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ZYX-1/Zyxin plays a minor role in oocyte transit through the spermatheca in C. elegans.

Perla G Castaneda, Nan Wu, Zhongqiang Qiu, Myeongwoo Lee, Erin J Cram,

In <i>C. elegans</i>, oocytes are ovulated into the spermatheca, where they are fertilized before being pushed into the uterus. Contraction in the <i>C. elegans</i> spermatheca is driven by circumferential acto-myosin fibers. The <i>C. elegans</i> zyxin homolog, <i>zyx-1</i>, is expressed in the body wall muscle, pharynx and spermatheca. To our surprise, ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The Caenorhabditis elegans tmc-1 is involved in egg-laying inhibition in response to harsh touch.

Eva Kaulich, Denise S Walker, Yi-Quan Tang, William Ronald Schafer,

The conserved family of Transmembrane channel-like (TMC) proteins has attracted significant interest since two members appear to be key components of the mammalian hair cell mechanotransducer involved in hearing. <i>C. elegans</i> expresses two TMC proteins, TMC-1 and TMC-2. TMC-1 is widely expressed in in both muscles and the nervous system. ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy.

Sanjib Guha, Aurora Pujol, Esther Dalfo,

X-linked Adrenoleukodystrophy (X-ALD) is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). We have characterized a nematode model of X-ALD with loss of the <i>pmp-4</i> gene, the worm orthologue of <i>ABCD1</i>. These mutants recapitulated the key hallmarks of X-ALD and importantly mitochondria ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Interspecific comparison of sensitivity to paralytic compounds.

Vivian Vy Le, Bryan Sanchez, Ray Hong,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Vibrio vulnificus iron transport mutant has normal pathogenicity in C. elegans.

Adria Bowles, David Wynne, Ryan Kenton,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Caenorhabditis elegans egg-laying and brood-size changes upon exposure to Serratia marcescens and Staphylococcus epidermidis are independent of DBL-1 signaling.

Bhoomi Madhu, Aileen Salazar, Tina Gumienny,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 3 times

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Embolic stroke of undetermined source: identification of patient subgroups for oral anticoagulation treatment.

Isabell Greeve, Wolf-Rüdiger Schäbitz,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1005-1006]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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Therapeutic potential of translocator protein ligands for age-related macular degeneration.

Xing Li, Zhiming He, Xinhua Shu,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):793-794]

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Axon regeneration: membrane expansion and lipidomics.

Sean Meehan, Sanjoy K Bhattacharya,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):989-990]

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Cholesterol synthesis inhibition or depletion in axon regeneration.

Bor Luen Tang,

Cholesterol is biosynthesized by all animal cells. Beyond its metabolic role in steroidogenesis, it is enriched in the plasma membrane where it has key structural and regulatory functions. Cholesterol is thus presumably important for post-injury axon regrowth, and this notion is supported by studies showing that impairment of local cholesterol ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):271-276]

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Measuring and Manipulating Membrane Cholesterol for the Study of Hedgehog Signaling.

Maia Kinnebrew, Kristen A Johnson, Arun Radhakrishnan, Rajat Rohatgi,

Cholesterol is an abundant lipid in mammalian plasma membranes that regulates the reception of the Hedgehog (Hh) signal in target cells. In vertebrates, cell-surface organelles called primary cilia function as compartments for the propagation of Hh signals. Recent structural, biochemical, and cell-biological studies have led to the model that Patched-1 ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2374:73-87]

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Imaging of the Ciliary Cholesterol Underlying the Sonic Hedgehog Signal Transduction.

Tatsuo Miyamoto, Kosuke Hosoba, Silvia Natsuko Akutsu, Shinya Matsuura,

Primary cilia are antenna-like structures that develop on the surface of quiescent G<sub>0</sub>-phase cells and receive extracellular signals including sonic hedgehog (Shh) for embryogenesis and adult tissue homeostasis. In mammalian cells, cholesterol activates the seven-transmembrane protein Smoothened to transduce the Shh signal. Germline mutations of the DHCR7 gene encoding the ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2374:49-57]

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An In Situ Fluorescence Assay for Cholesterol Transporter Activity of the Patched.

Wonhwa Cho, Arthur Ralko, Ashutosh Sharma,

We recently developed a simultaneous in situ quantitative imaging technique for cholesterol in both leaflets of the plasma membrane of mammalian cells. This ratiometric fluorescence technique allows real-time monitoring of the cholesterol transporter activity of plasma membrane-resident proteins in living cells. When applied to the hedgehog signaling system, it enables ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2374:37-47]

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The Effects of Exercise on Lipid Biomarkers.

Michael Vaughn F Mendoza, Sergey M Kachur, Carl J Lavie,

The World Health Organization has declared obesity to be a global epidemic that increases cardiovascular disease (CVD) mortality risk factors, such as hypertension, diabetes, dyslipidemia, and atherosclerosis. The increasing ratio of time spent in sedentary activities to that spent performing physically demanding tasks increases the trends to obesity and susceptibility ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:93-117]

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Analysis of Protein Cholesterylation by Biorthogonal Labeling.

Ao Hu, Meng Zhou, Bao-Liang Song,

Cholesterol modification (or cholesterylation) is a rare but important posttranslational lipid modification of proteins. So far, two proteins, namely Hedgehog and Smoothened, have been characterized to undergo cholesterylation. It is unknown whether other proteins are similarly modified. Here we present a protocol of a chemical biology method to analyze the ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2374:27-36]

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Obesity-related indices are associated with albuminuria and advanced kidney disease in type 2 diabetes mellitus.

