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Endogenous epitope tagging of a JAK/STAT ligand Unpaired1 in Drosophila.

Masahiko Takemura, Yi-Si Lu, Eriko Nakato, Hiroshi Nakato,

Unpaired1 (Upd1) is a ligand of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in <i>Drosophila</i>. In this study, using the CRISPR/Cas9 technique, we generate a transgenic fly strain in which a hemagglutinin (HA) epitope tag sequence is inserted into the endogenous locus of the <i>upd1</i> gene. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans.

Carlos Chávez-Pérez, Niusha Jafari, Brendan T Keenan, David M Raizen, Alex M Rohacek,

The interneurons ALA and RIS both regulate stress induced sleep in <i>C. elegans</i> but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS function. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 3 times

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Microglia regulation of synaptic plasticity and learning and memory.

Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou,

Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity. Through the C1q, C3 and CR3 "Eat Me" and CD47 and SIRPα ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):705-716]

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Improving cell transplantation by understanding and manipulating the phagocytic activity of peripheral glia.

Lynn Nazareth, James St John, Jenny Ekberg,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):313-314]

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Transneuronal delivery of designer cytokines: perspectives for spinal cord injury.

Daniel Terheyden-Keighley, Marco Leibinger, Dietmar Fischer,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):338-340]

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Pre-clinical study of human umbilical cord mesenchymal stem cell transplantation for the treatment of traumatic brain injury: safety evaluation from immunogenic and oncogenic perspectives.

Gang Wang, Hua-Ling Wu, Yue-Ping Liu, De-Qi Yan, Zi-Lin Yuan, Li Chen, Qian Yang, Yu-Song Gao, Bo Diao,

Stem cell therapy is a promising strategy for the treatment of traumatic brain injury (TBI). However, animal experiments are needed to evaluate safety; in particular, to examine the immunogenicity and tumorigenicity of human umbilical cord mesenchymal stem cells (huMSCs) before clinical application. In this study, huMSCs were harvested from human ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):354-361]

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Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration.

Alexis D Rickman, Addison Hilyard, Bradlee L Heckmann,

Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease (AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3 lipidation yet are distinct from traditional macro-autophagy. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):246-250]

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Gene and protein expression profiles of olfactory ensheathing cells from olfactory bulb versus olfactory mucosa.

Yuan-Xiang Lan, Ping Yang, Zhong Zeng, Neeraj Yadav, Li-Jian Zhang, Li-Bin Wang, He-Chun Xia,

Olfactory ensheathing cells (OECs) from the olfactory bulb (OB) and the olfactory mucosa (OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-derived OECs remains unclear. In this study, we extracted OECs from OB and OM and compared the gene ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):440-449]

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Inhibition of CXCR4/CXCL12 signaling: a translational perspective for Alzheimer's disease treatment.

Yuval Gavriel, Inna Rabinovich-Nikitin, Beka Solomon,

Neural Regen Res (Neural regeneration research)
[2022, 17(1):108-109]

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New perspectives for mesenchymal stromal cells as an adjuvant therapy for infectious disease-associated encephalopathies.

Maiara N Lima, Maria C Barbosa-Silva, Tatiana Maron-Gutierrez,

Knowledge of the mechanisms that trigger infection-related encephalopathies is still very limited and cell therapies are one of the most promising alternatives for neurodegenerative diseases, and its application in infectious diseases can be of great relevance. Mesenchymal stromal cells are cells with great immunomodulatory potential; therefore, their use in clinical ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):48-52]

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COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue.

Xi Yongzhi,

SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased interest in CSS's mechanisms, diagnosis and therapy. Although the prototypic concept of CSS was first proposed 116 years ago, we ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):266-276]

Cited: 7 times

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The roles of T cells in obese adipose tissue inflammation.

Qiong Wang, Yurong Wang, Danyan Xu,

Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):435-445]

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Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives.

Yuhang Miao, Jie Yang, Yinling Yun, Jie Sun, Xiaojing Wang,

Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes in the expression of related cytokines are closely related to the pathogenesis of RA. ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):450-461]

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Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease.

Alexey P Galkin,

The severe course of COVID-19 causes systemic chronic inflammation and thrombosis in a wide variety of organs and tissues. The nature of these inflammations remains a mystery, although they are known to occur against the background of a high level of cytokine production. The high level of cytokines provokes overproduction ... Read more >>

Prion (Prion)
[2021, 15(1):53-55]

Cited: 2 times

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Pro-inflammatory cytokines as potential predictors for intradialytic hypotension.

Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Xuesen Cao, Zhonghua Liu, Bo Shen, Jianzhou Zou, Xiaoqiang Ding,

<h4>Background</h4>Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of pro-inflammatory cytokines in IDH.<h4>Methods</h4>MHD patients starting ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):198-205]

Cited: 1 time

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Research advances on how metformin improves memory impairment in "chemobrain".

