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Drug Induced Pulmonary Toxicity

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Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control.

Xin Wang, Kaiyuan Deng, Cheng Wang, Yao Li, Tianqi Wang, Zhi Huang, Yakun Ma, Peiqing Sun, Yi Shi, Shengyong Yang, Yan Fan, Rong Xiang,

A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identification of compound X22 with a nanomolar potency against CDK4 and CDK9 and potent antiproliferative ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):414-423]

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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress.

Mayson H Alkhatib, Shaza A Alyamani, Faiza Abdu,

Methotrexate (MTX), a chemotherapeutic agent, has limited clinical applications due to its pulmonary and neurotoxicity. The antineoplastic activity of MTX-NE COCO, which is MTX formulated in coconut oil nanoemulsion (NE), was evaluated in A549 non-small cell lung cancer cells while its adverse side effects on the oxidative stress of the ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):422-430]

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Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles.

Zhanrong Li, Zhihua Guo, Dandan Chu, Huayang Feng, Junjie Zhang, Lei Zhu, Jingguo Li,

Celastrol, a Chinese herbal medicine, has already shown an inhibition effect on retinoblastoma growth activity in our previous research, but its mechanism is not well understood. Angiogenesis is a main driving force in many tumors. Here, we studied whether celastrol could inhibit angiogenesis-mediated retinoblastoma growth, if so, through what mechanism. ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):358-366]

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Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment.

Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Xue Zou, Zhixu Zhou, Zhenchao Wang, Guiping Ouyang, Longjia Yan,

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results displayed that some of the compounds had good activities, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):555-564]

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.

Giulia Costa, Maria Antonietta De Luca, Gessica Piras, Jacopo Marongiu, Liana Fattore, Nicola Simola,

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):802-816]

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Ebselen attenuates tobramycin-induced ototoxicity in mice.

Rende Gu, Ryan J Longenecker, Jennifer Homan, Jonathan Kil,

BACKGROUND:Cystic fibrosis patients are often adminstered tobramycin to treat pulmonary infections. Unfortunately, a common side effect is hearing loss, which can fluctuate. Ebselen has known anti-inflammatory properties and could reduce the incidence and severity of tobramycin-induced hearing loss. METHODS:In vitro: neonatal cochlear cultures were treated with tobramycin or cotreated with ... Read more >>

J. Cyst. Fibros. (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2020, :]

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Amikacin Liposome Inhalation Suspension for Mycobacterium avium Complex Lung Disease.

Austin Golia, Brenden R Mahmood, Yaniset Fundora, Krisy-Ann Thornby, Elias B Chahine,

OBJECTIVE: To review the pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, safety, administration, and role of amikacin liposome inhalation suspension (ALIS) in treatment of Mycobacterium avium complex (MAC) lung disease.<br/> DATA SOURCES: A PubMed search using the terms "amikacin inhaled," "nebulized," and "liposome suspension" was performed. Selected infectious diseaseconference posters were also ... Read more >>

Sr Care Pharm (The Senior care pharmacist)
[2020, 35(4):162-170]

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Severe Neutropenia and Agranulocytosis Related to Antithyroid Drugs: A Study of 30 Cases Managed in A Single Reference Center.

Emmanuel Andrès, Noel Lorenzo Villalba, Rachel Mourot-Cottet, Frédéric Maloisel, Martine Tebacher, Jacques-Eric Gottenberg, Bernard Goichot, Raoul Herbrecht, Abrar-Ahmad Zulfiqar,

BACKGROUND:The most important series devoted to antithyroid drug-induced severe neutropenia and agranulocytosis are Japanese studies, almost specifically in relation to the intake of methimazole. The clinical data of 30 Caucasian patients followed up for antithyroid drug-induced neutropenia at a third-level hospital are reported. Methods: The data of 30 patients with ... Read more >>

Medicines (Basel) (Medicines (Basel, Switzerland))
[2020, 7(3):]

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Tegafur/gimeracil/oteracil-induced eosinophilic pneumonia.

