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Clofarabine

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Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.

Handan Sevim, Haydar Çelik, Levent Düşünceli, Ceyda S Ceyhan, Anna Molotkova, Kay Nakazawa, Garrett T Graham, Jeffrey R Petro, Jeffrey A Toretsky, Aykut Üren,

Clofarabine, an FDA approved purine analog, is used in the treatment of relapsed or refractory acute lymphoblastic leukemia. Clofarabine acts by inhibiting DNA synthesis. We demonstrated that clofarabine may have a novel function though inhibiting CD99, a transmembrane protein highly expressed on Ewing Sarcoma (ES) cells. CD99 is a validated ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0253170]

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Erratum to "Toxicity associated with intensive postinduction therapy incorporating clofarabine in the very high-risk stratum of patients with newly diagnosed high-risk B-lymphoblastic leukemia: A report from the Children's Oncology Group study AALL1131".

Cancer (Cancer)
[2021, :]

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Successful combination chemotherapy involving clofarabine, cyclophosphamide, and etoposide for pediatric relapsed acute myeloid leukemia: A case report.

Sachio Fujita, Ryosuke Matsuno, Naoko Kawabata, Yumiko Sugishita, Ryota Kaneko, Masaya Koganesawa, Kosuke Akiyama, Daisuke Toyama, Shohei Yamamoto,

Limited salvage chemotherapies are available for relapsed/refractory acute myeloid leukemia. Herein, we described successful reinduction chemotherapy, involving a combination of clofarabine, cyclophosphamide, and etoposide, in a 12-year-old male with relapsed acute myeloid leukemia prior to allogeneic bone marrow transplantation from his father. Although treatment with a combination of fludarabine, cytarabine, ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2021, 9:2050313X211015511]

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Bilateral retinal involvement in juvenile xanthogranuloma-Successful treatment with clofarabine.

Maria Mifsud, Susan Picton, John Ainsworth,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29222]

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Long-term results of low-intensity chemotherapy with clofarabine or cladribine combined with low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia.

Tapan M Kadia, Farhad Ravandi, Gautam Borthakur, Marina Konopleva, Courtney D DiNardo, Naval Daver, Naveen Pemmaraju, Rashmi Kanagal-Shamanna, Xuemei Wang, Xuelin Huang, Sherry Pierce, Caitlin Rausch, Jan Burger, Alessandra Ferrajoli, Nitin Jain, Uday Popat, Zeev Estrov, Srdan Verstovsek, Elias Jabbour, Guillermo Garcia-Manero, Hagop Kantarjian,

The treatment of older patients with newly diagnosed acute myeloid leukemia (AML) using intensive chemotherapy is associated with treatment intolerance and poor survival. We evaluated two new lower-intensity regimens with clofarabine (n = 119) or cladribine (n = 129) combined with low-dose cytarabine (LDAC) alternating with decitabine. We reviewed response rates by subgroup and ... Read more >>

Am J Hematol (American journal of hematology)
[2021, 96(8):914-924]

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M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening.

Hiroshi Yamada, Satoshi Taniguchi, Masayuki Shimojima, Long Tan, Miyuki Kimura, Yoshitomo Morinaga, Takasuke Fukuhara, Yoshiharu Matsuura, Takashi Komeno, Yousuke Furuta, Masayuki Saijo, Hideki Tani,

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case fatality rates of approximately 30%. There are few treatment options for SFTSV infection. SFTSV RNA synthesis is conducted using a virus-encoded complex with RNA-dependent RNA polymerase activity that is required ... Read more >>

Viruses (Viruses)
[2021, 13(6):]

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Identification of anticancer drugs associated with atrial fibrillation: analysis of the WHO pharmacovigilance database.

