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Epilepsy

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Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in C. elegans carrying a mutation associated with Alzheimer's disease.

Madeline A Vaji, Guy A Caldwell, Kim A Caldwell,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy.

Madeline A Vaji, Guy A Caldwell, Kim A Caldwell,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Study on the Antiepileptic Effect of Brain Targeting Electric Field on Nano Hydrogel and miR-181.

Min Wang, Jianguo Liu, Masayuki Taira, Fartash Vasefi,

Epilepsy, as a kind of neurological disease, is harmful to human mental health. There are many problems in the corresponding drugs and treatment methods, such as poor targeting, side effects and drug resistance. The conventional treatment of epilepsy is mainly focused on its corresponding electrophysiological mechanism to limit the discharge ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1018-1024]

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UltraHigh Field MR Imaging in Epilepsy.

Gaurav Verma, Bradley N Delman, Priti Balchandani,

More than one million people in the United States suffer from seizures that are not controlled with antiseizure medications. Targeted interventions such as surgery and deep brain stimulation can confer seizure reduction or even freedom in many of these patients with drug-resistant epilepsy, but success critically depends on identification of ... Read more >>

Magn Reson Imaging Clin N Am (Magnetic resonance imaging clinics of North America)
[2021, 29(1):41-52]

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Functional Seizures.

Evie Marcolini, Benjamin Tolchin,

Functional or psychogenic seizures have proved a diagnostic and therapeutic challenge for centuries. Functional seizures can look and feel similar to epileptic seizures but are instead a common and highly disabling form of functional neurologic disorder, or conversion disorder. Consistent with the biopsychosocial model of mental illness, functional seizures are ... Read more >>

Emerg Med Clin North Am (Emergency medicine clinics of North America)
[2021, 39(1):123-132]

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Utilising Automated Electrophysiological Platforms in Epilepsy Research.

Carol J Milligan, Svenja Pachernegg,

Genetic mutations have long been implicated in epilepsy, particularly in genes that encode ion channels and neurotransmitter receptors. Among some of those identified are voltage-gated sodium, potassium and calcium channels, and ligand-gated gamma-aminobutyric acid (GABA), neuronal nicotinic acetylcholine (CHRN), and glutamate receptors, making them key therapeutic targets. In this chapter ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2188:133-155]

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High-Content Drug Discovery Screening of Endocytosis Pathways.

David A Cardoso, Ngoc Chau, Phillip J Robinson,

Endocytosis is the dynamic internalization of cargo (receptors, hormones, viruses) for cellular signaling or processing. It involves multiple mechanisms, classified depending on critical proteins involved, speed, morphology of the derived intracellular vesicles, or substance trafficked. Pharmacological targeting of specific endocytosis pathways has a proven utility for diverse clinical applications from ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2233:71-91]

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RNA Editing in Neurological and Neurodegenerative Disorders.

Pedro Henrique Costa Cruz, Yukio Kawahara,

The brain is one of the organs that are preferentially targeted by adenosine-to-inosine (A-to-I) RNA editing, a posttranscriptional modification. This chemical modification affects neuronal development and functions at multiple levels, leading to normal brain homeostasis by increasing the complexity of the transcriptome. This includes modulation of the properties of ion ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2181:309-330]

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Monitoring Activity-Dependent Bulk Endocytosis in Primary Neuronal Culture Using Large Fluorescent Dextrans.

Michael A Cousin, Karen J Smillie,

The efficient recycling of synaptic vesicles (SVs) during neuronal activity is central for sustaining brain function. During intense neuronal activity, the dominant mechanism of SV retrieval is activity-dependent bulk endocytosis (ADBE). Here, we describe a method to monitor ADBE in isolation from other SV endocytosis modes, via the uptake of ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2233:101-111]

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Monitoring Homologous Recombination Activity in Human Cells.

