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A null mutation of C. elegans vwa-8.

Ming Zhu, Andrew D Chisholm, Yishi Jin,

(microPublication biology)
[2020, 2020:]

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Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.

Jian Liu, Yuan-Shan Han, Lin Liu, Lin Tang, Hui Yang, Pan Meng, Hong-Qing Zhao, Yu-Hong Wang,

Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetes-related depression. However, the underlying mechanism remains unclear. We hypothesized that diabetes-related depression might be ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):727-733]

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Anxiety, depression, and quality of life in Parkinson's disease: the implications of multidisciplinary treatment.

Viviana Lo Buono, Rosanna Palmeri, Simona De Salvo, Matteo Berenati, Agata Greco, Rosella Ciurleo, Chiara Sorbera, Vincenzo Cimino, Francesco Corallo, Placido Bramanti, Silvia Marino, Giuseppe Di Lorenzo, Lilla Bonanno,

Anxiety and depression in Parkinson's disease (PD) reduce well-being of the patients. Emotional alterations influence motor skills and cognitive performance; moreover, they contribute significantly and independently to worsen rehabilitative treatment response. We investigated anxiety, depression, and quality of life in PD patients subjected to multidisciplinary rehabilitative training. The self-controlled study ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):587-590]

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Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive.

Yun-Wei Fu, Yan-Fang Peng, Xiao-Dan Huang, Yan Yang, Lu Huang, Yue Xi, Zheng-Fang Hu, Song Lin, Kwok-Fai So, Chao-Ran Ren,

Previous studies have shown that Lycium barbarum polysaccharide, the main active component of Lycium barbarum, exhibits anti-inflammatory and antioxidant effects in treating neurological diseases. However, the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied. In this investigation, we established mouse models of depression using aversive stimuli ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):543-549]

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Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder.

Xiao-Lie He, Li Yang, Zhao-Jie Wang, Rui-Qi Huang, Rong-Rong Zhu, Li-Ming Cheng,

Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative that exerts neuroprotective effects through anti-inflammatory and antioxidant effects. Curcumin exhibits antidepressant effects in the treatment of major depressive disorder. To investigate the antidepressant effects of solid lipid nanoparticles loaded with both curcumin and dexanabinol, and the underlying mechanisms associated with this ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):537-542]

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Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models.

Shelly A Cruz, Zhaohong Qin, Konrad M Ricke, Alexandre F R Stewart, Hsiao-Huei Chen,

Ischemic brain injury causes neuronal death and inflammation. Inflammation activates protein-tyrosine phosphatase 1B (PTP1B). Here, we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke: by photothrombosis, focal ischemic lesions were induced in the sensorimotor cortex (SM stroke) or in the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(1):129-136]

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Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD.

Nithila Mariam Roy, Lara Al-Harthi, Neela Sampat, Rawan Al-Mujaini, Sangeetha Mahadevan, Samir Al Adawi, Musthafa Mohamed Essa, Lyutha Al Subhi, Buthaina Al-Balushi, M Walid Qoronfleh,

Vitamin D deficiency has been estimated to affect roughly 30% to 50% of the global population and thus labeled as a silent pandemic. In addition to its role in skeletal and calcium homeostasis, vitamin D has been implicated in brain functioning across both preclinical research and human populations studies. These ... Read more >>

Front Biosci (Landmark Ed) (Frontiers in bioscience (Landmark edition))
[2021, 26:566-611]

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Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls.

Mikhail A Filippov, Olga G Tatarnikova, Natalia V Pozdnyakova, Vasily V Vorobyov,

Various inflammatory stimuli are able to modify or even "re-program" the mitochondrial metabolism that results in generation of reactive oxygen species. In noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies, type 2 diabetes and metabolic syndrome, these modifications become systemic and are characterized by chronic inflammation and, in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(2):223-233]

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Anxiety and Depressive Symptom Trajectories in Adolescence and the Co-Occurring Development of Cognitive Biases: Evidence from the CogBIAS Longitudinal Study.

Annabel Songco, Charlotte Booth, Olivia Spiegler, Sam Parsons, Elaine Fox,

The development of negative cognitive biases, together with symptoms of anxiety and depression, has yet to be investigated longitudinally. Using a three-wave design, the present study examined developmental trajectories of anxiety and depressive symptoms and the co-occurrence of cognitive biases, in a large normative sample of adolescents (N = 504). Data was ... Read more >>

J Abnorm Child Psychol (Journal of abnormal child psychology)
[2020, 48(12):1617-1633]

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Sluggish Cognitive Tempo and Depressive Symptoms in Children and Adolescents Predict Adulthood Psychopathology.

