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Complex Partial Seizures

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Social isolation and exclusion: the parents' experience of caring for children with rare neurodevelopmental disorders.

Genevieve Currie, Joanna Szabo,

Purpose: The experiences of parents caring for the complex care needs of children with rare neurodevelopmental disorders are not well understood. Parents struggle to meet their children's medical, behavioural, and social needs within and across health, social, and family systems. The purpose of this study was to explore the parents' ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1725362]

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Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus.

Dong-Qi Lin, Xin-Ying Cai, Chun-Hua Wang, Bin Yang, Ri-Sheng Liang,

Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we investigated the effects of necrostatin-1 on ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):936-943]

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Electroencephalogram studies of hypoxic ischemia in fetal and neonatal animal models.

Hamid Abbasi, Charles P Unsworth,

Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):828-837]

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Altered integrity of corpus callosum in generalized epilepsy in relation to seizure lateralization after corpus callosotomy.

Po Ching Chen, Steven A Messina, Eduardo Castillo, James Baumgartner, Joo Hee Seo, Holly Skinner, Elakkat D Gireesh, Ki Hyeong Lee,

OBJECTIVE:Generalized-onset seizures are usually conceptualized as engaging bilaterally distributed networks with no clear focus. However, the authors previously reported a case series demonstrating that in some patients with generalized-onset seizures, focal seizure onset could be discovered after corpus callosotomy. The corpus callosum is considered to be a major pathway for ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E15]

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Beneficial effects of AAV1-Rheb(S16H) administration in the adult hippocampus.

Sang Ryong Kim,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1479-1480]

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Analyzing clinical and genetic characteristics of a cohort with multiple congenital anomalies-hypotonia-seizures syndrome (MCAHS).

Xianru Jiao, Jiao Xue, Pan Gong, Xinhua Bao, Ye Wu, Yuehua Zhang, Yuwu Jiang, Zhixian Yang,

OBJECTIVE:To summarize and extend the phenotypic characterization of Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome, and to discuss genotype-phenotype correlations. METHODS:Collecting clinical information of 17 patients with pathogenic variants in PIGN, PIGA, and PIGT. Genetic studies were performed on all patients. RESULTS:There were 7 patients with 15 PIGN mutations (one patient carrying 3 ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):78]

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The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States.

Sarah N Gibbs, Jiyoon Choi, Ibrahim Khilfeh, K Hamzah Ahmed, Irina Yermilov, Eric Segal,

OBJECTIVE:To better understand the humanistic and economic burden of focal seizures in children 2-12 years old. METHODS:We conducted a targeted literature review by searching MEDLINE for English-language publications reporting on children 2-12 years old with focal seizures published in the United States since 2008. RESULTS:Thirty-five publications were included. Incidence of ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820911785]

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Anxiety as the only manifestation of focal non-convulsive status epilepticus: case report and review of the literature.

Mariarita Albini, Alessandra Morano, Jinane Fattouch, Martina Fanella, Federica Avorio, Luca Manfredi Basili, Emanuele Cerulli Irelli, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura,

Psychiatric disorders represent common comorbidities in epileptic patients. Sometimes anxiety is part of the ictal semiology, especially during seizures arising from/involving frontal or temporal lobes. We describe a patient with focal epilepsy and recurrent hyperkinetic seizures who also presented prolonged episodes characterized by massive anxiety, alarm and fear. A Video-Electroencephalographic ... Read more >>

Neurocase (Neurocase)
[2020, :1-5]

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Identification of a Novel MYH9 Mutation in a Young Adult With Inherited Thrombocytopenia and Recurrent Seizures by Targeted Exome Sequencing.

Eu Jeen Yang, Kyung Mi Park, Yoo-Mi Kim, Ki Sun Jung, Young Tak Lim, Chong Kun Cheon,

May-Hegglin anomaly (MHA) is a rare autosomal dominant disorder caused by a mutation in the myosin heavy chain 9 (MYH9) gene. MHA patients have variable clinical manifestations including thrombocytopenia, renal injury, hearing impairment, and cataracts. We describe a 25-year-old man with isolated thrombocytopenia initially. He experienced recurrent seizures with stable ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, 42(3):e188-e192]

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Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring.

