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2019 Novel coronavirus: where we are and what we know.

Zhangkai J. Cheng, Jing Shan,

There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of ... Read more >>

Infection (Infection)
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The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future.

Jin-Yan Li, Zhi You, Qiong Wang, Zhi-Jian Zhou, Ye Qiu, Rui Luo, Xing-Yi Ge,

At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or ... Read more >>

Microbes Infect. (Microbes and infection)
[2020, 22(2):80-85]

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E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis.

Ramya Billa, Cody Tigges, Niranjan Vijayakumar, Joshua Radke, Caitlin Pedati, Rebecca Weiner, Daniel McCabe,

IntroductionE-cigarette, or vaping, product use associated lung injury (EVALI) has become a recent concern among public health officials. Factors that contribute to the concern include an increasing number of cases over time, the severity of the illness, and an unknown understanding of the pathophysiology and etiology of the illness.Case SeriesWe ... Read more >>

J Med Toxicol (Journal of Medical Toxicology)
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Inhibitory Effects of Eriodictyol-7-O-β-d-glucuronide and 5,7-Dihydroxy-4-chromene Isolated from Chrysanthemum zawadskii var. latilobum in FcεRI-Mediated Human Basophilic KU812F Cell Activation.

Mina Lee, Sun-Yup Shim,

Chrysanthemum zawadskii var. latilobum (CZL) has been used in Eastern medicine for the treatment of various diseases, such as pneumonia, bronchitis, cough, the common cold, pharyngitis, bladder-related disorders, gastroenteric disorders, and hypertension. In the present study, we isolated two strong antiallergic compounds from CZL, namely, eriodictyol-7-O-β-d-glucuronide (EDG) and 5,7-dihydroxy-4-chromene (DC), ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(4):]

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Cutaneous Toxicities of Immune Checkpoint Inhibitors: The Role of the Dermatologist.

Ian William Tattersall, Jonathan Scott Leventhal,

The advent of immune checkpoint inhibition represents a paradigm shift in the treatment of an increasing number of cancers. However, the incredible therapeutic promise of immunotherapy brings with it the need to understand and manage its diverse array of potential adverse events. The skin is the most common site of ... Read more >>

Yale J Biol Med (The Yale Journal of Biology and Medicine)
[2020, 93(1):123-132]

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Dispensing errors and self-medication practice observed by community pharmacists in Jordan.

Esraa Gogazeh,

Background:Drug dispensing is the major function of community pharmacists, the pharmacists should have the ability to counsel the patients and be aware of dispensing errors. Self- medication is a universal phenomenon that is widely practiced in developing countries and it may lead to irrational usage of drugs. Objectives:The objectives of ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2020, 28(3):233-237]

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Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review.

Dominik Ochocinski, Mansi Dalal, L Vandy Black, Silvana Carr, Judy Lew, Kevin Sullivan, Niranjan Kissoon,

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion, insidious vital organ deterioration, early mortality, and diminished quality of life. Life-threatening acute physiologic crises may occur on a background of progressive diminishing vital organ function. Sickle hemoglobin polymerizes in the deoxygenated state, resulting in erythrocyte membrane deformation, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:38]

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Qualitative elemental analysis of selected potential anti-asthmatic medicinal plant taxa using EDXRF technique.

S Jyothsna, G Manjula, Sateesh Suthari, A S Nageswara Rao,

Qualitative elemental analysis was determined in various parts of potential anti-asthmatic medicinal plants using Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer. X-ray beam was used to excite each sample and spectra were recorded with a high resolution Si(Li) detector. The data analysis was carried out by the nEXT software. Trace elements ... Read more >>

Heliyon (Heliyon)
[2020, 6(2):e03260]

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New Pathological Lesions Developed in Pigs by a "Non-virulent" Strain of Glaesserella parasuis.

Cláudia Cerutti Dazzi, João Antônio Guizzo, Simone Ramos Prigol, Luiz Carlos Kreutz, David Driemeier, Somshukla Chaudhuri, Anthony Bernard Schryvers, Rafael Frandoloso,

Glaesserella parasuis is a Gram-negative bacterium that causes Glässer's disease, a common pathology found in young pigs characterized by polyarthritis, polyserositis, and meningitis. The bacterium has 15 known serovars that have been classified by virulence. Serovars 1, 4, 5, and 12 are considered highly virulent and used in most studies. ... Read more >>

Front Vet Sci (Frontiers in Veterinary Science)
[2020, 7:98]

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Self-Medication Practices and Associated Factors Among Health-Care Professionals in Selected Hospitals of Western Ethiopia.