Toshiyuki Sumi, Hisashi Nakata, Yuji Mori, Hiroki Takahashi,

Clinicians should be aware that eosinophilic pneumonia is one of the types of drug-induced lung injury that can be caused by tegafur/gimeracil/oteracil (TS-1). ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(4):e00551]

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Treatment Outcomes after Discontinuation of Ethambutol due to Adverse Events in Mycobacterium avium Complex Lung Disease.

Yong Shik Kwon, Byoung Soo Kwon, Ock Hwa Kim, Yea Eun Park, Tae Sun Shim, Yong Pil Chong, Kyung Wook Jo,

BACKGROUND:Long-term administration of ethambutol (EMB) for Mycobacterium avium complex lung disease (MAC-LD) sometimes leads to permanent discontinuation of EMB due to various adverse events. This study aimed to investigate treatment outcomes after discontinuation of EMB. METHODS:Among patients diagnosed with MAC-LD between January 2001 and December 2014, 508 patients whose treatment ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(9):e59]

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Adverse drug reaction prevalence and mechanisms of action of first-line anti-tubercular drugs.

Faisal Imam, Manju Sharma, Khalid Umer Khayyam, Naif O Al-Harbi, Mohd Khan Rashid, Mohammad Daud Ali, Ayaz Ahmad, Wajhul Qamar,

Purpose:Understanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity and mortality if not recognized early. Here, we aimed to characterize the mechanisms underlying adverse drug reactions due to combination anti-tuberculosis therapy of the Revised National ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2020, 28(3):316-324]

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Iatrogenic Decompensated Heart Failure.

Patrick Tran, Prithwish Banerjee,

PURPOSE OF REVIEW:To provide an overview of the potential iatrogenic causes of acute decompensated heart failure (AHF) and an evidence-based management strategy to address this. RECENT FINDINGS:As the heart failure (HF) population continues to age and become burdened with greater comorbidities and polypharmacy, patients become more susceptible to the iatrogenic ... Read more >>

Curr Heart Fail Rep (Current heart failure reports)
[2020, 17(2):21-27]

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Grade 4 Pneumonitis in a Patient Treated with a Combination of Gemcitabine and Docetaxel for Recurrent Leiomyosarcoma of the Uterus.

Connor Wang, Stephen Rose, Lori Mankowski Gettle, Ryan Spencer,

Gemcitabine and docetaxel combination chemotherapy is the standard of care for patients with unresectable recurrent or metastatic leiomyosarcoma of the uterus. Although they are generally well-tolerated agents, they can also cause severe and life-threatening pulmonary toxicities. Here, we describe a case of grade 4 pneumonitis due to gemcitabine and docetaxel ... Read more >>

Case Rep Obstet Gynecol (Case reports in obstetrics and gynecology)
[2020, 2020:4629452]

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Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective.

Yang Yang, Md Sahidul Islam, Jin Wang, Yuan Li, Xin Chen,

Currently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19)) has rapidly spread across China and around the world, causing an outbreak of acute infectious pneumonia. No specific anti-virus drugs or vaccines are available for the treatment of this sudden ... Read more >>

Int. J. Biol. Sci. (International Journal of Biological Sciences)
[2020, 16(10):1708-1717]

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Putative Abscopal Effect in Three Patients Treated by Combined Radiotherapy and Modulated Electrohyperthermia.

Mau-Shin Chi, Minesh P Mehta, Kai-Lin Yang, Hung-Chih Lai, Ying-Chu Lin, Hui-Ling Ko, Yu-Shan Wang, Kuang-Wen Liao, Kwan-Hwa Chi,

Purpose: True abscopal responses from radiation therapy are extremely rare; the combination of immune checkpoint inhibitors with radiation therapy has led to more reports of the abscopal effect, but even in this setting, the genuine magnitude remains unknown and is still considered generally uncommon. We report the occurrence of what ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:254]

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Single-lung stereotactic body radiotherapy: A case report and discussion of therapeutic challenges.

