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Cluster Headache

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Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?

Jonathan Wong So, Bérenger Largeau, Frédérique Beau-Salinas, Stephan Ehrmann, Christophe Magni, Jérôme Meunier,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1166-1168]

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Evolving options for the treatment of cluster headache.

Maria Dolores Villar-Martinez, Calvin Chan, Peter J Goadsby,

PURPOSE OF REVIEW:Cluster headache is a neurological disorder that patients consider the most severe pain they experience. Recognizing new treatments provides opportunities to advance current management. RECENT FINDINGS:In contrast to the classic treatments, new options narrow in on the therapeutic target and are better tolerated. Calcitonin gene-related peptide (CGRP) pathway ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, :]

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Direct and indirect costs of cluster headache: a prospective analysis in a tertiary level headache centre

Andrea Negro, Paolo Sciattella, Valerio Spuntarelli, Paolo Martelletti, Francesco Mennini,

<title>Abstract</title> <p> <bold>Background:</bold> Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (ECH) or chronic cluster headache (CCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment. The few data available on the economic burden of CH come from retrospective ... Read more >>

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Sphenopalatine Ganglion Pulsed Radiofrequency for the Treatment of Refractory Chronic SUNCT and SUNA: A Prospective Case Series.

Raffaele Ornello, Stefano Palmisani, Madeleine Murphy, Simona Sacco, Adnan Al-Kaisy, Giorgio Lambru,

OBJECTIVES:We aimed to evaluate the safety and effectiveness of sphenopalatine ganglion pulsed radiofrequency (SPG-PRF) for the treatment of patients with refractory chronic short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and with cranial autonomic symptoms (SUNA). BACKGROUND:SPG-PRF is a minimally invasive, non-neurodestructive procedure already tested in refractory ... Read more >>

Headache (Headache)
[2020, :]

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A cluster headache attack with ipsilateral temporomandibular joint pain: a case report.

Tommy Lik Hang Chan, David Dongkyung Kim, Werner J Becker,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, :1-6]

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Cervical Noninvasive Vagus Nerve Stimulation for Migraine and Cluster Headache: A Systematic Review and Meta-Analysis.

Yin-Hsuan Lai, Yu-Chen Huang, Liang-Ti Huang, Ruei-Ming Chen, Chiehfeng Chen,

BACKGROUND:Noninvasive vagus nerve stimulation (nVNS) has been proposed as a new neuromodulation therapy to treat primary headache disorders. The purpose of this study was to analyze the effectiveness and safety of peripheral nerve stimulation of the cervical branch of the vagal nerve for primary headache disorders. METHODS:A systematic review and ... Read more >>

Neuromodulation (Neuromodulation : journal of the International Neuromodulation Society)
[2020, :]

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Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Rare, Reversible Complication of Radiation Therapy.

Gabriel S Makar, Todd Siegal, Larisa Syrow,

Headache (Headache)
[2020, :]

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A Study of Clinical Features and Risk Factors of Self-Referring Emergency Department Headache Patients: A Comparison with Headache Center Outpatients.

Alessandro Viganò, Ersilia Savastano, Barbara Petolicchio, Massimiliano Toscano, Rita De Sanctis, Ilaria Maestrini, Vittorio Di Piero,

BACKGROUND:Nonlife-threatening headaches account for 3% of emergency department (ED) admissions, with social and economic negative consequences. We aim to investigate clinical features and risk factors of nonlife-threatening headache patients referring to ED versus those referring to headache outpatient clinics. METHODS:During 6 months, we promptly reevaluated in our headache unit (HU) ... Read more >>

Eur. Neurol. (European neurology)
[2020, :1-7]

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Cotard's Parasomnia: Le Délire de Negation that occur during the Sleep-Wake Dissociation?

Valentina Gnoni, Sean Higgins, Alexander David Nesbitt, Danielle Wasserman, Iain Duncan, Adam Birdseye, Laura Pérez-Carbonell, Panagis Drakatos, Michaelis Koutramanidis, Luigi Ferini-Strambi, Guy Doron Leschziner, Ivana Rosenzweig,

None:Unpleasant dreamlike mentation can occur during NREM parasomnias, leading to associated panic attacks. The mentations are rarely remembered, and are likely underreported. However, they may lead to significant personal distress, and if not addressed, may contribute to poorer clinical outcomes. Cotard's 'Le Délire de Negation', are very rare nihilistic delusions, ... Read more >>

J Clin Sleep Med (Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine)
[2020, :]

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Cotard's Parasomnia: Le Délire de Negation that occur during the Sleep-Wake Dissociation?

