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Chorioamnionitis

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Decreased expression of progesterone receptor membrane component 1 in fetal membranes with chorioamnionitis among women with preterm birth.

Soo Ran Choi, Hyung Eun Choi, Eunae Jo, Hwa Yeon Choi, Sukyung Jung, Shina Jang, Suk Jin Choi, Sung Ook Hwang,

PURPOSE:Progesterone receptor membrane component 1 (PGRMC1) have anti-inflammatory and anti-apoptotic properties. This study aimed to determine the expression of PGRMC1 in fetal membranes among women with preterm labor (PTL), preterm premature rupture of membranes (PPROM), and acute histologic chorioamnionitis (HCA) during preterm birth. METHODS:Full thickness fetal membranes were obtained from ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2020, :]

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Vaginal Ureaplasma urealyticum or Mycoplasma hominis and preterm delivery in women with threatened preterm labor.

Yasuhiro Miyoshi, Sachie Suga, So Sugimi, Nao Kurata, Hiroshi Yamashita, Ichiro Yasuhi,

Background: Amniotic fluid infection with Ureaplasma urealyticum or Mycoplasma hominis can cause chorioamnionitis and preterm birth. The aim of this study was to examine whether vaginal Ureaplasma urealyticum/Mycoplasma hominis colonization is predictive of preterm delivery in patients exhibiting signs of threatened preterm birth or those with asymptomatic short cervix.Methods: The ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-6]

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A250 SYSTEMATIC REVIEW WITH META-ANALYSIS: ADVERSE PREGNANCY-RELATED OUTCOMES WITH INFLAMMATORY BOWEL DISEASE.

V Govardhanam, P Tandon, K Leung, C Maxwell, V Huang,

AbstractBackgroundInflammatory bowel disease (IBD) is a chronic inflammatory condition. While it is reported that IBD may result in adverse pregnancy-related outcomes, its effects on placental related diseases are relatively not known.AimsThe aim of our work was to determine the risk of adverse pregnancy outcomes in patients with IBD.MethodsMedline, Embase, and ... Read more >>

J Can Assoc Gastroenterol (Journal of the Canadian Association of Gastroenterology)
[2020, 3(Suppl 1):127-128]

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Perinatal inflammation influences but does not arrest rapid immune development in preterm babies.

S Kamdar, R Hutchinson, A Laing, F Stacey, K Ansbro, M R Millar, K Costeloe, W G Wade, P Fleming, D L Gibbons,

Infection and infection-related complications are important causes of death and morbidity following preterm birth. Despite this risk, there is limited understanding of the development of the immune system in those born prematurely, and of how this development is influenced by perinatal factors. Here we prospectively and longitudinally follow a cohort ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1284]

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Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis.

Mitali Sahni, Pooja Patel, Akila Muthukumar,

Background:Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:5742394]

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A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim.

Schuyler A Chambers, Rebecca E Moore, Kelly M Craft, Harrison C Thomas, Rishub Das, Shannon D Manning, Simona G Codreanu, Stacy D Sherrod, David M Aronoff, John A McLean, Jennifer A Gaddy, Steven D Townsend,

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibiotic to which GBS is intrinsically resistant. Reductions ... Read more >>

mBio (mBio)
[2020, 11(2):]

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Separating the signal from the noise in metagenomic cell-free DNA sequencing.

Philip Burnham, Nardhy Gomez-Lopez, Michael Heyang, Alexandre Pellan Cheng, Joan Sesing Lenz, Darshana M Dadhania, John Richard Lee, Manikkam Suthanthiran, Roberto Romero, Iwijn De Vlaminck,

BACKGROUND:Cell-free DNA (cfDNA) in blood, urine, and other biofluids provides a unique window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating opportunities for the diagnosis of infection via metagenomic sequencing. The total biomass of microbial-derived cfDNA in clinical isolates is low, which makes metagenomic ... Read more >>

Microbiome (Microbiome)
[2020, 8(1):18]

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Intracervical Foley Catheter Plus Intravaginal Misoprostol vs Intravaginal Misoprostol Alone for Cervical Ripening: A Meta-Analysis.

Howard Hao Lee, Ben-Shian Huang, Min Cheng, Chang-Ching Yeh, I-Chia Lin, Huann-Cheng Horng, Hsin-Yi Huang, Wen-Ling Lee, Peng-Hui Wang,

Currently, there is no meta-analysis comparing intravaginal misoprostol plus intracervical Foley catheter versus intravaginal misoprostol alone for term pregnancy without identifying risk factors. Therefore, the purpose of this study is to conduct a systematic review and meta-analysis of randomized control trials (RCTs) comparing concurrent intravaginal misoprostol and intracervical Foley catheter ... Read more >>

Int J Environ Res Public Health (International Journal of Environmental Research and Public Health)
[2020, 17(6):]

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Safety and effectiveness of acellular pertussis vaccination during pregnancy: a systematic review.

