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Immunotherapy toxicity. Diagnosis and treatment.

Carlos Toribio-Vázquez, Juan Gómez Rivas, Alvaro Yebes, Diego M Carrión, José Quesada-Olarte, Carlos R Trelles, Mario Álvarez-Maestro, Henk van der Poel, Luis Martínez-Piñeiro,

Anti CTLA-4, anti PD-L1 and anti PD-1immune check point inhibitors (ICI) down regulate natural inhibitory pathways of the immune system, in turn increasing tumour surveillance and elimination. Cancer treatment through immune regulation has revolutionised many cancer therapies. However, these new treatments have also brought unique immune related adverse events (irAEs).<b>Objective: ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2021, 73(10):906-917]

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Distal radial approach versus conventional radial approach: a comparative study of feasibility and safety.

Rania Hammami, Fatma Zouari, Mohamed Aymen Ben Abdessalem, Awatef Sassi, Tarek Ellouze, Amine Bahloul, Souad Mallek, Faten Triki, Abdallah Mahdhaoui, Gouider Jeridi, Leila Abid, Selma Charfeddine, Samir Kammoun, Jihen Jdidi,

The distal radial approach (DRA) is suggested to have benefits over the conventional radial approach (CRA) in terms of local complications and comfort of both patient and operator. Therefore, we aimed to compare the feasibility and safety of DRA and CRA in a real life population. We conducted a prospective, ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1830600]

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Disparities in case frequency and mortality of coronavirus disease 2019 (COVID-19) among various states in the United States.

Rohit S Loomba, Gaurav Aggarwal, Saurabh Aggarwal, Saul Flores, Enrique G Villarreal, Juan S Farias, Carl J Lavie,

OBJECTIVE:To utilize publicly reported, state-level data to identify factors associated with the frequency of cases, tests, and mortality in the USA. MATERIALS AND METHODS:Retrospective study using publicly reported data collected included the number of COVID-19 cases, tests and mortality from March 14th through April 30th. Publicly available state-level data was ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):151-159]

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Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.

Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Francisco Javier Martínez-Marcos, Luis M Pérez-Belmonte, Alicia Hidalgo-Jiménez, Verónica Buonaiuto, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Davide Luordo, Paula Maria Pesqueira Fontan, Julio César Blázquez Encinar, Jeffrey Oskar Magallanes Gamboa, Andrés de la Peña Fernández, José David Torres Peña, Joaquim Fernández Solà, Jose Javier Napal Lecumberri, Francisco Amorós Martínez, María Esther Guisado Espartero, Carlos Jorge Ripper, Raquel Gómez Méndez, Natalia Vicente López, Berta Román Bernal, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Ricardo Gómez Huelgas, ,

BACKGROUND:Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS:This is a retrospective multi-centre study involving patients hospitalized in Spain. ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):103-116]

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Recognition of moyamoya disease and its hemorrhagic risk using deep learning algorithms: sourced from retrospective studies.

Yu Lei, Xin Zhang, Wei Ni, Heng Yang, Jia-Bin Su, Bin Xu, Liang Chen, Jin-Hua Yu, Yu-Xiang Gu, Ying Mao,

Although intracranial hemorrhage in moyamoya disease can occur repeatedly, predicting the disease is difficult. Deep learning algorithms developed in recent years provide a new angle for identifying hidden risk factors, evaluating the weight of different factors, and quantitatively evaluating the risk of intracranial hemorrhage in moyamoya disease. To investigate whether ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):830-835]

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Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies.

Marika Premoli, Maurizio Memo, Sara Anna Bonini,

Mice use ultrasonic vocalizations (USVs) to communicate each other and to convey their emotional state. USVs have been greatly characterized in specific life phases and contexts, such as mother isolation-induced USVs for pups or female-induced USVs for male mice during courtship. USVs can be acquired by means of specific tools ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(6):1158-1167]

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Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair.

Sigrun Lange,

Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes, including in the central nervous system. Peptidylarginine deiminases cause post-translational deimination/citrullination, leading to changes in structure and function of a wide range of target proteins. Deimination can facilitate protein moonlighting, modify protein-protein interaction, cause ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):934-938]

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Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study.

Marisa Lima, Miguel Tábuas-Pereira, Diana Duro, João Durães, Daniela Vieira, Inês Baldeiras, Maria Rosário Almeida, Isabel Santana,

The distinction between sporadic and genetic behavioural-variant frontotemporal dementia (bvFTD) regarding some neuropsychological (NP) features remains challenging. Specifically, progranulin (GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer's disease (AD) diagnosis. In this context, we aimed to characterize the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):910-915]

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Current scenario of the genetic testing for rare neurological disorders exploiting next generation sequencing.

