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Dexamethasone

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Protein profiling identified mitochondrial dysfunction and synaptic abnormalities after dexamethasone intervention in rats with traumatic brain injury.

Fei Niu, Bin Zhang, Jie Feng, Xiang Mao, Xiao-Jian Xu, Jin-Qian Dong, Bai-Yun Liu,

Dexamethasone has been widely used after various neurosurgical procedures due to its anti-inflammatory property and the abilities to restore vascular permeability, inhibit free radicals, and reduce cerebrospinal fluid production. According to the latest guidelines for the treatment of traumatic brain injury in the United States, high-dose glucocorticoids cause neurological damage. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2438-2445]

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Modified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4+ type 9 helper T cells and the VIP-VPAC2 signalling pathway.

Muhua Huang, Jinfeng Wu, Jingcheng Dong,

<h4>Context</h4>Modified BuShenYiQi formula (M-BYF) is derived from BuShenYiQi formula, used for the treatment of allergic asthma. The exact effect and mechanism of M-BYF on the improvement of asthma remain unclear.<h4>Objective</h4>We investigated the mechanism underlying the therapeutic effect of M-BYF on allergic asthma.<h4>Materials and methods</h4>The asthma model was established in female ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1216-1232]

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3-weekly daratumumab-lenalidomide/pomalidomide-dexamethasone is highly effective in relapsed and refractory multiple myeloma.

Chor Sang Chim, Shaji Kumar, Vincent Kai Chung Wong, Cheong Ngai, Yok Lam Kwong,

<h4>Objectives</h4>Myeloma relapse remains challenging. Daratumumab (dara) with immunomodulatory agents (IMiD) and dexamethasone (dex) was proven highly effective in relapsed or refractory multiple myeloma (RRMM) in randomized controlled trials. The recommended schedule of dara is weekly for eight doses, followed by 2-weekly for eight doses, and then every 4-weekly thereafter. However, ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):652-655]

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Preparation, characterization, and in vitro/vivo evaluation of dexamethasone/poly(ε-caprolactone)-based electrode coatings for cochlear implants.

Yanjing Luo, Anning Chen, Muqing Xu, Dongxiu Chen, Jie Tang, Dong Ma, Hongzheng Zhang,

With dexamethasone as the model drug and polycaprolactone (PCL) as the carrier material, a drug delivery coating for cochlear electrodes was prepared, to control cochlear fibrosis caused by cochlear implantation. A dexamethasone/poly (ε-caprolactone)-based electrode coating was prepared using the impregnation coating method. Preparation parameters were optimized, yielding 1 impregnation instance, ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1673-1684]

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2,4,6-Trihydroxy-3-geranyl acetophenone suppresses vascular leakage and leukocyte infiltration in lipopolysaccharide-induced endotoxemic mice.

Yee Han Chan, Nazmi Firdaus Musa, Yi Joong Chong, Siti Arfah Saat, Faizul Hafiz, Khozirah Shaari, Daud Ahmad Israf, Chau Ling Tham,

<h4>Context</h4>Lipopolysaccharide (LPS) exacerbates systemic inflammatory responses and causes excessive fluid leakage. 2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) has been revealed to protect against LPS-induced vascular inflammation and endothelial hyperpermeability <i>in vitro.</i><h4>Objective</h4>This study assesses the <i>in vivo</i> protective effects of tHGA against LPS-induced systemic inflammation and vascular permeability in endotoxemic mice.<h4>Materials and methods</h4>BALB/c mice were intraperitoneally ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):732-740]

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Feasibility of six cycles of lenalidomide-based triplet induction before stem cell collection for newly diagnosed transplant-eligible multiple myeloma.

Satoshi Yoshihara, Kyoko Yoshihara, Yoshifumi Shimizu, Takehito Imado, Hiroyuki Takatsuka, Hiroyuki Kawamoto, Mahito Misawa, Hideki Ifuku, Yokiko Ohe, Masaya Okada, Yoshihiro Fujimori,

<h4>Objectives</h4>Achieving a deep response with induction therapy has a major impact on outcomes following autologous stem cell transplantation. Although longer and intensified induction therapy may provide better disease control, longer exposure to lenalidomide negatively affects stem cell yield. We examined the feasibility of 6 cycles of lenalidomide-based triplet induction therapy ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):388-392]

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From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19?

