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Chronic Fatigue Syndrome

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Chronic fatigue syndrome: What nurses need to know.

Marianne Bush,

Chronic fatigue syndrome (CFS) is a long-term, often misunderstood disorder that involves the nervous, immune, metabolic, endocrine, and digestive systems. This article describes the pathophysiology of CFS, signs and symptoms of CFS in adults, diagnostic criteria for CFS, and nursing considerations for patients with CFS. ... Read more >>

Nursing (Nursing)
[2020, 50(4):50-54]

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Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes,

Background: Physiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. Methods: We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, ... Read more >>

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The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron Deficient Blood Donors: A Secondary Analysis of the Ironwoman Rct

Susanne Macher, Cornelia Herster, Magdalena Holter, Martina Moritz, Eva Maria Matzhold, Tatjana Stojakovic, Thomas Pieber, Peter Schlenke, Camilla Drexler, Karin Amrein,

Background: Besides anemia, iron deficiency may cause more subtle symptoms including those of the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. Objective: The aim of this pre-planned secondary analysis was to compare the frequency and severity of symptoms associated with iron deficiency before and after ... Read more >>

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Electrolyte and acid-base disorders in cancer patients and its impact on clinical outcomes: evidence from a real-world study in China.

Yang Li, Xiaohong Chen, Ziyan Shen, Yimei Wang, Jiachang Hu, Jiarui Xu, Bo Shen, Xiaoqiang Ding,

Background: This study aims to delineate the incidence of electrolyte and acid-base disorders (EAD) in cancer patients, to figure out the risk factors of EAD, then to assess the impact of EAD on patients' in-hospital clinical outcomes.Methods: Patients with the diagnosis of malignancies hospitalized during 1 October 2014 and 30 ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):234-243]

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Systemic Hyperalgesia in Females with Gulf War Illness, Chronic Fatigue Syndrome and Fibromyalgia.

Amber A Surian, James N Baraniuk,

Pain is a diagnostic criterion for Gulf War Illness (GWI), Chronic Fatigue Syndrome (CFS), and fibromyalgia (FM). The physical sign of systemic hyperalgesia (tenderness) was assessed in 920 women who were stratified by 2000 Kansas GWI, 1994 CFS, and 1990 FM criteria. Pressure was applied by dolorimetry at 18 traditional ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5751]

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Assessing functioning in adolescents with chronic fatigue syndrome: psychometric properties and factor structure of the School and Social Adjustment Scale and the Physical Functioning Subscale of the SF36.

M E Loades, S Vitoratou, K A Rimes, T Chalder,

BACKGROUND:Chronic fatigue syndrome (CFS) has a major impact on functioning. However, no validated measures of functioning for this population exist. AIMS:We aimed to establish the psychometric properties of the 5-item School and Social Adjustment Scale (SSAS) and the 10-item Physical Functioning Subscale of the SF-36 in adolescents with CFS. METHOD:Measures ... Read more >>

Behav Cogn Psychother (Behavioural and cognitive psychotherapy)
[2020, :1-11]

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Systematic Review and Meta-analysis of Postlicensure Observational Studies on Human Papillomavirus Vaccination and Autoimmune and Other Rare Adverse Events.

Corinne Willame, Kartini Gadroen, Wichor Bramer, Daniel Weibel, Miriam Sturkenboom,

BACKGROUND:Because of the limited number of subjects in prelicensure studies, autoimmune diseases and other rare adverse effects of vaccines may go undetected. Since 2006, millions of human papillomavirus (HPV) vaccine doses have been distributed and a considerable amount of postlicensure safety data has been generated. The objective of this study ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(4):287-293]

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How visiting nurses detect symptoms of disease progression in patients with chronic heart failure.

Chinatsu Taniguchi, Ayako Okada, Natsuko Seto, Yasuko Shimizu,

Purpose: Chronic heart failure patients are often rehospitalized because they fail to seek appropriate, timely care. However, both patients and nurses experience difficulties in detecting signs of heart failure exacerbation. We aimed to qualitatively investigate how visiting nurses detect symptoms of disease progression in chronic heart failure patients in their ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1735768]

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Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy.

