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Comparison of the performance of a chemiluminescence assay and an ELISA for detection of anti-GBM antibodies.

Ying Tan, Wei Pang, Xiaoyu Jia, Ming-Hui Zhao,

Objective: Autoantibodies to the α3 chain noncollagen 1 domain of type IV collagen (α3(IV)NC1) are a serological hallmark in the diagnosis of anti-glomerular basement membrane (GBM) disease. The objective of our study was to compare the performance of anti-glomerular basement membrane (GBM) antibody detection by chemiluminescence immunoassay (CIA) and by ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):48-53]

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Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards.

Susanne Koethe, Lorenz Ulrich, Reiner Ulrich, Susanne Amler, Annika Graaf, Timm C Harder, Christian Grund, Thomas C Mettenleiter, Franz J Conraths, Martin Beer, Anja Globig,

In 2016/2017, a severe epidemic of HPAIV H5N8 clade 2.3.4.4 group B (H5N8B) affected Europe. To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged with H5N8B. All experiments were controlled by ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):180-193]

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Carbonic anhydrase IX as a novel candidate in liquid biopsy.

Ozen Ozensoy Guler, Claudiu T Supuran, Clemente Capasso,

Among the diagnostic techniques for the identification of tumour biomarkers, the liquid biopsy is considered one that offers future research on precision diagnosis and treatment of tumours in a non-invasive manner. The approach consists of isolating tumor-derived components, such as circulating tumour cells (CTC), tumour cell-free DNA (ctDNA), and extracellular ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):255-260]

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Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks.

M Jeremiah Matson, Daniel S Chertow, Vincent J Munster,

The average time required to detect an Ebola virus disease (EVD) outbreak following spillover of Ebola virus (EBOV) to a primary human case has remained essentially unchanged for over 40 years, with some of the longest delays in detection occurring in recent decades. In this review, our aim was to ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):291-301]

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Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes.

Kai Ji, Yongchang Xu, Jian Sun, Man Huang, Xu Jia, Chengjian Jiang, Youjun Feng,

A growing number of tet(X)-type tigecycline resistance determinants [tet(X1) to tet(X5)] constitutes an expanding family of tetracycline-inactivating enzymes, posing a potential risk to global public health. Here, we report the development of an efficient multiplex PCR method to detect the family of tet(X) variants. This method is successfully applied in ... Read more >>

Virulence (Virulence)
[2020, 11(1):49-56]

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Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study.

N J Haley, D M Henderson, R Donner, S Wyckoff, K Merrett, J Tennant, E A Hoover, D Love, E Kline, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host's PRNP gene; ... Read more >>

Prion (Prion)
[2020, 14(1):76-87]

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Wza gene knockout decreases Acinetobacter baumannii virulence and affects Wzy-dependent capsular polysaccharide synthesis.

Tianshui Niu, Lihua Guo, Qixia Luo, Kai Zhou, Wei Yu, Yunbo Chen, Chen Huang, Yonghong Xiao,

To investigate the virulence of capsular polysaccharide export protein (Wza) in carbapenem-resistant Acinetobacter baumannii and its effect on capsule formation.wza gene knockout and complementation strains were constructed, and changes in bacterial virulence were observed using in vitro adhesion, antiserum complement killing, anti-oxidation experiments, and infections in Galleria mellonella and mice. ... Read more >>

Virulence (Virulence)
[2020, 11(1):1-13]

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A long journey for acute kidney injury biomarkers.

Dong-Jin Oh,

Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. However, it has only marginally declined over the past 25 years. Previous authoritative publications have been pointed out that the ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):154-165]

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

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Tick-borne encephalitis foci in northeast Italy revealed by combined virus detection in ticks, serosurvey on goats and human cases.

Niccolò Alfano, Valentina Tagliapietra, Fausta Rosso, Ute Ziegler, Daniele Arnoldi, Annapaola Rizzoli,

Tick-borne encephalitis (TBE) is a severe zoonotic neurological disease endemic in northeast Italy since 1992. In the Province of Trento, a sharp increase in TBE incidence has been recorded since 2012, despite the vaccination efforts. To assess current TBE infection hazard in this area, we applied an integrated approach combining ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):474-484]

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Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi, Peng Zhou,

In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):386-389]

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Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine.

Xinliang Fu, Yunmao Huang, Bo Fang, Yixing Liu, Mengkai Cai, Ruting Zhong, Junming Huang, Qi Wenbao, Yunbo Tian, Guihong Zhang,

Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):88-94]

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Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk.

N J Haley, R Donner, D M Henderson, J Tennant, E A Hoover, M Manca, B Caughey, N Kondru, S Manne, A Kanthasamay, S Hannaoui, S C Chang, S Gilch, S Smiley, G Mitchell, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a progressively fatal, horizontally transmissible prion disease affecting several members of the cervid species. Conventional diagnosis relies on ELISA or IHC evaluation using tissues collected post-mortem; however, recent research has focused on newly developed amplification techniques using samples collected antemortem. The present study sought to cross-validate ... Read more >>

Prion (Prion)
[2020, 14(1):47-55]

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The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan.

Tsai-Lu Lin, Shan-Chia Ou, Ken Maeda, Hiroshi Shimoda, Jacky Peng-Wen Chan, Wu-Chun Tu, Wei-Li Hsu, Chi-Chung Chou,

Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne zoonosis, has been rapidly spread in many Asian counties since 2010, which raises the great concern in East Asia. Nevertheless, the infection status of SFTS in Taiwan remains unclear. To investigate the existence of SFTSV in Taiwan, a total of 151 ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):148-151]

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Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway.

