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Epileptiform Discharges

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Epileptiform Neuronal Discharges Impair Astrocyte Syncytial Isopotentiality in Acute Hippocampal Slices.

Qi Wang, Wei Wang, Sydney Aten, Conrad M Kiyoshi, Yixing Du, Min Zhou,

Astrocyte syncytial isopotentiality is a physiological mechanism resulting from a strong electrical coupling among astrocytes. We have previously shown that syncytial isopotentiality exists as a system-wide feature that coordinates astrocytes into a system for high efficient regulation of brain homeostasis. Neuronal activity is known to regulate gap junction coupling through ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(4):]

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Effect of interictal epileptiform discharges on EEG-based functional connectivity networks.

Derek K Hu, Andrew Mower, Daniel W Shrey, Beth A Lopour,

OBJECTIVE:Functional connectivity networks (FCNs) based on interictal electroencephalography (EEG) can identify pathological brain networks associated with epilepsy. FCNs are altered by interictal epileptiform discharges (IEDs), but it is unknown whether this is due to the morphology of the IED or the underlying pathological activity. Therefore, we characterized the impact of ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(5):1087-1098]

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The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity.

Vasileios Kokkinos, Robert Mark Richardson, Alexandra Urban,

Front Hum Neurosci (Frontiers in Human Neuroscience)
[2020, 14:]

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Cone Waves: Another Normal Variant Overread as Epileptiform Discharges.

Carolina Cuello Oderiz, Selim R Benbadis,

Eur. Neurol. (European neurology)
[2020, :1-2]

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The intrinsic cell type-specific excitatory connectivity of the developing mouse subiculum is sufficient to generate synchronous epileptiform activity.

Michael Patrick Fiske, Max Anstötz, Leah J Welty, Gianmaria Maccaferri,

KEY POINTS:The activity of local excitatory circuits of the subiculum has been suggested to be involved in the initiation of pathological activity in epileptic patients and experimental animal models of temporal lobe epilepsy. We have taken advantage of multimodal techniques to classify subicular cells in distinct subclasses and have investigated ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2020, :]

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Burden of Epileptiform Activity Predicts Discharge Neurologic Outcomes in Severe Acute Ischemic Stroke.

Mohammad Tabaeizadeh, Hassan Aboul Nour, Maryum Shoukat, Haoqi Sun, Jing Jin, Farrukh Javed, Solomon Kassa, Muhammad Edhi, Elahe Bordbar, Justin Gallagher, Valdery Junior Moura, Manohar Ghanta, Yu-Ping Shao, Andrew J Cole, Eric S Rosenthal, M Brandon Westover, Sahar F Zafar,

BACKGROUND/OBJECTIVES:Clinical seizures following acute ischemic stroke (AIS) appear to contribute to worse neurologic outcomes. However, the effect of electrographic epileptiform abnormalities (EAs) more broadly is less clear. Here, we evaluate the impact of EAs, including electrographic seizures and periodic and rhythmic patterns, on outcomes in patients with AIS. METHODS:This is ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, :]

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Effect of Repetitive Transcranial Magnetic Stimulation on Seizure Frequency and Epileptiform Discharges in Drug-Resistant Epilepsy: A Meta-Analysis.

Archana Mishra, Rituparna Maiti, Biswa Ranjan Mishra, Monalisa Jena, Anand Srinivasan,

BACKGROUND AND PURPOSE:The role of low-frequency repetitive transcranial stimulation (rTMS) in drug-resistant epilepsy (DRE) has been conflicting and inconclusive in previous clinical trials. This meta-analysis evaluated the efficacy of rTMS on seizure frequency and epileptiform discharges in DRE. METHODS:A standard meta-analysis protocol was registered in the International Prospective Register of ... Read more >>

J Clin Neurol (Journal of clinical neurology (Seoul, Korea))
[2020, 16(1):9-18]

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The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study.

Tang Xinghua, Li Lin, Fan Qinyi, Wei Yarong, Pu Zheng, Liu Zhenguo,

BACKGROUD:This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):88]

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Prediction of regaining consciousness despite an early epileptiform EEG after cardiac arrest.

