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Conversion Disorders

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An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD.

Julius Obergassel, Lisa Lohmann, Sven G Meuth, Heinz Wiendl, Oliver Grauer, Christopher Nelke,

Sporadic Creutzfeldt-Jakob disease is the predominant type of human prion disease. While routine diagnostic in phenotypic cases has advanced considerably, the clinical heterogeneity and rarity of subtypes continue to constitute a major clinical and diagnostic challenge. Here, we report a peculiar case of the Heidenhain-variant of MM1 sporadic Creutzfeldt-Jakob disease ... Read more >>

Prion (Prion)
[2020, 14(1):24-28]

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Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk.

N J Haley, R Donner, D M Henderson, J Tennant, E A Hoover, M Manca, B Caughey, N Kondru, S Manne, A Kanthasamay, S Hannaoui, S C Chang, S Gilch, S Smiley, G Mitchell, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a progressively fatal, horizontally transmissible prion disease affecting several members of the cervid species. Conventional diagnosis relies on ELISA or IHC evaluation using tissues collected post-mortem; however, recent research has focused on newly developed amplification techniques using samples collected antemortem. The present study sought to cross-validate ... Read more >>

Prion (Prion)
[2020, 14(1):47-55]

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Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study.

N J Haley, D M Henderson, R Donner, S Wyckoff, K Merrett, J Tennant, E A Hoover, D Love, E Kline, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host's PRNP gene; ... Read more >>

Prion (Prion)
[2020, 14(1):76-87]

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

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Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate species.

Catherine I Cullingham, Rhiannon M Peery, Anh Dao, Debbie I McKenzie, David W Coltman,

Wildlife disease incidence is increasing, resulting in negative impacts on the economy, biodiversity, and potentially human health. Chronic wasting disease (CWD) is a fatal, transmissible spongiform encephalopathy of cervids (wild and captive) which continues to spread geographically resulting in exposure to potential new host species. The disease agent (PrPCWD) is ... Read more >>

Prion (Prion)
[2020, 14(1):56-66]

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Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus).

Mariella E Güere, Jørn Våge, Helene Tharaldsen, Sylvie L Benestad, Turid Vikøren, Knut Madslien, Petter Hopp, Christer M Rolandsen, Knut H Røed, Michael A Tranulis,

The emergence of CWD in Europe in 2016 and the first natural infection in wild reindeer warranted disease management. This led to the testing of 2424 hunted or culled reindeer during 2016-2018, from the infected subpopulation in the Nordfjella mountain range in Southern Norway. To identify any association between PRNP ... Read more >>

Prion (Prion)
[2020, 14(1):1-10]

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Neurocognitive functioning in patients with conversion disorder/functional neurological disorder.

Lars de Vroege, Iris Koppenol, Willem Johan Kop, Madelon M E Riem, Christina Maria van der Feltz-Cornelis,

Neurocognitive symptoms are common in individuals with somatic symptom and related disorders (SSRD), but little is known about the specific impairments in neurocognitive domains in patients with conversion disorder (CD)/functional neurological disorder (FND). This study examines neurocognitive functioning in patients with CD/FND compared to patients with other SSRD. The sample ... Read more >>

J Neuropsychol (Journal of neuropsychology)
[2020, :]

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Anxiety in Children with Selective Mutism: A Meta-analysis.

Jim Driessen, Jan Dirk Blom, Peter Muris, Roger K Blashfield, Marc L Molendijk,

This study evaluates the current conceptualization of selective mutism (SM) as an anxiety disorder in the DSM-5 using a meta-analytic approach. In the absence of any systematic assessment of anxiety in the field of SM, we pooled prevalence data of comorbid anxiety disorders in a random-effects meta-analysis. On the basis ... Read more >>

Child Psychiatry Hum Dev (Child psychiatry and human development)
[2020, 51(2):330-341]

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Nonepileptic attack disorder and functional movement disorder: A clinical continuum?

Mohammad Amir Rather, Andrea E Cavanna,

Nonepileptic attack disorder (NEAD) and functional movement disorder (FMD) are functional neurological disorders commonly seen in neuropsychiatry services. Although their initial referral pathways involve epileptologists (NEAD) and specialists in movement disorders (FMD), these conditions are currently classified as two possible manifestations of a single underlying conversion disorder. We set out ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107028]

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Somatic Symptom Disorder, Medically Unexplained Symptoms, Somatoform Disorders, Functional Neurological Disorder: How DSM-5 Got It Wrong.

