kassir, Jean Gugenheim,

BACKGROUND:The Montpellier bariatric team has recently proposed some technical alternatives to decrease the rate of gastroesophageal reflux disease (GERD) after bariatric surgery and also to offer patients an alternative in case of contraindication to Roux-en-Y gastric bypass (RYGBP): the Nissen-Sleeve (N-Sleeve). OBJECTIVES:We present here the results from a cohort of ... Read more >>

Obes Surg (Obesity surgery)
[2020, 30(9):3267-3272]

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Verification of oncological local control for hand-assisted laparoscopic abdominal lymph node dissection in esophageal cancer surgery: a propensity score-matched analysis.

Yutaka Miyawaki, Hiroshi Sato, Naoto Fujiwara, Junya Aoyama, Shuichiro Oya, Hirofumi Sugita, Yasumitsu Hirano, Shinichi Sakuramoto, Kojun Okamoto, Shigeki Yamaguchi, Isamu Koyama,

BACKGROUND:In esophageal cancer, long-term outcomes of minimally invasive surgery using endoscopic surgery are currently being verified. However, most trials have compared thoracic procedures; few studies have focused on the abdominal procedures, which are important for lymph node dissection in radical esophageal cancer surgery. Hand-assisted laparoscopic surgery (HALS) is a simple ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2020, :]

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Associations of dietary carbohydrate and salt consumption with esophageal cancer risk: a systematic review and meta-analysis of observational studies.

Kondwani-Joseph Banda, Hsiao-Yean Chiu, Sophia Hueylan Hu, Hsiu-Chun Yeh, Kuan-Chia Lin, Hui-Chuan Huang,

CONTEXT:Evidence has shown that essential nutrients are highly correlated with the occurrence of esophageal cancer (EC). However, findings from observational studies on the associations between dietary carbohydrate, salt consumption, and the risk of EC remain controversial. OBJECTIVE:The aim of this study was to conduct a systematic review and meta-analysis to ... Read more >>

Nutr. Rev. (Nutrition reviews)
[2020, 78(8):688-698]

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Trends in incidence and mortality of esophageal cancer in Inner Mongolia, 2010-2015.

Yunfeng Xi, Weiqi Dong, Liying Qiao, Ke Han, Wenjie Chen, Wenrui Wang,

BACKGROUND:Esophageal cancer is among the leading cancer types in Inner Mongolia. This study aimed to investigate the incidence and mortality rates of esophageal cancer in 2015 and the trends in these rates in the 2010-2015 period in this region. METHODS:National Colorectal Cancer Roundtable (NCCR) screening methods and criteria were used ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, :]

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Interaction Between Ethnicity and Helicobacter pylori Infection in the Occurrence of Reflux Disease.

Amnon Sonnenberg, Kevin O Turner, Robert M Genta,

BACKGROUND AND AIMS:Few reports are available to reliably assess the ethnic distribution of Barrett metaplasia and reflux esophagitis. The present study served to analyze the joint influence of Helicobacter pylori infection and patient demographics on the diagnoses of Barrett metaplasia and reflux esophagitis. METHODS:The Inform Diagnostics database is a national ... Read more >>

J. Clin. Gastroenterol. (Journal of clinical gastroenterology)
[2020, 54(7):614-619]

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Hazard Curves for Tumor Recurrence and Tumor-Related Death Following Esophagectomy for Esophageal Cancer.

Joerg Lindenmann, Melanie Fediuk, Nicole Fink-Neuboeck, Christian Porubsky, Martin Pichler, Luka Brcic, Udo Anegg, Marija Balic, Nadia Dandachi, Alfred Maier, Maria Smolle, Josef Smolle, Freyja Maria Smolle-Juettner,

BACKGROUND:The knowledge of both patterns and risk of relapse following resection for esophageal cancer is crucial for establishing appropriate surveillance schedules. The aim of this study was to evaluate the pattern of hazards for tumor recurrence and tumor-related death in the postoperative long-term follow-up after esophagectomy. METHODS:Retrospective single-center analysis of ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(8):]

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Comparison of End-to-Side Hand-Sewn and Side-to-Side Stapled Cervical Esophagogastric Anastomosis in Patients with Lower Thoracic Esophageal Cancer Undergoing Transhiatal Esophagectomy: An Iranian Retrospective Cohort Study

Seyed Ziaeddin Rasihashemi, Ali Ramouz, Samad Beheshtirouy, Hassan Amini,

Abstract Background: Controversies in terms of efficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the hand-sewn technique as a treatment for patients with esophageal cancer. The purpose of this study was to compare the clinical outcomes of hand-sewn end-to-side esophago-gastrostomy and side-to-side stapled cervical esophagogastric anastomosis after esophagectomy ... Read more >>

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Esophageal Cancer: A Case Study of a Rare Metastatic Esophageal Squamous Cell Carcinoma.

