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Complex Regional Pain Syndromes

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Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice.

Tian-Zhi Guo, Tzuping Wei, Maral Tajerian, J David Clark, Frank Birklein, Andreas Goebel, Wen-Wu Li, Peyman Sahbaie, Fabiola L Escolano, Myriam Herrnberger, Heidrum H Kramer, Wade S Kingery,

It has been proposed that complex regional pain syndrome (CRPS) is a post-traumatic autoimmune disease. Previously, we observed that B cells are required for the full expression of CRPS-like changes in a mouse tibia fracture model and that serum immunoglobulin M (IgM) antibodies from fracture mice have pronociceptive effects in ... Read more >>

Pain (Pain)
[2020, 161(4):797-809]

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[Exergames for patients with complex regional pain syndrome : A feasibility study].

Claudia Storz, Heike Schulte-Göcking, Matthias Woiczinski, Monica Azqueta-Gavaldon, Shahnaz Christina Azad, Eduard Kraft,

BACKGROUND:Complex regional pain syndrome (CRPS) is a disease of the limbs composed of various disorders and defined by the cardinal symptom of pain. So-called exergames with a combination of physical activity and fun are increasingly being offered as part of treatment. Exergame therapy could also provide CRPS patients with repetitive training, reward ... Read more >>

Schmerz (Schmerz (Berlin, Germany))
[2020, 34(2):166-171]

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Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome.

Francis Sahngun Nahm, Jae-Sung Lee, Pyung-Bok Lee, Eunjoo Choi, Woong Ki Han, Sang-Soep Nahm,

Background:Among various diseases that accompany pain, complex regional pain syndrome (CRPS) is one of the most frustrating for patients and physicians. Recently, many studies have shown functional and anatomical abnormalities in the brains of patients with CRPS. The calcium-related signaling pathway is important in various physiologic processes via calmodulin (CaM) ... Read more >>

Korean J Pain (The Korean journal of pain)
[2020, 33(2):131-137]

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Photobiomodulation Decreases Hyperalgesia in Complex Regional Pain Syndrome: An Experimental Mouse Model Subjected to Nicotine.

Mariana Rodrigues, Ramon B Cardoso, Heloyse U Kuriki, Alexandre M Marcolino, Elaine Caldeira de Oliveira Guirro, Rafael I Barbosa,

BACKGROUND AND OBJECTIVES:Complex regional pain syndrome (CRPS) is defined as an extreme and chronic pain condition, and photobiomodulation has relevance as a complementary treatment for CRPS. The objective of this study was to verify the effects of photobiomodulation (PBMT) therapy protocols at two wavelengths 660 and 830 nm, associated or not ... Read more >>

Lasers Surg Med (Lasers in surgery and medicine)
[2020, :]

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Prism adaptation treatment for upper-limb Complex Regional Pain Syndrome: a double-blind randomized controlled trial

Monika Halicka, Axel Vitterso, Hayley McCullough, Andreas Goebel, Leila Heelas, Michael Proulx, Janet Bultitude,

Initial evidence suggested that people with Complex Regional Pain Syndrome (CRPS) have reduced attention to the affected side of their body and the surrounding space, which might be related to pain and other clinical symptoms. Three previous unblinded, uncontrolled studies showed pain relief following treatment with prism adaptation, an intervention ... Read more >>

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Disputing space-based biases in unilateral complex regional pain syndrome.

Monika Halicka, Axel D Vittersø, Hayley McCullough, Andreas Goebel, Leila Heelas, Michael J Proulx, Janet H Bultitude,

There is some evidence that people with Complex Regional Pain Syndrome (CRPS) show reduced attention to the affected relative to unaffected limb and its surrounding space, resembling hemispatial neglect after brain injury. These neuropsychological symptoms could be related to central mechanisms of pathological pain and contribute to its clinical manifestation. ... Read more >>

Cortex (Cortex; a journal devoted to the study of the nervous system and behavior)
[2020, 127:248-268]

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Optimizing the Treatment of CRPS with Ketamine.

Anthony F Kirkpatrick, Abolfazl Saghafi, Kai Yang, Peihua Qiu, James Alexander, Egle Bavry, Robert Schwartzman,

OBJECTIVES:This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS. METHODS:All patients were diagnosed with ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, :]

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Utilization of Concurrent Dorsal Root Ganglion Stimulation and Dorsal Column Spinal Cord Stimulation in Complex Regional Pain Syndrome.

Priyanka Ghosh, Semih Gungor,

INTRODUCTION:Complex regional pain syndrome (CRPS) can be effectively treated with spinal cord stimulation (t-SCS). There is also evidence that dorsal root ganglion (DRG) stimulation may be superior to t-SCS in CRPS. However, there has been no published data, to our knowledge, that looked at the concurrent use of t-SCS and ... Read more >>

Neuromodulation (Neuromodulation : journal of the International Neuromodulation Society)
[2020, :]

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Cost-Effectiveness of Dorsal Root Ganglion Stimulation or Spinal Cord Stimulation for Complex Regional Pain Syndrome.

