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Chronic Obstructive Pulmonary Disease

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema.

Zhiming Shen, Wenting Xuan, Huanhuan Wang, Fei Sun, Chengxin Zhang, Qian Gong, Shenglin Ge,

Smoking is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is commonly characterised by cellular senescence and inflammation. Recently, miR-200b has emerged as an important target to cure lung disease; however, the function of miR-200b in reducing cellular senescence and inflammatory responses has not been ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):656-663]

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Mutation on lysX from Mycobacterium avium hominissuis impacts the host-pathogen interaction and virulence phenotype.

Greana Kirubakar, Hubert Schäfer, Volker Rickerts, Carsten Schwarz, Astrid Lewin,

The lysX gene from Mycobacterium avium hominissuis (MAH) is not only involved in cationic antimicrobial resistance but also regulates metabolic activity. An MAH lysX deficient mutant was shown to exhibit a metabolic shift at the extracellular state preadapting the bacteria to the conditions inside host-cells. It further showed stronger growth ... Read more >>

Virulence (Virulence)
[2020, 11(1):132-144]

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How do people with rheumatoid arthritis experience participation in a smoking cessation trial: a qualitative study.

Ida Kristiane Roelsgaard, Thordis Thomsen, Mikkel Østergaard, Anne Grete Semb, Lena Andersen, Bente Appel Esbensen,

Purpose: The aim of this study was to gain more knowledge on how people with rheumatoid arthritis (RA) experienced participation in a randomized controlled trial (RCT) testing the effect of a smoking cessation intervention since this intervention have not been tested on an RA population beforeMethods: We conducted a qualitative ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1725997]

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Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma.

Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Hamid Reza Sadeghipour,

Context: Airway remodelling is one of the most refractory problems in asthma. According to the critical roles of oxidative stress and inflammation in airway remodelling, it is supposed that ascorbic acid and calcitriol have beneficial effects. However, a combination of antioxidants may be more effective for asthma therapy.Objective: This study ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):107-115]

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Acquired long QT syndrome in chronic kidney disease patients.

Peng Liu, Lu Wang, Dan Han, Chaofeng Sun, Xiaolin Xue, Guoliang Li,

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):54-65]

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Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China.

Jiangtao Lin, Bin Xing, Huaping Tang, Lan Yang, Yadong Yuan, Yuhai Gu, Ping Chen, Xiaoju Liu, Jie Zhang, Huiguo Liu, Changzheng Wang, Wei Zhou, Dejun Sun, Yiqiang Chen, Zhuochang Chen, Mao Huang, Qichang Lin, Chengping Hu, Xiaohong Yang, Jianmin Huo, Xianwei Ye, Xin Zhou, Ping Jiang, Wei Zhang, Yijiang Huang, Luming Dai, Rongyu Liu, Shaoxi Cai, Jianying Xu, Jianying Zhou, ,

PURPOSE:Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is indispensable. This study aimed to investigate the clinical characteristics and outcomes of such patients. METHODS:A retrospective study was conducted on patients ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(3):485-495]

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The bidirectional relationship between chronic obstructive pulmonary disease and coronary artery disease.

Ayham Daher, Michael Dreher,

Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) not only have smoking as a common risk factor, they also share epidemiological relationships and important mutual effects. There is good evidence to suggest that COPD is highly prevalent but underdiagnosed among CAD patients and vice versa. The symptoms of the ... Read more >>

Herz (Herz)
[2020, 45(2):110-117]

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Comparative safety of biologic versus conventional synthetic DMARDs in rheumatoid arthritis with COPD: a real-world population study.

Marie Hudson, Sophie Dell'Aniello, Sophie Shen, Teresa A Simon, Pierre Ernst, Samy Suissa,

OBJECTIVES:Abatacept, a biologic DMARD, was associated with respiratory adverse events in a small subgroup of RA patients with chronic obstructive pulmonary disease (COPD) in a trial. Whether this potential risk is specific to abatacept or extends to all biologics and targeted synthetic DMARDs (tsDMARDs) is unclear. We assessed the risk ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(4):820-827]

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Community-acquired pneumonia in chronic obstructive pulmonary disease.

