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Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 1 time

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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.

Huan Han, Qingfeng Ma, Cong Li, Rui Liu, Li Zhao, Wei Wang, Pingan Zhang, Xinghui Liu, Guosheng Gao, Fang Liu, Yingan Jiang, Xiaoming Cheng, Chengliang Zhu, Yuchen Xia,

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1123-1130]

Cited: 1 time

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Socheongryongtang suppresses COPD-related changes in the pulmonary system through both cytokines and chemokines in a LPS COPD model.

Soon-Young Lee, Seung-Sik Cho, Chun-Sik Bae, Min-Suk Bae, Dae-Hun Park,

Context: Socheongryongtang is a traditional Korean medical prescription used to treat pulmonary diseases.Objective: This study investigated the therapeutic mechanism of socheongryongtang for pulmonary diseases.Materials and methods: Seventy BALB/c mice were used: control, 0.8 mg/kg/study LPS intranasal instillation, 1 mg/kg/day Spiriva oral administration for five days, two socheongryongtang groups (150 or 1500 mg/kg/day orally treatment ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):538-544]

Cited: 0 times

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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

Cited: 23 times

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T-lymphocyte subsets and Th1/Th2 cytokines in convalescent patients with Epstein-Barr virus-associated aplastic anemia.

Tingting Chen, Yimin Chen, Wenting Bao, Wei Lu,

Objective: The aim of this study was to analyze T-lymphocyte subsets and Th1/Th2 cytokines in convalescent patients with Epstein-Barr virus (EBV)-associated aplastic anemia (AA).Methods: Sixty AA patients were enrolled, who were in remission following immunosuppressive therapy, including 34 EBV-negative cases and 26 EBV-positive cases. Their complete blood count (CBC), T-lymphocyte ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):11-16]

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Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria.

Lisa L Drewry, John T Harty,

Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to severe anemia and fatality. However, the same inflammatory response that controls parasite replication is also ... Read more >>

Virulence (Virulence)
[2020, 11(1):159-169]

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Setting the stage: The initial immune response to blood-stage parasites.

Allison N Bucşan, Kim C Williamson,

Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which ... Read more >>

Virulence (Virulence)
[2020, 11(1):88-103]

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Bacterial membrane vesicles from Acinetobacter baumannii induced by ceftazidime are more virulent than those induced by imipenem.

Chun-Hsiang Chiu, Yi-Tzu Lee, Yu-Chun Lin, Shu-Chen Kuo, Ya-Sung Yang, Yung-Chih Wang, Yu-Han Liu, Jung-Chung Lin, Feng-Yee Chang, Te-Li Chen,

Patients with Acinetobacter baumannii bacteremia treated with antipseudomonal cephalosporins showed higher 14-day mortality than patients treated with antipseudomonal carbapenems. We hypothesized that the bacterial membrane vesicles (BMVs) induced by antipseudomonal cephalosporins are more virulent than BMVs induced by antipseudomonal carbapenems.To simulate the clinical condition with inadequate antimicrobial treatment, carbapenem-resistant A. ... Read more >>

Virulence (Virulence)
[2020, 11(1):145-158]

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Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9.

Jinsong Jiang, Guangji Wang,

Context: Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae).Objective: This study was designed to uncover the potential application of matrine in treating spinal cord injury (SCI).Materials and methods: Neuron-like PC12 cells in experimental groups were pre-treated with/without matrine (200 μM) for 24 h and then ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):314-320]

Cited: 0 times

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Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway.

Juan Li, Haiyan Chou, Lei Li, Hao Li, Zhengjun Cui,

The diabetic foot ulcer (DFU) may be associated with late healing and septic manifestation, subsequently lead to amputation which is an overpriced incident. Neferine is an alkaloid found lotus. Neferine possesses many physiological functions such as anti-inflammatory, antioxidant, antimicrobial activity and anticancer effect. The aim of the present study was ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):96-106]

Cited: 0 times

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Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics.

Cris Kamperschroer, Jacintha Shenton, Hervé Lebrec, John K Leighton, Paul A Moore, Oliver Thomas,

Currently, there is a multitude of CD3 bispecifics with different molecular designs and binding properties in preclinical and clinical development for the treatment of liquid or solid tumors. The key safety concerns with CD3 bispecifics are excessive release of cytokines, which may translate to potentially life-threating cytokine release syndrome (CRS), ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):67-85]

Cited: 1 time

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Mutation on lysX from Mycobacterium avium hominissuis impacts the host-pathogen interaction and virulence phenotype.

Greana Kirubakar, Hubert Schäfer, Volker Rickerts, Carsten Schwarz, Astrid Lewin,

The lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift at the extracellular state preadapting the bacteria to the conditions inside host-cells. It further showed stronger growth ... Read more >>

Virulence (Virulence)
[2020, 11(1):132-144]

Cited: 0 times

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Rheumotologitsts' view on the use of hydroxychloroquine to treat COVID-19.

Xiaoxuan Sun, Yicheng Ni, Miaojia Zhang,

The current pandemic coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) calls urgently for effective therapies. Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):830-832]

Cited: 0 times

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The protective effects of bexarotene against advanced glycation end-product (AGE)-induced degradation of articular extracellular matrix (ECM).

Zhuqing Zha, Qingmin Han, Shaochuan Huo,

Osteoarthritis (OA) is a common debilitating disease primarily characterised by excessive loss of the articular ECM, which is composed of up to 95% type II collagen. Among the factors that contribute to the pathogenesis of OA, the natural process of aging is regarded as the most significant risk factor. AGEs, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):1-7]

Cited: 0 times

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Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis.