Chiara Di Resta, Giovanni Battista Pipitone, Paola Carrera, Maurizio Ferrari,

Next generation sequencing is currently a cornerstone of genetic testing in routine diagnostics, allowing for the detection of sequence variants with so far unprecedented large scale, mainly in genetically heterogenous diseases, such as neurological disorders. It is a fast-moving field, where new wet enrichment protocols and bioinformatics tools are constantly ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):475-481]

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Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis: a retrospective case-control study.

Xue-Ping Chen, Qian-Qian Wei, Ru-Wei Ou, Yan-Bing Hou, Ling-Yu Zhang, Xiao-Qin Yuan, Yun-Qian Yao, De-Sheng Jia, Qian Zhang, Wei-Xue Li, Hui-Fang Shang,

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. In the present retrospective case-control study, we included 582 patients with amyotrophic lateral sclerosis and 582 age- and sex-matched healthy controls. All amyotrophic lateral sclerosis participants received treatment ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):591-595]

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Laboratory Diagnostic Methods for Clostridioides difficile Infection: the First Systematic Review and Meta-analysis in Korea.

Hae-Sun Chung, Jeong Su Park, Bo-Moon Shin,

Background:Various methods are used for the diagnosis of Clostridioides difficile infection (CDI). We systematically analyzed and investigated the performance of current laboratory diagnostic methods for CDI. Methods:We performed systematic review and meta-analysis of studies in PubMed, Web of Science, Cochrane Library, and KoreaMed. The following methods were evaluated: glutamate dehydrogenase ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2021, 41(2):171-180]

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Regulated upon activation, normal T cell expressed and secreted (RANTES) levels in the peripheral blood of patients with Alzheimer's disease.

Gabriela Vacinova, Daniela Vejražkova, Robert Rusina, Iva Holmerová, Hana Vaňková, Eva Jarolímová, Josef Včelák, Běla Bendlová, Markéta Vaňková,

Alzheimer's disease (AD) is the most common type of dementia, but it is very difficult to diagnose with certainty, so many AD studies have attempted to find early and relevant diagnostic markers. Regulated upon activation, normal T cell expressed and secreted (RANTES, also known as C-C chemokine ligand) is a ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):796-800]

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Nanobubble Lung Ultrasound Application in the Treatment of Neonatal Pneumonia.

Jia Zhou, Qingyu Zhang, Qi Zhang, Zhiyi Zhang, Henoc Soude, Robert Abo,

This article studies the effect of pulmonary ultrasound in the diagnosis and treatment of neonatal pneumonia. In this experiment, 33 children with pneumonia diagnosed and treated in the hospital were selected as the research objects, and all were performed by X-ray examination and lung ultrasound. After the test was completed, ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1244-1249]

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Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation.

Hui-Ling Wang, Fei-Lai Liu, Rui-Qing Li, Ming-Yue Wan, Jie-Ying Li, Jing Shi, Ming-Li Wu, Jun-Hua Chen, Wei-Juan Sun, Hong-Xia Feng, Wei Zhao, Jin Huang, Ren-Chao Liu, Wen-Xue Hao, Xiao-Dong Feng,

Electroacupuncture has been widely used to treat cognitive impairment after cerebral ischemia, but the underlying mechanism has not yet been fully elucidated. Studies have shown that autophagy plays an important role in the formation and development of cognitive impairment, and the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway plays an important role ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(6):1011-1016]

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Application of Multi-Modal Imaging Mediated by Iron Carbon Nanoparticles Based on Reinforcement Learning in the Diagnosis of Breast Nodules.

Yanni Zeng, Jiuxia Zhang, Jun Meng, Sonthaya Numthuam, K Naruse,

Breast cancer has become the first malignant tumor in women. Early detection and early treatment are the key to improve the prognosis of breast cancer patients. The key to the screening and diagnosis of breast cancer lies in the qualitative differential diagnosis of breast nodules. With the rapid development of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1154-1160]

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Application of Abdominal Imaging Based on Nano Drug Delivery System for Diagnosis and Treatment of Liver Cancer.

Zhenzhen Fan, Qingsheng Liu, Fangfang Lu, Zhihui Dong, Peng Gao, Nassima Bouadem, Bashir Yahya,

Liver cancer has a high incidence and a poor prognosis, which seriously affects human health. Doxorubicin is one of the chemotherapeutics used in the treatment of tumours, but its severe adverse reactions, especially cardiac toxicity, have limited its clinical application. The nanometre drug delivery system enables drug-loaded nanoparticles to be ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):824-832]

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New Horizons in Imaging and Diagnosis in Rhinoplasty.

Gregory P Mueller, Husain Ali Khan, James D Frame,

Three-dimensional (3D) surface imaging has found its place in aesthetic surgery globally. The first attempt to use 3D surface imaging technique in clinic was in 1944 by Thalmaan, who used stereo photogrammetry to examine an adult with facial asymmetry and a baby with Pierre Robin syndrome. Three-dimensional photography is becoming ... Read more >>

Oral Maxillofac Surg Clin North Am (Oral and maxillofacial surgery clinics of North America)
[2021, 33(1):1-5]

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Effects of Nano-Sulfides on Learning and Memory Abilities and Expression of Related Genes in Cyclic Adenosine Monophosphate-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway in Rats.

