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Abnormal brain activity in adolescents with Internet addiction who attempt suicide: an assessment using functional magnetic resonance imaging.

Yan Huang, Lu Xu, Li Kuang, Wo Wang, Jun Cao, Mu-Ni Xiao,

Internet addiction is associated with an increased risk of suicidal behavior and can lead to brain dysfunction among adolescents. However, whether brain dysfunction occurs in adolescents with Internet addiction who attempt suicide remains unknown. This observational cross-sectional study enrolled 41 young Internet addicts, aged from 15 to 20 years, from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1554-1559]

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[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].

Sarah Kittel-Schneider, Andreas Reif,

All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety and in particular affective disorders. In these investigations the risk for one of these comorbid disorders increased with increasing age of the ADHD patients. The most recent genome-wide association and ... Read more >>

Nervenarzt (Der Nervenarzt)
[2020, :]

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Association between cigarette use and adolescents' behavior.

Jamile Francelino Cruz, Jonathan Lopes de Lisboa, Patricia Maria Pereira de Araújo Zarzar, Carolina da Franca Bandeira Ferreira Santos, Paula Andréa de Melo Valença, Valdenice Aparecida de Menezes, Viviane Colares,

OBJECTIVE:To determine the prevalence of cigarette use among adolescents and to identify associated health risk behaviors. METHODS:This is a cross-sectional study with a representative sample, composed of 1059 adolescents between 13 and 19 years old, enrolled in primary and secondary public schools of Olinda, Pernambuco, in 2014. Information was obtained ... Read more >>

Rev Saude Publica (Revista de saude publica)
[2020, 54:31]

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Psychiatric comorbidity in compulsive sexual behavior disorder (CSBD).

R Ballester-Arnal, J Castro-Calvo, C Giménez-García, B Gil-Juliá, M D Gil-Llario,

Compulsive Sexual Behavior Disorder (CSBD) is characterized by a persistent failure to control intense and recurrent sexual impulses, urges, and/or thoughts, resulting in repetitive sexual behavior that causes a marked impairment in important areas of functioning. Data collected from clinical populations suggest that CSBD frequently co-occurs with other Axis I ... Read more >>

Addict Behav (Addictive behaviors)
[2020, 107:106384]

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DDC expression is not regulated by NFAT5 (TonEBP) in dopaminergic neural cell lines.

Laura Pineda-Cirera, Judit Cabana-Domínguez, Noelia Benetó, Hector Diez, Concepció Arenas, Bru Cormand, Noèlia Fernàndez-Castillo,

The nuclear factor of activated T-cells 5 (NFAT5), also known as tonicity-responsive enhancer-binding protein (TonEBP), is a transcription factor that regulates osmoadaptive response in multiple tissues and is highly expressed in the developing central nervous system. A former study reported that NFAT5 activation through hypertonic stress increases the expression of ... Read more >>

Gene (Gene)
[2020, 742:144569]

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Editorial: The Role of Immediate Early Genes in Neuropsychiatric Illness.

Amelia L Gallitano,

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2020, 14:16]

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Metabolomics in Psychiatric Disorders: What We Learn from Animal Models.

Elke Humer, Thomas Probst, Christoph Pieh,

Biomarkers are a recent research target within biological factors of psychiatric disorders. There is growing evidence for deriving biomarkers within psychiatric disorders in serum or urine samples in humans, however, few studies have investigated this differentiation in brain or cerebral fluid samples in psychiatric disorders. As brain samples from humans ... Read more >>

Metabolites (Metabolites)
[2020, 10(2):]

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The Promise of Neuroimmune Targets for Treating Drug Addiction and Other Psychiatric Disorders: Granulocyte-Colony Stimulating Factor Exemplification.

Mehdi Farokhnia, Anthony L. Berger, Hollis C. Karoly, Lara S. Hwa, Florence P. Varodayan,

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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Association of Alcohol Screening Scores With Adverse Mental Health Conditions and Substance Use Among US Adults.

Maria R Khan, Kailyn E Young, Ellen C Caniglia, David A Fiellin, Stephen A Maisto, Brandon D L Marshall, E Jennifer Edelman, Julie R Gaither, Natalie E Chichetto, Janet Tate, Kendall J Bryant, MacRegga Severe, Elizabeth R Stevens, Amy Justice, Scott R Braithwaite,

Importance:Alcohol screening may be associated with health outcomes that cluster with alcohol use (ie, alcohol-clustering conditions), including depression, anxiety, and use of tobacco, marijuana, and illicit drugs. Objective:To quantify the extent to which alcohol screening provides additional information regarding alcohol-clustering conditions and to compare 2 alcohol use screening tools commonly ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e200895]

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Once-Monthly Long-Acting Injectable Aripiprazole for the Treatment of Patients with Schizophrenia and Co-occurring Substance Use Disorders: A Multicentre, Observational Study.