Valentina Gnoni, Sean Higgins, Alexander David Nesbitt, Danielle Wasserman, Iain Duncan, Adam Birdseye, Laura Pérez-Carbonell, Panagis Drakatos, Michaelis Koutramanidis, Luigi Ferini-Strambi, Guy Doron Leschziner, Ivana Rosenzweig,

None:Unpleasant dreamlike mentation can occur during NREM parasomnias, leading to associated panic attacks. The mentations are rarely remembered, and are likely underreported. However, they may lead to significant personal distress, and if not addressed, may contribute to poorer clinical outcomes. Cotard's 'Le Délire de Negation', are very rare nihilistic delusions, ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Dynamic Pressure Pain Hypersensitivity as Assessed by Roller Pressure Algometry in Episodic Cluster Headache.

Maria Palacios-Cena, Victor Gomez-Mayordomo, David Garcia-Azorin, Nuria Gonzalez-Garcia, Maria L Cuadrado, Cesar Fernandez-de-Las-Penas, Lars Arendt-Nielsen, Angel L Guerrero,

BACKGROUND:A method for assessing dynamic muscle hyperalgesia (dynamic pressure algometry) has been developed and applied in tension-type and migraine headaches. OBJECTIVES:To investigate differences in dynamic pressure pain assessment over the trigeminal area between men with cluster headache (CH) and headache-free controls, and the association between dynamic and static pressure pain ... Read more >>

Pain Physician (Pain physician)
[2020, 23(2):219-227]

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Disability, Quality of Life, and Socioeconomic Burden of Cluster Headache: A Critical Review of Current Evidence and Future Perspectives.

Domenico D'Amico, Alberto Raggi, Licia Grazzi, Giorgio Lambru,

OBJECTIVE:To summarize the available evidence on disability, quality of life (QoL), and economic burden on societies of cluster headache (CH), and to present which tools have been used to measure these domains with indications for future research. BACKGROUND:CH is a rare and severe primary headache. The focus of research on ... Read more >>

Headache (Headache)
[2020, 60(4):809-818]

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PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Jan Hoffmann, Silke Miller, Margarida Martins-Oliveira, Simon Akerman, Weera Supronsinchai, Hong Sun, Licheng Shi, Judy Wang, Dawn Zhu, Sonya Lehto, Hantao Liu, Ruoyuan Yin, Bryan D Moyer, Cen Xu, Peter J Goadsby,

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclinical evidence suggests that PACAP38 modulates trigeminal nociceptive activity mainly through PAC1 receptors while clinical studies report that plasma concentrations of PACAP38 are elevated in spontaneous attacks of cluster headache and migraine and normalize after treatment ... Read more >>

Pain (Pain)
[2020, :]

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[Pathophysiological role of calcitonin gene-related peptide (CGRP) in migraine and cluster headache].

Karl Meßlinger,

Calcitonin gene-related peptide (CGRP) is released from trigeminal afferents during migraine and cluster headache attacks and can be detected in the jugular plasma. Infusion of CGRP can induce headache attacks in migraine and cluster patients. Inhibition of the CGRP signal system is therapeutic in migraine and cluster headache. CGRP is ... Read more >>

Schmerz (Schmerz (Berlin, Germany))
[2020, :]

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SMART (Stroke-Like Migraine Attacks After Radiation Therapy) Syndrome: A Case Study with Imaging Supporting the Theory of Vascular Dysfunction.

Rakesh Danny Biju, Ashraf Dower, Benjamin G Moon, Peter Gan,

BACKGROUND SMART (Stroke-like Migraine Attacks after Radiation Therapy) syndrome is an uncommon delayed complication of cerebral radiotherapy. Less than 50 cases have been reported in the literature since it was first described in 1995. On average, presentation is about 20 years after radiotherapy, and patients commonly present with headaches, complex ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e921795]

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A Markov chain method for counting and modelling migraine attacks.

Mathias Barra, Fredrik A Dahl, Kjersti Grøtta Vetvik, E Anne MacGregor,

To ensure reproducibility in research quantifying episodic migraine attacks, and identifying attack onset, a sound theoretical model of a migraine attack, paired with a uniform standard for counting them, is necessary. Many studies report on migraine frequencies-e.g. the fraction of migraine-days of the observed days-without paying attention to the number ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3631]

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Brain Awareness Week, CoVID-19 infection and Neurological Sciences.