Rodrigo Cavallazzi, Julio Ramirez,

PURPOSE OF REVIEW:The aim of this study was to discuss the literature on community-acquired pneumonia (CAP) in patients with chronic obstructive pulmonary disease (COPD). RECENT FINDINGS:Well designed studies show that COPD is the strongest risk factor for development of CAP. Lung microbiome, abnormal lung immunity and pathogen virulence are important ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(2):173-181]

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Benzodiazepine Prescribing in People with Chronic Obstructive Pulmonary Disease: Clinical Considerations.

David C Currow, Meera R Agar,

Benzodiazepines, available clinically for almost six decades, are still one of the most widely prescribed classes of medication. The proportion of the population prescribed benzodiazepines increases with age, and harms also increase with age. The prevalence of prescribing in people > 85 years of age is as high as one in three, including ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):263-270]

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Urgent need of a management plan for survivors of COVID-19.

Bartolome Celli, Leonardo M. Fabbri,

Acute exacerbations of COPD (AECOPD) or “COPD crises” [1], are crucial events in the natural course of COPD. Although they can occur at any severity stage, their impact increases as patients develop more severe airflow limitation. ... Read more >>

Eur. Respir. J. (The European Respiratory Journal)
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Evaluating Mobile Apps and Biosensing Devices to Monitor Physical Activity and Respiratory Function in Smokers With and Without Respiratory Symptoms or Chronic Obstructive Pulmonary Disease: Protocol for a Proof-of-Concept, Open-Label, Feasibility Study.

Almaz Sharman, Baurzhan Zhussupov, Dana Sharman, Irina Kim,

BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a global public health problem, and continuous monitoring is essential for both its management as well as the management of other chronic diseases. Telemonitoring using mobile health (mHealth) devices has the potential to promote self-management, improve control, increase quality of life, and prevent hospital ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e16461]

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Intercept of minute ventilation vs. carbon dioxide output relationship in chronic obstructive pulmonary disease: utility as an index of ventilatory inefficiency

Haoyan Wang, Fang Lin, Shan Nie, Ranran Zhao, Min Cao, Wei Yuan, Yunxiao Li, Chunting Tan, Bo Xu,

<title>Abstract</title> <p> <bold>Background</bold>: Ventilatory inefficiency is known to be a contributor to exercise intolerance in chronic obstructive pulmonary disease (COPD). The intercept of the minute ventilation (V̇<sub>E</sub>) vs. carbon dioxide output (V̇CO<sub>2</sub>) plot is a key ventilator inefficiency parameter. However, its relationships with lung hyperinflation (LH) and airflow ... Read more >>

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Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis

Jaber Alqahtani, Tope Oyelade, Abdulelah Aldhahir, Saeed Alghamdi, Mater Almehmadi, Abdullah Alqahtani, Shumonta Quaderi, Swapna Mandal, John Hurst,

Background: Coronavirus disease 2019 (COVID-19) is an evolving infectious disease that dramatically spread all over the world in the early part of 2020. No studies have yet summarised the potential severity and mortality risks caused by COVID-19 in patients with chronic obstructive pulmonary disease (COPD), and we update information in ... Read more >>

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Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease.

Fernanda Borowsky da Rosa, Adriane Schmidt Pasqualoto, Catriona M Steele, Renata Mancopes,

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications ... Read more >>

Am J Speech Lang Pathol (American journal of speech-language pathology)
[2020, :1-9]

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Comprehensive profiling of the gut microbiota in patients with chronic obstructive pulmonary disease of varying severity

Lawrence Wu, Yu-Chi Chiu, Shih-Wei Lee, Chi-Wei Liu, Rebecca Lin, Yung-Chia Huang, Tzuo-Yun Lan,

<title>Abstract</title> <p> Background Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that reduces lung and respiratory function, with a high mortality rate. Severe and acute deterioration of COPD can easily lead to respiratory failure, resulting in personal, social, and medical burden. Recent studies have shown a ... Read more >>

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The rat model of COPD skeletal muscle dysfunction induced by progressive cigarette smoke exposure: a pilot study.

