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Epilepsia Partialis Continua

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Epilepsia Partialis Continua as an Early Sign of Anti-Myelin Oligodendrocyte Glycoprotein Antibody-positive Encephalitis.

Kazuto Katsuse, Genki Shimizu, Naoko Saito Sato, Keiko Hatano, Shintaro Yagi, Toshikazu Kimura, Koreaki Irie, Shunsuke Ichi, Toshiyuki Takahashi, Hideji Hashida,

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been associated with steroid-responsive cortical encephalitis and comorbid generalized epilepsy. A 44-year-old woman developed repeated epilepsia partialis continua (EPC) without generalized seizures and was anti-MOG antibody-positive. Radiological abnormalities were detected in the bilateral medial frontoparietal cortices, but there were no cerebrospinal fluid abnormalities. She ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, :]

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"Negative T2 shine through" in patients with hyperglycemia and seizures: a frequently overlooked MRI pattern.

Horst Urbach, Benjamin Berger, Laszlo Solymosi, Julian Zimmermann,

Epileptic seizures associated with hyperglycemia have a rare but characteristic MR imaging pattern which however is frequently missed. It consists of a T2 hypointensity and an apparent diffusion coefficient (ADC) decrease of the white matter underlying the epileptic cortex; the cortex itself may be DWI hyperintense and show a blood-brain ... Read more >>

Neuroradiology (Neuroradiology)
[2020, :]

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Spontaneous interhemispheric subdural hematoma presenting as epilepsia partialis continua.

Bon D Ku, Sang Joon An, Sung Sang Yoon, Hyun Young Shin,

Acta Neurol Belg (Acta neurologica Belgica)
[2020, :]

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Bilateral asymmetric auricular myoclonus as a manifestation of focal motor seizure: Phenomenology, potential lateralizing value, and insights into auricular motor control.

Krongkamol Ponglikitmongkol, Apisit Boongird, Pichet Termsarasab,

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 413:116762]

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Very late-onset mitochondrial cytopathy featuring epilepsia partialis continua and bilateral deafness: A case report.

Michael C H Li, Mkael Symmonds, Pieter M Pretorius, Fintan Sheerin, Kannan Nithi, Monika Hofer, Joanna Poulton, Arjune Sen,

Seizure (Seizure)
[2020, 76:153-155]

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Genotypes and estimated prevalence of phosphomannomutase 2 deficiency in Turkey differ significantly from those in Europe.

Yılmaz Yıldız, Mutluay Arslan, Gökalp Çelik, Çiğdem Seher Kasapkara, Serdar Ceylaner, Ali Dursun, Hatice Serap Sivri, Turgay Coşkun, Ayşegül Tokatlı,

Phosphomannomutase 2 deficiency (PMM2-CDG) is an autosomal recessive congenital disorder of glycosylation, characterized by multisystem phenotypes, mostly including neurological involvement. In Turkey, due to high rates of consanguinity, many patients with autosomal recessive disorders have homozygous variants and these diseases are more common, compared to Europe. However, published reports of ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2020, 182(4):705-712]

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Epilepsia partialis continua revealing idelalisib-associated PML-IRIS: clinical and pathological features.

Alberto Vogrig, Gian Luigi Gigli, Annacarmen Nilo, Maria Elena Pessa, Stefano Volpetti, Enrico Pegolo, Mariarosaria Valente,

Idelalisib, a selective phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor, is a newly approved second-line drug for patients with chronic lymphocytic leukemia. Recent clinical trials have suggested a possible association between idelalisib treatment and development of progressive multifocal leukoencephalopathy (PML) due to John Cunningham virus (JCV) reactivation. Nevertheless, clinical course and radiological ... Read more >>

J. Neurovirol. (Journal of neurovirology)
[2019, :]

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Epilepsia partialis continua and cortical motor control: insights into physiology.

José L Fernández-Torre, María Martín-García, Ernesto Orozco-Sevilla, David Mato-Mañas, Miguel A Hernández-Hernández, Enrique Marco de Lucas,

Motor epilepsia partialis continua is a widely described variant of simple focal motor status epilepticus. However, few studies have addressed associated pathophysiological anomalies that may help us understand the cortical organization, basic functioning and control of voluntary movement. We describe the clinical, video-EEG and neuroimaging findings from two cases of ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2019, 21(6):603-607]

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Homoplasmy of the Mitochondrial DNA Mutation m.616T>C Leads to Mitochondrial Tubulointerstitial Kidney Disease and Encephalopathia.

Robin Lorenz, Uwe Ahting, Cornelia Betzler, Sigrid Heimering, Ingo Borggräfe, Bärbel Lange-Sperandio,

Autosomal-dominant tubulointerstitial kidney disease -(ADTKD) describes tubulointerstitial kidney disease with autosomal-dominant inheritance. In 2017, the term mitochondrial tubulointerstitial kidney disease (MITKD) was introduced for tubulointerstitial kidney disease caused by mitochondrial DNA (mtDNA) mutations. To date, there are few mutations described in literature causing MITKD, one of them is m.616T>C. A ... Read more >>

Nephron (Nephron)
[2020, 144(3):156-160]

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No effect of electrical transcranial direct current stimulation adjunct treatment for epilepsia partialis continua in POLG disease.