Antonio Federico,

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Reversible Cerebral Vasoconstriction Syndrome Triggered by Typhoon Hagibis in 2019: Report of 2 Cases.

Yuji Kato, Shugo Fujita, Takashi Osada, Shinichi Takahashi, Masaki Takao,

Although reversible cerebral vasoconstriction syndrome (RCVS) is a relatively rare condition, we encountered 2 consecutive patients with RCVS during Typhoon Hagibis in 2019. The first patient developed headache when the atmospheric pressure rapidly fell, and the second patient developed headache when the atmospheric pressure rapidly rose. Extreme atmospheric pressure fluctuations ... Read more >>

Headache (Headache)
[2020, 60(4):781-786]

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Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study.

Yohannes W Woldeamanuel, Bharati M Sanjanwala, Addie M Peretz, Robert P Cowan,

Heterogeneity in chronic migraine (CM) presents significant challenge for diagnosis, management, and clinical trials. To explore naturally occurring clusters of CM, we utilized data reduction methods on migraine-related clinical dataset. Hierarchical agglomerative clustering and principal component analyses (PCA) were conducted to identify natural clusters in 100 CM patients using 14 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2804]

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A prospective case series of sphenopalatine ganglion pulsed radiofrequency therapy for refractory chronic cluster headache.

Zachary T Lazzari, Stefano Palmisani, Bethany Hill, Adnan Al-Kaisy, Giorgio Lambru,

BACKGROUND:The management options for chronic cluster headache (CCH) are limited and a significant proportion of patients become refractory to pharmacological treatments. Pulsed radiofrequency (PRF) of the sphenopalatine ganglion (SPG) may present an efficacious, minimally invasive treatment modality for refractory patients with CCH. We describe the clinical outcomes of 14 patients ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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Idiopathic Intracranial Hypertension: The Monster Within.

Aastha Takkar, Vivek Lal,

Idiopathic intracranial hypertension (IIH) is defined as a syndrome of raised intracranial pressure with normal imaging of the brain and cerebrospinal fluid (CSF) composition. There are many controversies and myths that surround IIH. Although patients of IIH may present "typical" symptoms and signs of raised intracranial pressure, clinical scenarios often ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):159-166]

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Prevalence of Familial Cluster Headache: A Systematic Review and Meta-Analysis

Emer OConnor, Simpson, Houlden, Vandrovcova, Manjit Matharu,

<title>Abstract</title> <p> Introduction: The population rate of familial cluster headache (CH) has been reported to be as high as 20%, however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data. Methods: ... Read more >>

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Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials.

Yanbo Yang, Zilan Wang, Bixi Gao, He Xuan, Yun Zhu, Zhouqing Chen, Zhong Wang,

BACKGROUND:Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomized clinical trials (RCTs) and have been found to reduce headache frequency. METHODS:We systematically searched PubMed and Embase on Cochrane Central ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):14]

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Tolosa-Hunt Syndrome: Long-Term Outcome and Role of Steroid-Sparing Agents.

Anupriya Arthur, Ajith Sivadasan, Pavitra Mannam, A T Prabakhar, Sanjith Aaron, Vivek Mathew, M Karthik, Rohith Ninan Benjamin, Shaikh Atif Iqbalahmed, Gideon Lyngsyun Rynjah, Mathew Alexander,

Background:Tolosa-Hunt Syndrome (THS) is one of the causes of cavernous sinus syndrome causing painful ophthalmoplegia. Literature on long-term outcome of this rare condition is scarce. Aims and Objectives:The aim is to study the recurrence and role of steroid-sparing agents in THS. Methodology:All cases of THS treated at a tertiary-level teaching ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):201-205]

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Clinical factors influencing the impact of cluster headache from a prospective multicenter study.

Jong-Hee Sohn, Jeong-Wook Park, Mi Ji Lee, Pil-Wook Chung, Min Kyung Chu, Jae Myun Chung, Jin-Young Ahn, Byung-Su Kim, Soo-Kyoung Kim, Yun-Ju Choi, Daeyoung Kim, Tae-Jin Song, Kyungmi Oh, Heui-Soo Moon, Kwang-Yeol Park, Byung-Kun Kim, Dae-Woong Bae, Chin-Sang Chung, Soo-Jin Cho,

Although many patients with cluster headaches (CH) are disabled by their condition, few studies have examined this in detail. This cross-sectional, multicenter observational study prospectively collected demographic and clinical questionnaire data from 224 consecutive patients with CH. We assessed headache impact using the six-item Headache Impact Test (HIT-6) and evaluated ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2428]

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