Anemone von Blomberg, Lara Kay, Susanne Knake, Sven Fuest, Johann Philipp Zöllner, Philipp S Reif, Eva Herrmann, Ümniye Balaban, Susanne Schubert-Bast, Felix Rosenow, Adam Strzelczyk,

BACKGROUND:An efficient, well tolerated, and safe emergency treatment with a rapid onset of action is needed to prevent seizure clusters and to terminate prolonged seizures and status epilepticus. OBJECTIVES:This study aimed to examine the efficacy, tolerability, and safety of intranasal midazolam (in-MDZ) spray in clinical practice. METHODS:In this retrospective, multicenter ... Read more >>

CNS Drugs (CNS drugs)
[2020, :]

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Electroencephalographic analysis in soman-exposed 21-day-old rats and the effects of midazolam or LY293558 with caramiphen.

Marcio De Araujo Furtado, Vassiliki Aroniadou-Anderjaska, Taiza H Figueiredo, James P Apland, Maria F M Braga,

Acute nerve agent exposure induces status epilepticus (SE), which can cause brain damage or death. Research aiming at developing effective therapies for controlling nerve agent-induced SE is commonly performed in adult rats. The characteristics of nerve agent-induced SE in young rats are less clear; relevant knowledge is necessary for developing ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2020, :]

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Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.

M N Savini, A Mingarelli, A Peron, F La Briola, F Cervi, R M Alfano, M P Canevini, A Vignoli,

BACKGROUND:Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely influence developmental outcome. Although early diagnosis of TSC has offered a tremendous opportunity to monitor affected patients before seizure onset, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):36]

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Buproprion associated seizures following acute overdose: who develops late seizures.

Steve Offerman, Jasmin Gosen, Stephen H Thomas, Angie Padilla-Jones, Anne-Michelle Ruha, Michael Levine,

Objectives: Bupropion is an antidepressant that is commonly known to cause seizures in overdose. Because of concern for delayed onset of seizures, patients are frequently observed for prolonged periods after overdose. The primary objective is to evaluate the incidence and clinical parameters associated with late seizures following bupropion overdose.Methods: This ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2020, :1-7]

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A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment.

Mathieu Milh, Pierre Roubertoux, Najoua Biba, Julie Chavany, Adeline Spiga Ghata, Camille Fulachier, Stephan Christopher Collins, Christel Wagner, Jean-Christophe Roux, Binnaz Yalcin, Marie-Solenne Félix, Florence Molinari, Pierre-Pascal Lenck-Santini, Laurent Villard,

OBJECTIVE:Early onset epileptic encephalopathy with suppression-burst is one of the most severe epilepsy phenotypes in human patients. A significant proportion of cases have a genetic origin, and the most frequently mutated gene is KCNQ2, encoding Kv7.2, a voltage-dependent potassium channel subunit, leading to so-called KCNQ2-related epileptic encephalopathy (KCNQ2-REE). To study ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Electrographic seizures and ictal-interictal continuum (IIC) patterns in critically ill patients.

Sahar F Zafar, Thanujaa Subramaniam, Gamaleldin Osman, Aline Herlopian, Aaron F Struck,

Critical care long-term continuous electroencephalogram (cEEG) monitoring has expanded dramatically in the last several decades spurned by technological advances in EEG digitalization and several key clinical findings: 1-Seizures are relatively common in the critically ill-large recent observational studies suggest that around 20% of critically ill patients placed on cEEG have ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107037]

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Anti-Epileptogenic Effects of Antiepileptic Drugs.

Barbara Miziak, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, Stanisław J Czuczwar,

Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

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Astrocytic modulation of potassium under seizures.