Alex G Gauthier, Mosi Lin, Jiaqi Wu, Thomas P Kennedy, Lee-Anne Daley, Charles R Ashby, Lin L Mantell,

The coronavirus SARS-CoV-2 of 2019 (COVID-19) causes a pandemic that has been diagnosed in more than 70 million people worldwide. Mild-to-moderate COVID-19 symptoms include coughing, fever, myalgia, shortness of breath, and acute inflammatory lung injury (ALI). In contrast, acute respiratory distress syndrome (ARDS) and respiratory failure occur in patients diagnosed ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):23-29]

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Dexamethasone on absent end-diastolic flow in umbilical artery, in growth restricted fetuses from early-onset preeclamptic pregnancies and the perinatal outcome.

Oana Sorina Tica, Andrei Adrian Tica, Doriana Cojocaru, Mihaela Gheonea, Irina Tica, Dragos Ovidiu Alexandru, Victor Cojocaru, Lucian Cristian Petcu, Vlad Iustin Tica,

<h4>Background</h4>Absent end-diastolic flow (AEDF) in the umbilical artery (UA) worsens the already poor prognosis of growth-restricted fetuses (GRFs) in pregnancies complicated by early-onset preeclampsia with severe features (ESP).<h4>Method</h4>We assessed the correlation between the effect of maternal dexamethasone (Dex) on AEDF in the UA and perinatal outcomes, in 59 GRFs from ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1455-1463]

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An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer.

Josephina P M Vrouwe, Ingrid M C Kamerling, Michiel J van Esdonk, Josbert M Metselaar, Frederik E Stuurman, Gabri van der Pluijm, Jacobus Burggraaf, Susanne Osanto,

Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer (mCRPC). We aimed to investigate intravenous liposome-encapsulated dexamethasone disodium phosphate (liposomal dexamethasone) administration in mCRPC patients. In this exploratory first-in-man study, patients in part A received a starting dose of 10 mg followed by five doses of 20 mg liposomal dexamethasone at ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(5):e00845]

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Post COVID 19 multisystem inflammatory syndrome in an older adult.

Alexander Parpas, Michael Yudd, Albert W Dreisbach, Jennine Michaud,

Ren Fail (Renal failure)
[2021, 43(1):530-532]

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Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia.

Run-Qing Lu, Li-Xin Wu, Jing Zhang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai, Hao Jiang, Ying-Jun Chang, Guo-Rui Ruan, Xiao-Jun Huang,

<h4>Objectives</h4>Ras-related dexamethasone-induced 1 (<i>RASD1</i>) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, <i>RASD1</i>, as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL.<h4>Methods</h4>The ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):9-15]

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Dexamethasone or methylprednisolone therapy in covid-19 pneumonia: A retrospective and comparative study of 513 cases

Sanae El mezzeoui, Ghizlane El aidouni, Manal Merbouh, Abderrahim El Kaouini, Fatima Zahra Aftiss, Samia berrichi, Sara Berrajaa, Houssam Bkiyer, Naima Abda, Brahim Housni,

<h4>Backgrounds</h4> Corona virus disease 19 (Covid-19) affects especially the respiratory tract, and induces lung injury which may progress to the acute respiratory distress syndrome (ARDS). Various treatment options were tried all over the world, corticosteroids had showed beneficial effects. The Objective of this study, is to compare the safety and ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2021, :]

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Persistent hiccups after treatment of COVID-19 with dexamethasone: A case report.

Sajad Karampoor, Fatemeh Afrashteh, Azadeh Laali,

Hiccups are involuntary and spasmodic contractions of the diaphragm, and multiple etiological factors have been suggested to be involved. Medications, such as dexamethasone, as well as some diseases, such as pneumonia, can cause persistent (>48 h) hiccups. Here, we report a 58-years-old male who had a fever, myalgia, cough, and ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2021, 34:101515]

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Perineural dexamethasone reduces rebound pain after ropivacaine single injection interscalene block for arthroscopic shoulder surgery: a randomized controlled trial.

Jae Hee Woo, Hyun Jung Lee, Hye-Won Oh, Jong Wha Lee, Hee Jung Baik, Youn Jin Kim,

<h4>Background and objectives</h4>A single injection interscalene block (ISB) is a common regional analgesic technique in patients undergoing arthroscopic shoulder surgery. However, rebound pain after ISB resolution may reduce its overall benefit. Our primary aim was to assess whether perineural dexamethasone reduces the intensity and incidence of rebound pain in patients ... Read more >>

Reg Anesth Pain Med (Regional anesthesia and pain medicine)
[2021, :]

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Effect of regular and irregular stimulation cycles of dexamethasone on circadian clock in NIH3T3 cells.