Weilai Chen, Meng Chen, Shuanghong Jin, Shaoxun Li, Chenwei Pan, Baohua Liu, Congduc Pham, Fatma Somaa,

In recent years, with the rapid development of nano-biotechnology and biomedicine, people have provided new ideas and methods for disease diagnosis and treatment. Nano-sulfides with unique two-dimensional structures and special physicochemical properties have begun to be applied to biology and medical field. Relevant research results show that nano-sulfides have good ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1142-1147]

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Application of Hydrogen Peroxide Sensitive Fluorescen Nanoparticles in Atherosclerosis.

Yuchao Zhang, Gang Xu, Maozhen Chen, Ziliang Chen, Mingyang Shen, Ping Wang, Guillaume Terrasson, Usman Raza,

ROS plays an important role in the formation of atherosclerotic plaque, especially hydrogen peroxide, which can stimulate macrophages to express pro-inflammatory cytokines and chemokines to enhance the inflammatory activity of macrophages. Therefore, the development of drugs with sensitive release of hydrogen peroxide is safe and effective for the treatment of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):833-842]

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Serum total prostate-specific antigen (tPSA): correlation with diagnosis and grading of prostate cancer in core needle biopsy.

Nina Čamdžić, Suada Kuskunović-Vlahovljak, Mirsad Dorić, Svjetlana Radović, Edina Lazović Salčin, Mirsad Babić,

Aim To investigate the impact of pre-treatment serum total prostate-specific antigen (PSA) level on prevalence of prostate carcinoma detection in prostate core needle biopsy, and its correlation with established prognostic factors. Methods Prostate needle biopsy samples of 115 patients with available pre-treatment serum total PSA (tPSA) level were analysed. For ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

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Evaluation of Patients with Neurogenic Thoracic Outlet Syndrome.

Nikhil Panda, Dean M Donahue,

Neurogenic thoracic outlet syndrome (NTOS) results from the compression or irritation of the brachial plexus within the thoracic outlet. The associated symptoms result in significant disability and negative effects on patient health-related quality of life. The diagnosis of NTOS, despite being the most common type of TOS, remains challenging for ... Read more >>

Thorac Surg Clin (Thoracic surgery clinics)
[2021, 31(1):55-59]

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Headache in the Emergency Department: Avoiding Misdiagnosis of Dangerous Secondary Causes, An Update.

Ryan Raam, Ramin R Tabatabai,

In the initial assessment of the headache patient, the emergency physician must consider several dangerous secondary causes of headache. A thorough history and physical examination, along with consideration of a comprehensive differential diagnosis may alert the emergency physician to the diagnosis of a secondary headache particularly when the history is ... Read more >>

Emerg Med Clin North Am (Emergency medicine clinics of North America)
[2021, 39(1):67-85]

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Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.

Raud Razzaghi, Shreya Agarwal, Nikita Kotlov, Olga Plotnikova, Krystle Nomie, Da Wei Huang, George W Wright, Grace A Smith, Moyi Li, Katsuyoshi Takata, Maryam Yamadi, Chen Yao, John J O'Shea, James D Phelan, Stefania Pittaluga, David W Scott, Jagan R Muppidi,

Fas is highly expressed on germinal center (GC) B cells, and mutations of FAS have been reported in diffuse large B cell lymphoma (DLBCL). Although GC-derived DLBCL has better overall outcomes than other DLBCL types, some cases are refractory, and the molecular basis for this is often unknown. We show ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(3):]

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Evaluation of the Efficacy and Performance of a New Nano-Drug Carrier in the Treatment of Recurrent Oral Ulcerper.

Yuqi He, Zhiqiang Xu, Zhuwen Qiu, Dechun Zheng, Liting Xie, Torsten Oekermann, Bijan Shirinzadeh,

Recurrent oral ulcer is a common oral mucosal disease. Due to its periodic and recurrent characteristics, the onset of burning pain is unbearable, which brings great inconvenience to the patient's life and seriously affects the patient's quality of life. There are certain limitations to conventional drug therapy. With the rapid ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1107-1117]

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Novel approaches in occupational asthma diagnosis and management.

Santiago Quirce, Javier Domínguez-Ortega, Juan A Luna,

<b>Purpose of review: </b>To describe the recent findings of the last 2 years on the epidemiology and phenotypes of occupational asthma, as well as new developments in its diagnosis and management.<br><br><b>Recent findings: </b>Data from nine longitudinal studies showed a population attributable fraction for the occupational contribution to incident asthma of ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2021, 27(1):9-14]

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