Meetakshi Gupta, Naveen Mummudi, Ritesh Mhatre, Jai Prakash Agarwal,

Lung India (Lung India : official organ of Indian Chest Society)
[2020, 37(2):177-179]

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Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial.

Xiangyu Zhang, Yi Xiong, Qing Xia, Fang Wu, Lingli Liu, Yuling Zhou, Liang Zeng, Chunhua Zhou, Chen Xia, Wenjuan Jiang, Dehua Liao, Lili Xiao, Li Liu, Haiyan Yang, Rui Guan, Kunyan Li, Jing Wang, Guang Lei, Yongchang Zhang, Nong Yang,

Importance:There is currently no standard treatment strategy for patients with advanced non-small cell lung cancer (NSCLC) without driver gene variation after failure of 2 or more lines of chemotherapy. Objective:To assess the efficacy and safety of apatinib combined with oral vinorelbine. Design, Setting, and Participants:This phase 2 prospective nonrandomized clinical ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201226]

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Anticancer Effects of Antihypertensive L-Type Calcium Channel Blockers on Chemoresistant Lung Cancer Cells via Autophagy and Apoptosis.

Bing-Sang Wong, Ling-Yen Chiu, Dom-Gene Tu, Gwo-Tarng Sheu, Ting-Tat Chan,

Purpose:Hypertension and cancer are frequently found comorbidity occurring in same individual. This study was intended to evaluate the anticancer effects of commonly used antihypertensive medications and chemotherapy on chemoresistant lung cancer cells. Methods:Calcium channel blockers (CCBs), including Verapamil, Diltiazem, and Nifedipine, either alone or combined with docetaxel (DOC) or vincristine ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:1913-1927]

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Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity.

Rachel A Schlaak, Gopika SenthilKumar, Marjan Boerma, Carmen Bergom,

Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

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The Hepatorenal Toxicity and Tumor Response of Chemotherapy With or Without Aidi Injection in Advanced Lung Cancer: A Meta-Analysis of 80 Randomized Controlled Trials.

Zheng Xiao, Yuan Jiang, Xiao-Fan Chen, Cheng-Qiong Wang, Wei-Hong Xu, Yao Liu, Shan-Shan Hu, Xiao-Rong Huang, Li-Jing Shan, Yu-Hong Tang, Yi-Bin Yang, Ji-Hong Feng, Xue Xiao, Xiao-Fei Li,

PURPOSE:Chemotherapy-induced hepatorenal toxicity often decreases tolerance for further therapies and results in poor quality of life and prognosis for patients with lung cancer. In this meta-analysis, all related studies were systematically re-evaluated to determine whether Aidi injection relieves hepatorenal toxicity and improves tumor response, and to determine its threshold and ... Read more >>

Clin Ther (Clinical therapeutics)
[2020, :]

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Influenza and Bacterial Coinfection in Adults With Community-Acquired Pneumonia Admitted to Conventional Wards: Risk Factors, Clinical Features, and Outcomes.

Gabriela Abelenda-Alonso, Alexander Rombauts, Carlota Gudiol, Yolanda Meije, Lucía Ortega, Mercedes Clemente, Carmen Ardanuy, Jordi Niubó, Jordi Carratalà,

Background:Relevance of viral and bacterial coinfection (VBC) in non-intensive care unit (ICU) hospitalized adults with community-acquired pneumonia (CAP) is poorly characterized. We aim to determine risk factors, features, and outcomes of VBC-CAP in this setting. Methods:This is a prospective cohort of adults admitted to conventional wards with CAP. Patients were ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(3):ofaa066]

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Smoking is associated with pneumonia development in lung cancer patients

Hye Kang, Jung Heo, Chang Yeo, Chan Park, Sung Kim, Ju Kim, Jin Kim, Seung Kim, Sang Lee,

<title>Abstract</title> <p> Background: Various host factors can promote pneumonia susceptibility of lung cancer patients. However, data about risk factors for pneumonia in lung cancer patients receiving active treatments such as chemotherapy, radiotherapy, and surgical intervention are limited. Thus, the purpose of this study was to identify risk factors ... Read more >>

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