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Full Text Journal Articles about
Community Acquired Pneumonia

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Update in adult community-acquired pneumonia: key points from the new American Thoracic Society/Infectious Diseases Society of America 2019 guideline.

Joshua P Metlay, Grant W Waterer,

PURPOSE OF REVIEW:The American Thoracic Society and Infectious Diseases Society of America recently released their joint guideline for the diagnosis and treatment of adults with community-acquired pneumonia (CAP). The co-chairs of the guideline committee provide a summary of the guideline process, key recommendations from the new guideline and future directions ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):203-207]

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Strategies for prediction of drug-resistant pathogens and empiric antibiotic selection in community-acquired pneumonia.

Ryan Gil, Brandon J Webb,

PURPOSE OF REVIEW:Although most patients with community-acquired pneumonia (CAP) are appropriately treated with narrow-spectrum antibiotics, predicting which patients require coverage of drug-resistant pathogens (DRP) remains a challenge. The 2019 American Thoracic Society/Infectious Diseases Society of America CAP guidelines endorse using locally validated prediction models for DRP. Here we review risk ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):249-259]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Advances in molecular diagnostic tests for pneumonia.

Catia Cilloniz, Adamanthia Liapikou, Antoni Torres,

PURPOSE OF REVIEW:Pneumonia is the main global cause of sepsis, and has been associated with high morbidity and high short and long-term mortality rates. As it may be caused by a wide spectrum of microorganisms, microbial diagnosis is challenging and the choice of adequate therapy remains an important problem. This ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):241-248]

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Viral respiratory infections: a cause of community-acquired pneumonia or a predisposing factor?

Forest W Arnold, Joshua L Fuqua,

PURPOSE OF REVIEW:A cause for community-acquired pneumonia (CAP) is only identified in ∼50% of cases. Nasopharyngeal PCR panels contain more viruses than previously. The problem then becomes determining the relevance of the organisms identified rather than figuring out which virus is present. This review addresses how to distinguish between viral ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):208-214]

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Automated Respiratory Rate Counter to Assess Children for Symptoms of Pneumonia: Protocol for Cross-Sectional Usability and Acceptability Studies in Ethiopia and Nepal.

Kevin Baker, Alice Maurel, Charlotte Ward, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlström, Max Petzold, Karin Källander,

BACKGROUND:Manually counting a child's respiratory rate (RR) for 60 seconds using an acute respiratory infection timer is the World Health Organization (WHO) recommended method for detecting fast breathing as a sign of pneumonia. However, counting the RR is challenging and misclassification of an observed rate is common, often leading to ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e14405]

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The benefits of non-invasive ventilation for Community-Acquired Pneumonia: A meta-analysis.

Giovana Klefti, Adam T Hill,

BACKGROUND:There is an observed international increase in NIV application as an alternative to endotracheal intubation in non-COPD patients admitted with community acquired pneumonia despite the lack of strong evidence for its use. The aim of this study is the meta-analysis of data from randomised-controlled trials on the effectiveness of non-invasive ... Read more >>

QJM (QJM : monthly journal of the Association of Physicians)
[2020, :]

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Pneumococcal virulence factors in community-acquired pneumonia.

Charles Feldman, Ronald Anderson,

PURPOSE OF REVIEW:This manuscript reviews the recent literature related to new developments in the understanding of existing and novel virulence factors of the pneumococcus that are of potential importance in the development of novel preventive and therapeutic strategies. RECENT FINDINGS:The pneumococcal capsule and pneumolysin have long been recognized as being ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):222-231]

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Community-acquired pneumonia in chronic obstructive pulmonary disease.

Rodrigo Cavallazzi, Julio Ramirez,

PURPOSE OF REVIEW:The aim of this study was to discuss the literature on community-acquired pneumonia (CAP) in patients with chronic obstructive pulmonary disease (COPD). RECENT FINDINGS:Well designed studies show that COPD is the strongest risk factor for development of CAP. Lung microbiome, abnormal lung immunity and pathogen virulence are important ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):173-181]

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Socioeconomic Position and the Incidence, Severity, and Clinical Outcomes of Hospitalized Patients With Community-Acquired Pneumonia.

Timothy L Wiemken, Ruth M Carrico, Stephen P Furmanek, Brian E Guinn, William A Mattingly, Paula Peyrani, Julio A Ramirez,

OBJECTIVES:The influence of socioeconomic disparities on adults with pneumonia is not well understood. The objective of our study was to evaluate the relationship between community-level socioeconomic position, as measured by an area deprivation index, and the incidence, severity, and outcomes among adults with community-acquired pneumonia (CAP). METHODS:This was an ancillary ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2020, :33354920912717]

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Lefamulin: A Novel Semisynthetic Pleuromutilin Antibiotic for Community-Acquired Bacterial Pneumonia.

Richard R Watkins, Thomas M File,

Community-acquired bacterial pneumonia (CABP) remains a significant cause of morbidity and mortality worldwide. Antimicrobial resistance, including in pathogens that cause CABP, continues to spread at an alarming rate. Because of these factors, the development of new antibiotic classes is urgently needed. Lefamulin, previously known as BC-3781, is a semisynthetic pleuromutilin ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Psychotropic Drug-Associated Pneumonia in Older Adults.

Blair Rajamaki, Sirpa Hartikainen, Anna-Maija Tolppanen,

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19-29% among community dwelling older adults. These drugs are often prescribed for off-label use, including neuropsychiatric symptoms. The older adult population also has high rates of pneumonia and some of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):241-261]

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[Antibiotic Stewardship in Community-Acquired Pneumonia].