Anton Scamvougeras, Andrew Howard,

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2020, :706743720912858]

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Attentional avoidance of emotions in functional movement disorders.

Angela Marotta, Fiorio Mirta, Marianna Riello, Benedetta Demartini, Ginevra Tecilla, Carlo Dallocchio, Michele Tinazzi,

OBJECTIVE:Emotional difficulties are common in functional movement disorders (FMD), yet their contribution to the disease remains unclear. We explored the potential role of emotional difficulties as risk and maintaining factors of FMD by looking at the effect of emotions on attention. METHOD:The dot-probe task was used to investigate attentional biases ... Read more >>

J Psychosom Res (Journal of psychosomatic research)
[2020, 133:110100]

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Opinions and clinical practices related to diagnosing and managing functional (psychogenic) movement disorders: changes in the last decade.

K LaFaver, A E Lang, J Stone, F Morgante, M Edwards, S Lidstone, C W Maurer, M Hallett, A K Dwivedi, A J Espay,

BACKGROUND AND PURPOSE:There is large variability in the diagnostic approach and clinical management in functional movement disorders (FMD). This study aimed to examine whether opinions and clinical practices related to FMD have changed over the past decade. METHODS:Adapted from a 2008 version, we repeated the survey to members of the ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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Childhood sexual abuse predicts treatment outcome in conversion disorder/functional neurological disorder. An observational longitudinal study.

Christina M Van der Feltz-Cornelis, Sarah F Allen, Jonna F Van Eck van der Sluijs,

OBJECTIVE:Explore trauma, stress, and other predictive factors for treatment outcome in conversion disorder/functional neurological disorder (CD/FND). METHODS:Prospective observational design. Clinical cohort study among consecutive outpatients with DSM-IV CD/FND in a specialized mental health institution for somatic symptom disorders and related disorders (SSRD), presented between 1 February 2010 and 31 December ... Read more >>

Brain Behav (Brain and Behavior)
[2020, 10(3):e01558]

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Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi,

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those ... Read more >>

Prion (Prion)
[2020, 14(1):20-23]

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Zinc Phosphides as Outstanding Sodium-Ion Battery Anodes.

Ki-Hun Nam, Yoon Hwa, Cheol-Min Park,

To design a high-performance sodium-ion battery anode, binary zinc phosphides (ZnP2 and Zn3P2) were synthesized by a facile solid-state heat treatment process, and their Na storage characteristics were evaluated. The Na reactivity of ZnP2 was better than that of Zn3P2. Therefore, a C-modified ZnP2-based composite (ZnP2-C) was fabricated to achieve ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(13):15053-15062]

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Maladaptive emotional regulation in patients diagnosed with psychogenic non-epileptic seizures (PNES) compared with healthy volunteers.

Lenka Krámská, Lucia Hrešková, Zdeněk Vojtěch, David Krámský, Lorna Myers,

PURPOSE:The term PNES refers to a conversion disorder that mimics epileptic seizures but has a psychological etiology. Recent studies report that in patients with PNES, there is reduced understanding of emotions, impulse control difficulties, and limited access to emotional regulation strategies. The aim of this study was to compare patients ... Read more >>

Seizure (Seizure)
[2020, 78:7-11]

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Pushing periodic-disorder-induced phase matching into the deep-ultraviolet spectral region: theory and demonstration.

Mingchuan Shao, Fei Liang, Haohai Yu, Huaijin Zhang,

Nonlinear frequency conversion is a ubiquitous technique that is used to obtain broad-range lasers and supercontinuum coherent sources. The phase-matching condition (momentum conservation relation) is the key criterion but a challenging bottleneck in highly efficient conversion. Birefringent phase matching (BPM) and quasi-phase matching (QPM) are two feasible routes but are ... Read more >>

Light Sci Appl (Light, science & applications)
[2020, 9:45]

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Achieving High Lithium Storage Capacity and Long-Term Cyclability of Novel Cobalt Germanate Hydroxide/Reduced Graphene Oxide Anodes with Regulated Electrochemical Catalytic Conversion Process of Hydroxyl Groups.