Nestor Szerman, Ignacio Basurte-Villamor, Pablo Vega, Jose Martinez-Raga, Carlos Parro-Torres, Julia Cambra Almerge, Lara Grau-López, Mario De Matteis, Francisco Arias,

AIM:To evaluate the efficacy and impact of long-acting injectable (LAI) aripiprazole in patients with schizophrenia with a coexisting substance use disorder (SUD). PATIENTS AND METHODS:A multicenter, observational, descriptive and retrospective study was conducted in patients with a DSM-5 diagnosis of schizophrenia who had a coexisting SUD and were treated with ... Read more >>

Drugs Real World Outcomes (Drugs - real world outcomes)
[2020, 7(1):75-83]

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Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic Inflammation.

Heather E Soder, Amber M Berumen, Kira E Gomez, Charles E Green, Robert Suchting, Margaret C Wardle, Jessica Vincent, Antonio L Teixeira, Joy M Schmitz, Scott D Lane,

Objective:The neutrophil to lymphocyte ratio (NLR) is a non-specific, easy-to-obtain marker of inflammation associated with morbidity and mortality in systemic, psychiatric, and age-related inflammatory conditions. Given the growing trend of substance use disorder (SUD) in older adults, and the relationship between inflammation and SUD elevated NLR may serve as a ... Read more >>

Clin Psychopharmacol Neurosci (Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology)
[2020, 18(1):32-40]

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Transcranial direct current stimulation (tDCS) as an intervention to improve empathic abilities and reduce violent behavior in forensic offenders: study protocol for a randomized controlled trial.

Carmen S Sergiou, Adam J Woods, Ingmar H A Franken, Josanne D M van Dongen,

BACKGROUND:Recent studies show that changes in one of the brain areas related to empathic abilities (i.e. the ventromedial prefrontal cortex (vmPFC)) plays an important role in violent behavior in abusers of alcohol and cocaine. According to the models of James Blair, empathy is a potential inhibitor of violent behavior. Individuals ... Read more >>

Trials (Trials)
[2020, 21(1):263]

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Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction.

April C. May, Robin L. Aupperle, Jennifer L. Stewart,

Methamphetamine use is associated with substantial adverse outcomes including poor mental and physical health, financial difficulties, and societal costs. Despite deleterious long-term consequences associated with methamphetamine, many people use drugs for short-term reduction of unpleasant physical or emotional sensations. By removing these aversive states, drug use behaviors are negatively reinforced. ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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Problem Gambling in the Fitness World-A General Population Web Survey.

Anders Håkansson, Artin Entezarjou, Göran Kenttä, Fernando Fernández-Aranda, Susana Jiménez-Murcia, Björn Gunnarsson,

The world of sports has a complex association to problem gambling, and the sparse research examining problem gambling in athletes has suggested an increased prevalence and particularly high male predominance. The present study aimed to study frequency and correlates of problem gambling in populations with moderate to high involvement in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(4):]

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Impact of Removing Nonprescription Codeine in Australia: Protocol for a Prospective Cohort Study.

Jacqui McCoy, Suzanne Nielsen, Raimondo Bruno,

BACKGROUND:On February 1, 2018, Australia rescheduled codeine to a prescription-only medication. Many concerns were associated with this change, including increased financial costs, reduced service accessibility, the potential for poorer pain management, and a decline in physical and mental health if codeine could not be accessed. In the research literature, there ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e15540]

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Effectiveness of the First German-Language Group Psychotherapy Manual to Accompany Short-Term Treatment in Methamphetamine Dependence.

Johannes Petzold, Benjamin Weber, Tyler Ray Bassett, Michael Bauer, Nadine Bernhardt, Cornelius Groß, Helena Hasler, Matthias Schützwohl, Maximilian Pilhatsch,

Background: Methamphetamine abuse is expanding in Europe, leading to a shortfall in medical care for related disorders in many regions. Research focusing on the effectiveness and feasibility of methamphetamine-specific treatment programs is scarce, especially in short-term settings. Methods: To this end, we treated 31 patients with methamphetamine dependence using a ... Read more >>

Front Psychiatry (Frontiers in Psychiatry)
[2020, 11:130]

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Reward Circuitry and Motivational Deficits in Social Anxiety Disorder: What Can Be Learned From Mouse Models?

Corinne N Carlton, Holly Sullivan-Toole, Merage Ghane, John A Richey,

Social anxiety disorder (SAD) is a common and serious psychiatric condition that typically emerges during adolescence and persists into adulthood if left untreated. Prevailing interventions focus on modulating threat and arousal systems but produce only modest rates of remission. This gap in efficacy suggests that most mainstream treatment concepts do ... Read more >>

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:154]

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Focus on Clozapine Withdrawal- and Misuse-Related Cases as Reported to the European Medicines Agency (EMA) Pharmacovigilance Database.