Naif Aljuhani, Raed S Ismail, Mohammed S El-Awady, Memy H Hassan,

Cisplatin-induced nephrotoxicity limits its anticancer effectiveness, thus this study's aim was to assess the potential modulatory effect of perindopril on cisplatin-induced nephrotoxicity and to elucidate the possible underlying mechanisms. Renal dysfunction was induced in mice by a single injection of cisplatin (10 mg kg-1, i.p.) and perindopril was administered orally ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2020, 70(4):515-525]

Cited: 0 times

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Antidepressant effect of Gentiana olivieri Griseb. in male rats exposed to chronic mild stress.

Ahmet Berk, İsmet Yılmaz, Nurettin Abacıoğlu, Mustafa Bahadır Kaymaz, Merve Gökşin Karaaslan, Ebru Kuyumcu Savan,

Background: The flowering parts of Gentiana olivieri, known as 'Afat' in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression. The purpose of this study is to investigate the antidepressant effect of G. olivieri ethanol extract ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1725991]

Cited: 0 times

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The role of TRPV1 channels in atherosclerosis.

Chenyang Zhang, Lifang Ye, Qinggang Zhang, Fei Wu, Lihong Wang,

Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):141-150]

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Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study.

Abhilasha Madhvi, Hridesh Mishra, Novel N Chegou, Gerard Tromp, Carel J Van Heerden, R D Pietersen, Gina Leisching, Bienyameen Baker,

The comparison of the host immune response when challenged with pathogenic and nonpathogenic species of mycobacteria can provide answers to the unresolved question of how pathogens subvert or inhibit an effective response. We infected human monocyte derived macrophages (hMDMs) with different species of mycobacteria, in increasing order of pathogenicity, i.e. ... Read more >>

Virulence (Virulence)
[2020, 11(1):170-182]

Cited: 0 times

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Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages.

K McKernan, M Varghese, R Patel, K Singer,

In obesity, high levels of saturated fatty acids (SFAs) contribute to adipose tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itself may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):212-222]

Cited: 0 times

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Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia.

Ling Lin, Lianfeng Lu, Wei Cao, Taisheng Li,

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):727-732]

Cited: 31 times

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Effect of lead exposure and nutritional iron-deficiency on immune response: A vaccine challenge study in rats.

Srinivasa Reddy Yathapu, Narendra Babu Kondapalli, Sarath Babu Srivalliputturu, Rajkumar Hemalatha, Dinesh Kumar Bharatraj,

The prevalence of iron (Fe) deficiency and subclinical lead (Pb) toxicity is high in developing countries like India, and information on their potential additive effects on immune responses is scant. The current study assessed immune parameters in dual Pb-exposed\Fe-deficient weanling SD rats. Rats were fed a control (CD) or Fe-deficient ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):144-152]

Cited: 0 times

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Potential classification of chemical immunologic response based on gene expression profiles.

Stacey E Anderson, Rachel Baur, Michael Kashon, Ewa Lukomska, Lisa Weatherly, Hillary L Shane,

Occupational immune diseases are a serious public health burden and are often a result of exposure to low molecular weight (LMW) chemicals. The complete immunological mechanisms driving these responses are not fully understood which has made the classification of chemical allergens difficult. Antimicrobials are a large group of immunologically-diverse LMW ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):122-134]

Cited: 0 times

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Emodin in Rheum undulatum inhibits oxidative stress in the liver via AMPK with Hippo/Yap signalling pathway.

Eun Hye Lee, Su Youn Baek, Ji Young Park, Young Woo Kim,

Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a causative agent of liver inflammation that may lead to fibrosis and hepato-carcinoma. In this study, we investigated the antioxidant effects of emodin and its mechanism.Materials ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):333-341]

Cited: 0 times

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Relevance of inducible nitric oxide synthase for immune control of Mycobacterium avium subspecies paratuberculosis infection in mice.

Ketema Abdissa, Nanthapon Ruangkiattikul, Wiebke Ahrend, Andreas Nerlich, Andreas Beineke, Kristin Laarmann, Nina Janze, Ulrike Lobermeyer, Abdulhadi Suwandi, Christine Falk, Ulrike Schleicher, Siegfried Weiss, Christian Bogdan, Ralph Goethe,

Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease (JD), an incurable chronic intestinal bowel disease in ruminants. JD occurs worldwide and causes enormous economic burden in dairy industry. Research on JD pathobiology is hampered by its complexity which cannot completely be mimicked by small animal models. As a model the ... Read more >>

Virulence (Virulence)
[2020, 11(1):465-481]

Cited: 0 times

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Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro.

Yousra M El-Far, Ahmed E Khodir, Ahmad O Noor, Deina M Almasri, Alaa A Bagalagel, Reem M Diri, Hussam I Kutbi, Mohammed M H Al-Gayyar,

Objectives: Hepatocellular carcinoma (HCC) is characterized by elevated in oxidative stress and inflammatory cytokines, which enhance destructive effects of the tumor. Therefore, we conducted this study to investigate the protective effects of sodium ascorbate against thioacetamide-induced HCC in rats through studying its effect on the apoptotic pathway in rats. In ... Read more >>

Redox Rep. (Redox report : communications in free radical research)
[2020, 25(1):17-25]

Cited: 0 times

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