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Degenerative Disk Disease

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PBN protects NP cells from AAPH-induced degenerative changes by inhibiting the ERK1/2 pathway.

Zhenggang Zhou, Yini Wang, Haifei Liu, Lu Wang, Zonghan Liu, Huimei Yuan, Lantao Liu, Mingbo Guo, Dechun Wang,

Aim: Intervertebral disc (IVD) degeneration (IDD) is one of the main causes for spinal degenerative diseases, such as disk herniation, spinal canal stenosis, and spinal deformities. Growing evidence has highlighted the contribution of oxidative stress in pathogenesis of IDD, and antioxidant treatment is thus considered to be a promising therapeutic ... Read more >>

Connect. Tissue Res. (Connective tissue research)
[2020, :1-10]

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Does hyperuricemia correlate with intervertebral disc degeneration?

Yvang Chang, Ming Yang, Yu Zhang, Gang Xu, Zhonghai Li,

Gout is a form of crystal arthropathy associated with deposition of monosodium urate (MSU) crystals, and is directly related to hyperuricemia arising from abnormal purine metabolism and/or decreased uric acid excretion. Uric acid is the final oxidation product of purine metabolism and plays an important role as an in vivo ... Read more >>

Med. Hypotheses (Medical hypotheses)
[2020, 140:109673]

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Ciliary IFT80 is essential for intervertebral disc development and maintenance.

Xinhua Li, Shuting Yang, Lin Han, Keya Mao, Shuying Yang,

The intervertebral disc degeneration (IVDD)-related diseases occur in more than 90% of the population older than 50 years. Owing to the lack of understanding of the cellular mechanisms involved in IVDD formation effective treatment options are still unavailable. Primary cilia are microtubule-based organelles that play important roles in the organ development. ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, :]

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[Research progress on the role of adipokines in intervertebral disc degeneration].

Chaoyang Gong, Guanghai Zhao, Gao Xiang, Kaixin Liu, Haihong Zhang,

Objective:To review the research progress of the role and mechanism of adipokines in intervertebral disc degeneration (IVDD) in recent years. Methods:The domestic and foreign literature related to adipokines in the process of IVDD was extensively reviewed. The types and functions of adipokines, the role and mechanism in the process of ... Read more >>

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery)
[2020, 34(3):399-403]

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The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes.

Tao Yang, Renzhi Li, Ning Liang, Jing Li, Yi Yang, Qian Huang, Yuedan Li, Wei Cao, Qian Wang, Hongxin Zhang,

OBJECTIVE:Based on the theoretical basis of Gabor wavelet transformation, the application effects of feature extraction algorithm in Magnetic Resonance Imaging (MRI) and the role of feature extraction algorithm in the diagnosis of lumbar vertebra degenerative diseases were explored. METHOD:The structure of lumbar vertebra and degenerative changes were respectively introduced to ... Read more >>

PLoS ONE (PloS one)
[2020, 15(2):e0227894]

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Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport.

Beth G Ashinsky, Edward D Bonnevie, Sai A Mandalapu, Stephen Pickup, Chao Wang, Lin Han, Robert L Mauck, Harvey E Smith, Sarah E Gullbrand,

The intervertebral disc is the largest avascular structure in the body, and cells within the disc rely on diffusive transport via vasculature located within the vertebral endplate to receive nutrients, eliminate waste products, and maintain disc health. However, the mechanisms by which small molecule transport into the disc occurs in ... Read more >>

J. Bone Miner. Res. (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2020, :]

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Lumbar spinal stenosis and disc alterations affect the upper lumbar spine in adults with achondroplasia.

Thomas Huet, Martine Cohen-Solal, Jean-Denis Laredo, Corinne Collet, Geneviève Baujat, Valérie Cormier-Daire, Alain Yelnik, Philippe Orcel, Johann Beaudreuil,

In achondroplasia, lumbar spinal stenosis arises from congenital dysplasia and acquired degenerative changes. We here aimed to describe the changes of the lumbar spinal canal and intervertebral disc in adults. We included 18 adults (age ≥ 18 years) with achondroplasia and lumbar spinal stenosis. Radiographs were used to analyze spinal-pelvic ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4699]

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LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells.

Shuting Cui, Zizhen Liu, Bin Tang, Zhizhen Wang, Baojian Li,

BACKGROUND:It is known that Fas ligand (FasL) is involved in the development of intervertebral disc degeneration (IDD). A recent study reported that lncRNA MAGI2-AS3 up-regulated the expression of FasL to promote breast cancer. Therefore, we investigated the roles that lncRNA MAGI2-AS3 might play in IDD. METHODS:A total of 66 IDD ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2020, 21(1):149]

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A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration.