Ginenus Fekadu, Dinka Dugassa, Getandale Zeleke Negera, Tilahun Bakala Woyessa, Ebisa Turi, Tadesse Tolossa, Getahun Fetensa, Lemessa Assefa, Motuma Getachew, Tesfaye Shibiru,

Background:Even though the type, extent and reasons for self-medication practice (SMP) vary, globally self-medication (SM) is rising to relieve burdens on health services. However, inappropriate SMP results in economic wastes, damage of vital organs, incorrect therapy selection, risk of adverse drug reactions and development of antimicrobial-resistant pathogens. These consequences have ... Read more >>

Patient Prefer Adherence (Patient preference and adherence)
[2020, 14:353-361]

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A Benefit Risk Review of Pediatric Use of Hydrocodone/Chlorpheniramine, a Prescription Opioid Antitussive Agent for the Treatment of Cough.

Victor S Sloan, Alphia Jones, Chidi Maduka, Jürgen W G Bentz,

Hydrocodone/chlorpheniramine is a prescription opioid licensed in the USA for the relief of cough and upper respiratory symptoms associated with allergy or cold in adults, previously contraindicated in children aged < 6 years. We present findings from a modern benefit risk review of hydrocodone/chlorpheniramine use as an antitussive agent in patients aged 6 ... Read more >>

Drugs Real World Outcomes (Drugs - real world outcomes)
[2019, 6(2):47-57]

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A Precision Medicine Approach to Rhinitis Evaluation and Management.

Carlos D. Crisci, Ledit R. F. Ardusso,

Purpose of ReviewPrecision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. The PM approach focuses on the characterization of different phenotypes and pathogenic pathways in order to allow the selection of specific biomarkers that will be useful in disease management. Rhinitis is a highly prevalent and ... Read more >>

Curr Treat Options Allergy (Current Treatment Options in Allergy)
[2020, 7(1):93-109]

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A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials.

Jianxin Wang, Rui Sun, Ruiyin Wang, Jing Han, Shuhua Zhang, Zetao Yin, Zelu Han, Ying Nong, Jiangtao Lin,

BACKGROUND:Many people with cough variant asthma use Traditional Chinese Patent Medicine-Suhuang anti-tussive capsule to help reduce symptoms. However there is no systematic reviews had promising its efficacy and safety for cough variant asthma. METHODS:Four English databases (PubMed, Web of science, EMBASE, and Springer Cochrane Library) and 4 Chinese databases (Wanfang ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(50):e18335]

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Prevalence of ethanol and other potentially harmful excipients in pediatric oral medicines: survey of community pharmacies in a Nigerian City.

Rebecca Soremekun, Irene Ogbuefi, Roseline Aderemi-Williams,

OBJECTIVE:Excipients are needed in the formulation of oral liquid medicines intended for children; they have however been reported to trigger safety issues. This study evaluated the concentrations and prevalence of ethanol and other potentially harmful excipients in pediatric formulations marketed in South Eastern Nigeria in line with international labeling guidelines ... Read more >>

BMC Res Notes (BMC research notes)
[2019, 12(1):460]

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Non-Analgesic Symptomatic or Disease-Modifying Potential of TRPA1.

Stefan Heber, Michael J M Fischer,

TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or phosphoinositolphosphate modulation. At first, TRPA1 was found on sensory neurons, where it ... Read more >>

Med Sci (Basel) (Medical sciences (Basel, Switzerland))
[2019, 7(10):]

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Ethnopharmacology, Phytochemistry, and Pharmacology of the Genus Glehnia: A Systematic Review.

Min Yang, Xue Li, Lei Zhang, Congcong Wang, Mingyue Ji, Jianping Xu, Keyong Zhang, Jicheng Liu, Chunhong Zhang, Minhui Li,

Glehnia littoralis Fr. Schmidt ex Miq, the sole species in the genus Glehnia (Apiaceae), has long been used in traditional Chinese medicine to treat fatigue, weakness, stomach-yin deficiency, lung heat, cough, dry throat, and thirst. Recently, G. littoralis has also been incorporated into a wide range of Chinese vegetarian cuisines. ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:1253493]

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Survey of the pattern of antibiotic dispensing in private pharmacies in Nepal.