Grace Cullen,

The expected pattern of spread in metastatic esophageal squamous cell carcinoma involves the upper torso and thorax. This article presents an unusual instance of an isolated osseous metastasis of esophageal squamous cell carcinoma to the distal bone of the left ankle and describes the contributions of advanced practice nursing assessment ... Read more >>

Clin J Oncol Nurs (Clinical journal of oncology nursing)
[2020, 24(4):352-355]

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Development of a prognostic model for esophageal cancer based on nine immune related genes

Zhi Zhang, Cheng Chen, Ying Fang, Sheng Li, Xiaohua Wang, Lei Sun, Guoren Zhou, Jinjun Ye,

Abstract Background : Function of the immune system is correlated with the prognosis of the tumor. The effect of immune microenvironment on esophageal cancer (EC) development has not been fully investigated. Methods : This study aimed to explore a prognostic model based on immune-related genes (IRGs) for EC. We obtained ... Read more >>

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Integrated bioinformatics analysis to decipher molecular mechanism of compound Kushen injection for esophageal cancer by combining WGCNA with network pharmacology.

Wei Zhou, Jiarui Wu, Jingyuan Zhang, Xinkui Liu, Siyu Guo, ShanShan Jia, Xiaomeng Zhang, Yingli Zhu, Miaomiao Wang,

Compound Kushen injection (CKI), a medicine in widespread clinical use in China, has proven therapeutic effects on cancer. However, few molecular mechanism analyses have been carried out. To address this problem, bioinformatics approaches combining weighted gene co-expression network analysis with network pharmacology methods were undertaken to elucidate the underlying molecular ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12745]

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Hydroxysafflor Yellow A of Carthamus Tinctorius L., Represses the Malignant Development of Esophageal Cancer Cells via Regulating NF-κB Signaling Pathway.

Xiumei Chen, Yanfang Wang, Lianjun Zhang, Yujun Gao,

Esophageal cancer (EC) is a common digestive tract malignant tumor and the clinical outcome of patients with EC after surgery remains unsatisfactory. Hence, it is necessary to identify some effective drugs or methods to improve the prognosis of patients with EC. In this study, we attempted to analyze the potential ... Read more >>

Cell Biochem. Biophys. (Cell biochemistry and biophysics)
[2020, :]

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Correction to: ASO Author Reflections: Minimally Invasive Esophagectomy for Esophageal Cancer in the Prone and Lateral Position.

Susumu Miura, Yoshihiro Kakeji,

This article is a duplicate publication. It was originally published under. ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, :]

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Hospital volume of esophageal cancer surgery in relation to outcomes from primary anti-reflux surgery.

Sheraz Markar, Giola Santoni, John Maret-Ouda, Jesper Lagergren,

No previous study has sought to identify the effect of hospital volume of esophagectomy on anti-reflux surgery outcomes. The hypothesis under investigation was hospitals performing esophagectomies, particularly those of higher annual volume, have better outcomes from primary anti-reflux surgery. This population-based cohort study included adult individuals (≥18 years) in Sweden receiving ... Read more >>

Dis. Esophagus (Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus)
[2020, :]

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Open, Minimally Invasive, and Robotic Approaches for Esophagectomy: What Is the Approach Algorithm?

Tadeusz D Witek, Thomas J Melvin, James D Luketich, Inderpal S Sarkaria,

Esophageal cancer requires a multimodality treatment approach, with surgical resection a key component in many cases. When it comes to esophagectomy, several approaches and techniques exist, including transhiatal versus transthoracic and open versus minimally invasive. Each approach has its associated risks and advantages. When determining the optimal approach and technique, ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2020, 30(3):269-277]

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Multidisciplinary treatment of esophageal cancer: The role of active surveillance after neoadjuvant chemoradiation.