Madison Irwin, Meghana Tare, Aditi Singh, Oorvashi Roy Puli, Neha Gogia, Matthew Riccetti, Prajakta Deshpande, Madhuri Kango-Singh, Amit Singh,

Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques. These plaques induce oxidative stress and aberrant signaling, which result in the death of neurons ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:117]

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Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration.

Chenghao Zhang, Sarah E Gullbrand, Thomas P Schaer, Yian Khai Lau, Zhirui Jiang, George R Dodge, Dawn M Elliott, Robert L Mauck, Neil R Malhotra, Lachlan J Smith,

Intervertebral disc degeneration is implicated as a leading cause of low back pain. Persistent, local inflammation within the disc nucleus pulposus (NP) and annulus fibrosus (AF) is an important mediator of disc degeneration and negatively impacts the performance of therapeutic stem cells. There is a lack of validated large animal ... Read more >>

J. Orthop. Res. (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2020, :]

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Central retinal vein occlusion secondary to severe iron-deficiency anaemia resulting from a plant-based diet and menorrhagia: a case presentation.

Verlyn Yang, Liam Daniel Turner, Fraser Imrie,

In this case presentation, we present a young vegan patient who developed a CRVO secondary to severe iron-deficiency anaemia (IDA) attributable to menstrual losses and limited iron intake. CRVO is a rare complication of IDA.With rising calls for sustainable diets and rising evidence for a plant-based diet, there has been ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):112]

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LncRNA MALAT1 exhibits positive effects on nucleus pulposus cell biology in vivo and in vitro by sponging miR-503.

Hongyu Zheng, Tingting Wang, Xiangmin Li, Wei He, Zhiqiang Gong, Zhenkai Lou, Bing Wang, Xingguo Li,

BACKGROUND:Intervertebral disc degeneration (IDD) is characterized by the loss of nucleus pulposus cells (NPCs) and phenotypic abnormalities. Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are involved in the pathogenesis of IDD. In this study, we aimed to investigate the functional effects of lncRNA MALAT1 on NPCs in IDD and ... Read more >>

BMC Mol Cell Biol (BMC molecular and cell biology)
[2020, 21(1):23]

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Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis.

Mohamad Bydon, F M Moinuddin, Yagiz U Yolcu, Waseem Wahood, Mohammed Ali Alvi, Anshit Goyal, Mohammed Elminawy, Catalina Galeano-Garces, Amel Dudakovic, Ahmad Nassr, A Noelle Larson, Andre J van Wijnen,

Lumbar degenerative disc disease (DDD) is a multifaceted progressive condition and often accompanied by disc herniation (DH) and/or degenerative spondylolisthesis (DS). Given the high prevalence of the disease (up to 20% according to some estimates) and the high costs associated with its care, there is a need to explore novel ... Read more >>

Gene (Gene)
[2020, :144634]

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Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature.

Hyeun Sung Kim, Pang Hung Wu, Il-Tae Jang,

Degenerative disc disease is a leading cause of chronic back pain in the aging population in the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with the pain pathway as a result of neurotization. Our goal is to perform a prospective study using radiofrequency ablation on sinuvertebral ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.

Cong Deng, Shanshan Chen, Xiongfeng Li, Hongdou Luo, Qinglin Zhang, Piaopiao Hu, Feifei Wang, Chan Xiong, Tao Sun, Xu Zhang,

Purpose:To investigate the function and expression of the PGE2 receptors EP1-4 in rat retinal ischemia-reperfusion (I/R) injury and to determine the regulatory role of resveratrol (RES) in this process. Methods:In vitro, we stimulated primary astrocytes extracted from the optic disc of rats with epidermal growth factor (EGF) and RES, and ... Read more >>

Mol. Vis. (Molecular vision)
[2020, 26:36-47]

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Decompression alone versus fusion and Coflex in the treatment of lumbar degenerative disease: A network meta-analysis.

Yunpeng Fan, Liulong Zhu,

BACKGROUND:Lumbar degenerative disease (LDD) is a very common disease. And decompression alone, posterior lumbar interbody fusion (PLIF), and interspinous device (Coflex) are generally accepted surgical techniques. However, the effectiveness and safety of the above techniques are still not clear. Network meta-analysis a comprehensive technique can compare multiple treatments based on ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(11):e19457]

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Procyanidin B3 alleviates intervertebral disc degeneration via interaction with the TLR4/MD-2 complex.

