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Doxazosin

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Acute hepatocellular drug-induced liver injury probably caused by Doxazosin.

Javier Jiménez Sánchez, Lidia Serrano Díaz, Juan José Martínez Crespo,

Drug-induced liver injury is a diagnostic challenge for any clinician. The alpha-blockers are safe and well tolerated. Acute symptomatic liver injury and severe hepatotoxicity due to doxazosin is quite rare. We present the case of a 73-year-old man who developed acute hepatocellular damage after starting treatment with doxazosin, which was ... Read more >>

Rev Esp Enferm Dig (Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva)
[2020, :]

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Safety of preoperative carvedilol in a patient with recent atenolol-induced pheochromocytoma crisis and cardiomyopathy: A case report.

Taweesak Wannachalee, Paweena Chunharojrith,

Introduction:Beta-adrenergic blockade without adequate alpha blockade is an established trigger of pheochromocytoma crisis (PC). Carvedilol is a nonselective beta-adrenergic and alpha 1-adrenergic blocking agent, and its use for preoperative preparation of pheochromocytoma patients with prior cardiomyopathy secondary to PC resulting from unopposed beta-blocker therapy has never been reported. Case presentation:A ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2020, 60:360-364]

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Worsening Kidney Function Is the Major Mechanism of Heart Failure in Hypertension: The ALLHAT Study.

Maedeh Khayyat-Kholghi, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko,

OBJECTIVES:The authors aimed to quantify the extent to which the effect of antihypertensive drugs on incident heart failure (HF) is mediated by their effect on kidney function. BACKGROUND:The authors hypothesized that the dynamic change in kidney function is the mechanism behind differences in the rate of incident HF in ALLHAT ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2020, :]

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Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults.

Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm,

BACKGROUND:Shock wave lithotripsy (SWL) is a widely used method to treat renal and ureteral stone. It fragments stones into smaller pieces that are then able to pass spontaneously down the ureter and into the bladder. Alpha-blockers may assist in promoting the passage of stone fragments, but their effectiveness remains uncertain.  OBJECTIVES: ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 11:CD013393]

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Canadian Consensus Conference on Diagnosis and Treatment of Dementia (CCCDTD)5: Guidelines for management of vascular cognitive impairment.

Eric E Smith, Philip Barber, Thalia S Field, Aravind Ganesh, Vladimir Hachinski, David B Hogan, Krista L Lanctôt, M Patrice Lindsay, Mukul Sharma, Richard H Swartz, Zahinoor Ismail, Serge Gauthier, Sandra E Black,

Introduction:Vascular disease is a common cause of dementia, and often coexists with other brain pathologies such as Alzheimer's disease to cause mixed dementia. Many of the risk factors for vascular disease are treatable. Our objective was to review evidence for diagnosis and treatment of vascular cognitive impairment (VCI) to issue ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12056]

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Preoperative Management of Pheochromocytoma and Paraganglioma.

Fang Fang, Li Ding, Qing He, Ming Liu,

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, characterized by excessive release of catecholamines (CAs), and manifested as the classic triad of headaches, palpitations, profuse sweating, and a variety of other signs and symptoms. The diagnosis of PPGL requires both evidence of excessive release of CAs and anatomical localization of ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:586795]

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Efficacy and Safety of Doxazosin in Medical Expulsive Therapy for Distal Ureteral Stones: A Systematic Review and Meta-analysis.

Li Ma, Shiyue Zou, Lu Yang, Fan Wang,

PURPOSE:Alpha-blockers have been proven as an effective method for increasing the stone expulsion rate of distal ureteral stones. Limited studies have focused on doxazosin; its efficacy remained unclear. We performed this meta-analysis to investigate the efficacy and safety of doxazosin for patients diagnosed with distal ureteral stones less than 10mm. ... Read more >>

Urol J (Urology journal)
[2020, 17(5):449-455]

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Letrozole targets the human ether-a-go-go-related gene potassium current in glioblastoma.

Tyler Shugg, Nimita Dave, Enoch Amarh, Abdullah A Assiri, Karen E Pollok, Brian R Overholser,

Aberrant expression of human ether-a-go-go-related gene (hERG) potassium channels has been implicated in the pathophysiology of glioblastoma (GBM). Letrozole has demonstrated efficacy in pre-clinical GBM models. The objective of this research was to assess the potential for hERG inhibition by letrozole to mediate efficacy in GBM. hERG currents were assessed ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2020, :]

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Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study.

Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood,

RATIONALE & OBJECTIVES:Alpha-blockers (ABs) are commonly prescribed for control of resistant or refractory hypertension in patients with and without chronic kidney disease (CKD). The association between AB use and kidney, cardiac, mortality, and safety-related outcomes in CKD remains unknown. STUDY DESIGN:Population-based retrospective cohort study. SETTINGS & PARTICIPANTS:Ontario (Canada) residents 66 ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, :]

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Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing.

Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Masashi Okada, Takashi Yoshioka, Chifumi Kitanaka,

Osimertinib, which is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an important anticancer drug because of its high efficacy and excellent safety profile. However, resistance against osimertinib is inevitable; therefore, therapeutic strategies to overcome the resistance are needed. Doxazosin, a classic quinazoline-based alpha 1-adrenoceptor antagonist is used ... Read more >>

Biomedicines (Biomedicines)
[2020, 8(8):]

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Late Worsening of COVID-19 Pneumonia: Successful Treatment with Ruxolitinib and Steroid.

Mauro Betelli, Fabio De Stefano, Alberto Tedeschi,

We describe the case of a patient hospitalized for the second time in a month due to delayed worsening of lung lesions in COVID-19 infection without bacterial superinfection. He was treated with hydroxychloroquine, IV dexamethasone and ruxolitinib with rapid improvement of respiratory failure; 1 month after the second discharge, maintaining ... Read more >>

Eur J Case Rep Intern Med (European journal of case reports in internal medicine)
[2020, 7(11):001938]

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Effectiveness of drugs acting on adrenergic receptors in the treatment for tobacco or alcohol use disorders: systematic review and meta-analysis.

Paul Vanderkam, Marcello Solinas, Isabelle Ingrand, Nicolas Doux, Soghra Ebrahimighavam, Nematollah Jaafari, Claire Lafay-Chebassier,

AIM:To assess the efficacy of drugs directly acting on alpha- and beta-adrenergic receptors in the treatment of patients suffering from tobacco or alcohol use disorder. METHODS:Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, studies were identified through PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials and ... Read more >>

Addiction (Addiction (Abingdon, England))
[2020, :]

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Effects of Autonomic Nervous System Activation on Endothelial Function in Response to Acute Exercise in Hypertensive Individuals: Study Protocol for A Randomized Double-Blind Study

Gustavo Waclawovsky, Liliana FC Boll, Salvador Gomes Neto, Maria Cláudia Irigoyen, Alexandre Machado Lehnen,

Abstract Background: Arterial hypertension has a direct association with endothelial dysfunction and major cardiovascular events. There is evidence showing the benefits of aerobic exercise on flow-mediated dilation (FMD) in hypertensive individuals but little is known about the effect of autonomic nervous system (ANS) activation on FMD of the brachial artery ... Read more >>

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Cost analysis of alpha blocker treatments for benign prostatic hyperplasia in Medicare beneficiaries.

Yulia Sidi, Yinghui Duan, Taeho Greg Rhee, Z Helen Wu,

OBJECTIVES:Tamsulosin is the most widely used alpha-1 blocker medication for managing benign prostatic hyperplasia (BPH) as indicated in the current practice guideline. The aim of this study was to compare all-cause medical costs and BPH-specific medical costs in older male adults with BPH treated with tamsulosin vs other alpha-1 blockers ... Read more >>

Res Social Adm Pharm (Research in social & administrative pharmacy : RSAP)
[2020, :]

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Repurposing of α1-Adrenoceptor Antagonists: Impact in Renal Cancer.

Meredith Mihalopoulos, Zachary Dovey, Maddison Archer, Talia G Korn, Kennedy E Okhawere, William Nkemdirim, Hassan Funchess, Ami Rambhia, Nihal Mohamed, Steven A Kaplan, Reza Mehrazin, Dara Lundon, Che-Kai Tsao, Ketan K Badani, Natasha Kyprianou,

Renal cancer ranks twelfth in incidence among cancers worldwide. Despite improving outcomes due to better therapeutic options and strategies, prognosis for those with metastatic disease remains poor. Current systemic therapeutic approaches include inhibiting pathways of angiogenesis, immune checkpoint blockade, and mTOR inhibition, but inevitably resistance develops for those with metastatic ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms.

Yeon Joo Kim, Bum Sik Tae, Jae Hyun Bae,

Special considerations should be made when selecting medications for the treatment of lower urinary tract symptoms (LUTS) in older patients especially those over 65 years old. This review summarizes the relationship between current treatments for LUTS and cognitive impairment. Although the recently reported association between dementia and tamsulosin is debatable, ... Read more >>

Int Neurourol J (International neurourology journal)
[2020, 24(3):231-240]

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Pharmacotherapeutic strategies for treating cocaine use disorder-what do we have to offer?