Anant Nepal, Delia Hendrie, Suzanne Robinson, Linda A Selvey,

OBJECTIVES:Private pharmacies are widely established in most low/middle-income countries (LMICs) including Nepal, and are often considered as a patient's first point of contact for seeking healthcare. The aim of this study was to investigate the pattern of antibiotic dispensing in private pharmacies through exit interviews with patients to review their ... Read more >>

BMJ Open (BMJ open)
[2019, 9(10):e032422]

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Monpa, memory, and change: an ethnobotanical study of plant use in Mêdog County, South-east Tibet, China.

Shan Li, Yu Zhang, Yongjie Guo, Lixin Yang, Yuhua Wang,

BACKGROUND:Due to their relative isolation, the previous studies of Monpa plant use were only conducted in north-east India. In October 2013, Mêdog County was no longer remote, thanks to completion of a highway into the county. This study of plant species used by the Monpa had three research objectives. These ... Read more >>

J Ethnobiol Ethnomed (Journal of ethnobiology and ethnomedicine)
[2020, 16(1):5]

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Safety of local anesthetics.

Ana Carolina Figueiredo Pereira Cherobin, Glaysson Tassara Tavares,

Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types. Systemic toxicity with reflex on the central nervous and cardiovascular systems is their most feared adverse reactions, and the anaphylactic ... Read more >>

An Bras Dermatol (Anais brasileiros de dermatologia)
[2020, 95(1):82-90]

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Traditional Uses, Bioactive Constituents, Biological Functions, and Safety Properties of Oviductus ranae as Functional Foods in China.

Yang Zhang, Yifei Wang, Mingzhu Li, Shuyue Liu, Jialu Yu, Zhaowei Yan, Hongli Zhou,

Oviductus ranae is an animal-based traditional Chinese material widely used as tonics in China for hundreds of years. Various bioactive components are present in OR including proteins, amino acids, steroids, fatty acids, phospholipids, nucleosides, vitamins, hydantoins, and mineral elements. These constituents exert a myriad of biological functions such as immunomodulatory, ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2019, 2019:4739450]

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Fulminant Type 1 Diabetes Mellitus Caused by Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): A Case Report and Review of the Literature.

Bizhen Zhu, Jinzhun Wu, Guobing Chen, Yungang Yang, Cuili Yi,

Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS) is a rare, severe cutaneous adverse drug reaction characterized by fever, skin rashes, lymphadenopathy, leukocytosis with eosinophilia, and/or atypical lymphocytosis, and multiple visceral organ involvement. Moreover, patients with DRESS are at risk of developing autoimmune ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in Endocrinology)
[2019, 10:474]

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CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.

Michael N Fein, David A Fischer, Andrew W O'Keefe, Gord L Sussman,

Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side effects including sedation, impairment with decreased cognitive function, poor sleep quality, dry mouth, dizziness, and orthostatic hypotension. These drugs have also been found ... Read more >>

Allergy Asthma Clin Immunol (Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology)
[2019, 15:61]

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Acute parenchymal lung involvement in a 68-year-old woman with systemic lupus erythematosus, anemia, and thrombocytopenia.

Michela Dimitri, Vito Liotino, Silvano Dragonieri, Agnese Caringella, Luciana Labate, Pierluigi Carratu, Onofrio Resta,

Lung India (Lung India : official organ of Indian Chest Society)
[2019, 36(3):261-263]

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Toxicities associated with checkpoint inhibitors-an overview.

Laura Spiers, Nicholas Coupe, Miranda Payne,

Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2019, 58(Suppl 7):vii7-vii16]

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Ethnomedicine study on traditional medicinal plants in the Wuliang Mountains of Jingdong, Yunnan, China.

Lunlun Gao, Neng Wei, Guoping Yang, Zhenxian Zhang, Guizhou Liu, Chuantao Cai,

BACKGROUND:The Wuliang Mountains of the Jingdong region is a settlement area of the Yi community located in south-western Yunnan Province in China. Due to its unique geographical location, this area harbours abundant medicinal plant resources. The medicinal plants used by the local people have a long history and play an ... Read more >>

J Ethnobiol Ethnomed (Journal of ethnobiology and ethnomedicine)
[2019, 15(1):41]

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