Nagy Mekhail, Timothy R Deer, Lawrence Poree, Peter S Staats, Allen W Burton, Allison T Connolly, Edward Karst, Diana S Mehanny, Youssef Saweris, Robert M Levy,

OBJECTIVES:ACCURATE, a randomized controlled trial, compared safety and effectiveness of stimulation of the dorsal root ganglion (DRG) vs. conventional spinal cord stimulation (SCS) in complex regional pain syndrome (CRPS-I and II) of the lower extremities. This analysis compares cost-effectiveness of three modalities of treatment for CRPS, namely DRG stimulation, SCS, ... Read more >>

Neuromodulation (Neuromodulation : journal of the International Neuromodulation Society)
[2020, :]

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Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy.

Yehuda Shoenfeld, Varvara A Ryabkova, Carmen Scheibenbogen, Louise Brinth, Manuel Martinez-Lavin, Shuichi Ikeda, Harald Heidecke, Abdulla Watad, Nicola L Bragazzi, Joab Chapman, Leonid P Churilov, Howard Amital,

Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these ... Read more >>

Clin. Immunol. (Clinical immunology (Orlando, Fla.))
[2020, 214:108384]

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Altered sensory-motor plasticity in amyotrophic lateral sclerosis and complex regional pain type I syndrome: a shared mechanism?

Dario Ricciardi, Vincenzo Todisco, Gioacchino Tedeschi, Francesca Trojsi, Giovanni Cirillo,

Besides the prominent motor syndrome, some patients affected by amyotrophic lateral sclerosis (ALS) complain of many non-motor symptoms during the disease course, in particular chronic pain that significantly reduces the patients' quality of life. Complex regional pain syndrome (CRPS) is a rare painful condition, rarely described in ALS patients. We ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.

Monica Azqueta-Gavaldon, Andrew M Youssef, Claudia Storz, Jordan Lemme, Heike Schulte-Göcking, Lino Becerra, Shahnaz C Azad, Anselm Reiners, Birgit Ertl-Wagner, David Borsook, Jaymin Upadhyay, Eduard Kraft,

Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with ... Read more >>

Pain (Pain)
[2020, 161(3):595-608]

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Spinal cord stimulation improves functional outcomes in children with CRPS: Case presentation and review of the literature.

S M Bakr, J Knight, S K Johnson, A E Williams, J A Tolley, J S Raskin,

In the pediatric population, complex regional pain syndrome (CRPS) is a debilitating chronic pain syndrome that is classically treated with escalating polypharmacy and physical therapy; with failure of therapy oftentimes encountered in both adult and pediatric CRPS patients after which invasive neuromodulatory therapy might be considered1,2 . Intrathecal drug delivery ... Read more >>

Pain Pract (Pain practice : the official journal of World Institute of Pain)
[2020, :]

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Effectiveness, safety, and predictive potential in ultrasound-guided stellate ganglion blockades for the treatment of sympathetically maintained pain.

Ruben Aleanakian, Boo-Young Chung, Robert E Feldmann, Justus Benrath,

BACKGROUND:Evaluating effectiveness of stellate ganglion blockades (SGBs) proves challenging as criteria defining a successful blockade, are controversial. This may be one reason for the scarcity of studies on this topic, thus forcing clinical guidelines to remain conservative in recommending SGBs. Moreover, factors to predict which patients benefit from blockade series, ... Read more >>

Pain Pract (Pain practice : the official journal of World Institute of Pain)
[2020, :]

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Miller Fisher syndrome and Guillain-Barré syndrome: dual intervention rehabilitation of a complex patient case.

Jill E Mayer, Christine A McNamara, John Mayer,

Purpose: Guillain-Barré syndrome (GBS) presents with acute peripheral neuropathy leading to ascending motor and sensory deficits. Miller Fisher syndrome (MFS), a GBS variant, is characterized by ophthalmoplegia, ataxia, and areflexia. In unusual cases, MFS and GBS overlap. The purpose of this case report is to illustrate the effects of an ... Read more >>

Physiother Theory Pract (Physiotherapy theory and practice)
[2020, :1-10]

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Changing hand appearance using visual illusions modulates body perception disturbance and pain in longstanding Complex Regional Pain Syndrome: A randomised trial

Jennifer Sarah Lewis, Roger Newport, Gordon Taylor, Mike Smith, Candy McCabe,

Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence of pain reduction when the affected limb is visually altered in size, suggests that visual illusions used to target central ... Read more >>

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Altered updating of bodily and spatial representations after tool-use in complex regional pain syndrome.

Axel D Vittersø, Gavin Buckingham, Monika Halicka, Michael J Proulx, Janet H Bultitude,

Distorted representations of the body and peripersonal space are common in complex regional pain syndrome (CRPS), and might modulate its symptoms (eg, asymmetric limb temperature). In pain-free people, such representations are malleable, and update when we interact with objects in our environment (eg, during tool-use). Distortions are also common after ... Read more >>

Pain (Pain)
[2020, :]

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Prednisone for Acute Complex Regional Pain Syndrome: A Retrospective Cohort Study.