Ping Shang, Qian Tang, Zhichao Hu, Shiyuan Huang, Yuezheng Hu, Jianhong Zhu, Haixiao Liu,

As a chronic musculoskeletal degeneration disease, intervertebral disc degeneration (IVDD) has been identified as a crucial cause for low back pain. This condition has a prevalence of 80% among adults without effective preventative therapy. Procyanidin B3 (Pro-B3) is a procyanidin dimer, which is widely present in the human diet and ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, 24(6):3701-3711]

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Degenerative Cervical Myelopathy: Changing Frontiers.

Ali Moghaddamjou, Jetan H Badhiwala, Michael G Fehlings,

World Neurosurg (World neurosurgery)
[2020, 135:377-378]

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Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway.

Yang Lu, Li Zhou, Shan He, Hong-Lei Ren, Nian Zhou, Zhen-Ming Hu,

Intervertebral disc degeneration (IDD) is a main cause of diseases such as discogenic low back pain, cervical and lumbar disc herniation, degenerative spinal stenosis, and lumbar spondylolisthesis. Nuclear factor erythroid 2-related factor 2 (Nrf2), an important transcription factor, regulates antioxidant genes and induces cellular defense mechanisms against oxidative stress. In ... Read more >>

Mol. Cell. Probes (Molecular and cellular probes)
[2020, :101559]

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Gender differences in the surgical management of lumbar degenerative disease: a scoping review.

Mark A MacLean, Charles J Touchette, Jae H Han, Sean D Christie, Gwynedd E Pickett,

OBJECTIVE:Despite efforts toward achieving gender equality in clinical trial enrollment, females are often underrepresented, and gender-specific data analysis is often unavailable. Identifying and reducing gender bias in medical decision-making and outcome reporting may facilitate equitable healthcare delivery. Gender disparity in the utilization of surgical therapy has been exemplified in the ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2020, :1-18]

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Autophagy and mTOR signaling during intervertebral disc aging and degeneration.

Takashi Yurube, Masaaki Ito, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutani,

Degenerative disc disease is a highly prevalent, global health problem that represents the primary cause of back pain and is associated with neurological disorders, including radiculopathy, myelopathy, and paralysis, resulting in worker disability and socioeconomic burdens. The intervertebral disc is the largest avascular organ in the body, and degeneration is ... Read more >>

JOR Spine (JOR spine)
[2020, 3(1):e1082]

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Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop.

Fan Chen, Guowei Jiang, Hui Liu, Zemin Li, Yuxin Pei, Hua Wang, Hehai Pan, Haowen Cui, Jun Long, Jianru Wang, Zhaomin Zheng,

The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration (IVDD). NLR pyrin domain containing 3 (NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in ... Read more >>

Bone Res (Bone research)
[2020, 8:10]

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Effect of (m)RVD-hemopressin against Aβ1-42-induced apoptosis and inhibition of neurite outgrowth in SH-SY5Y cells.

Ruisan Zhang, Jing Luan, Fengrui Hu, Jiaming Lv, Jieyuan Zhang, Kang Li, Huifang Guo, Jianghong Cheng, Peng Chen, Yuelin Zhang, Qiang Cai, Xingchun Gou,

Alzheimer's disease (AD) is a serious neurodegenerative disease. Senile plaques (SPs) in the extracellular space and neurofibrillary tangles (NFTs) in the intracellular areas of the brain are two typical features of AD. SPs and NFTs are composed of amyloid-β (Aβ) aggregates and hyperphosphorylated Tau, respectively. (m)RVD-hemopressin (RVD), which is derived ... Read more >>

Neuropeptides (Neuropeptides)
[2020, :102044]

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Identification of significant gene biomarkers of low back pain caused by changes in the osmotic pressure of nucleus pulposus cells.

Changsong Zhao, Xuemin Quan, Jie He, Rugang Zhao, Yao Zhang, Xin Li, Sheng Sun, Rui Ma, Qiang Zhang,

The incidence of intervertebral disc (IVD) degeneration disease, caused by changes in the osmotic pressure of nucleus pulposus (NP) cells, increases with age. In general, low back pain is associated with IVD degeneration. However, the mechanism and molecular target of low back pain have not been elucidated, and there are ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3708]

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A prediction model of low back pain risk: a population based cohort study in Korea.

David Mukasa, Joohon Sung,

Background:Well-validated risk prediction models help to identify individuals at high risk of diseases and suggest preventive measures. A recent systematic review reported lack of validated prediction models for low back pain (LBP). We aimed to develop prediction models to estimate the 8-year risk of developing LBP and its recurrence. Methods:A ... Read more >>

Korean J Pain (The Korean journal of pain)
[2020, 33(2):153-165]

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