Joachim Alexandre, Joe-Elie Salem, Javid Moslehi, Marion Sassier, Camille Ropert, Jennifer Cautela, Franck Thuny, Stéphane Ederhy, Ariel Cohen, Ghandi Damaj, Jean-Pierre Vilque, Anne-Flore Plane, Damien Legallois, Laure Champ-Rigot, Paul Milliez, Christian Funck-Brentano, Charles Dolladille,

<h4>Aims</h4>The explosion of novel anticancer therapies has meant emergence of cardiotoxicity signals including atrial fibrillation (AF). Reliable data concerning the liability of anticancer drugs in inducing AF are scarce. Using the World Health Organization individual case safety report database, VigiBase®, we aimed to determine the association between anticancer drugs and ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, 7(4):312-320]

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Therapeutic Drug Monitoring of Busulfan in Patients Undergoing Hematopoietic Cell Transplantation: A Pilot Single-Center Study in Taiwan.

Rong-Long Chen, Li-Hua Fang, Xin-Yi Yang, Mohsin El Amrani, Esther Veronique Uijtendaal, Yen-Fu Chen, Wei-Chi Ku,

(1) Background: Busulfan has been used as a conditioning regimen in allogeneic hematopoietic cell stem transplantation (HSCT). Owing to a large inter-individual variation in pharmacokinetics, therapeutic drug monitoring (TDM)-guided busulfan dosing is necessary to reduce graft failure and relapse rate. As there exists no TDM of busulfan administration for HCT ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(7):]

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Mixed Langerhans Cell Histiocytosis and Erdheim-Chester Disease in a Girl: A Rare and Puzzling Diagnosis.

Suheyla Ocak, Zuhal Bayramoglu, Deniz Tugcu, Serap Karaman, Aysegul Unuvar, Zeynep Karakas,

<h4>Objective</h4>The objective of this study was to report the case of a girl diagnosed as suffering from multisystem, BRAF V600E-positive refractory Langerhans cell histiocytosis (LCH) and coexistent Erdheim-Chester disease (ECD) with perirenal, intracranial involvement and the dramatic response to clofarabine treatment.<h4>Observations</h4>Histiocytoses are rare diseases with a broad clinical spectrum. Recent ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(3):e375-e379]

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A computational multi-targeting approach for drug repositioning for psoriasis treatment.

Akachukwu Ibezim, Emmanuel Onah, Ebubechukwu N Dim, Fidele Ntie-Kang,

<h4>Background</h4>Psoriasis is an autoimmune inflammatory skin disease that affects 0.5-3% of the world's population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for repositioned drug candidates and the time and cost-effectiveness has popularized drug reposition and computational methods in the drug research ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2021, 21(1):193]

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Phase 1 study of bendamustine in combination with clofarabine, etoposide, and dexamethasone in pediatric patients with relapsed or refractory hematologic malignancies.

Sima Jeha, Kristine R Crews, Deqing Pei, Melissa Peyton, John C Panetta, Raul C Ribeiro, Xujie Zhao, Patrick Campbell, Monika L Metzger, Jun J Yang, Cheng Cheng, Ching-Hon Pui, Deepa Bhojwani,

<h4>Background</h4>A phase 1 study was conducted to determine the maximum tolerated dose of bendamustine when given in combination with clofarabine, etoposide, and dexamethasone daily for 5 days in children and adolescents with relapsed or refractory hematologic malignancies.<h4>Methods</h4>Patients younger than 22 years with second or greater relapsed or refractory acute leukemia ... Read more >>

Cancer (Cancer)
[2021, 127(12):2074-2082]

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Combination Therapy With Chemotherapy, Donor Lymphocyte Infusion With Concurrent Blinatumomab in Relapsed/Refractory Acute Precursor B-Lymphoblastic Leukemia.

Ho Jung Choi, Jung Yoon Choi, Bo Kyung Kim, Hong Yul An, Kyung Taek Hong, Hee Young Shin, Hyoung Jin Kang,

The therapeutic approach for relapsed/refractory acute lymphoblastic leukemia (ALL) remains to be a challenge. The patient was diagnosed as B-cell ALL at 6 months of age and relapsed for the second time following repeat allogeneic hematopoietic stem cell transplantation (one after first complete remission [CR1] and the other after CR2). ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(2):e280-e283]

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Allogeneic hematopoietic cell transplantation with non-myeloablative conditioning for patients with hematologic malignancies: Improved outcomes over two decades.