Wen-Qiang Cao, Xiao-Qian Zhai, Ji-Wei Ma, Xue-Qi Fu, Bai-Song Zhao, Pu Zhang, Xiao-Yan Fu,

Context: Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.Objective: To verify whether natural borneol (NB) can enhance cisplatin-induced glioma cell apoptosis and explore the mechanism.Materials and methods: Cytotoxicity of cisplatin and/or NB towards U251 and U87 cells were determined with ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):72-79]

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Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS.

Rabab M Soliman, Randa A Abdel Salam, Basma G Eid, Ahdab Khayyat, Thikryat Neamatallah, Mostafa K Mesbah, Ghada M Hadad,

The aim of this study was to investigate the stability of three major antioxidants of Nigella sativa: thymoquinone (TQ), carvacrol (CR) and thymol (THY), under different stress conditions using HPLC and LC-MS/MS. Forced degradation for each compound was performed under different conditions, including oxidation, hydrolysis, photolysis and thermal decomposition. The ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2020, 70(3):325-342]

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Clinical risk factors and outcomes of massive ascites accumulation after discontinuation of peritoneal dialysis.

Ming-Shan Chang, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang, Chien-Liang Chen,

Background: Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD), with high morbidity and mortality that requires an early diagnosis for effective treatment. PD withdrawal and bacterial peritonitis are important triggers for the onset of EPS. However, few studies have focused on cases of PD withdrawal without ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):1-9]

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Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis.

Irina M Zyrianova, Svetlana N Kovalchuk,

Bovine leukemia virus (BLV) is an oncogenic retrovirus of the Deltaretrovirus genus, which causes persistent infection in its natural hosts - cattle, zebu, and water buffalo with diverse clinical manifestations through the defeat of B-cells. The BLV proviral genome, along with structural genes (gag, pro, pol, and env), includes nonstructural ... Read more >>

Virulence (Virulence)
[2020, 11(1):80-87]

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Seroreactivity against Marburg or related filoviruses in West and Central Africa.

Imke Steffen, Kai Lu, Nicole A Hoff, Prime Mulembakani, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A Brennan, John Hackett, William M Switzer, Sentob Saragosti, Guy O Mbensa, Syria Laperche, Anne W Rimoin, Graham Simmons,

A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries. Serum samples were screened for neutralizing antibodies in a pseudotype micro-neutralization assay and confirmed by enzyme-linked immunosorbent assay (ELISA). Surprisingly, a seroprevalence for ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):124-128]

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Nanoparticles for treatment of bovine Staphylococcus aureus mastitis.

Samah Attia Algharib, Ali Dawood, Shuyu Xie,

Staphylococcus aureus (S. aureus) is one of the most important zoonotic bacterial pathogens, infecting human beings and a wide range of animals, in particular, dairy cattle. Globally. S. aureus causing bovine mastitis is one of the biggest problems and an economic burden facing the dairy industry with a strong negative ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):292-308]

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Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145.

Rongli Ge, Guanglei Gao,

Background: CircZNF609 (cZNF609) is previously revealed as an essential mediator in oxidative stress. This paper determined the role of cZNF609 in skin oxidative damage to evaluate its importance in pressure ulcer.Methods: HaCaT cells treated by H2O2 were considered as a cell model of pressure ulcer. The role of cZNF609 in ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):384-392]

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Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design.

Mengjia Zhang, Wan Li, Peng Zhou, Dejian Liu, Rui Luo, Anan Jongkaewwattana, Qigai He,

Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus that causes severe diarrhea, resulting in high mortality in neonatal piglets. Despite widespread outbreaks in many countries, no effective PDCoV vaccines are currently available. Here, we generated, for the first time, a full-length infectious cDNA clone of PDCoV. We further manipulated the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):20-31]

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Simultaneous determination of warfarin and 7-hydroxywarfarin in rat plasma by HPLC-FLD.

Aref Zayed, Wahby M Babaresh, Ruba S Darweesh, Tamam El-Elimat,

In this study, high-performance liquid chromatography with fluorescence detection (HPLC-FLD) has been used for the first time, for direct determination of warfarin and its major metabolite, 7-hydroxywarfarin, in rat plasma. The simple and sensitive method was developed using Fortis® reversed-phase diphenyl column (150 × 4.6 mm, 3 μm) and a ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2020, 70(3):343-357]

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Methyl lucidone induces apoptosis and G2/M phase arrest via the PI3K/Akt/NF-κB pathway in ovarian cancer cells.

Jae-Hwan Yoon, Jong-Woon Shin, Thu-Huyen Pham, Youn-Jin Choi, Hyung-Won Ryu, Sei-Ryang Oh, Jae-Wook Oh, Do-Young Yoon,

Context: Methyl lucidone (ML) from the dried fruit of Lindera erythrocarpa Makino (Lauraceae) exhibits cytotoxic effects in various cancer cell lines. However, its effects on ovarian cancer cells remain unknown.Objective: This study evaluates the mechanism of ML-induced apoptosis, cell cycle distribution in ovarian cells.Materials and methods: The cytotoxic effect of ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):51-59]

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Expanding the role of bitter taste receptor in extra oral tissues: TAS2R38 is expressed in human adipocytes.

Raffaella Cancello, Giancarlo Micheletto, Dorela Meta, Rosalia Lavagno, Emanuele Bevilacqua, Valerio Panizzo, Cecilia Invitti,

Increasing evidence indicates that taste receptors mediate a variety of functions in extra-oral tissues. The present study investigated the expression of bitter taste receptor TAS2R38 in human adipocytes, the possible link with genetic background and the role of TAS2R38 in cell delipidation and lipid accumulation rate in vitro. Subcutaneous (SAT) and visceral (VAT) adipose ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):7-15]

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