Yu-Lun Ou, Mei-Yueh Lee, I-Ting Lin, Wei-Lun Wen, Wei-Hao Hsu, Szu-Chia Chen,

Obesity is an important risk factor for the development of diseases including diabetes, hypertension, and cardiovascular disease. However, few reports have investigated the relationships between these obesity-related indices and diabetic nephropathy. The aim of this study was to evaluate associations between obesity-related markers with albuminuria and advanced kidney disease in ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):1250-1258]

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Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells.

Chung-Yao Hsu, Jia-Yin Yeh, Chun-Ya Chen, Hui-Yu Wu, Meng-Hsuan Chiang, Chia-Lin Wu, Hwai-Jeng Lin, Cheng-Hsun Chiu, Chih-Ho Lai,

<i>Helicobacter pylori</i> infection is associated with several gastrointestinal diseases, including gastritis, peptic ulcers, and gastric cancer. Infection of cells with <i>H. pylori</i> is dependent on lipid rafts, which are cholesterol-rich microdomains located in the cell membrane. <i>H. pylori</i> cholesterol-α-glucosyltransferase (CGT) catalyzes the conversion of membrane cholesterol to cholesteryl glucosides, which ... Read more >>

Virulence (Virulence)
[2021, 12(1):2341-2351]

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Association between high-density lipoprotein cholesterol and apolipoprotein A-I and severe acute pancreatitis: a case-control study.

Yaling Li, Rui Zheng, Feng Gao, Li Wang, Shuyi Feng, Jie Li, Zhiming Huang,

<h4>Background</h4>Evidence is limited concerning the association between serum concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (APO A-I) and severe acute pancreatitis (SAP). This study was designed to explore whether HDL-C and APO A-I were independently correlated to SAP after adjusting for covariates.<h4>Methods</h4>There were 1127 patients with acute pancreatitis ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(12):1517-1523]

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Management of familial hypercholesterolemia in pregnancy.

Dorothy F Graham, Frederick J Raal,

<h4>Purpose of review</h4>To highlight quandaries and review options for the management of familial hypercholesterolemia (FH) during pregnancy.<h4>Recent findings</h4>Women with FH face barriers to effective care and consequently face significant disease related long term morbidity and mortality.Pregnancy includes major maternal physiological changes resulting in exacerbation of maternal hypercholesterolemia compounded by the ... Read more >>

Curr Opin Lipidol (Current opinion in lipidology)
[2021, 32(6):370-377]

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Polygenic contribution for familial hypercholesterolemia (FH).

Ana Margarida Medeiros, Mafalda Bourbon,

<h4>Purpose of review</h4>The present review summarizes different polygenic risk scores associated with hypercholesterolemia applied to cohorts with a genetic diagnosis of familial hypercholesterolemia (FH).<h4>Recent findings</h4>Several single-nucleotide polymorphisms associated with increased levels of LDL-C or Lp(a) have been genotyped in population cohorts with FH phenotype, to identify the cause of hypercholesterolemia ... Read more >>

Curr Opin Lipidol (Current opinion in lipidology)
[2021, 32(6):392-395]

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Histopathological assessment of radial artery calcification in patients with end-stage kidney disease.

Zhenwei Chen, Youjian Zhou, Tiecheng Yang,

<h4>Background</h4>A comprehensive understanding of vascular calcification pathology is significant for the development of cardiovascular disease therapy in high-risk populations. This cross-sectional study aimed to evaluate the prevalence and characteristics of radial artery calcification (RAC) and to identify the factors that are associated with RAC in end-stage kidney disease (ESKD).<h4>Methods</h4>Detailed medical ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):362-370]

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Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999-2016.

Chun-On Lee, Hang-Long Li, Man-Fung Tsoi, Ching-Lung Cheung, Bernard Man Yung Cheung,

<h4>Background</h4>The liver fat score (LFS) has been proposed to be a simple non-invasive marker of non-alcoholic fatty liver disease (NAFLD), which is highly prevalent in the general population. We tested its association with cardiovascular diseases (CVDs) and prognosis.<h4>Methods</h4>17,244 adult participants from the National Health and Nutrition Examination Survey 1999-2016 were ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1065-1073]

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Association between Systemic Lupus Erythematosus and Coronary Heart Disease: a retrospective case-control analysis and Mendelian Randomization Study

Jinyun Chen, Junmei Tian, Wen Wang, Shiliang Zhou, Lu Zhang, Wanlan Jiang, Mingyuan Cai, Peirong Zhang, Ting Xu, Min Wu,

<h4>Objectives</h4> To appraise the causal effect of systemic lupus erythematosus (SLE) for risk of Coronary heart disease (CHD). <h4>Methods</h4> We selected single nucleotide polymorphisms (SNPs) associated with SLE as instrumental variables (IVs) from three independent genome-wide association studies (GWAS), the three largest to date for SLE of European ancestry. Then ... Read more >>

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Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.

Wen Hu, Ziyu Liu, Weinan Yu, Surong Wen, Xiaoqing Wang, Xing Qi, Hairong Hao, Yanwen Lu, Jing Li, Shayan Li, Hongwen Zhou,

<h4>Objective</h4>This study aimed to investigate the effects of <i>PPM1K</i> rs1440581 and rs7678928 single nucleotide polymorphisms (SNPs) on the serum branched-chain amino acids (BCAAs) levels and cardiovascular disease (CVD) risk.<h4>Methods</h4>Anthropometric and biochemical examinations were performed at baseline and the end of 4 years in 234 individuals who were randomly recruited from ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1316-1326]

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