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Optimizing expression of a single copy transgene in C. elegans.

Scott Dour, Michael Nonet,

The utility of single copy transgenic insertions in <i>C. elegans</i> is often limited by low expression. We examined the effects of modifying the trans-splicing signal, the Kozak ribosome binding site, the N-terminal amino acid of the reporter and the 3' UTR sequences on the expression level of a <i>mec-4</i> promoter ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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SIMR foci are found in the progenitor germ cells of C. elegans embryos.

Celja J Uebel, Kevin I Manage, Carolyn M Phillips,

RNA interference is a widely conserved mechanism of gene regulation and silencing across eukaryotes. In <i>C. elegans</i>, RNA silencing is coordinated through perinuclear nuage containing at least four granules: P granules, Z granules, <i>Mutator</i> foci, and SIMR foci. Embryonic localization of these granules is known for all except SIMR foci. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Estimation of C. elegans cell- and tissue volumes.

Jonathan J Froehlich, Nikolaus Rajewsky, Collin Y Ewald,

Although <i>C. elegans</i> is one of the best-studied model organisms, an estimate of its cell sizes and tissues is missing. Here we used the Virtual Worm that is based on electron microscopy images to calculate a zeroth-order approximation of cell and tissue sizes of <i>C. elegans</i>. We conclude that the ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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A histamine-gated channel is an efficient negative selection marker for C. elegans transgenesis.

Sonia El Mouridi, Sarah AlHarbi, Christian Frøkjær-Jensen,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos.

Fan-Suo Geng, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Ryan Lister, Ozren Bogdanovic,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome initiation in Arabidopsis thaliana.

Amy Hark, Elizabeth McCain,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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The Role of Diazepam in Epigenetics: From the Molecular Level to Clinical Implications.

Sachchidanand Pathak, Gaurav Gupta, Ritu M Gilhotra,

There is growing evidence linking epigenetic mutations to neurologic disorders such as epilepsy. The effect of the medications primarily used to treat neurologic disorders has recently been studied, including research on epilepsy and the epigenetic process. The impact of the widely used medication diazepam on epigenomics, microRNA levels, the ensuing ... Read more >>

Adv Mind Body Med (Advances in mind-body medicine)
[2021, 35(1):25-33]

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Epigenetic control of ion channel expression and cell-specific splicing in nociceptors: Chronic pain mechanisms and potential therapeutic targets.

Diane Lipscombe, E Javier Lopez-Soto,

Ion channels underlie all forms for electrical signaling including the transmission of information about harmful events. Voltage-gated calcium ion channels have dual function, they support electrical signaling as well as intracellular calcium signaling through excitation-dependent calcium entry across the plasma membrane. Mechanisms that regulate ion channel forms and actions are ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):156-164]

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Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults: a quasi-experimental pilot study.

Iasmin Fraga, Camila Weber, Wériton Baldo Galiano, Lucio Iraci, Mariana Wohlgemuth, Gabriela Morales, Camila Cercato, Juliana Rodriguez, Daniela Pochmann, Caroline Dani, Pérsia Menz, Adriane Dal Bosco, Viviane Rostirola Elsner,

Epigenetic changes have been shown to be associated with both aging process and aging-related diseases. There is evidence regarding the benefits of physical activity on the functionality, cognition, and quality of life of institutionalized older adults, however, the molecular mechanisms involved are not elucidated. The purpose of this pilot study ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2479-2485]

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Visfatin and global histone H3K9me levels in colon cancer.

Eman A Al Abdulsalam, Rowyda N Al Harithy,

<h4>Background</h4>Visfatin is considered to be a biomarker in various types of cancers, including colon cancer. Moreover, evidence for epigenetic mechanism must be reported for an association between visfatin level and colon cancer. Therefore, this study was designed to investigate the status of visfatin expression and the global histone three modifications ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):647-652]

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Genetic features and efficacy of decitabine-based chemotherapy in elderly patients with acute myeloid leukemia.

Bianhong Wang, Wei Guan, Na Lv, Ting Li, Fan Yu, Yuehua Huang, Yanying Wang, Lihong Li, Li Yu,

<h4>Objectives</h4>The outcome of elderly acute myeloid leukemia (AML) patients is poor, which was traditionally attributed to patient- and leukemia-related factors. However, studies about the genetic features of these elderly patients have not been integrated and the genetic mechanism of their poor outcome is less known.<h4>Methods</h4>Here, we used next generation sequencing ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):371-379]

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Influence of gut microbiota on eye diseases: an overview.

Pasquale Napolitano, Mariaelena Filippelli, Sergio Davinelli, Silvia Bartollino, Roberto dell'Omo, Ciro Costagliola,

The microbiota is a dynamic ecosystem that plays a major role in the host health. Numerous studies have reported that alterations in the intestinal microbiota (dysbiosis) may contribute to the pathogenesis of various common diseases such as diabetes, neuropsychiatric diseases, and cancer. However, emerging findings also suggest the existence of ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):750-761]

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Cafeteria diet induces global and Slc27a3-specific hypomethylation in male Wistar rats.

Amsha Viraragavan, Tarryn Willmer, Oelfah Patel, Albertus Basson, Rabia Johnson, Carmen Pheiffer,

Increased visceral adipose tissue (VAT) is associated with metabolic dysfunction, while subcutaneous adipose tissue (SAT) is considered protective. The mechanisms underlying these differences are not fully elucidated. This study aimed to investigate molecular differences in VAT and SAT of male Wistar rats fed a cafeteria diet (CD) or a standard ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):108-118]

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Drosophila melanogaster: a fruitful model for oncohistones.