Sabine Vygen-Bonnet, Wiebke Hellenbrand, Edeltraut Garbe, Rüdiger von Kries, Christian Bogdan, Ulrich Heininger, Marianne Röbl-Mathieu, Thomas Harder,

BACKGROUND:Infants < 3 months of age are at highest risk for developing severe complications after pertussis. The majority of pregnant women has low concentrations of pertussis-specific antibodies and thus newborns are insufficiently protected by maternally transferred antibodies. Acellular pertussis vaccination during pregnancy was recently implemented in various countries. Here, we assessed the ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):136]

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Placental histopathology in late preterm infants: clinical implications.

Kristina Ericksen, Joshua Fogel, Rita P Verma,

BACKGROUND:The etiopathogenesis of late preterm (LPT) birth is undetermined. Placental histopathology, which reflects an adverse intrauterine environment and is reportedly associated with preterm labor and neonatal morbidities, has not been studied in LPT infants. PURPOSE:We investigated placental pathological lesion as markers of an adverse intrauterine environment during LPT labor. METHODS:This ... Read more >>

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(2):48-51]

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Histological villous maturation in placentas of complicated pregnancies.

Philippe Vangrieken, Sizzle F Vanterpool, Frederik J van Schooten, Salwan Al-Nasiry, Peter Andriessen, Ellen Degreef, Joachim Alfer, Boris W Kramer, Ulrike von Rango,

Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effects of placental inflammation in chorioamnionitis on villous ... Read more >>

Histol. Histopathol. (Histology and histopathology)
[2020, :18205]

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Fetal membrane bacterial load is increased in histologically confirmed inflammatory chorioamnionitis: A retrospective cohort study.

Rochelle Hockney, Gareth J Waring, Gillian Taylor, Stephen P Cummings, Stephen C Robson, Caroline H Orr, Andrew Nelson,

INTRODUCTION:It is widely debated whether fetal membranes possess a genuine microbiome, and if bacterial presence and load is linked to inflammation. Chorioamnionitis is an inflammation of the fetal membranes. This research focussed on inflammatory diagnosed histological chorioamnionitis (HCA) and aimed to determine whether the bacterial load in fetal membranes correlates ... Read more >>

Placenta (Placenta)
[2020, 91:43-51]

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Perinatal Outcomes with Longer Second Stage of Labor: A Risk Analysis Comparing Expectant Management to Operative Intervention.

Elizabeth B Ausbeck, Sara F Jennings, Macie Champion, Meredith Gray, Christina Blanchard, Alan T Tita, Lorie M Harper,

OBJECTIVE: The aim of this study is to assess the impact of a prolonged second stage of labor on maternal and neonatal outcomes by comparing women who had expectant management versus operative intervention beyond specified timeframes in the second stage of labor. STUDY DESIGN: Retrospective cohort including live singletons at ≥36 weeks ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

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Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes.

George U Eleje, Cornelius O Ukah, Igwebuike V Onyiaorah, Euzebus C Ezugwu, Emmanuel O Ugwu, Samuel R Ohayi, Lydia I Eleje, Richard O Egeonu, Ifeanyichukwu U Ezebialu, Chukwudi C Obiora, Joseph T Enebe, Leonard O Ajah, Chigozie G Okafor, Chukwuemeka C Okoro, Augustine O Asogwa, Doris K Ogbuokiri, Joseph I Ikechebelu, Ahizechukwu C Eke,

OBJECTIVE:To determine the accuracy of a semi-quantitative interleukin-6 (IL-6) vaginal secretion rapid test (Chorioquick) for detecting chorioamnionitis in women with premature rupture of membranes (PROM). METHODS:A prospective cohort study in five tertiary hospitals in Nigeria involved women with confirmed PROM at term and preterm PROM with or without suspected chorioamnionitis ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 149(1):98-105]

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Prevalence of surgical site infection and its associated factors after cesarean section in Ethiopia: systematic review and meta-analysis

Temesgen Getaneh, Ayenew Negesse, Getenet Dessie,

<title>Abstract</title> <p> Background Surgical site infection (SSI) affects up to one third of patients who have undergone a surgical procedure. It is a significant cause of surgical patient morbidity, mortality and human and financial costs threat. The national prevalence of SSI among mothers who undergo for cesarean section ... Read more >>

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Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes.

Jose Galaz, Roberto Romero, Rebecca Slutsky, Yi Xu, Kenichiro Motomura, Robert Para, Percy Pacora, Bogdan Panaitescu, Chaur-Dong Hsu, Marian Kacerovsky, Nardhy Gomez-Lopez,

Background Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2020, 48(3):222-233]

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Subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis in women with spontaneous preterm delivery.

Nam-Kyeong Kim, Yae Ji Choi, Subeen Hong, Jee Yoon Park, Kyung Joon Oh, Joon-Seok Hong,

Objective:To compare subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis (HCA) in women with spontaneous preterm delivery (SPTD). Methods:Among 1,706 women who gave birth twice or more at our institution, 138 women delivered spontaneously at preterm (<37.0 weeks). Subsequent deliveries occurred at our institution and placental biopsy ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2020, 63(2):126-132]

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The impact of residual oligohydramnios following preterm premature rupture of membranes on adverse pregnancy outcomes: a meta-analysis.