Dan Yang, Hideaki Oike, Mitsuhiro Furuse, Shinobu Yasuo,

Animal studies have shown that irregular light-dark cycles cause circadian desynchronization, while few studies have addressed the effect of regular/irregular stimulation cycles of signaling hormones on the cellular clock <i>in vitro</i>. Here, we examined how cellular clocks respond to regular and irregular stimulation cycles of dexamethasone, using NIH3T3 cells transfected ... Read more >>

Chronobiol Int (Chronobiology international)
[2021, :1-9]

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A Randomized, Multicenter, Open-Label, Blinded End Point, Phase 2, Feasibility, Efficacy, and Safety Trial of Preoperative Microvascular Protection in Patients Undergoing Major Abdominal Surgery.

Fumitaka Yanase, Shervin H Tosif, Leonid Churilov, Ken Yee, Rinaldo Bellomo, Kerry Gunn, Chang Kim, Camilla Krizhanovskii, Robert G Hahn, Bernhard Riedel, Laurence Weinberg,

<h4>Background</h4>The endothelial glycocalyx, a carbohydrate-rich layer coating all endothelial surfaces, plays a fundamental role in the function of microcirculation. The primary aim of this study was to evaluate the feasibility of using dexamethasone and albumin to protect the endothelial glycocalyx in patients undergoing abdominal surgery. Secondary and exploratory outcomes included ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(4):1036-1047]

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Dexamethasone is associated with early deaths in light chain amyloidosis patients with severe cardiac involvement.

Mélanie Bézard, Silvia Oghina, Damien Vitiello, Mounira Kharoubi, Ekaterini Kordeli, Arnault Galat, Amira Zaroui, Soulef Guendouz, Floriane Gilles, Jason Shourick, David Hamon, Vincent Audard, Emmanuel Teiger, Elsa Poullot, Valérie Molinier-Frenkel, François Lemonnier, Onnik Agbulut, Fabien Le Bras, Thibaud Damy,

<h4>Background</h4>Cardiac light chain amyloidosis (AL-CA) patients often die within three months of starting chemotherapy. Chemotherapy for non-immunoglobulin M gammopathy with AL-CA frequently includes bortezomib (Bor), cyclophosphamide (Cy), and dexamethasone (D). We previously reported that NT-ProBNP levels can double within 24h of dexamethasone administration, suggesting a deleterious impact on cardiac function. ... Read more >>

PLoS One (PloS one)
[2021, 16(9):e0257189]

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Effects of the addition of dexamethasone on postoperative analgesia after anterior cruciate ligament reconstruction surgery under quadruple nerve blocks.

Yuki Aoyama, Shinichi Sakura, Shoko Abe, Erika Uchimura, Yoji Saito,

<h4>Background</h4>Anterior cruciate ligament (ACL) reconstruction is an invasive surgical procedure for the knee. Quadruple nerve blocks including continuous femoral nerve block and single-injection sciatic, obturator, and lateral femoral cutaneous nerve blocks can provide effective intraoperative anesthesia and analgesia in the early postoperative period. However, severe pain often appears after the ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2021, 21(1):218]

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Treatment of moderate to severe respiratory COVID-19: a cost-utility analysis.

Stephen E Congly, Rhea A Varughese, Crystal E Brown, Fiona M Clement, Lynora Saxinger,

Despite COVID-19's significant morbidity and mortality, considering cost-effectiveness of pharmacologic treatment strategies for hospitalized patients remains critical to support healthcare resource decisions within budgetary constraints. As such, we calculated the cost-effectiveness of using remdesivir and dexamethasone for moderate to severe COVID-19 respiratory infections using the United States health care system ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):17787]

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Fentanyl versus dexamethasone or both as adjuvants to bupivacaine in an ultrasound-guided paravertebral block in patients undergoing modified radical mastectomy: a randomized double-blind clinical study.

Amani H Abdel-Wahab, Amonios K Gegres, Rasha Hamed, Mohamed M Abdellatif,

<h4>Background</h4>This study aimed to compare the effect of dexamethasone added to fentanyl and bupivacaine with the effect of either dexamethasone or fentanyl alone when combined with bupivacaine.in the thoracic paravertebral block (TPVB).<h4>Methods</h4>Sixty female patients (aged 18-60 years), scheduled for modified radical mastectomy were enrolled. Patients received preoperative unilateral paravertebral block ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, :]

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Direct oral anticoagulant plasma levels in hospitalized COVID-19 patients treated with dexamethasone.