Zoe R Smith, David H Zald, Benjamin B Lahey,

Sluggish cognitive tempo (SCT) is characterized by behavioral symptoms reflecting slowness and lethargy (e.g., sluggishness, appearing sleepy) and inconsistent alertness/mental confusion (e.g., daydreaming, fogginess). SCT is substantially correlated with the inattentive symptoms of attention-deficit/hyperactivity disorder (ADHD) and may be part of that domain, but in cross-sectional data, SCT is also ... Read more >>

J Abnorm Child Psychol (Journal of abnormal child psychology)
[2020, 48(12):1591-1601]

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Mothers' and fathers' lived experiences of postpartum depression and parental stress after childbirth: a qualitative study.

Maude Johansson, Ylva Benderix, Idor Svensson,

Purpose: The study aims are to explore the lived experiences of mothers and fathers of postpartum depression and parental stress after childbirth.Methods: Qualitative interviews conducted, and analysed from an interpretative phenomenological analysis (IPA) perspective.Results: Both mothers and fathers described experiences of inadequacy, although fathers described external requirements, and mothers described ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1722564]

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Depression and mental wellbeing in people affected by leprosy in southern Nepal.

Marloes M A R van Dorst, Wiebrich J van Netten, Mitzi M Waltz, Basu D Pandey, Ramesh Choudhary, Wim H van Brakel,

BACKGROUND:Leprosy, a leading cause of disability, remains endemic in southern Nepal. Alongside physical impairment and stigmatization, many people affected by leprosy suffer from mental health problems. OBJECTIVES:This study had two objectives: (a) Establishing a baseline level of mental wellbeing and depression among people affected by leprosy in southern Nepal, and ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1815275]

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Serum Levels of Vitamin D, Calcium, Magnesium, and Copper, and their Relations with Mental Health and Sexual Function in Pregnant Iranian Adolescents.

Parishan Bahramy, Sakineh Mohammad-Alizadeh-Charandabi, Fatemeh Ramezani-Nardin, Mojgan Mirghafourvand,

Pregnant adolescents are at risk for micronutrient deficiency, psychological problems, and sexual dysfunction. We aimed to determine serum levels of vitamin D, calcium, magnesium, and copper, and also their relations with stress, anxiety, depression, and sexual function in pregnant adolescents. This cross-sectional study was conducted on two hundred 11-19-year-old healthy ... Read more >>

Biol Trace Elem Res (Biological trace element research)
[2020, 198(2):440-448]

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Searching for the HERO in Youth: Does Psychological Capital (PsyCap) Predict Mental Health Symptoms and Subjective Wellbeing in Australian School-Aged Children and Adolescents?

Jules Finch, Lara J Farrell, Allison M Waters,

Psychological capital (PsyCap) comprising the positive psychological resources of hope, efficacy, resilience, and optimism (HERO) has strong empirical associations with increased wellbeing and reduced mental health symptoms in adult samples. Emerging studies of PsyCap among school-age students have also shown preliminary, positive associations between PsyCap and student wellbeing. The present ... Read more >>

Child Psychiatry Hum Dev (Child psychiatry and human development)
[2020, 51(6):1025-1036]

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Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice.

Lan Zhang, Yue Yang, Lei Di, Jun-Long Li, Ning Li,

Context: In folk medicine, erxian decoction (EXD) is used to treat perimenopausal syndrome in women. It is also used clinically to treat depression, but the mechanism remains unknown.Objectives: To investigate the neuroprotective effect of EXD, and its antidepressant potential.Materials and methods: ICR mice were treated with EXD (0.5, 1.5 and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):498-509]

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A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium.

Tong Liu, Ning Zhou, Ruihao Xu, Yangang Cao, Yanli Zhang, Zhen Liu, Xiaoke Zheng, Weisheng Feng,

Chrysanthemum morifolium (Chr) is a traditional Chinese medicine (TCM) that has been used in the treatment of inflammation-linked diseases for hundreds of years. Naringenin (Nar) and apigenin (Api) are the major active components in aqueous extracts of C. morifolium. The aim of our study was to clarify the roles of ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):718-727]

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Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress.

