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Prognosis of severe drug-induced acute interstitial nephritis requiring renal replacement therapy.

Li Huang, Shaoshan Liang, Jianhua Dong, Wenjing Fan, Caihong Zeng, Ti Zhang, Shuiqin Cheng, Yongchun Ge,

<h4>Objective</h4>Drug-induced acute interstitial nephritis (DAIN) is often associated with improved outcomes, whereas some patients may still progress to chronic kidney disease (CKD). The aim of this study was to evaluate the prognosis of patients with severe DAIN requiring renal replacement therapy (RRT) at baseline, and to explore the risk factors ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):1020-1027]

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Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats.

Benjamin M Dungar, Chad D Schupbach, Jessie R Jacobson, Phillip G Kopf,

Polybrominated diphenyl ethers (PBDEs) have been previously shown to alter various endocrine biosynthetic pathways. Growing epidemiological evidence suggests that PBDEs alter cardiovascular function. The goal of this study was to examine the effects of BDE-47 on adrenal corticosteroid pathways that play vital roles in cardiovascular homeostasis and pathophysiology. The effect ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(11):]

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Long-term outcomes after coronary artery bypass surgery in patients with rheumatoid arthritis.

Markus Malmberg, Antti Palomäki, Jussi O T Sipilä, Päivi Rautava, Jarmo Gunn, Ville Kytö,

<h4>Objective</h4>To investigate the long-term outcomes of coronary artery bypass grafting surgery (CABG) in patients with rheumatoid arthritis (RA).<h4>Methods</h4>Patients with RA (<i>n</i> = 378) were retrospectively compared to patients without RA (<i>n</i> = 7560), all treated with CABG in a multicentre, population-based cohort register study in Finland. The outcomes were studied with propensity score-matching adjustment ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1512-1519]

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IL-6 and other biomarkers as predictors of severity in COVID-19.

N Broman, K Rantasärkkä, T Feuth, M Valtonen, M Waris, U Hohenthal, E Rintala, A Karlsson, H Marttila, V Peltola, T Vuorinen, J Oksi,

<h4>Objective</h4>Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.<h4>Methods</h4>We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):410-412]

Cited: 7 times

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Variability of blood eosinophil count and prognosis of COPD exacerbations.

Sandra Martínez-Gestoso, María-Teresa García-Sanz, Uxío Calvo-Álvarez, Liliana Doval-Oubiña, Sandra Camba-Matos, Francisco-Javier Salgado, Xavier Muñoz, Purificación Perez-Lopez-Corona, Francisco-Javier González-Barcala,

<h4>Background</h4>Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to describe the serum eosinophilia levels in COPD patients and to ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1152-1158]

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Performance of fractional exhaled nitric oxide in predicting response to inhaled corticosteroids in chronic cough: a meta-analysis.

Pasquale Ambrosino, Mariasofia Accardo, Marco Mosella, Antimo Papa, Salvatore Fuschillo, Giorgio Alfredo Spedicato, Andrea Motta, Mauro Maniscalco,

<b>Background.</b> Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic review ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1659-1672]

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Time-course analysis reveals that corticosteroids resuscitate diminished CD8+ T cells in COVID-19: a retrospective cohort study.

Fangzhou Ye, Jing Liu, Liangkai Chen, Bin Zhu, Li Yu, Boyun Liang, Ling Xu, Sumeng Li, Sihong Lu, Lei Fan, Dongliang Yang, Xin Zheng,

<h4>Objective</h4>To illustrate the effect of corticosteroids and heparin, respectively, on coronavirus disease 2019 (COVID-19) patients' CD8+ T cells and D-dimer.<h4>Methods</h4>In this retrospective cohort study involving 866 participants diagnosed with COVID-19, patients were grouped by severity. Generalized additive models were established to explore the time-course association of representative parameters of coagulation, ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):181-188]

Cited: 2 times

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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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May mepolizumab used in asthma correct subfertility?

Guzin Ozden, Pelin Pınar Deniz,

<h4>İntroduction</h4>Asthma is one of the most common chronic airway disease among reproductive period of women. Chronic inflammation in asthma, eosinophilia, high steroid treatment and uncontrolled asthma may cause infertility by affecting the reproductive organs, menstrual cycle and quality of life. Some patients with severe asthma have frequent exacerbations associated with ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):456-458]

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Cardiac sarcoidosis: systematic review of literature on corticosteroid and immunosuppressive therapies.

Julien Stievenart, Guillaume Le Guenno, Marc Ruivard, Virginie Rieu, Marc André, Vincent Grobost,

<h4>Background</h4>Cardiac sarcoidosis (CS) is a life-threatening condition in which clear recommendations are lacking. We aimed to review systematically the literature on cardiac sarcoidosis treated by corticosteroids and/or immunosuppressive agents in order to update the management of CS.<h4>Methods</h4>Using Pubmed, Embase and Cochrane Library databases, we found original articles on corticosteroid and/or ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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Effectiveness of corticosteroids to treat severe COVID-19: A systematic review and meta-analysis of prospective studies.