Stefania Chiappini, Fabrizio Schifano, John Martin Corkery, Amira Guirguis,

BACKGROUND:Clozapine is of high clinical relevance for the management of both treatment-resistant schizophrenia and psychotic disturbances with concurrent drug misuse. Although the molecule presents with a range of well-known side-effects, its discontinuation/withdrawal syndrome has been only anecdotally described. AIMS:the 2005-2018 European Medicines Agency (EMA) dataset of Adverse Drug Reactions (ADRs) ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(2):]

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The Prevalence and Burden of Non-AIDS Comorbidities among Women living with or at-risk for HIV Infection in the United States.

Lauren F Collins, Anandi N Sheth, C Christina Mehta, Susanna Naggie, Elizabeth T Golub, Kathryn Anastos, Audrey L French, Seble Kassaye, Tonya Taylor, Margaret A Fischl, Adaora A Adimora, Mirjam-Colette Kempf, Frank J Palella, Phyllis C Tien, Ighovwerha Ofotokun,

INTRODUCTION:The prevalence and burden of age-related non-AIDS comorbidities (NACM) is poorly characterized among women living with HIV (WLWH). METHODS:Virologically-suppressed WLWH and HIV-seronegative participants followed in the Women's Interagency HIV Study (WIHS) through ≥2009 (when >80% WLWH used antiretroviral therapy) were included, with outcomes measured through 3/31/2018. Covariates, NACM number and ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Neural substrates of smoking and reward cue reactivity in smokers: a meta-analysis of fMRI studies.

Xiao Lin, Jiahui Deng, Le Shi, Qiandong Wang, Peng Li, Hui Li, Jiajia Liu, Jianyu Que, Suhua Chang, Yanping Bao, Jie Shi, Daniel R Weinberger, Ping Wu, Lin Lu,

Smoking is partly attributed to alterations of reward processing. However, findings on the neurobiological mechanisms that underlie smoking-related and smoking-unrelated reward processing in smokers have been inconsistent. Neuroimaging experiments that used functional magnetic resonance imaging (fMRI) and reported brain responses to smoking-related cues and nonsmoking reward-related cues in smokers and ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):97]

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Precision Psychiatry Applications with Pharmacogenomics: Artificial Intelligence and Machine Learning Approaches.

Eugene Lin, Chieh-Hsin Lin, Hsien-Yuan Lane,

A growing body of evidence now suggests that precision psychiatry, an interdisciplinary field of psychiatry, precision medicine, and pharmacogenomics, serves as an indispensable foundation of medical practices by offering the accurate medication with the accurate dose at the accurate time to patients with psychiatric disorders. In light of the latest ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Essential fatty acids and Barratt impulsivity in gambling disorder.

Patricia Sanchez-Paez, Josefa Perez-Templado, Jeronimo Saiz-Ruiz, Oscar Pastor, Angela Ibañez,

BACKGROUND:Polyunsaturated fatty acids (PUFA) have been long implicated in the etiopathogenesis of mental illnesses, including disorders characterized by high impulsivity. The objective of most of the studies in this field is to determine the effect of omega-3 supplementation on the impulsive symptoms. In contrast, studies analyzing basal PUFA composition in ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):109]

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Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity.

Adellah Sariah, Shuixia Guo, Jing Zuo, Weidan Pu, Haihong Liu, Edmund T. Rolls, Zhimin Xue, Zhening Liu, Xiaojun Huang,

BackgroundThe active alkaloid in Betel quid is arecoline. Consumption of betel quid is associated with both acute effects and longer-term addictive effects. Despite growing evidence that betel quid use is linked with altered brain function and connectivity, the neurobiology of this psychoactive substance in initial acute chewing, and long-term dependence, ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

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Cannabis Use Disorder Among First-Year Undergraduate Students in Gaborone, Botswana.

Anthony A Olashore, Philip R Opondo, John A Ogunjumo, James O Ayugi,

Cannabis use disorder (CUD) poses major clinical and public health concerns globally. It is a growing problem among the youth in Botswana, yet little research has been done on this subject. The present study hoped to address this gap in knowledge by determining the prevalence and associated factors of CUD ... Read more >>

Subst Abuse (Substance abuse : research and treatment)
[2020, 14:1178221820904136]

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Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Francky Teddy Endomba, Aurel T Tankeu, Jan René Nkeck, Joel Noutakdie Tochie,

Antipsychotic-induced weight gain is the most prevalent somatic adverse event occurring in patients treated by antipsychotics, especially atypical antipsychotics. It is of particular interest because of its repercussion on cardiovascular morbidity and mortality especially now that the use of second-generation antipsychotics has been extended to other mental health illnesses such ... Read more >>

Lipids Health Dis (Lipids in health and disease)
[2020, 19(1):22]

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