Andrew Jamroz, Michael Berger, Paul Winston,

Objective:The objective of this study was to evaluate prednisone effectiveness on complex regional pain syndrome (CRPS) features in a community-based outpatient rehabilitation setting. Design:A single-centre, retrospective inception cohort design was used. Inclusion criteria were CRPS diagnosis according to the Budapest criteria, involvement of multiple joints, treatment with prednisone, and duration ... Read more >>

Pain Res Manag (Pain research & management)
[2020, 2020:8182569]

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Spinal Cord Stimulator Placement in Patient With von Willebrand Disease: A Case Report.

Priyanka Singla, Lynn R Kohan,

Complex regional pain syndrome (CRPS) is a regional neuropathic pain syndrome. Excruciating pain often interferes with patients' ability to function normally. Spinal cord stimulators (SCS) have been effective in treating pain along with signs of sympathetic overactivity in patients with CRPS. Implantation of SCS is a high-risk interventional procedure with ... Read more >>

A A Pract (A&A practice)
[2020, 14(5):149-151]

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Neurogenic Thoracic Outlet Syndrome and other Forms of Cervical Brachial Syndrome Treated with Plasma Concentrate Enriched for Alpha 2 Macroglobulin.

Sheldon Jordan, Jessica Iovine, Taylor Kuhn, Hugh Gelabert,

BACKGROUND:Existing therapies for myofascial and neuralgic forms of cervicobrachial pain may have unsatisfactory outcomes. Alternative therapies may be considered, particularly for individuals who have failed to respond. Contemporary conceptualizations of chronic pain mechanisms include the contribution of inflammatory factors; therefore, locally targeted antiinflammatory administrations may play a role in treatment ... Read more >>

Pain Physician (Pain physician)
[2020, 23(2):229-233]

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Spinal cord stimulation in chronic pain: technical advances.

Emil Isagulyan, Konstantin Slavin, Nikolay Konovalov, Eugeny Dorochov, Alexey Tomsky, Andrey Dekopov, Elizaveta Makashova, David Isagulyan, Pavel Genov,

Chronic severe pain results in a detrimental effect on the patient's quality of life. Such patients have to take a large number of medications, including opioids, often without satisfactory effect, sometimes leading to medication abuse and the pain worsening. Spinal cord stimulation (SCS) is one of the most effective technologies ... Read more >>

Korean J Pain (The Korean journal of pain)
[2020, 33(2):99-107]

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Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study.

Paula Ruth L Siongco, Raymond L Rosales, Austen Peter Moore, Rainer Freynhagen, Kimiyoshi Arimura, Petr Kanovsky, Ryuji Kaji, Hubert H Fernandez, Dirk Dressler,

Apart from the known efficacy of Botulinum Neurotoxin Type A (BoNT/A) in hyperactive striated and smooth muscles, different pain states have become potential targets of toxin effects. This present study determined the comparative toxin effectiveness in pain reduction among those patients injected with BoNT/A in muscle-based and in non-muscle-based conditions. ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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Combining Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to Relieve Persistent Pain in a Patient Suffering from Complex Regional Pain Syndrome: A Case Report.

Francis Houde, Marie-Philippe Harvey, Pierre-François Tremblay Labrecque, Francis Lamarche, Alexandra Lefebvre, Guillaume Leonard,

Purpose:Complex regional pain syndrome (CRPS) is a rare neuropathic pain condition characterized by sensory, motor and autonomic alterations. Previous investigations have shown that transcranial direct current stimulation (tDCS) and transcutaneous electrical nerve stimulation (TENS) can alleviate pain in various populations, and that a combination of these treatments could provide greater ... Read more >>

J Pain Res (Journal of Pain Research)
[2020, 13:467-473]

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Appropriate referral and selection of patients with chronic pain for spinal cord stimulation: European consensus recommendations and e-health tool.

Simon Thomson, Frank Huygen, Simon Prangnell, José De Andrés, Ganesan Baranidharan, Hayat Belaïd, Neil Berry, Bart Billet, Jan Cooil, Giuliano De Carolis, Laura Demartini, Sam Eldabe, Kliment Gatzinsky, Jan W Kallewaard, Kaare Meier, Mery Paroli, Angela Stark, Matthias Winkelmüller, Herman Stoevelaar,

BACKGROUND:Spinal cord stimulation (SCS) is an established treatment for chronic neuropathic, neuropathic-like and ischaemic pain. However, the heterogeneity of patients in daily clinical practice makes it often challenging to determine which patients are eligible for this treatment, resulting in undesirable practice variations. This study aimed to establish patient-specific recommendations for ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, :]

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Bodily changes and sensory sensitivity in complex regional pain syndrome and fibromyalgia.

Antonia F Ten Brink, Louisa Peters, Paraskevi-Ioanna Kompouli, Abbie Jordan, Candida S McCabe, Andreas Goebel, Janet H Bultitude,

Complex regional pain syndrome (CRPS) and fibromyalgia are chronic pain conditions of unexplained origins. In addition to symptoms in the diagnostic criteria, patients can report changes to vision and other sensations or bodily functions. It is unclear whether these are greater than would be expected due to normal ageing, living ... Read more >>

Pain (Pain)
[2020, :]

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