Ahmet Berk, İsmet Yılmaz, Nurettin Abacıoğlu, Mustafa Bahadır Kaymaz, Merve Gökşin Karaaslan, Ebru Kuyumcu Savan,

Background: The flowering parts of Gentiana olivieri, known as 'Afat' in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression. The purpose of this study is to investigate the antidepressant effect of G. olivieri ethanol extract ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1725991]

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Measuring mental health burden in humanitarian settings: a critical review of assessment tools.

Ashley Moore, Joris Adriaan Frank van Loenhout, Maria Moitinho de Almeida, Pierre Smith, Debarati Guha-Sapir,

BACKGROUND:The effects of disasters and conflicts are widespread and heavily studied. While attention to disasters' impacts on mental health is growing, mental health effects are not well understood due to inconsistencies in measurement. OBJECTIVE:The purpose of this study is to review mental health assessment tools and their use in populations ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1783957]

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Can Mobile Health Improve Depression Treatment Access and Adherence Among Rural Indian Women? A Qualitative Study.

A Bhat, B Ramakrishna Goud, J R Pradeep, G Jayaram, R Radhakrishnan, K Srinivasan,

Major Depressive Disorder (MDD) is associated with low rates of treatment and medication non-adherence, more so in low- and middle-income countries (LMICs). Mobile mental health (mHealth) interventions offer promise as a tool to address these problems. However, the feasibility and acceptability of mHealth interventions among rural women in LMICs is ... Read more >>

Cult Med Psychiatry (Culture, medicine and psychiatry)
[2020, 44(4):461-478]

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Determination of high-temperature and low-humidity treatment time for larch boxed-heart timber

Chun-Won Kang, Chengyuan Li, Yao-Xing Sun,

The larch boxed-heart timbers with a cross section of 100 × 100 mm were dried after steamed at 100 °C dry-bulb temperature and 0 °C wet-bulb depression for 5 h, and then dried at 120 °C dry-bulb temperature and 30 °C wet-bulb depression for 8, 12 and 16 h, respectively, ... Read more >>

(Journal of wood science.)
[2020, 66(1):22]

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An exploration of medical student attitudes towards disclosure of mental illness.

Ian Fletcher, Michael Castle, Aaron Scarpa, Orrin Myers, Elizabeth Lawrence,

Background: Medical students are reluctant to access mental health services, despite having high rates of anxiety and depression. This reluctance persists through residency and into practice. Physicians and trainees who are unwell deliver lower quality patient care, behave less professionally, communicate less effectively and are at an increased risk for ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1727713]

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Using relevance mapping methodology to design an adolescent mental health intervention in India.

Maya M Boustani, Eric Daleiden, Adam Bernstein, Daniel Michelson, Resham Gellatly, Kanika Malik, Vikram Patel, Bruce Chorpita,

BACKGROUND:Adolescents in low and middle-income countries experience pronounced mental health needs in contexts where infrastructure and resources are scarce. While evidence-based treatment are readily available, they may not fit the unique needs of certain contexts. OBJECTIVE:This manuscript illustrates the systematic process of applying 'relevance mapping' methodology to leverage the youth ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1775062]

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Mathematical Modeling and Optimization of Cryopreservation in Single Cells.

James D Benson,

Cryobiology is a multiscale and interdisciplinary field. The scope and scale of interactions limit the gains that can be made by one theory or experiment alone. Because of this, modeling has played a critical role in both explaining cryobiological phenomena and predicting improved protocols. Modeling facilitates understanding of the biophysical ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2021, 2180:129-172]

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Health care utilisation changes among Alaska Native adults after participation in an indigenous community programme to address adverse life experiences: a propensity score-matched analysis.

Lily Ray, Bobbi Outten, Katherine Gottlieb,

The aim of this study was to investigate whether participation in Family Wellness Warriors Initiative (FWWI), an Alaska Native program that addresses adverse life experiences, is associated with changes in health care utilisation. The study method was a propensity score-matched cohort analysis using retrospective electronic health record data from Southcentral ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1705048]

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Yoga Therapy For Medically Unexplained Physical Symptoms.

Amit Kashyap, Sakshi Chopra, Piyush Ranjan, Siddharth Sarkar, Anna Poorna, Upendra Baitha,

Medically unexplained physical symptoms (MUPS) is a common, yet neglected disease with a prevalence of around 25% in primary care setting. These patients present with multiple physical and psychological symptoms, without an underlying diagnosis, hampering their functional and mental wellbeing. The management of these undiagnosed symptoms through conventional treatment has ... Read more >>

Adv Mind Body Med (Advances in mind-body medicine)
[2020, 34(1):17-21]

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