Jason P Cooper, Barry E Storer, Noa Granot, Boglark Gyurkocza, Mohamed L Sorror, Thomas R Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A Langston, Parameswaran Hari, Edward D Agura, Søren Lykke Petersen, Richard T Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A Gutman, Gitte Olesen, Andrew M Yeager, Kai Hübel, William J Hogan, David G Maloney, Marco Mielcarek, Paul J Martin, Mary E D Flowers, George E Georges, Ann E Woolfrey, Joachim H Deeg, Bart L Scott, George B McDonald, Rainer Storb, Brenda M Sandmaier,

We have used a non-myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation for the past twenty years. During that period, changes in clinical practice have been aimed at reducing morbidity and mortality from infections, organ toxicity, and graft-versus-host disease. We hypothesized that improvements in clinical practice led to better transplantation ... Read more >>

Haematologica (Haematologica)
[2021, 106(6):1599-1607]

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Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.

A Laura Nijstad, Stefan Nierkens, Caroline A Lindemans, Jaap Jan Boelens, Marc Bierings, A Birgitta Versluys, Kim C M van der Elst, Alwin D R Huitema,

<h4>Aims</h4>Clofarabine has recently been evaluated as part of the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HCT) in children. Pharmacokinetic (PK) exposure of different agents commonly used in conditioning regimens is strongly related to HCT outcome. Consequently, the PK of clofarabine may be important for outcome. This report describes ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, 87(8):3218-3226]

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M Segment-Based Minigenome System of Severe Fever with Thrombocytopenia Syndrome Virus as a Tool for Antiviral Drug Screening

Hiroshi Yamada, Satoshi Taniguchi, Masayuki Shimojima, Long Tan, Miyuki Kimura, Yoshitomo Morinaga, Takasuke Fukuhara, Yoshiharu Matsuura, Takashi Komeno, Yousuke Furuta, Masayuki Saijo, Hideki Tani,

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes severe disease in humans with case fatality rates of approximately 30%. There are few treatment options for SFTSV infection. SFTSV RNA synthesis is conducted using a virus-encoded complex with RNA-dependent RNA polymerase activity that is required ... Read more >>

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Identification of natural product modulators of Merkel cell carcinoma cell growth and survival.

Emily A Smith, Natasha T Hill, Tara Gelb, Khalid A Garman, Ekaterina I Goncharova, Heidi R Bokesch, Chang-Kwon Kim, Karen L Wendt, Robert H Cichewicz, Kirk R Gustafson, Isaac Brownell, Curtis J Henrich,

Merkel cell carcinoma (MCC) is a rare, but aggressive skin cancer the incidence of which has increased significantly in recent years. The majority of MCCs have incorporated Merkel cell polyomavirus (VP-MCC) while the remainder are virus-negative (VN-MCC). Although a variety of therapeutic options have shown promise in treating MCC, there ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):13597]

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Successful treatment of pulmonary hypertension following hematopoietic stem cell transplant with a single oral tadalafil: a case report.

Toshikazu D Tanaka, David C Ishizawar, Takeshi Saito, Akira Yoshii, Michihiro Yoshimura,

A 46-year-old man who had undergone hematopoietic stem cell transplant twice because of acute lymphoblastic leukemia with recurrence presented with dyspnea, leading to a diagnosis of pulmonary arterial hypertension which was quickly and effectively treated with the phosphodiesterase type 5 inhibitor tadalafil. To our knowledge, pulmonary arterial hypertension related to ... Read more >>

Pulm Circ (Pulmonary circulation)
[2021, 11(3):20458940211027791]

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Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.

Sophie Voruz, Laurence de Leval, Anne Cairoli,

Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach is defined due to the low frequency of the disease and lack of prospective ... Read more >>

Exp Hematol Oncol (Experimental hematology & oncology)
[2021, 10(1):32]

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Effectiveness and Safety of Clofarabine Monotherapy or Combination Treatment in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia: A Pragmatic, Non-interventional Study in Korea.