Ahmad Alhowail, Sridevi Chigurupati,

Cognitive impairment caused by chemotherapy, referred to as "chemobrain," is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):15-19]

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Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers.

Venkatanaidu Karri, Carola Lidén, Nanna Fyhrquist, Johan Högberg, Hanna L Karlsson,

Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well as the role played by different cell types present in skin, may be ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):74-84]

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Highly sensitive in vitro cytokine release assay incorporating high-density preculture.

Shiho Ito, Kyoko Miwa, Chiharu Hattori, Tetsuo Aida, Yoshimi Tsuchiya, Kazuhiko Mori,

Immunostimulatory effects of monoclonal antibodies (mAb) through binding to F<sub>cγ</sub> receptors (F<sub>cγ</sub>R) on immune cells are a likely cause of cytokine release syndrome. However, it is difficult to detect the potential risk of F<sub>cγ</sub>R-dependent cytokine release associated with mAb in the current standard cytokine release assays (CRA), including the air-drying ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):136-143]

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Cytokine release syndrome after haploidentical hematopoietic stem cell transplantation with antithymocyte globulin: risk factors analysis and poor impact on outcomes for non-remisssion patients.

Ziwei Xu, Xi Zhou, Xiaoyan Zhao, Xuan Lu, Liang Tang, Wei Shi, Han Yan, Yong You, Huafang Wang,

<h4>Introduction</h4>Cytokine release syndrome (CRS) is a common complication after T-replete HLA haploidentical hematopoietic cell transplantation (haplo-HCT) with PTCy. We aim to assess the incidence, severity, and impact of CRS on clinical outcomes of patients who received haplo-HCT using Beijing Protocol.<h4>Methods</h4>This was a single-enter retrospective analysis of 286 subjects who received ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):809-817]

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Ibrutinib-induced acute kidney injury via interstitial nephritis.

Csilla Markóth, Ibolya File, Róbert Szász, László Bidiga, József Balla, János Mátyus,

The introduction of Bruton's tyrosine kinase inhibitor ibrutinib has made a significant progress in the treatment of chronic lymphocytic leukemia and other B-cell malignancies. Due to the reduction of cytokine release, it is effective in chronic graft-versus-host disease, and its use has also been suggested in autoimmune diseases and in ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):335-339]

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Identification of biomarkers, pathways and potential therapeutic target for docetaxel resistant prostate cancer.

Rui-Ji Liu, Shu-Ying- Li, Li-Quan Liu, Bin Xu, Ming Chen,

Docetaxel has been proved to provide survival benefit for advanced prostate cancer (PCa) patients. Resistance to docetaxel further reduces the survival of these patients. Herein, we performed a comprehensive bioinformatic analysis to identify differentially expressed genes (DEGs) between docetaxel sensitive and resistant PCa (DRPC) cell based on Gene Expression Omnibus ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2377-2388]

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Integrated analysis on mRNA microarray and microRNA microarray to screen immune-related biomarkers and pathways in myelodysplastic syndrome.

Chunyi Lyu, Kui Liu, Yuehua Jiang, Teng Wang, Yan Wang, Ruirong Xu,

<h4>Background</h4>Myelodysplastic syndrome (MDS) is a haematopoietic malignancy that is characterized by a heterogeneous clinical course and dysplastic maturation of blood lineages. Immune dysregulation has gained attention as one of the fundamental mechanisms responsible for the development of MDS. This study aimed to screen immune-related biomarkers and pathways in MDS.<h4>Methods</h4>Differentially expressed ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):417-431]

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Phenol-soluble modulins α are major virulence factors of Staphylococcus aureus secretome promoting inflammatory response in human epidermis.

Alexia Damour, Brandon Robin, Luc Deroche, Lauranne Broutin, Nicolas Bellin, Julien Verdon, Gérard Lina, Franck Marie Leclère, Magali Garcia, Julie Cremniter, Nicolas Lévêque, Charles Bodet,

<i>Staphylococcus aureus</i> is a skin commensal microorganism commonly colonizing healthy humans. Nevertheless, <i>S. aureus</i> can also be responsible for cutaneous infections and contribute to flare-up of inflammatory skin diseases such as atopic dermatitis (AD), which is characterized by dysbiosis of the skin microbiota with <i>S. aureus</i> as the predominant species. ... Read more >>

Virulence (Virulence)
[2021, 12(1):2474-2492]

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Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells.

Michiel M Kroes, Alberto Miranda-Bedate, Elise S Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H M Raeven, Arno A J van der Ark, Jos P M van Putten, Jelle de Wit, Rob Mariman, Elena Pinelli,

Respiratory infections caused by <i>Bordetella pertussis</i> are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating <i>B. pertussis</i> strains increasingly lack expression of the vaccine component pertactin (Prn). In some countries, up to 90% of the circulating <i>B. pertussis</i> ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1358-1368]

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