Fushun Wang, Xiaoming Qi, Jun Zhang, Jason H Huang,

The contribution of an impaired astrocytic K+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade. A defective K+ regulation leads to an elevated extracellular K+ concentration ([K+]o). When [K+]o reaches peaks of 10-12 mM, it is strongly associated with seizure initiation during hypersynchronous neuronal ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):980-987]

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Factors Associated With Seizure Onset in Children With Autism Spectrum Disorder.

Jamie K Capal, Eric A Macklin, Frances Lu, Gregory Barnes,

BACKGROUND AND OBJECTIVES:Children with autism spectrum disorder (ASD) have a higher prevalence of epilepsy compared with general populations. In this pilot study, we prospectively identified baseline risk factors for the development of seizures in individuals with ASD and also identified characteristics sensitive to seizure onset up to 6 years after ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(Suppl 1):S117-S125]

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Long-term safety, efficacy, and quality of life outcomes with adjunctive brivaracetam treatment at individualized doses in patients with epilepsy: An up to 11-year, open-label, follow-up trial.

Terence J O'Brien, Simon Borghs, Qin Jane He, Anne-Liv Schulz, Stephen Yates, Victor Biton,

OBJECTIVE:To evaluate long-term safety/tolerability of brivaracetam at individualized doses ≤200 mg/d (primary) and maintenance of efficacy over time (secondary) in adults with focal seizures or primary generalized seizures (PGS) enrolled in phase 3, open-label, long-term follow-up trial N01199 (NCT00150800). METHODS:Patients ≥16 years of age who had completed double-blind, placebo-controlled adjunctive brivaracetam trials ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Uni-hemispheric hyperperfusion in the early postictal state: case report.

A Velasco Gonzalez, C Schülke, B Buerke,

BACKGROUND:In the emergency setting of acute ischemic stroke, seizures have been reported in up to 4% of patients. In the absence of arterial occlusion, seizures may also cause abnormalities in CT perfusion in 78% of cases when the time window from onset to imaging is short. Both hyperperfusion and hypoperfusion ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):108]

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Nonconvulsive status epilepticus in the elderly.

S Dupont, K Kinugawa,

There is a higher incidence of status epilepticus in the older adult population that commonly presents as nonconvulsive status epilepticus (NCSE). NCSE most often corresponds to prolonged focal seizures with impaired consciousness with three main clinical presentations: i) an unexplained acute confusional state, ii) subtle eye, motor or behavioral signs ... Read more >>

Rev. Neurol. (Paris) (Revue neurologique)
[2020, :]

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A model for focal seizure onset, propagation, evolution, and progression.

Jyun-You Liou, Elliot H Smith, Lisa M Bateman, Samuel L Bruce, Guy M McKhann, Robert R Goodman, Ronald G Emerson, Catherine A Schevon, L F Abbott,

We developed a neural network model that can account for major elements common to human focal seizures. These include the tonic-clonic transition, slow advance of clinical semiology and corresponding seizure territory expansion, widespread EEG synchronization, and slowing of the ictal rhythm as the seizure approaches termination. These were reproduced by ... Read more >>

Elife (eLife)
[2020, 9:]

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Carbamazepine Toxicity Masquerading as Complex Febrile Seizures in a Pediatric Patient.

Richard J Chen, Muhammad Ershad, Maricel Dela Cruz, Ahmed Mamdouh Taha Mostafa,

Carbamazepine is an antiepileptic drug that can cause seizures in overdose. In certain patient populations, this may be misdiagnosed as a seizure disorder. We describe a case of a 20-month-old female who presented with fever and seizure-like activity who was initially thought to have complex febrile seizures. Further historical information ... Read more >>

Case Rep Emerg Med (Case Reports in Emergency Medicine)
[2020, 2020:]

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Drug Treatment of Progressive Myoclonic Epilepsy.

Gregory L Holmes,

The progressive myoclonic epilepsies (PMEs) represent a rare but devastating group of syndromes characterized by epileptic myoclonus, typically action-induced seizures, neurological regression, medically refractory epilepsy, and a variety of other signs and symptoms depending on the specific syndrome. Most of the PMEs begin in children who are developing as expected, ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(2):149-164]

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