Jianqing Su, Jian Li, Yufan Lu, Ning Li, Peijun Li, Zhengrong Wang, Weibing Wu, Xiaodan Liu,

BackgroundChronic obstructive pulmonary disease (COPD) skeletal muscle dysfunction is a prevalent malady that significantly affects patients’ prognosis and quality of life. Although the study of this disease has attracted considerable attention, a definite animal model is yet to be established. This study investigates whether smoke exposure could lead to the ... Read more >>

BMC Pulm Med (BMC Pulmonary Medicine)
[2020, 20:]

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Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis

Glenn Crater, James Donohue, Edward Kerwin, Chris Barnes, Edmund Moran, Brett Haumann,

<title>Abstract</title> <p> Background : Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 second (FEV 1 ) in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) in prior phase 3 trials. We evaluated the efficacy of ... Read more >>

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PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile.

H Dean Hosgood Iii, Roberto Díaz-Peña, Deanna Blansky, Sergio Jaime, Viviana Parra, Felix Boekstegers, Justo Lorenzo Bermejo, José García-Valero, Juan F Montes, Gonzalo Valdivia, Marc Miravitlles, Àlvar Agustí, Rafael S Silva, Jordi Olloquequi,

BACKGROUND:Genome-wide association studies (GWAS) have accelerated our understanding of the genetic underpinnings of chronic obstructive pulmonary disease (COPD); however, GWAS populations have typically consisted of European descent, with ∼1% of Latin American ancestry. OBJECTIVE:To overcome this limitation, we conducted a GWAS in a rural Chilean population with increased COPD risk ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2020, :1-9]

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Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease.

Eunmi Bae, Sang-Eun Choi, Haeyoung Lee, Gyeongseon Shin, Daewon Kang,

BackgroundThe discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD) is an unsettled issue. This study investigated the quality of life of patients with COPD with three different HRQoL instruments and examined ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20:]

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Patterns and Correlates of Sedentary Behaviour Accumulation and Physical Activity in People with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.

Sonia W M Cheng, Jennifer A Alison, Emmanuel Stamatakis, Sarah M Dennis, Zoe J McKeough,

Few studies have used 24-hour accelerometery to characterise posture and movement patterns in people with chronic obstructive pulmonary disease (COPD). This study aimed to quantify sedentary behaviour (SB), patterns of SB accumulation and physical activity (PA) in people with COPD, and to examine physiological and functional capacity correlates of total ... Read more >>

COPD (COPD)
[2020, :1-9]

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Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis.

Hui Bi, Gui Wang, Zhiying Li, Lin Zhou, Ming Zhang, Jiru Ye, Zhigang Wang,

BACKGROUND Chronic obstructive pulmonary disease (COPD), a general airway disease, is featured by progressive and chronic immunoreaction in the lung. Increasing evidences have showed that cigarette smoking is the main reason in the COPD progression, and human pulmonary microvascular endothelial cell (HPMEC) apoptosis often be observed in COPD, while its ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e920793]

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PET/Computed Tomography in Pulmonary and Thoracic Inflammatory Diseases (Including Cardiac Sarcoidosis): The Current Role and Future Promises.

Ashwini Kalshetty, Sandip Basu,

18F-fluorodeoxyglucose PET/computed tomography (CT) can play a valuable adjunct role in initial and post-treatment assessment of thoracic and pulmonary inflammatory disorders and is particularly helpful when the conventional biomarkers and anatomical imaging are non-contributory or inconclusive. PET/CT can potentially help in chronic obstructive pulmonary disease (COPD). Quantitative regional parameters of ... Read more >>

PET Clin (PET clinics)
[2020, 15(2):163-173]

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