Laura Brandt, Thomas Chao, Sandra D Comer, Frances R Levin,

BACKGROUND:Cocaine use contines to be a significant public health problem world-wide. However, despite substantial research efforts, no pharmacotherapies are approved for the treatment of cocaine use disorder (CUD). ARGUMENT:Studies have identified positive signals for a range of medications for treating CUD. These include long-acting amphetamine formulations, modafinil, topiramate, doxazosin and ... Read more >>

Addiction (Addiction (Abingdon, England))
[2020, :]

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Pharmacological treatment of lower urinary tract symptoms in benign prostatic hyperplasia: consequences on sexual function and possible endocrine effects.

Sandro La Vignera, Antonio Aversa, Rossella Cannarella, Rosita A Condorelli, Ylenia Duca, Giorgio I Russo, Aldo E Calogero,

INTRODUCTION:Benign prostate hyperplasia (BPH) is one of the most prevalent diseases in aging men. It may adversely affect quality-of-life due to the presence of low urinary tract symptoms (LUTS) and its effects on sexuality. AREAS COVERED:The impact of α1-blockers, 5α-reductase inhibitors (5-ARI), and phosphodiesterase 5 inhibitors (PDE-5i) on erectile and ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2020, :1-11]

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The effects of a Chinese herbal medicine (VGHBPH0) on patients with benign prostatic hyperplasia: A pilot study.

Hsin-Fu Yeh, Tsai-Feng Li, Cheng-Hung Tsai, Pei-Wen Wu, Yi-Hsiu Huang, William J Huang, Fun-Jou Chen, Shinn-Jang Hwang, Fang-Pey Chen, Ta-Peng Wu,

BACKGROUND:The current Western medicine treatment options for benign prostatic hyperplasia (BPH) have various degrees of documented effectiveness. However, the uses of these interventions are limited to specific patient populations or have certain side effects that interfere with patient quality of life. This study evaluated the clinical effects of a Chinese ... Read more >>

J Chin Med Assoc (Journal of the Chinese Medical Association : JCMA)
[2020, 83(10):967-971]

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Paraganglioma in the posterior mediastinum: a case report.

Jong-Ho Nam, Jong-Seon Park, Joon Hyuk Choi,

BACKGROUND:Paragangliomas are tumors that arise from extra-adrenal chromaffin cells. Herein, we present a rare case of a functional paraganglioma in the posterior mediastinum. CASE PRESENTATION:A 36-year-old man presented with paroxysms of chest pain and headache. At presentation, the patient's blood pressure was 190/120 mmHg. Chest computed tomography and magnetic resonance imaging ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):492]

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Haemodynamic instability of the phaeochromocytoma.

Eugénie S Lim, Scott A Akker,

(Gland surgery)
[2020, 9(4):869-871]

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Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.

Marcelo F Lopez, Sarah E Reasons, Benjamin A Carper, Tracy L Nolen, Rick L Williams, Howard C Becker,

The comorbidity between alcohol use disorder and post-traumatic stress disorder represents a serious health care burden with few effective treatment options. The current study was designed to evaluate the effect of an alpha 1 receptor antagonist (doxazosin) and a novel anticonvulsant (zonisamide) in a model of alcohol (ethanol) dependence and ... Read more >>

Alcohol (Alcohol (Fayetteville, N.Y.))
[2020, 89:37-42]

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Management of hypertensive crisis with clevidipine in the perioperative setting of a critically ill patient, non-responder to high doses of nitroglycerin, labelatol, urapidil, doxazosin and furosemide.

V López Pérez, M Y Tebar Cuesta, J L Mesa Ruiz, J J Arcas Bellas,

Rev Esp Anestesiol Reanim (Revista espanola de anestesiologia y reanimacion)
[2020, :]

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Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth.

Cody M Orahoske, Yaxin Li, Aaron Petty, Fatma M Salem, Jovana Hanna, Wenjing Zhang, Bin Su, Bingcheng Wang,

EphA2 receptor kinase could become a novel target for anti-glioblastoma treatment. Doxazosin previously identified acts like the endogenous ligand of EphA2 and induces cell apoptosis. Through lead structure modification a derivative of Doxazosin possessing unique dimeric structure showed an improvement in the activity. In the current study, we expanded the ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2020, 28(18):115656]

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Doxazosin for the treatment of nightmare disorder: A diary-based case study.

Ståle Pallesen, Hilde Sofie Hamre, Nina Lang, Bjørn Bjorvatn,

The α1-adrenergic antagonist prazosin has showed good effect against posttraumatic stress disorder-related nightmares in several randomized controlled trials. The α1-adrenergic antagonist doxazosin, which has a longer half-live than prazosin, has received far less attention in the treatment of such nightmares. Here, we report a case of a patient suffering from ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2020, 8:2050313X20936079]

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