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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Tumor necrosis factor inhibition attenuates white matter gliosis after systemic inflammation in preterm fetal sheep.

Robert Galinsky, Simerdeep K. Dhillon, Justin M. Dean, Joanne O. Davidson, Christopher A. Lear, Guido Wassink, Fraser Nott, Sharmony B. Kelly, Mhoyra Fraser, Caroline Yuill, Laura Bennet, Alistair Jan Gunn,

BackgroundIncreased circulating levels of tumor necrosis factor (TNF) are associated with greater risk of impaired neurodevelopment after preterm birth. In this study, we tested the hypothesis that systemic TNF inhibition, using the soluble TNF receptor Etanercept, would attenuate neuroinflammation in preterm fetal sheep exposed to lipopolysaccharide (LPS).MethodsChronically instrumented preterm fetal ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17:]

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Coexistence of Anti-SOX1 and Anti-GABAB Receptor Antibodies with Autoimmune Encephalitis in Small Cell Lung Cancer: A Case Report.

Wei Qin, Xiao Wang, Jing Yang, Wenli Hu,

Anti-γ-aminobutyric acid B receptor (anti-GABABR) encephalitis is a rare type of autoimmune encephalitis (AE). Although it responds well to immunomodulating therapy and has favorable prognosis, anti-GABABR AE has often been misdiagnosed as infectious encephalitis. Herein, we present a case of a 59-year-old female with anti-GABABR AE associated with small cell ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2020, 15:171-175]

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Detection of after-discharges during intraoperative functional brain mapping in awake brain tumor surgery using a novel high-density circular grid.

William O Tatum, Jake H McKay, Karim ReFaey, Anteneh M Feyissa, Dan Ryan, Anthony Ritaccio, Erik Middlebrooks, Kirsten Yelvington, Grayson Roth, Emily Acton, Sanjeet Grewal, Kaisorn Chaichana, Alfredo Quinones-Hinojosa,

OBJECTIVE:To evaluate intraoperative use of a novel high-density circular grid in detecting after-discharges (AD) on electrocorticography (ECoG) during functional brain mapping (FBM). METHODS:FBM during glioma surgery (10/2016 to 5/2019) recorded ADs using a 22-channel circular grid compared to conventional strip electrodes. ADs were analyzed for detection, duration, amplitude, morphology, histology, ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(4):828-835]

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The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study.

Tang Xinghua, Li Lin, Fan Qinyi, Wei Yarong, Pu Zheng, Liu Zhenguo,

BACKGROUD:This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):88]

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Comparison of Smoothing Filters in Analysis of EEG Data for the Medical Diagnostics Purposes.

Aleksandra Kawala-Sterniuk, Michal Podpora, Mariusz Pelc, Monika Blaszczyszyn, Edward Jacek Gorzelanczyk, Radek Martinek, Stepan Ozana,

This paper covers a brief review of both the advantages and disadvantages of the implementation of various smoothing filters in the analysis of electroencephalography (EEG) data for the purpose of potential medical diagnostics. The EEG data are very prone to the occurrence of various internal and external artifacts and signal ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(3):]

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Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery.

Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Sou Takai, Masashi Shibata, Sachiko Kato, Jun Natsume, Minoru Hoshiyama, Toshihiko Wakabayashi,

Deep-seated epileptic focus estimation using magnetoencephalography is challenging because of its low signal-to-noise ratio and the ambiguity of current sources estimated by interictal epileptiform discharge (IED). We developed a distributed source (DS) analysis method using a volume head model as the source space of the forward model and standardized low-resolution ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5263]

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Advanced neuroimaging techniques for evaluating pediatric epilepsy.

Yun Jeong Lee,

Accurate localization of the seizure onset zone is important for better seizure outcomes and preventing deficits following epilepsy surgery. Recent advances in neuroimaging techniques have increased our understanding of the underlying etiology and improved our ability to noninvasively identify the seizure onset zone. Using epilepsy-specific magnetic resonance imaging (MRI) protocols, ... Read more >>

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(3):88-95]

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Abdominal Epilepsy Masked with Hiccups in a Patient with Intracranial Malignant Glioma.

Salman Assad, Varun Dobariya, Mehr Zahid, Shuja A Malik,

Abdominal hiccups are often masked by abdominal epilepsy (AE) in clinical settings. Spontaneous arrhythmic muscular movements sometimes raise the suspicion for abdominal myoclonus as well. AE is an atypical and rare cause of seizure disorder. It is a manifestation of different transient abdominal complaints correlating with abnormal electroencephalogram (EEG) changes ... Read more >>

Cureus (Cureus)
[2019, 11(12):e6338]

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[Surgical treatment of epilepsy in children with gloneuronal brain tumors: morphology, MRI semiology and factors affecting the outcome].