Jung Yoon Choi, Che Ry Hong, Kyung Taek Hong, Hyoung Jin Kang, Seongkoo Kim, Jae-Wook Lee, Pil Sang Jang, Nack-Gyun Chung, Bin Cho, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Jong Jin Seo, Seung Min Hahn, Jung Woo Han, Chuhl Joo Lyu, Eu Jeen Yang, Young Tak Lim, Keon Hee Yoo, Hong Hoe Koo, Hoon Kook, In Sang Jeon, Hana Cho, Hee Young Shin,

<h4>Purpose</h4>Effectiveness and safety of clofarabine (one of the treatment mainstays in pediatric patients with relapsed/refractory acute lymphoblastic leukemia [ALL]) was assessed in Korean pediatric patients with ALL to facilitate conditional coverage with evidence development.<h4>Materials and methods</h4>In this multicenter, prospective, observational study, patients receiving clofarabine as mono/combination therapy were followed-up every ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2021, :]

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Early assessment of clofarabine effectiveness based on measurable residual disease, including AML stem cells.

Diana Hanekamp, Lok Lam Ngai, Jeroen J W M Janssen, Arjan van de Loosdrecht, Gert J Ossenkoppele, Jacqueline Cloos,

Blood (Blood)
[2021, 137(12):1694-1697]

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5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice.

Ferdinand Sedlmayer, Anne-Kathrin Woischnig, Vincent Unterreiner, Florian Fuchs, Daniel Baeschlin, Nina Khanna, Martin Fussenegger,

Antibiotic-resistant pathogens often escape antimicrobial treatment by forming protective biofilms in response to quorum-sensing communication via diffusible autoinducers. Biofilm formation by the nosocomial pathogen methicillin-resistant Staphylococcus aureus (MRSA) is triggered by the quorum-sensor autoinducer-2 (AI-2), whose biosynthesis is mediated by methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) and S-ribosylhomocysteine lyase (LuxS). Here, we present ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, 49(13):e73]

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Cost-Effectiveness Analysis of Tisagenlecleucel for the Treatment of Pediatric and Young Adult Patients with Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia in Japan.

Shiho Wakase, Takanori Teshima, Jie Zhang, Qiufei Ma, Yoko Watanabe, Hongbo Yang, Cynthia Z Qi, Xinglei Chai, Yanwen Xie, Eric Q Wu, Ataru Igarashi,

Until recently, treatment options were relatively limited for children and young adults with relapsed or refractory (r/r) acute lymphoblastic leukemia (ALL). Tisagenlecleucel is a chimeric antigen receptor T cell (CAR-T) immunotherapy with promising efficacy and manageable safety that was approved in Japan in 2019 for the treatment of CD19-positive r/r ... Read more >>

Transplant Cell Ther (Transplantation and cellular therapy)
[2021, 27(3):241.e1-241.e11]

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Presentation of External Ear Rosai-Dorfman Disease With Laryngeal Involvement.

Kenji R Kobayashi, Yusif Hajiyev, Maren Y Fuller, Gunes Orman, Elton M Lambert,

Rosai-Dorfman disease (RDD) is a rare benign systemic histiocytic proliferation characterized by massive lymph node enlargement and sometimes associated with extranodal involvement. Even though it is considered to be benign, death can occur depending on the extent and location. Our case highlights a primary extranodal site of the right pinna ... Read more >>

Ear Nose Throat J (Ear, nose, & throat journal)
[2021, :1455613211016704]

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Second Relapse of Pediatric Patients with Acute Myeloid Leukemia: A Report on Current Treatment Strategies and Outcome of the AML-BFM Study Group.

Mareike Rasche, Emma Steidel, Martin Zimmermann, Jean-Pierre Bourquin, Heidrun Boztug, Iveta Janotova, E Anders Kolb, Thomas Lehrnbecher, Nils von Neuhoff, Naghmeh Niktoreh, Nora Mühlegger, Lucie Sramkova, Jan Stary, Christiane Walter, Ursula Creutzig, Michael Dworzak, Dirk Reinhardt,

Successful management of relapse is critical to improve outcomes of children with acute myeloid leukemia (AML). We evaluated response, survival and prognostic factors after a second relapse of AML. Among 1222 pediatric patients of the population-based AML-Berlin-Frankfurt-Munster (BFM) study group (2004 until 2017), 73 patients met the quality parameters for ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature.

Ashley R P Hinson, Niraj Patel, Joel Kaplan,

A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is thought to be quite rare. In this report, we review the presentation of ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):24-27]

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