Tania Triantafyllou, Bas Wijnhoven,

The optimal treatment of esophageal cancer is still controversial. Neoadjuvant chemoradiotherapy followed by radical esophagectomy is a standard treatment. Morbidity after esophagectomy however is still considerable and has an impact on patients' quality of life. Given a pathologic complete response rate of approximately 30% in patients after neoadjuvant chemoradiation followed ... Read more >>

Ann Gastroenterol Surg (Annals of gastroenterological surgery)
[2020, 4(4):352-359]

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Prognostic evaluation of esophageal cancer patients with stages I-III.

Meng-Jun Qiu, Sheng-Li Yang, Meng-Meng Wang, Ya-Nan Li, Xin Jiang, Zao-Zao Huang, Zhi-Fan Xiong,

PURPOSE:The purpose of this study was to investigate the impact of clinicopathological factors and treatments on the overall survival (OS) and esophageal cancer-specific survival (ECSS) of stages I-III esophageal cancer (EC) patients and to establish a prognostic visual nomogram. METHODS:We collected clinical data of patients diagnosed with stages I-III EC ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12:]

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A DNA Methylation-based Test for Esophageal Cancer Detection

Sofia Salta, Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nair Lopes, Davide Gigliano, Rita Guimarães, Mónica Farinha, Olga Sousa, Rui Henrique, Carmen Jeronimo,

Abstract Background Esophageal cancer (ECa) is the 7th most incident cancer and the 6th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Biomarkers enabling early cancer detection may improve patient management, treatment effectiveness and survival are urgently needed. In ... Read more >>

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Does Risk of Progression from Barrett's Esophagus to Esophageal Adenocarcinoma Change Based on the Number of Non-dysplastic Endoscopies?

Andrew T Kunzmann, Helen G Coleman, Brian T Johnston, Richard C Turkington, Damian McManus, Lesley A Anderson, Aaron P Thrift,

BACKGROUND:There is a large Barrett's esophagus patient population undergoing endoscopic surveillance. Methods to stratify patients into higher and lower risk groups may enable more varied surveillance intervals for patients with non-dysplastic Barrett's esophagus that could optimize use of endoscopy resources. OBJECTIVE:We aimed to assess whether risk of progression to esophageal ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2020, :]

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Endoscopic surveillance of esophageal cancer before the treatment of achalasia.

Shali Tan, Yan Peng, Xiaowei Tang,

Gastrointest. Endosc. (Gastrointestinal endoscopy)
[2020, 92(2):457-458]

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Quercetin as an anticancer agent: Focus on esophageal cancer.

Amirhossein Davoodvandi, Mohammad Shabani Varkani, Cain C T Clark, Sadegh Jafarnejad,

Esophageal cancer (EC) is regarded as the sixth highest contributor to all cancer-related mortality, worldwide. In spite of advances in the treatment of EC, currently used methods remain ineffective. Quercetin, as a dietary antioxidant, is a plant flavonol from the flavonoid group of polyphenols, and can be found in numerous ... Read more >>

J. Food Biochem. (Journal of food biochemistry)
[2020, :e13374]

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Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: a multi-institutional study.

Suzuki Takashi, Yajima Satoshi, Okamura Akihiko, Yoshida Naoya, Taniyama Yusuke, Murakami Kentaro, Ohkura Yu, Nakajima Yasuaki, Yagi Koichi, Fukuda Takashi, Ogawa Ryo, Hoshino Isamu, Kunisaki Chikara, Narumiya Kosuke, Tsubosa Yasuhiro, Yamada Kazuhiko, Shimada Hideaki,

BACKGROUND:Although the clinicopathological significance of serum p53 antibodies (s-p53-Abs) in esophageal cancer have been evaluated previously, previous reports only analyzed around 100-200 patients. This study was a multi-institutional study promoted by the Japan Esophageal Society to evaluate the clinical significance of preoperative s-p53-Ab status and antibody titers in 1487 esophageal ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2020, :]

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The utility of a methylation panel in the assessment of clinical response to radiofrequency ablation for Barrett's esophagus.

Wladyslaw Januszewicz, Vinod V Subhash, William Waldock, Daniel I Fernando, Giorgio Bartalucci, Hamza Chettouh, Ahmad Miremadi, Maria O'Donovan, Rebecca C Fitzgerald, Massimiliano di Pietro,

BACKGROUND:Radiofrequency ablation (RFA) is an effective treatment for dysplastic Barrett's esophagus (BE), but recurrence can occur after initial response. Currently there is uncertainty about how to best define histological remission. A DNA methylation panel on esophageal samples was previously shown to have high diagnostic accuracy for BE. We aimed to ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 58:102877]

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