Yehuda Shoenfeld, Varvara A Ryabkova, Carmen Scheibenbogen, Louise Brinth, Manuel Martinez-Lavin, Shuichi Ikeda, Harald Heidecke, Abdulla Watad, Nicola L Bragazzi, Joab Chapman, Leonid P Churilov, Howard Amital,

Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these ... Read more >>

Clin. Immunol. (Clinical immunology (Orlando, Fla.))
[2020, 214:108384]

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Striking the balance with epistemic injustice in healthcare: the case of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Eleanor Alexandra Byrne,

Miranda Fricker's influential concept of epistemic injustice (Oxford University Press, Oxford, 2007) has recently seen application to many areas of interest, with an increasing body of healthcare research using the concept of epistemic injustice in order to develop both general frameworks and accounts of specific medical conditions and patient groups. ... Read more >>

Med Health Care Philos (Medicine, health care, and philosophy)
[2020, :]

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Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome.

Nadja Scherbakov, Marvin Szklarski, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Antje Meyer, Patricia Grabowski, Wolfram Doehner, Carmen Scheibenbogen,

AIMS:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. The aim of the present study was to examine peripheral endothelial ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, :]

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Cytomegalovirus, Epstein-Barr virus, and human herpesvirus-6 infections in patients with myalgic еncephalomyelitis/chronic fatigue syndrome.

Evelina Shikova, Valentina Reshkova, Аntoniya Kumanova, Sevdalina Raleva, Dora Alexandrova, Natasa Capo, Modra Murovska, ,

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling multisystem chronic disease. The etiology and pathogenesis of ME/CFS are unknown. Infections of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus-6 (HHV-6) are suspected as etiological agents for ME/CFS. This study aims to estimate prevalence and type (active/latent) of EBV, CMV, and ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Asgeir Lande, Øystein Fluge, Elin B Strand, Siri T Flåm, Daysi D Sosa, Olav Mella, Torstein Egeland, Ola D Saugstad, Benedicte A Lie, Marte K Viken,

The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are hallmarks of autoimmune disease, and have not been thoroughly investigated in a large ME/CFS patient cohort. We performed high resolution HLA -A, -B, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5267]

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Associations of occupational stress, workplace violence, and organizational support on chronic fatigue syndrome among nurses.

Mengyao Li, Qianyi Shu, Hao Huang, Wen Bo, Lulu Wang, Hui Wu,

AIMS:Chronic fatigue syndrome is an agnogenic disease worldwide. Nurses are at a high risk of chronic fatigue syndrome. However, no research has been done to examine the associations of workplace violence, organizational support, and occupational stress with chronic fatigue syndrome among Chinese nurses. This study aimed to examine effects of ... Read more >>

J Adv Nurs (Journal of advanced nursing)
[2020, 76(5):1151-1161]

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Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach.

Divesh Deepak Pednekar, Md Rafiul Amin, Hamid Fekri Azgomi, Kirstin Aschbacher, Leslie J Crofford, Rose T Faghih,

OBJECTIVE:Fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) are complicated medical disorders, with little known etiologies. The purpose of this research is to characterize FMS and CFS by studying the variations in cortisol secretion patterns, timings, amplitudes, the number of underlying pulses, as well as infusion and clearance rates of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

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Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations.

Alexandra H Mandarano, Jessica Maya, Ludovic Giloteaux, Daniel L Peterson, Marco Maynard, C Gunnar Gottschalk, Maureen R Hanson,

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease with no known cause or mechanism. There is an increasing appreciation for the role of immune and metabolic dysfunction in the disease. ME/CFS has historically presented in outbreaks, often has a flu-like onset, and results in inflammatory symptoms. Patients suffer from ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(3):1491-1505]

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Interventions to treat pain in paediatric CFS/ME: a systematic review.

Caitlin Ascough, Hayley King, Teona Serafimova, Lucy Beasant, Sophie Jackson, Luke Baldock, Anthony Edward Pickering, Jonathan Brooks, Esther Crawley,

Background:Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is common (prevalence 1%-2%). Two-thirds of children experience moderate or severe pain, which is associated with increased fatigue and poorer physical function. However, we do not know if treatment for CFS/ME improves pain. Objective:Identify whether specialist treatment of paediatric CFS/ME improves pain. Methods:We conducted ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2020, 4(1):e000617]

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Syncope and hypermobile joints: Not rare, but rarely diagnosed.