Giuseppina Barbella, Jong Woo Lee, Vincent Alvarez, Jan Novy, Mauro Oddo, Louis Beers, Andrea O Rossetti,

OBJECTIVE:After cardiac arrest (CA), epileptiform EEG, occurring in about 1/3 of patients, often but not invariably heralds poor prognosis. We tested the hypothesis that a combination of specific EEG features identifies patients who may regain consciousness despite early epileptiform patterns. METHODS:We retrospectively analyzed a registry of comatose patients post-CA (2 ... Read more >>

Neurology (Neurology)
[2020, :]

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"Sleep Surge": The impact of sleep onset and offset on epileptiform discharges in idiopathic generalized epilepsies.

Udaya Seneviratne, Alan Lai, Mark Cook, Wendyl D'Souza, Ray C Boston,

OBJECTIVE:To investigate the impact of sleep onset and offset on the rate of epileptiform discharges (ED) in idiopathic generalized epilepsies (IGE). METHODS:We studied the temporal distribution of EDs with mixed-effects Poisson regression modeling in a cohort of patients diagnosed with IGE who underwent 24-hour ambulatory electroencephalography (EEG) recordings. We defined ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(5):1044-1050]

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Landau-Kleffner Syndrome: A Diagnostic Challenge.

Mushtaq Ahmed, Ayesha Saleem, Saad Nasir, Madiha Ariff, Pulwasha Iftikhar,

The Landau-Kleffner syndrome (LKS), formerly known as acquired epileptic aphasia, is a rare syndrome that typically presents in early childhood with language regression and seizures. We report a case of LKS in an 7-year-old boy who presented with aggressive behavior, difficulty in maintaining posture, and language regression. Systemic examination, including neurological ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7182]

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The metabolic hypothesis is more likely than the epileptogenic hypothesis to explain stroke-like lesions

Josef Finsterer,

Stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome but occur in other mitochondrial disorders (MIDs) as well. The morphological equivalent of the SLE is the stroke-like lesion (SLL) on magnetic resonance imaging (MRI). The pathophysiology of SLLs is under debate, but several ... Read more >>

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Contribution of Transferrin and Ceruloplasmin Neurotransmission and Oxidant/Antioxidant Status to the Effects of Everolimus: A Case Series.

Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Shigemi Yoshihara,

Tuberous sclerosis complex (TSC) is a genetic disorder with a high prevalence of associated autism spectrum disorder (ASD). The pathophysiology of TSC mainly involves the hyperactivation of mammalian target of rapamycin (mTOR) induced by TSC1 (hamartin) and TSC2 (tuberin) heterozygosity. The mTOR inhibitor, everolimus, is a therapeutic target for TSC-related ASD. ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6920]

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Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment.

Valerio Brunetti, Aurora D'Atri, Giacomo Della Marca, Catello Vollono, Camillo Marra, Maria Gabriella Vita, Serena Scarpelli, Luigi De Gennaro, Paolo Maria Rossini,

OBJECTIVE:Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. THE AIMS OF OUR STUDY WERE:(A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(5):1011-1018]

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Resection of the suprameatal tubercle in microvascular decompression for trigeminal neuralgia.

Takuro Inoue, Yukihiro Goto, Mustaqim Prasetya, Takanori Fukushima,

BACKGROUND:The suprameatal tubercle (SMT) may obscure the neurovascular compression (NVC) in microvascular decompression (MVD) for trigeminal neuralgia (TGN). The aim of this study is to address the necessity of resecting SMT in MVD for TGN. METHODS:We retrospectively analyzed radiological findings of 461 MVDs in patients with TGN, focusing on the ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2020, :]

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Therapeutic management of stroke-like episodes varies from that of encephalitis.

Josef Finsterer,

INTRODUCTION:Stroke-like episodes (SLEs) are typical cerebral manifestations of certain mitochondrial disorders (MIDs). They are characterised by a vasogenic edema in a non-vascular distribution. PATIENTS CONCERNS:: none DIAGNOSIS:: SLEs show up on cerebral MRI as stroke-like lesions (SLLs), characterised by vasogenic edema in a non-vascular distribution. SLLs expand in the acute ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(8):e19141]

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Etiology and Clinical Impact of Interictal Periodic Discharges on the Routine Outpatient Scalp EEG.

Fábio Carneiro, Carla Bentes, Ana Rita Peralta,

PURPOSE:Periodic discharges (PDs) are common in acute structural or metabolic brain lesions, but their occurrence during follow-up of epileptic patients in an outpatient setting is rare. Aim of this article was to study whether PDs on the routine outpatient scalp EEG of patients with epilepsy, as compared with nonperiodic epileptiform ... Read more >>

J Clin Neurophysiol (Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society)
[2020, :]

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Detection of mesial temporal lobe epileptiform discharges on intracranial electrodes using deep learning.