Nicola Potere, Matteo Candeloro, Ettore Porreca, Stefano Marinari, Camilla Federici, Raffaella Auciello, Marcello Di Nisio,

Direct oral anticoagulants (DOACs) are not recommended in COVID-19 patients receiving dexamethasone because of potential drug-drug and drug-disease interactions affecting anticoagulant concentration and activity. To evaluate short- and long-term pharmacokinetic interactions, serial through and peak DOAC plasma levels were prospectively measured during and after dexamethasone therapy, as well as during ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, :]

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Systemic and topical Ginkgo biloba leaf extract ameliorated rat paw inflammation in comparison to dexamethasone.

Rania A Abdel-Emam, Ahmed M Abd-Eldayem,

<h4>Ethnopharmacological relevance</h4>Ginkgo Biloba leaf extract (Egb-761) is used for treating various inflammatory disease conditions therefore this study was performed.<h4>Aim of the study</h4>The present study aimed at comparing the therapeutic efficacy of both systemic and topical Egb-761 versus dexamethasone on carrageenan-induced hind paw inflammation in rats.<h4>Material and methods</h4>Wistar albino rats were ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, :114619]

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Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: a randomised phase 2 trial by the Nordic Myeloma Study Group.

Henrik Gregersen, Valdas Peceliunas, Kari Remes, Fredrik Schjesvold, Niels Abildgaard, Hareth Nahi, Niels Frost Andersen, Annette Juul Vangsted, Tobias Wirenfeldt Klausen, Carsten Helleberg, Kristina Carlson, Ulf Christian Frølund, Per Axelsson, Olga Stromberg, Cecilie Hveding Blimark, Jacob Crafoord, Galina Tsykunova, Henrik Rode Eshoj, Anders Waage, Markus Hansson, Nina Gulbrandsen,

We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma. This randomised, open-label, phase 2 trial included patients with first relapse of multiple myeloma after upfront ASCT who were ... Read more >>

Eur J Haematol (European journal of haematology)
[2021, :]

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Effect of Dexamethasone In Patients With ARDS And COVID-19 (REMED Trial) – Study Protocol For A Prospective, Multi-Centre, Open-Label, Parallel-Group, Randomized Controlled Trial

Jan Maláska, Jan Stašek, František Duška, Martin Balík, Jan Máca, Jan Hruda, Tomáš Vymazal, Olga Klementová, Jan Zatloukal, Tomáš Gabrhelík, Pavel Novotný, Regina Demlová, Jana Kubátová, Jana Vinklerová, Adam Svobodník, Milan Kratochvíl, Jozef Klučka, Roman Gál, Mervyn Singer,

<h4>Background: </h4> Since December 2019, SARS-Co-2 virus has infected millions of people worldwide. In patients with COVID-19 pneumonia in need for oxygen therapy or mechanical ventilation, dexamethasone 6 mg per day is currently recommended. However, the dose of 6 mg of dexamethasone is currently being reappraised and may miss important ... Read more >>

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Indatuximab ravtansine plus dexamethasone with lenalidomide or pomalidomide in relapsed or refractory multiple myeloma: a multicentre, phase 1/2a study.

Kevin R Kelly, Sikander Ailawadhi, David S Siegel, Leonard T Heffner, George Somlo, Sundar Jagannath, Todd M Zimmerman, Nikhil C Munshi, Sumit Madan, Asher Chanan-Khan, Sagar Lonial, Suraj Chandwani, Ashot Minasyan, Markus Ruehle, Farima Barmaki-Rad, Afsaneh Abdolzade-Bavil, Faiza Rharbaoui, Eva Herrmann-Keiner, Thomas Haeder, Andrea Wartenberg-Demand, Kenneth C Anderson,

<h4>Background</h4>Indatuximab ravtansine (BT062) is an antibody-drug conjugate that binds to CD138 and synergistically enhances the antitumor activity of lenalidomide in preclinical models of multiple myeloma. This phase 1/2a study was done to determine the safety, activity, and pharmacokinetics of indatuximab ravtansine in combination with immunomodulatory drugs in patients with relapsed ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2021, :]

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