Lynn Marquardt, Tom Eichele, Laurence A Bindoff, Henning Kristian Olberg, Gyri Veiby, Heike Eichele, Isabella Kusztrits, Marco Hirnstein,

We report a 15-year-old female with POLG-related mitochondrial disease who developed severe multifocal epilepsia partialis continua, unresponsive to standard anti seizure drug treatment and general anesthesia. Based on an earlier case report, we treated her focal seizures that affected her right upper limb with 20-min sessions of transcranial direct current ... Read more >>

Epilepsy Behav Rep (Epilepsy & behavior reports)
[2019, 12:100339]

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Long-term outcome of unilateral deep brain stimulation of the subthalamic nucleus for a patient with drug-resistant focal myoclonic seizure.

Xueyuan Wang, Jialin Du, Di Wang, Cuiping Xu, Zhiwei Ren, Yuping Wang, Yongjie Li, Tao Yu, Liankun Ren,

It remains an unsolved problem in the treatment of patients with refractory focal epilepsy originating from the motor cortex since resection surgery can result in significant morbidity. Neurostimulation has emerged as an effective method for treating patients who are not suitable for conventional surgical procedures due to its relative safety, ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(1):18]

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[Clinical and genetic characteristics of 62 children with mitochondrial epilepsy].

X D Han, F Fang, H Li, Z M Liu, Y Q Shi, J L Wang, X T Ren, C H Ding, C H Chen, J W Li, W H Zhang, J Deng,

Objective: To summarize the clinical and genetic characteristics of children with mitochondrial epilepsy. Methods: Clinical data of 62 children who were clinically and genetically diagnosed with mitochondrial epilepsy by the Department of Neurology, Beijing Children's Hospital from October 2011 to December 2018 were analyzed retrospectively, and the control of epilepsy ... Read more >>

Zhonghua Er Ke Za Zhi (Zhonghua er ke za zhi = Chinese journal of pediatrics)
[2019, 57(11):844-851]

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Combined Hemichorea and Seizures in a Patient with Nonketotic Hyperglycemia.

Ryul Kim, Hee-Jin Cho, Ho-Won Lee, Jin-Sun Jun,

J Mov Disord (Journal of movement disorders)
[2020, 13(1):72-73]

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Efficacy and tolerability of mycophenolate mofetil in a pediatric Rasmussen syndrome.

A Orsini, G Costagliola, D Perna, M G Esposito, L Bonfiglio, P Striano, D Peroni, R Consolini, A Bonuccelli,

Rasmussen syndrome (RS) is a chronic encephalopathy with uncertain etiology and immune-mediated pathogenesis. The only definitive treatment is represented by functional hemispherectomy. We describe the case of a 6.5-year-old female patient who developed several episodes of focal, unilateral clonic seizures. Following laboratory and instrumental investigations, the patient was diagnosed as ... Read more >>

Epilepsy Behav Rep (Epilepsy & behavior reports)
[2020, 13:100334]

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Adult-onset Rasmussen's encephalitis with persistent infection of herpes simplex virus.

Yusuke Toda, Mineo Yamazaki, Yukiko Ozawa, Tomohiro Ota, Kazumi Kimura,

eNeurologicalSci (eNeurologicalSci)
[2019, 17:100210]

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Autoimmune Encephalitis and CSF Anti-GluR3 Antibodies in an MS Patient after Alemtuzumab Treatment.

Maria Chiara Buscarinu, Arianna Fornasiero, Giulia Pellicciari, Roberta Reniè, Anna Chiara Landi, Alessandro Bozzao, Cristina Cappelletti, Pia Bernasconi, Giovanni Ristori, Marco Salvetti,

A 45-year-old Italian woman, affected by relapsing-remitting multiple sclerosis (RR-MS) starting from 2011, started treatment with alemtuzumab in July 2016. Nine months after the second infusion, she had an immune thrombocytopenic purpura (ITP) with complete recovery after steroid treatment. Three months after the ITP, the patient presented with transient aphasia, ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(11):]

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Endovascular Mechanical Thrombectomy and On-Site Chemical Thrombolysis for Severe Cerebral Venous Sinus Thrombosis.

Chih-Hsiang Liao, Nien-Chen Liao, Wen-Hsien Chen, Hung-Chieh Chen, Chiung-Chyi Shen, Shun-Fa Yang, Yuang-Seng Tsuei,

Cerebral venous sinus thrombosis (CVST) is a rare cause of cerebral infarction. Once patients survive the acute phase, long-term prognosis is generally satisfactory. CVST patients who harbored risk factors known for poor prognosis (e.g., deterioration of consciousness/neurological functions and seizures) were oftentimes unresponsive to systemic heparin treatment. The advantage of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4937]

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Noninvasive Localization of Language Cortex in an Awake 4-Year-Old Child with Rasmussen Encephalitis: A Case Report.