Elnur Tahirovic,

Postural orthostatic tachycardia syndrome (POTS) is a chronic, debilitating condition characterized by heterogeneous symptoms, such as lightheadedness, palpitations, pre-syncope, syncope, and weakness or heaviness, especially of the legs. It is frequently associated with hypermobile joints or conditions such as chronic fatigue syndrome, chronic abdominal pain, migraine headache, and diabetes mellitus. ... Read more >>

Turk Kardiyol Dern Ars (Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir)
[2020, 48(2):177-179]

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From IBS to ME - The dysbiotic march hypothesis.

Arnold Berstad, Olav Hauso, Ketil Berstad, Johanna E R Berstad,

Irritable bowel syndrome (IBS) is often associated with other unexplained complaints like chronic fatigue syndrome (CFS), fibromyalgia and myalgic encephalopathy (ME). The pathogenesis of the relationship is unknown. Intestinal dysbiosis may be a common abnormality, but based on 1100 consecutive IBS patients examined over a nine years period, we hypothesize ... Read more >>

Med. Hypotheses (Medical hypotheses)
[2020, 140:109648]

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Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Eun-Jin Lim, Yo-Chan Ahn, Eun-Su Jang, Si-Woo Lee, Su-Hwa Lee, Chang-Gue Son,

BACKGROUND:Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has been emerging as a significant health issue worldwide. This study aimed to systemically assess the prevalence of CFS/ME in various aspects of analyses for precise assessment. METHODS:We systematically searched prevalence of CFS/ME from public databases from 1980 to December 2018. Data were extracted according ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):100]

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BEYOND BONES - THE RELEVANCE OF VARIANTS OF CONNECTIVE TISSUE (HYPERMOBILITY) TO FIBROMYALGIA, ME/CFS AND CONTROVERSIES SURROUNDING DIAGNOSTIC CLASSIFICATION: AN OBSERVATIONAL STUDY

Jessica Eccles, Beth Thompson, Kristy Themelis, Marisa Amato, Robyn Stocks, Amy Pound, Anna-Marie Jones, Zdenka Cipinova, Lorraine Shah-goodwin, Jean Timeyin, Charlotte Thompson, Thomas Batty, Neil Harrison, Hugo Critchley, Kevin Davies,

Objectives: To understand the relevance of symptomatic hypermobility and related connective tissue variants to the expression of symptoms in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The study further tested if specific subfactors within the diagnostic classification of hypermobility predict clinical presentations. Design: We report part of a larger case-control ... Read more >>

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The relationship between shift-work, sleep, and mental health among paramedics in Australia.

Wahaj Anwar A Khan, Russell Conduit, Gerard A Kennedy, Melinda L Jackson,

OBJECTIVES:This study aimed to investigate the prevalence of sleep and mental health issues, the role of chronotype, and the relationship between these variables in Australian paramedics. DESIGN:A cross-sectional study. SETTINGS:Cross-sectional survey. MEASUREMENTS:Paramedics were invited to complete an online survey to assess stress, posttraumatic stress disorder (PTSD), depression, anxiety, daytime sleepiness, ... Read more >>

Sleep Health (Sleep health)
[2020, :]

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Can the light of immunometabolism cut through "brain fog"?

Mady Hornig,

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a highly debilitating disease with heterogeneous constitutional and neurological complaints. Infection-like symptoms often herald disease onset, but no pathogen or immune defect has been conclusively linked. In this issue of the JCI, Mandarano et al. illuminate bioenergetic derangements of ME/CFS T cell subsets. CD4+ ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(3):1102-1105]

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Effectiveness of exercise on fatigue in hemodialysis patients: a randomized controlled trial.

Farzaneh Salehi, Mahlagha Dehghan, Parvin Mangolian Shahrbabaki, Mohammad Reza Ebadzadeh,

Background:Hemodialysis is one of the common therapies in patients with end-stage renal disease. Even patients who receive regular treatment suffer from fatigue, which is one of the main factors leading to poor quality of life. This study aimed to determine the effectiveness of exercising on mini-bikes on fatigue in hemodialysis ... Read more >>

BMC Sports Sci Med Rehabil (BMC Sports Science, Medicine and Rehabilitation)
[2020, 12:19]

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Managing functional disorders: opportunities and threats.

Helena Liira,

Scand J Prim Health Care (Scandinavian journal of primary health care)
[2020, 38(1):1-2]

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