Amel Chaouch, Paul Lasko,

<i>Drosophila melanogaster</i> has proven to be a powerful genetic model to study human disease. Approximately 75% of human disease-associated genes have homologs in the fruit fly and regulatory pathways are highly conserved in <i>Drosophila</i> compared to humans. <i>Drosophila</i> is an established model organism for the study of genetics and developmental ... Read more >>

Fly (Austin) (Fly)
[2021, 15(1):28-37]

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Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications.

Mario Daidone, Marco Cataldi, Antonio Pinto, Antonino Tuttolomondo,

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses, resulting in necrosis of brain parenchyma. Stroke pathogenesis is characterized by neuroinflammation and endothelial dysfunction. Some of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells (microglia, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(11):2154-2158]

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DNMT1-dependent regulation of cortical interneuron function and survival.

Daniel Pensold, Geraldine Zimmer-Bensch,

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2405-2406]

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Prevention in psychiatry: a role for epigenetics?

Katharina Domschke,

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2021, 20(2):227-228]

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Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs.

Föhr Tiina, Waller Katja, Viljanen Anne, Sanchez Riikka, Ollikainen Miina, Rantanen Taina, Kaprio Jaakko, Elina Sillanpää,

<h4>Background</h4>Epigenetic clocks are based on DNA methylation (DNAm). It has been suggested that these clocks are useable markers of biological aging and premature mortality. Because genetic factors explain variations in both epigenetic aging and mortality, this association could also be explained by shared genetic factors. We investigated the influence of ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2021, 13(1):128]

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Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model.

Yuya Kawarai, Seon Ho Jang, Seunghwan Lee, Magali Millecamps, HyungMo Kang, Stephanie Gregoire, Miyako Suzuki-Narita, Seiji Ohtori, Laura S Stone,

<h4>Background context</h4>Chronic low back pain (LBP) is a multifactorial disorder with complex underlying mechanisms, including associations with intervertebral disc (IVD) degeneration in some individuals. It has been demonstrated that epigenetic processes are involved in the pathology of IVD degeneration. Epigenetics refers to several mechanisms, including DNA methylation, that have the ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2021, :]

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Recognition, Staging, and Management of Melanoma.

Sarem Rashid, Hensin Tsao,

Melanoma accounts for approximately 1% of all skin cancers but contributes to almost all skin cancer deaths. The developing picture suggests that melanoma phenotypes are driven by epigenetic mechanisms that reflect a complex interplay between genotype and environment. Furthermore, the growing consensus is that current classification standards, notwithstanding pertinent clinical ... Read more >>

Med Clin North Am (The Medical clinics of North America)
[2021, 105(4):643-661]

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Associations of Body Composition and Physical Activity Level With Multiple Measures of Epigenetic Age Acceleration.

Jacob K Kresovich, Emma L Garval, Alexandra M Martinez Lopez, Zongli Xu, Nicole M Niehoff, Alexandra J White, Dale P Sandler, Jack A Taylor,

Epigenetic clocks use DNA methylation to estimate biological age. Whether body composition and physical activity are associated with these clocks is not well understood. Using blood samples collected at enrollment (2003-2009) from 2,758 women in the US nationwide Sister Study, we calculated 6 epigenetic age acceleration metrics using 4 epigenetic ... Read more >>

Am J Epidemiol (American journal of epidemiology)
[2021, 190(6):984-993]

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GLEANER: a web server for GermLine cycle Expression ANalysis and Epigenetic Roadmap visualization.

Shiyang Zeng, Yuwei Hua, Yong Zhang, Guifen Liu, Chengchen Zhao,

<h4>Background</h4>Germline cells are important carriers of genetic and epigenetic information transmitted across generations in mammals. During the mammalian germline cell development cycle (i.e., the germline cycle), cell potency changes cyclically, accompanied by dynamic transcriptional changes and epigenetic reprogramming. Recently, to understand these dynamic and regulatory mechanisms, multiomic analyses, including transcriptomic ... Read more >>

BMC Bioinformatics (BMC bioinformatics)
[2021, 22(1):289]

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Diet-Induced Mild Hyperhomocysteinemia in Mice Fed a Ketogenic Diet Does Not Alter the Development of Atherosclerosis nor Specific Epigenetic Content

Courtney Whalen, Sean Gullette, Floyd Mattie, Thomas Neuberger, A Catharin Ross, Rita Castro,

Abstract <h4>Objectives</h4> Elevated plasma homocysteine (Hcy), or hyperhomocysteinemia (HHcy), is a risk factor for atherosclerosis by mechanisms still elusive. A possibility includes the alteration of specific epigenetic tags at lysine 27 of histone H3 (H3K27) due to hypomethylating stress. Similarly, ketogenic diets (KD), or very-low carbohydrate diets, which stimulate ketosis, ... Read more >>

Curr Dev Nutr (Current developments in nutrition)
[2021, 5(Suppl 2):953-953]

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Roles for growth factors and mutations in metastatic dissemination.

Nishanth Belugali Nataraj, Ilaria Marrocco, Yosef Yarden,

Cancer is initiated largely by specific cohorts of genetic aberrations, which are generated by mutagens and often mimic active growth factor receptors, or downstream effectors. Once initiated cells outgrow and attract blood vessels, a multi-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2021, :]

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Epigenetic features improve TALE target prediction

Annett Erkes, Stefanie Mücke, Maik Reschke, Jens Boch, Jan Grau,

The yield of many crop plants can be substantially reduced by plant-pathogenic Xanthomonas bacteria. The infection strategy of many Xanthomonas strains is based on transcription activator-like effectors (TALEs), which are secreted into the host cells and act as transcriptional activators of plant genes that are beneficial for the bacteria. The ... Read more >>

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