Han Li, Bingdi Yan, Rong Gao, Jin Ren, Junling Yang,

<h4>Objectives</h4>To assess the effects of corticosteroid therapy for patients with severe coronavirus disease 2019 (COVID-19).<h4>Methods</h4>We comprehensively searched articles published in the Cochrane Library, PubMed, Embase, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases from January 1, 2019, to March 20, 2021.<h4>Results</h4>A total of 6771 patients ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 100:108121]

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Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability.

Sharon K Hunter, Robert Freedman, Amanda J Law, Uwe Christians, Jacob B W Holzman, Zachary Johnson, M Camille Hoffman,

<h4>Objective</h4>Maternal depression during gestation is an adverse factor in fetal brain development that manifests in later childhood behavioral problems. Fetal heart rate variability (FHRV) mediated by parasympathetic input is a marker of gestational nervous system development. Biological mediators of adverse effects of maternal depression may involve the mother's corticosteroids; however, ... Read more >>

Neuroreport (Neuroreport)
[2021, 32(14):1170-1174]

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Reduced Systemic Corticosteroid Use among Pediatric Patients With Inflammatory Bowel Disease in a Large Learning Health System.

Prashanthi Kandavel, Sally J Eder, Jeremy Adler, ,

<h4>Objectives</h4>Corticosteroids have long been used to treat inflammatory bowel disease. However, cumulative corticosteroid exposure is associated with adverse effects, particularly in growing children. Professional guidelines recommend steroid-sparing strategies. It remains unknown whether corticosteroid use has decreased in children with inflammatory bowel disease.<h4>Methods</h4>We performed retrospective cohort study using data from 2007 ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2021, 73(3):345-351]

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The Correlation of Clinical Corticosteroid Responsiveness With Expression of IL-6 in Peripheral Blood Immune Cells (PBMC) in Patients With Autoimmune Inner Ear Disease (AIED).

Scott W Gorthey, Shresh Pathak, Andrea Vambutas,

<h4>Hypothesis</h4>Autoimmune inner ear disease (AIED) patients will differentially express interleukin (IL)-6 based on corticosteroid responsiveness.<h4>Background</h4>AIED is characterized by periods of acute sensorineural hearing loss (SNHL). In a majority of patients corticosteroid responsiveness is lost over time. The mechanisms that control corticosteroid responsiveness have not been fully elucidated.<h4>Methods</h4>Thirty-five AIED patients and ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(9):1422-1428]

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Overuse of Oral Corticosteroids, Underuse of Inhaled Corticosteroids, and Implications for Biologic Therapy in Asthma.

Katrien Eger, Marijke Amelink, Simone Hashimoto, Pieter-Paul Hekking, Cristina Longo, Elisabeth H Bel,

<h4>Background</h4>Asthma patients using high cumulative doses of oral corticosteroids (OCSs) are at risk of serious adverse events and are increasingly being treated with steroid-sparing asthma biologics. However, it is unknown whether prescribing these expensive biologics is always justified.<h4>Objectives</h4>This study aimed to (1) assess the prevalence of asthma patients using high ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-6]

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Use of Systemic Corticosteroids for Reasons Other than Asthma in Subjects with Asthma.

Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Nobuaki Kobayashi, Takeshi Kaneko,

<h4>Backgrounds</h4>Recent studies have reported increased risks of adverse events from systemic corticosteroids even with only low-dose or short-term use. Some patients with asthma experience complications requiring systemic corticosteroids. However, few studies have examined issues associated with administration of systemic corticosteroids for reasons other than asthma among subjects with asthma.<h4>Objectives</h4>We investigated ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-7]

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Corticosteroid overuse in adults with immune thrombocytopenia: Cause for concern.

Adam Cuker, Howard A Liebman,

Corticosteroids remain a crucial component of first-line therapy for immune thrombocytopenia (ITP) due to low cost, high initial response rates, and acceptable short-term tolerability. However, extended and recurrent use of corticosteroids is associated with substantial toxicity. Survey studies indicate that >95% of patients with ITP treated with corticosteroids report adverse ... Read more >>

Res Pract Thromb Haemost (Research and practice in thrombosis and haemostasis)
[2021, 5(6):e12592]

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Assessing the relationship between topical corticosteroid phobia and susceptibility to misinformation in patients with atopic dermatitis.

Matthew L Hrin, Jeremy K Bray, Alan B Fleischer, Steven R Feldman,

While topical corticosteroids (TCSs) are safe and effective therapies for atopic dermatitis (AD), poor treatment adherence is a hurdle to successful management. Non-adherence can be due to TCS phobia, characterized by negative patient feelings and beliefs towards TCSs. The Topical Corticosteroid Phobia (TOPICOP) scale can measure TCS phobia in AD ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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The effectiveness of corticosteroid injection and splint in diabetic de Quervain's tenosynovitis patients: A single-blind, randomized clinical consort study.