A G Melikyan, L V Shishkina, P A Vlasov, A B Kozlova, E I Schultz, Yu V Kushel, M B Korsakova, S B Buklina, M D Varukhina,

INTRODUCTION:Glioneuronal tumors (GNT) are usually found in children (less than 1.5% of all neoplasms of the brain). With rare exceptions, they are benign and usually manifest only by epilepsy, which is quite often resistant to treatment with AE drugs. Tumor removal usually helps to cope with epileptic seizures, however, a ... Read more >>

Zh Vopr Neirokhir Im N N Burdenko (Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko)
[2020, 84(1):6-22]

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Seizures in Patients With Metastatic Brain Tumors: Prevalence, Clinical Characteristics, and Features on EEG.

Shaun Ajinkya, Jonah Fox, Peter Houston, Adam Greenblatt, Alain Lekoubou, Scott Lindhorst, David Cachia, Adriana Olar, Ekrem Kutluay,

INTRODUCTION:Metastases to the brain (MB) occur in up to 30% of adults with cancer; of these, 15% to 35% may have seizures. We investigated clinical and pathologic associations with seizure and EEG findings in patients with MB, given the sparse literature in this area. METHODS:We performed a retrospective chart review ... Read more >>

J Clin Neurophysiol (Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society)
[2019, :]

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The exploration of the spectrum of motor manifestations of anti-LGI1 encephalitis beyond FBDS.

Xiaoyun Liu, Yuxiang Han, Liling Yang, Bao Wang, Sai Shao, Yabo Feng, Zaiying Pang, Yifeng Du, Youting Lin,

PURPOSE:The purpose of this study was to characterize the spectrum of motor events in patients with acute anti-leucine-rich glioma-inactivated protein 1 (anti-LGI1) encephalitis through video-electroencephalogram (VEEG) recordings. METHOD:We collected data retrospectively from 16 patients diagnosed with anti-LGI1 encephalitis who had completed VEEG recording during hospitalization. RESULTS:VEEG monitoring lasted a median ... Read more >>

Seizure (Seizure)
[2020, 76:22-27]

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Infantile Spasms: An Update on Pre-Clinical Models and EEG Mechanisms.

Remi Janicot, Li-Rong Shao, Carl E Stafstrom,

Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic features, which affects children in the middle of the first year of life. The pathophysiology of IS remains incompletely understood, despite the heterogeneity of IS etiologies, more than 200 of which are known. In particular, the neurobiological basis ... Read more >>

Children (Basel) (Children)
[2020, 7(1):]

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Posterior Reversible Encephalopathy Syndrome: Clinical Features and Outcome.

Archana Hinduja,

Background: Posterior reversible encephalopathy syndrome (PRES) is an acute neurotoxic syndrome that is characterized by a spectrum neurological and radiological feature from various risk factors. Common neurological symptoms includes headache, impairment in level of consciousness, seizures, visual disturbances, and focal neurological deficits. Common triggering factors include blood pressure fluctuations, renal ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:71]

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Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder.

Ji Sun Kim, Eun-Sook Kang, Yong Chun Bahk, Sunglee Jang, Kyung Sue Hong, Ji Hyun Baek,

Introduction: Non-suicidal self-injury (NSSI) is a rapidly increasing mental health problem that requires more clinical attention. In this study, we aimed to explore the biobehavioral markers of NSSI in participants with mood disorders. Methods: A total of 45 participants with mood disorders (bipolar I, II, and major depressive disorder) were ... Read more >>

Front Psychiatry (Frontiers in Psychiatry)
[2020, 11:124]

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Pilomotor Seizures in a Patient With LGI1 Encephalitis.

Jinxia Yang, Qiying Sun, Guang Yang,

Limbic encephalitis (LE) with antibodies against leucine-rich glioma inactivated protein 1 (LGI1) is an autoimmune disease with variable clinical features, including seizures, cognitive disorders, psychiatric disturbances, and hyponatremia. The majority of these patients present faciobrachial dystonic seizures (FBDS), which are regarded as a characteristic symptom. A few cases have reported ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:61]

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An update on pediatric surgical epilepsy: Part II.