Shalini Narayana, Luke M Embury, Namrata Shah, Sarah Weatherspoon, Asim F Choudhri, Frederick A Boop,

BACKGROUND AND IMPORTANCE:Presurgical mapping of eloquent cortex in young patients undergoing neurosurgery is critical for timely intervention, surgical planning, and minimizing postoperative deficits. However, invasive direct cortical stimulation has limited success in young children and noninvasive modalities, such as magnetoencephalography and functional MRI, require sedation, often precluding localization of critical ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2019, :]

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Epilepsia partialis continua complicated by disseminated tuberculosis and hemophagocytic lymphohistiocytosis: a case report.

Gashirai K Mbizvo, Isabel C Lentell, Clifford Leen, Huw Roddie, Christopher P Derry, Susan E Duncan, Kristiina Rannikmäe,

BACKGROUND:We describe a patient copresenting with epilepsia partialis continua, tuberculosis, and hemophagocytic lymphohistiocytosis. To our knowledge, this is the first documented case of this triad. CASE PRESENTATION:A 54-year-old black South African woman presented to a hospital in Scotland with an acute history of right-sided facial twitching, breathlessness, and several months ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):191]

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Abdominal epilepsia partialis continua in neurocysticercosis.

Ajay Asranna, Sachin Sureshbabu, Gaurav Mittal, Sudhir Peter, Shobhana Chindripu, Leena Saini,

Epilepsia partialis continua (EPC) of abdominal muscles is a rare entity with variable clinical localization and aetiology. A 25-year-old man presented with sudden onset of intermittent focal myoclonic movements involving the abdominal muscles on the right side exclusively, lasting from 20 minutes to an hour. Brain MRI revealed a ring-enhancing ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2019, 21(3):302-306]

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Acute myeloid leukemia with central nervous system extension and subdural seeding of vancomycin-resistant Enterococcus faecium after bilateral subdural hematomas treated with subdural daptomycin administration.

Nicholas Dietz, Megan Barra, Mingjuan Zhang, Marcus Zacharaiah, Jean-Valery Coumans,

Background:We present a rare case of comorbid relapsed acute myeloid leukemia (AML) with the involvement of the central nervous system (CNS) and subdural seeding of vancomycin-resistant Enterococcus faecium (VRE). The safety profile, treatment approach with pharmacokinetic considerations, and evaluation of success for bilateral subdural administration of daptomycin after subdural hematoma ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2019, 10:171]

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Hyperglycemia-induced seizures - Understanding the clinico- radiological association.

Shivaprakash B Hiremath, Amol A Gautam, Prince J George, Agnes Thomas, Reji Thomas, Geena Benjamin,

Objectives:To highlight the typical magnetic resonance imaging (MRI) findings in hyperglycemia-induced seizures and compare the results with similar previous studies with a brief mention of pathophysiological mechanisms. Materials and Methods:This retrospective study included medical and imaging records of six consecutive patients with hyperglycemia-induced seizures. The data analysis included a clinical ... Read more >>

Indian J Radiol Imaging (The Indian journal of radiology & imaging)
[2019, 29(4):343-349]

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The importance of timing in epilepsia partialis continua.

Á Gutiérrez-Viedma, M Romeral-Jiménez, I Serrano-García, B Parejo-Carbonell, M L Cuadrado-Pérez, I Sanz-Graciani, I García-Morales,

INTRODUCTION:Timing is one of the most important modifiable prognostic factors in the management of status epilepticus. Epilepsia partialis continua (EPC) is a status epilepticus subtype of highly variable, occasionally prolonged, duration. The aim of this study was to analyze the relationship between EPC duration and outcomes. METHODS:We performed an observational ... Read more >>

Neurologia (Neurologia (Barcelona, Spain))
[2019, :]

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Infantile epilepsy with multifocal myoclonus caused by TBC1D24 mutations.

Jing Zhang, Jiaoyang Chen, Qi Zeng, Liping Zhang, Xiaojuan Tian, Xiaoling Yang, Zhixian Yang, Ye Wu, Xiru Wu, Yuehua Zhang,

PURPOSE:To summarize the clinical features and neuroimaging changes of epilepsy associated with TBC1D24 mutations. METHODS:Genetic testing was conducted in all epilepsy patients without acquired risk factors for epilepsy. Epilepsy patients identified with TBC1D24 compound heterozygous mutations by next-generation sequencing (NGS) epilepsy panel or whole exome sequencing (WES) were enrolled. The ... Read more >>

Seizure (Seizure)
[2019, 69:228-234]

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Magnetic resonance imaging volumetric analysis for diabetic striatopathy with two episodes of hemichorea-hemiballism syndrome: A case report.

Yi-Te Lin, Shih-Chung Chen, Ping-Keung Yip, Vinchi Wang,

RATIONALE:Diabetic striatopathy (DS) is an uncommon movement disorder among diabetic patients characterized by clinical hemichorea-hemiballism with neuroimage change of the striatum. Here, we report a case of DS with relapsed hemichorea-hemiballism attacks even during euglycemic period, and the MRI changes by volumetric analysis. PATIENT CONCERNS:A 69-year-old diabetic female suffered from ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(38):e17249]

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