Domagoj Vugic, Åsa Ehlén, Aura Carreira,

DNA double-strand breaks (DSBs) are among the most toxic lesions. This type of DNA damage is repaired by two major pathways, homologous recombination (HR), operating only in S/G2 cell-cycle phases and nonhomologous end joining (NHEJ) which is operative throughout the cell cycle. Because HR is a template-directed repair, it is ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2153:115-126]

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The COVID-19 pandemic and Community Health Workers: An opportunity to maintain delivery of care and education for families of children with epilepsy in Zambia.

Lauren Sham, Ornella Ciccone, Archana A Patel,

J Glob Health (Journal of global health)
[2020, 10(2):020329]

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Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients.

Ru Yang, Xixi Zhao, Jun Liu, Xufeng Yao, Feng Hou, Yikai Xu, Qianjin Feng,

Growing evidence has supported that the nucleus accumbens (NAc), especially its shell portion, has been involved in epileptogenesis. However, relevant studies on vivo human brain are quite limited. In this study, we investigated left mesial temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc subregions using resting-state functional ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, 14(6):2659-2667]

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1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.

Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T Supuran, Tomasz Plech,

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole-3-thione derivatives were evaluated for the antioxidant activity and anticonvulsant effect in the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):993-1002]

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Prevalence and Trends in Cigarette Smoking Among Adults with Epilepsy - United States, 2010-2017.

Sanjeeb Sapkota, Rosemarie Kobau, Janet B Croft, Brian A King, Craig Thomas, Matthew M Zack,

Cigarette smoking remains the leading cause of preventable disease and death in the United States (1). Although the percentage of all U.S. adults who smoke cigarettes has declined substantially since the mid-1960s (1,2), marked disparities persist, and declines have not been consistent across population groups (1,2). Studies have shown that ... Read more >>

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2020, 69(47):1792-1796]

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Reduced structural covariance connectivity of defaut mode network and salience network in MRI-normal focal epilepsy.

Ting Shu, Xinlan Xiao, Zhiliang Long, Ran Zhang,

Neuroimaging studies have found altered functional connectivity of default mode network (DMN) and salience network (SN) in patients with focal epilepsy (FE). However, the structural basis underlying the functional connectivity disturbance in the patients is still unclear. Sixteen MRI-normal FE and 22 healthy controls were included in the current study. ... Read more >>

Neuroreport (Neuroreport)
[2020, 31(18):1289-1295]

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Connectome biomarkers of drug-resistant epilepsy.

Sara Larivière, Andrea Bernasconi, Neda Bernasconi, Boris C Bernhardt,

Drug-resistant epilepsy (DRE) considerably affects patient health, cognition, and well-being, and disproportionally contributes to the overall burden of epilepsy. The most common DRE syndromes are temporal lobe epilepsy related to mesiotemporal sclerosis and extratemporal epilepsy related to cortical malformations. Both syndromes have been traditionally considered as "focal," and most patients ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Would people living with epilepsy benefit from palliative care?

Benzi M Kluger, Cornelia Drees, Thomas R Wodushek, Lauren Frey, Laura Strom, Mesha-Gay Brown, Jacquelyn L Bainbridge, Sarah N Fischer, Archana Shrestha, Mark Spitz,

Palliative care (PC) is an approach to the care of persons living with serious illness and their families that focuses on improving quality of life and reducing suffering by addressing complex medical symptoms, psychosocial needs, spiritual well-being, and advance care planning. While PC has traditionally been associated with hospice care ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, :107618]

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Cognitive decline in older adults with epilepsy: The Cardiovascular Health Study.

Hyunmi Choi, Evan L Thacker, William T Longstreth, Mitchell S V Elkind, Amelia K Boehme,

OBJECTIVE:Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age-related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy. METHODS:The Cardiovascular Health ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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MINDSET: Clinic-based decision support demonstrates longitudinal efficacy for increased epilepsy self-management adherence among Spanish speaking patients.