Betül Başar, Ahmet Aybar, Gökhan Basar, Hakan Başar,

<h4>Background</h4>There is no clear information on the efficacy of corticosteroids, and splints in the treatment of patients with diabetes mellitus (DM). The aim of this study was to compare the outcomes of isolated corticosteroid injection therapy with splint treatment with corticosteroid injection in patients with and without DM.<h4>Methods</h4>84 diabetics, and ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(35):e27067]

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Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.

Mohammad Mahdevar, Jafar Vatandoost, Farzad Seyed Forootan, Abbas Kiani-Esfahani, Maryam Esmaeili, Maryam Peymani, Hamid Tavakkoli, Ali Osmay Gure, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi,

<h4>Background</h4>The steroid receptor RNA activator 1 (SRA1) gene is involved in the progression of various cancers via different molecular mechanisms mediated by long non-coding RNA SRA (lncRNA SRA). This study aimed to evaluate the lncRNA SRA effect on the tumor progression of colorectal cancer (CRC).<h4>Methods</h4>SRA1 expression was assessed in the ... Read more >>

Life Sci (Life sciences)
[2021, :119950]

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Clinical outcome of patients with COVID-19 Pneumonia treated with corticosteroids and colchicine in Colombia.

Miguel Alejandro Pinzón, Doris Cardona Arango, Juan Felipe Betancur, Santiago Ortiz, Héctor Holguín, Carolina Arias Arias, Bernardo J Muñoz Palacio, Michael Amarillo, Juan Felipe Llano, Pablo Montoya,

<h4>Background</h4>To date, there is no specific antiviral therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, current efforts aim to prevent contagion through public health measures and develop a protective vaccine. While waiting for the latter, ... Read more >>

Ann Clin Microbiol Antimicrob (Annals of clinical microbiology and antimicrobials)
[2021, 20(1):66]

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Comparison of a Platelet-Rich Plasma Injection and a Conventional Steroid Injection for Pain Relief and Functional Improvement of Partial Supraspinatus Tears.

Marvin Thepsoparn, Phark Thanphraisan, Thanathep Tanpowpong, Thun Itthipanichpong,

<h4>Background</h4>Partial supraspinatus tendon tears have frequently been treated using a subacromial corticosteroid injection or surgery. The clinical use of a platelet-rich plasma (PRP) injection is an alternative treatment method for the condition, despite the paucity of evidence of its efficacy.<h4>Purpose</h4>To compare pain relief, functional improvement, and complications after an intratendinous ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2021, 9(9):23259671211024937]

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Corticosteroids in adult respiratory distress syndrome - an inconvenient truth?

Rob Shulman, Cecilia Montanari, Inês Pinheiro, Alessia Longobardo, Suzanne Benhalm, Sara Polhill, Mervyn Singer, Geoff Bellingan, Nishkantha Arulkumaran,

<h4>Objectives</h4>Recent studies have demonstrated mortality benefits from corticosteroid use in COVID-19 patients requiring respiratory support. However, clinical practice may warrant the use of corticosteroids outside the context of a clinical trial. Such data are rarely, if ever, reported. We explored the use of corticosteroids for adult respiratory distress syndrome (ARDS) ... Read more >>

Int J Pharm Pract (The International journal of pharmacy practice)
[2021, :]

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Infliximab-induced liver injury: Clinical phenotypes, autoimmunity and the role of corticosteroid treatment.

Helgi Kristinn Björnsson, Bjorn Gudbjornsson, Einar Stefan Björnsson,

<h4>Background & aims</h4>Infliximab has been associated with drug-induced liver injury (DILI), particularly drug-induced autoimmune hepatitis (DIAIH). DIAIH is commonly treated with corticosteroids, but there is limited data on the efficacy of corticosteroids in infliximab-induced DILI.<h4>Material and methods</h4>Patients treated with infliximab in Iceland 2009-2020 developing elevated liver tests were assessed. Other ... Read more >>

J Hepatol (Journal of hepatology)
[2021, :]

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The Need for Studies on Oral Corticosteroids After Sialendoscopy for Obstructive Salivary Gland Disease: Systematic Review.

Gabriella Donaldson, Sandro de Paiva Leite, Tim Hardcastle, Zahoor Ahmad, Randall P Morton,

<h4>Objectives</h4>This qualitative systematic review evaluates the evidence in support of the use of oral corticosteroids in patients undergoing sialendoscopy for the treatment of obstructive sialadenitis.<h4>Design</h4>Qualitative systematic review.<h4>Methods</h4>A literature search was conducted from January 1985 and September 2020. Inclusion criteria embraced peer-reviewed articles in which adult patients undergoing interventional sialendoscopy for ... Read more >>

Ann Otol Rhinol Laryngol (The Annals of otology, rhinology, and laryngology)
[2021, :34894211045262]

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