Nisha Gadgil, Matthew Muir, Melissa A Lopresti, Sandi K Lam,

Background:Recent advances may allow surgical options for pediatric patients with refractory epilepsy not previously deemed surgical candidates. This review outlines major technological developments in the field of pediatric surgical epilepsy. Methods:The literature was comprehensively reviewed and summarized pertaining to stereotactic electroencephalography (sEEG), laser ablation, focused ultrasound (FUS), responsive neurostimulation (RNS), ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2019, 10:258]

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Patents and Innovation Among Neurosurgeons from the American Association of Neurological Surgeons.

Rebecca B Baron, Remi A Kessler, Ansh Bhammar, Nicholas Boulis, John R Adler, Karan Kohli, Constantinos Hadjipanayis,

Objective Neurosurgeons have taken on the role of innovators, continuing to move the field forward over the centuries. More recently, innovation has taken the form of new technological devices and therapeutics, which require patenting. The aim of this study is to identify major areas of innovation in the field of ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7031]

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Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient.

Tania Cellucci, Heather Van Mater, Francesc Graus, Eyal Muscal, William Gallentine, Marisa S Klein-Gitelman, Susanne M Benseler, Jennifer Frankovich, Mark P Gorman, Keith Van Haren, Josep Dalmau, Russell C Dale,

OBJECTIVE:Autoimmune encephalitis (AE) is an important and treatable cause of acute encephalitis. Diagnosis of AE in a developing child is challenging because of overlap in clinical presentations with other diseases and complexity of normal behavior changes. Existing diagnostic criteria for adult AE require modification to be applied to children, who ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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Status Epilepticus Manifested as Continuous Epileptic Spasms.

Jianxiang Liao, Tieshuan Huang, Myriam Srour, Yuhan Xiao, Yan Chen, Sufang Lin, Li Chen, Yan Hu, Lina Men, Jialun Wen, Bing Li, Feiqiu Wen, Lan Xiong,

Objective: The etiology and outcome of status epilepticus with continuous epileptic spasms have not been fully understood; and only rare cases have been reported in the literature. Here, we described 11 children, who manifested continuous epileptic spasms with various etiologies and different outcomes. Methods: This is a case series study ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:65]

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The Potential of Stereotactic-EEG for Brain-Computer Interfaces: Current Progress and Future Directions.

Christian Herff, Dean J Krusienski, Pieter Kubben,

Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set of brain regions including deeper brain structures such as ... Read more >>

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:123]

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Statin treatment can reduce incidence of early seizure in acute ischemic stroke: A propensity score analysis.

Soichiro Matsubara, Tomotaka Tanaka, Shinya Tomari, Kazuki Fukuma, Hiroyuki Ishiyama, Soichiro Abe, Takuro Arimizu, Yoshitaka Yamaguchi, Soshiro Ogata, Kunihiro Nishimura, Masatoshi Koga, Yukio Ando, Kazunori Toyoda, Masafumi Ihara,

A previous study showed early statin administration in patients with acute ischemic stroke (AIS) was associated with a lower risk of early-onset seizure (ES), which is a high risk of epilepsy, but this retrospective study design may not have eliminated confounding factor effects. We aimed to verify the determinants and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1968]

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Non-convulsive seizures in the encephalopathic critically ill cancer patient does not necessarily portend a poor prognosis.

Cristina Gutierrez, Merry Chen, Lei Feng, Sudhakar Tummala,

Background:Non-convulsive status epilepticus (NCSE) is present in 10-30% of ICU patients with altered mental status (AMS) and is associated to poor outcomes. To our knowledge, there is no data describing the prevalence and outcomes of critically ill cancer patients with AMS associated to non-convulsive seizures (NCS) or NCSE. We aim ... Read more >>

J Intensive Care (Journal of Intensive Care)
[2019, 7:62]

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Mind body medicine: a tangible link between the gut and the brain.

Luis Vitetta,

Ann Transl Med (Annals of translational medicine)
[2020, 8(4):64]

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Immune mediated pediatric encephalitis - need for comprehensive evaluation and consensus guidelines.

Julia Shekunov, Caren J Blacker, Jennifer L Vande Voort, Jan-Mendelt Tillema, Paul E Croarkin, Magdalena Romanowicz,

BACKGROUND:Autoimmune encephalitis is characterized by neuropsychiatric symptoms associated with brain inflammation. The differential is usually broad and Psychiatry often collaborates with Neurology in diagnostic clarification and symptom management. At least 40% of neuroencephalitis cases are of unknown etiology which adds to difficulties in making the right diagnosis and deciding on ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):44]

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