Ross Shegog, Charles Begley, Jenny Chong, Refugio Sepulveda, Robert Addy, Kimberly Martin, Omar Rosales, Noelia Halavacs, David Labiner,

BACKGROUND:MINDSET, a bilingual (Eng./Span.) decision support tool was found feasible for facilitating goal-based epilepsy self-management (ESM) in the clinic. PURPOSE:To evaluate the efficacy of MINDSET to increase ESM adherence among Hispanic patients. METHODS:A RCT was conducted from August 2017 through January 2019. Spanish and English speaking Hispanic adult patients (n=94) ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 113:107552]

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The Role of the Persistent Sodium Current in Epilepsy.

Eric R Wengert, Manoj K Patel,

Voltage-gated sodium channels (VGSCs) are foundational to excitable cell function: Their coordinated passage of sodium ions into the cell is critical for the generation and propagation of action potentials throughout the nervous system. The classical paradigm of action potential physiology states that sodium passes through the membrane only transiently (1-2 ... Read more >>

Epilepsy Curr (Epilepsy currents)
[2020, :1535759720973978]

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Advantages of methohexital over amobarbital in determining hemispheric language and memory lateralization in the Wada test - A retrospective study.

Nadine Conradi, Friederike Rosenberg, Louise Biermann, Anja Haag, Anke Hermsen, Iris Gorny, Viola von Podewils, Marianna Gurschi, Fee Keil, Elke Hattingen, Katja Menzler, Sebastian Bauer, Susanne Schubert-Bast, Susanne Knake, Felix Rosenow, Adam Strzelczyk,

OBJECTIVE:Due to supply shortage, amobarbital, the traditional anesthetic agent in Wada testing, was replaced by methohexital in many epilepsy centers. This study aimed to compare the two barbiturates to identify possible advantages or disadvantages of methohexital as compared to amobarbital with regard to the adequacy of language and memory testing ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 113:107551]

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The impact of severe pediatric epilepsy on experienced stress and psychopathology in parents.

Anne Vagner Jakobsen, Rikke Steensbjerre Møller, Marina Nikanorova, Ask Elklit,

OBJECTIVES:To assess the prevalence of psychopathology and the level of stress in parents of children with severe epilepsy to gain a better understanding of parental support needs. METHODS:Questionnaires were completed by parents of children with severe epilepsy during the hospitalization of their child at the Danish Epilepsy Center. The questions ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 113:107538]

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Psychiatric and psychosocial morbidity 1 year after epilepsy surgery.

S Patel, M Clancy, H Barry, N Quigley, M Clarke, M Cannon, N Delanty, K C Murphy, D Cotter,

OBJECTIVES:There is a high rate of psychiatric comorbidity in patients with epilepsy. However, the impact of surgical treatment of refractory epilepsy on psychopathology remains under investigation. We aimed to examine the impact of epilepsy surgery on psychopathology and quality of life at 1-year post-surgery in a population of patients with ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2020, :1-8]

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Effect of the COVID-19 pandemic on drug compliance and stigmatization in patients with epilepsy.

Zeynep Bastug Gul, Hayrunisa Dilek Atakli,

OBJECTIVE:Pandemics like coronavirus disease 2019 (COVID-19) bring along many individual and social problems. We aimed to investigate what changes the COVID-19 pandemic can cause in patients with epilepsy on drug compliance and stigmatization. MATERIAL AND METHOD:Modified Morisky Scale (MMS) and stigmatization scales were used between October and November 2019 to ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, :107610]

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A cross-sectional study of errors in physicians orders' of antiseizure medications among people with epilepsy from rural India.

Sulena, Ramandeep Kaur, Naveen Kumar, Gagandeep Singh,

AIMS:To enumerate and classify errors in physicians' orders of antiseizure medications (ASMs) to people with epilepsy presenting to neurology clinic. METHODS:This cross-sectional study was conducted in the neurology clinic of a teaching hospital catering to a predominantly rural population. People in whom a diagnosis of epilepsy was confirmed and who ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 113:107575]

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