Maurice Abou Jaoude, Jin Jing, Haoqi Sun, Claire S Jacobs, Kyle R Pellerin, M Brandon Westover, Sydney S Cash, Alice D Lam,

OBJECTIVE:Develop a high-performing algorithm to detect mesial temporal lobe (mTL) epileptiform discharges on intracranial electrode recordings. METHODS:An epileptologist annotated 13,959 epileptiform discharges from a dataset of intracranial EEG recordings from 46 epilepsy patients. Using this dataset, we trained a convolutional neural network (CNN) to recognize mTL epileptiform discharges from a ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2019, 131(1):133-141]

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A novel method for extracting interictal epileptiform discharges in multi-channel MEG: Use of fractional type of blind source separation.

Teppei Matsubara, Naruhito Hironaga, Taira Uehara, Hiroshi Chatani, Shozo Tobimatsu, Kuniharu Kishida,

OBJECTIVE:Visual inspection of interictal epileptiform discharges (IEDs) in multi-channel MEG requires a time-consuming evaluation process and often leads to inconsistent results due to variability of IED waveforms. Here, we propose a novel extraction method for IEDs using a T/k type of blind source separation (BSST/k). METHODS:We applied BSST/k with seven ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(2):425-436]

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Recurrent epileptic seizures following cardiac catheterization with iodixanol: a case report.

Pingping Lei, Weiping He, Quan Shi, Meiying Sun, Zhigang Sun,

BACKGROUND:Contrast-induced encephalopathy (CIE) is a rare complication of cardiac catheterization; clinical manifestations include cortical blindness, seizures and focal neurological deficits. In general, recurrent epileptic seizures following cardiac catheterization with iodixanol occur more rarely than do other complications. CASE PRESENTATION:Here, we report a case of a 76-year-old male patient who experienced ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):79]

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Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome.

Archana Hinduja,

Background: Posterior reversible encephalopathy syndrome (PRES) is an acute neurotoxic syndrome that is characterized by a spectrum neurological and radiological feature from various risk factors. Common neurological symptoms includes headache, impairment in level of consciousness, seizures, visual disturbances, and focal neurological deficits. Common triggering factors include blood pressure fluctuations, renal ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:71]

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What are the epileptic encephalopathies?

Marina Trivisano, Nicola Specchio,

PURPOSE OF REVIEW:To review the evolution of the concept of epileptic encephalopathy during the course of past years and analyze how the current definition might impact on both clinical practice and research. RECENT FINDINGS:Developmental delay in children with epilepsy could be the expression of the cause, consequence of intense epileptiform ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(2):179-184]

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Astrocytic modulation of potassium under seizures.

Fushun Wang, Xiaoming Qi, Jun Zhang, Jason H Huang,

The contribution of an impaired astrocytic K+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade. A defective K+ regulation leads to an elevated extracellular K+ concentration ([K+]o). When [K+]o reaches peaks of 10-12 mM, it is strongly associated with seizure initiation during hypersynchronous neuronal ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):980-987]

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MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons.

Rong Li, Yuetao Wen, Bing Wu, Miaoqing He, Peng Zhang, Qinbin Zhang, Yangmei Chen,

MicroRNA-25-3p (miR-25-3p) has been reported to be closely related with oxidative stress and apoptosis. Here, we aimed to detect the effects of miR-25-3p in the primarily cultured hippocampal neurons. Kainic acid (KA) was used to induce epileptic seizures in the rats. We predicted that oxidative stress responsive 1 (OXSR1) might ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 523(4):859-866]

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Seizures in Patients With Metastatic Brain Tumors: Prevalence, Clinical Characteristics, and Features on EEG.

Shaun Ajinkya, Jonah Fox, Peter Houston, Adam Greenblatt, Alain Lekoubou, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay,

INTRODUCTION:Metastases to the brain (MB) occur in up to 30% of adults with cancer; of these, 15% to 35% may have seizures. We investigated clinical and pathologic associations with seizure and EEG findings in patients with MB, given the sparse literature in this area. METHODS:We performed a retrospective chart review ... Read more >>

J Clin Neurophysiol (Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society)
[2019, :]

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