Vasilios Pergialiotis, Ioannis Bellos, Maria Fanaki, Aris Antsaklis, Dimitrios Loutradis, George Daskalakis,

OBJECTIVE:Residual oligohydramnios following preterm premature rupture of the membranes (pPROM) can lead to adverse perinatal outcome 1-3 but the nature and extent of complications has not been fully elucidated. The purpose of the present meta-analysis is to accumulate existing evidence in this field to determine the nature and extent of ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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Surgical ligation of patent ductus arteriosus in very low birth weight infants: A 9-year single center experience

Hyuck Kim, Jun Lee, Hyun Lee, Hyun-Kyung Park, Ja-Hye Ahn, Hee Kim, Hyo Jang, Sun Ro,

<title>Abstract</title> <p> Background We analyzed the feasibility and outcomes of early surgical ligation in very low birth weight infants (VLBWIs) with hemodynamically significant patent ductus arteriosus (HSPDA) and investigated predictors for surgical treatment after unsuccessful medical management. Methods Medical records from the neonatal intensive care unit of Hanyang ... Read more >>

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Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis.

Khaldoon Aljerian,

Introduction:Chorioamnionitis that is associated with high rates of morbidity and mortality needs an early diagnosis for effective treatment. However, views are conflicting on the effectiveness of a clinical versus a histological diagnosis of the disease. The accuracy of clinical diagnoses should be evaluated by determining their correlation with histopathological data. ... Read more >>

Indian J Pathol Microbiol (Indian journal of pathology & microbiology)
[2020, 63(1):44-48]

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Cellular immune responses in amniotic fluid of women with preterm clinical chorioamnionitis.

Jose Galaz, Roberto Romero, Yi Xu, Derek Miller, Rebecca Slutsky, Dustyn Levenson, Chaur-Dong Hsu, Nardhy Gomez-Lopez,

OBJECTIVE:Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Some preterm births are associated with clinical chorioamnionitis; yet, this condition has been poorly investigated. Herein, we characterized the amniotic fluid cellular immune responses in women with preterm clinical chorioamnionitis. METHODS AND SUBJECTS:Amniotic fluid samples were obtained from ... Read more >>

Inflamm. Res. (Inflammation research : official journal of the European Histamine Research Society ... [et al.])
[2020, 69(2):203-216]

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Hydrocortisone for Preventing Mortality and Bronchopulmonary Dysplasia in Preterm Infants with or without Chorioamnionitis Exposure: A Meta-Analysis of Randomized Trials.

Jianguo Zhou, Zhuowen Yu, Chao Chen,

OBJECTIVE: This study sought to assess whether infants exposed to chorioamnionitis are the optimal population to benefit the most from early postnatal hydrocortisone delivery in preventing bronchopulmonary dysplasia (BPD). This meta-analysis was conducted to discover the efficacy of hydrocortisone in preterm infants with and without chorioamnionitis. STUDY DESIGN: From the earliest available ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

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A238 FECAL CALPROTECTIN AND CLINICAL ASSESSMENT TOOLS MAY CORRELATE WITH POOR PREGNANCY-RELATED OUTCOMES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.

P Tandon, E Lee, L Hitz, C Maxwell, V Huang,

AbstractBackgroundPatients with inflammatory bowel disease (IBD) are at risk of developing adverse pregnancy-related outcomes. Though active disease has been associated with these outcomes, the optimal method of disease assessment in these patients remains unknown.AimsTo determine whether clinical and/or objective disease activity correlates with poor maternal and neonatal outcomes in patients ... Read more >>

J Can Assoc Gastroenterol (Journal of the Canadian Association of Gastroenterology)
[2020, 3(Suppl 1):115-116]

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Maternal characteristics and pregnancy outcomes of Chinese women with infertility undergoing assisted reproductive technology treatment:a retrospective cohort study

Jiumei Author), Jingxue Author), Qiwei Liu, Boer Deng, Fang Chen, Xiaowei Liu,

<title>Abstract</title> <p> Background : To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent assisted reproductive technology (ART) treatment. Methods: This retrospective cohort study included women with various causes of infertility who used ART. Data on demographic characteristics, ... Read more >>

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Effects of Labor Epidural Analgesia on Short Term Neonatal Morbidity.

Khalil Mohd Salameh, Vellamgot Anvar Paraparambil, Abedin Sarfrazul, Habboub Lina Hussain, Salim Sajid Thyvilayil, Alhoyed Samer Mahmoud,

Background:Epidural Analgesia (EA) is the most effective and most commonly used method for pain relief during labor. Some researchers have observed an association between EA and increased neonatal morbidity. But this observation was not consistent in many other studies. Objectives:The primary objective of the study was to examine whether exposure ... Read more >>

Int J Womens Health (International Journal of Women's Health)
[2020, 12:59-70]

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