Fabian Leo, Miriam Songa Stegemann, Florian Maurer,

Antibiotic stewardship (ABS) denotes structured and continuous measures to improve the quality of prescribing anti-infectives. The aim is to achieve optimal treatment results and to minimize undesirable effects, especially the emergence of antibiotic resistance. This review summarizes the most important ABS principles based on recently published studies with implications for ... Read more >>

Dtsch. Med. Wochenschr. (Deutsche medizinische Wochenschrift (1946))
[2020, 145(6):383-392]

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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

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Clinical factors influencing the performance of bacterial multiplex polymerase chain reaction in patients with community-onset pneumonia.

Ga Eun Park, Kyong Ran Peck, Jae-Hoon Ko, Cheol-In Kang, Sun Young Cho, Doo Ryeon Chung, Nam Yong Lee,

The etiologic diagnostic yield of community-onset pneumonia (COP) using conventional methods is low. Bacterial multiplex polymerase chain reaction (mPCR) has been shown to be more sensitive than conventional methods. This study assessed the clinical factors influencing bacterial mPCR results in patients with COP. Patients with COP admitted to a tertiary ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, :]

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Central Nervous System Depressants and Risk of Hospitalization due to Community Acquired Pneumonia in the Very Old.

Jeronimo Espinosa, Paulino Alvarez, Veronica Castro, Maria Caceres, Maria Soler-Riera, Fernando Bril,

BACKGROUND:Central nervous system (CNS) depressants like antipsychotics, opioids, benzodiazepines and zolpidem are frequently used by patients within a wide range of ages. Uncertainty remains about their effect in very old adults (>80 years old) and their potential for pharmacodynamic and pharmacokinetic drug-drug interactions in this population. OBJECTIVE:Assess if the use ... Read more >>

Curr Drug Saf (Current drug safety)
[2020, :]

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Admission to hospital in the UK at a weekend does not influence the prognosis of adults with community-acquired pneumonia.

Hannah Lawrence, Tricia M McKeever, Wei Shen Lim, ,

Outcomes for adults with community-acquired pneumonia (CAP) admitted to hospital at the weekend were compared with those admitted during weekdays using data from the British Thoracic Society national CAP audits. Of 31 400 cases, 40.7% were weekend admissions; these patients were older (mean age 72 vs 71.3 years, p=0.001) and more ... Read more >>

Thorax (Thorax)
[2020, :]

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Reasons and Risk Factors for Readmission Following Hospitalization for Community-acquired Pneumonia in South Korea.

Jong Geol Jang, June Hong Ahn,

BACKGROUND:Limited studies have been performed to assess readmission following hospitalization for community-acquired pneumonia (CAP) in an Asian population. We evaluated the rates, reasons, and risk factors for 30-day readmission following hospitalization for CAP in the general adult population of Korea. METHODS:We performed a retrospective observational study of 1,021 patients with ... Read more >>

Tuberc Respir Dis (Seoul) (Tuberculosis and respiratory diseases)
[2020, 83(2):147-156]

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[Community-acquired pneumonia in adults].

Agata Mikolajewska, Martin Witzenrath,

Community-acquired pneumonia (CAP) is one of the most common infectious diseases worldwide. To reduce the high morbidity and mortality of CAP, appropriate diagnosis, risk stratification and therapy are necessary. This review summarizes the current recommendations for the management of CAP in Germany. CAP is often a medical emergency. The management ... Read more >>

Dtsch. Med. Wochenschr. (Deutsche medizinische Wochenschrift (1946))
[2020, 145(6):359-370]

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The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia

Jesús Reiné, Jamie Rylance, Daniela Ferreira, Shaun Pennington, Ingeborg Welters, Robert Parker, Ben Morton,

<title>Abstract</title> <p> OBJECTIVE: To refine and validate a neutrophil function assay with clinical relevance for patients with community-acquired pneumonia (CAP). Design: Two phase cross-sectional study to standardise and refine the assay in blood from healthy volunteers and test neutrophil phagocytic function in hospital patients with CAP. Participants : ... Read more >>

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HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?

mathieu nacher, Antoine Adenis, Philippe Abboud, Felix Djossou, Magalie Demar, Loïc Epelboin, Pierre Couppié,

<title>Abstract</title> <p> Objective Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana’s HIV cohort taking into account the immunological status, the main opportunistic ... Read more >>

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Discovery and Predictive Modeling of Urine Microbiome, Metabolite and Cytokine Biomarkers in Hospitalized Patients with Community Acquired Pneumonia

Joseph Pierre, Oguz Akbilgic, Heather Smallwood, Xueyuan Cao, Elizabeth Fitzpatrick, Senen Pena, Stephen Furmanek, Julio Ramirez, Colleen Jonsson,

Abstract Pneumonia is the leading cause of infectious related death costing 12 billion dollars annually in the United States alone. Despite improvements in clinical care, total mortality remains around 4%, with inpatient mortality reaching 5-10%. For unknown reasons, mortality risk remains high even after hospital discharge and there is a ... Read more >>

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

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Assessment of Bronchiectasis in HIV Patients among an Urban Population.

Veena Dronamraju, Navneet Singh, Justin Poon, Sachi Shah, Joseph Gorga, Hector Ojeda-Martinez, Samy McFarlane,

Bronchiectasis is characterized by permanent destruction of the airways that presents with productive cough, as well as bronchial wall thickening and luminal dilatation on computed tomographic (CT) scan of the chest; it is associated with high mortality. Accumulating data suggests higher rates of bronchiectasis among the HIV-positive population. This case ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:8903809]

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