Ya-Qiong Jing, Jin Qu, Xian-Zhi Zhai, Zhe Chen, Hong-Jun Liu, Wei Chang, Zhong-Zhen Yu,

To develop ternary transition-metal germanate anodes with superior lithium storage performances for lithium-ion batteries, a novel capacity counterbalance approach in one compound is designed by introducing an electrocatalytic conversion-type component with a positive cycling trend to compensate the negative cycling trend of the GeO2 component. Novel cobalt germanate hydroxide (CGH) ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(12):14037-14048]

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Stroke Mimics: Experience of a Moroccan Stroke Unit.

Naima Chtaou, Siham Bouchal, Aouatef E L Midaoui, Zouhayr Souirti, Nabil Tachfouti, Mohammed Faouzi Belahsen,

BACKGROUND:Stroke mimic is a medical condition presenting with acute neurological deficit and simulate real stroke. The objective of this study was to evaluate the frequency and the various etiologies of stroke mimics in our center. METHODS:We retrospectively reviewed the Thrombolysis Alert registry and we studied the frequency and characteristics of ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, :104651]

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Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.

Ibai Diez, Anna G Larson, Vihang Nakhate, Erin C Dunn, Gregory L Fricchione, Timothy R Nicholson, Jorge Sepulcre, David L Perez,

Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatment (ELM) is a risk factor for developing FND, yet few studies have investigated brain network-trauma relationships in this population. In this neuroimaging-gene expression study, we used two graph ... Read more >>

Mol. Psychiatry (Molecular psychiatry)
[2020, :]

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Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS.

Neda Emami, AliReza Alizadeh, Ashraf Moini, Parichehreh Yaghmaei, Maryam Shahhosseini,

The objective was to determine the differences in fatty acid (FA) profiles in subcutaneous adipose tissue (AT) between pregnant women with polycystic ovary syndrome (PCOS) and those without PCOS. FA profiles of AT samples from 13 PCOS and 32 non-PCOS, all of whom underwent caesarean section were compared using gas ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):16-23]

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Neuropsychological Contribution to Predict Conversion to Dementia in Patients with Mild Cognitive Impairment Due to Alzheimer's Disease.

Dina Silva, Sandra Cardoso, Manuela Guerreiro, João Maroco, Tiago Mendes, Luísa Alves, Joana Nogueira, Inês Baldeiras, Isabel Santana, Alexandre de Mendonça,

BACKGROUND:Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, :]

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Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders.

Masato Shizuku, Hideya Kamei, Hiroyuki Kimura, Nobuhiko Kurata, Kanta Jobara, Atsushi Yoshizawa, Kanako Ishizuka, Aoi Okada, Shinichi Kishi, Norio Ozaki, Yasuhiro Ogura,

BACKGROUND In the field of living donor liver transplantation (LDLT), it is important to ensure donor's psychological well-being. We report on clinical features and long-term outcomes of LDLT donors who developed psychiatric disorders after their donor operations. Additionally, we compare patient backgrounds, as well as surgical and perioperative aspects between ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2020, 25:e918500]

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Child with acute weakness: don't forget the salts.

Kathryn Boyle, Ben McNaughten, Andrew Thompson, Stephen Mullen,

Case summaryA 10-year-old boy presented with severe progressive generalised weakness on a background of 3 days of diarrhoea and vomiting. Vital signs were normal. Peripheral neurological examination revealed grade 1-2 power in all limbs, hypotonia and hyporeflexia. Sensation was fully intact. Cranial nerve examination and speech were normal. The ECG (figure ... Read more >>

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, :]

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Bimetal Synergistic Effect Induced High Reversibility of Conversion-Type [email protected] as a Free-Standing Anode for Sodium Ion Batteries.

Jiyu Zhang, Keming Song, Liwei Mi, Chuntai Liu, Xiangming Feng, Jianmin Zhang, Weihua Chen, Changyu Shen,

Conversion-type anode materials for sodium ion batteries have received extensive attention because of their relatively high theoretical capacity. However, multiple challenging obstacles stand in the way of their commercial application, especially their poor cycling stability resulting from the bad reversibility of the conversion reaction. Herein, Ni-Co bimetal sulfide was selected ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2020, 11(4):1435-1442]

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