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Chlamydial Pneumonias

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Gemykibivirus Genome in Lower Respiratory Tract of Elderly Woman With Unexplained Acute Respiratory Distress Syndrome.

Jian Wang, Yanpeng Li, Xi He, Jinmin Ma, Wenxin Hong, Fengyu Hu, Lingzhai Zhao, Qiongfang Li, Jianhui Zhang, Chiyu Zhang, Fuchun Zhang,

Using metagenomics analysis, we are the first to identify the presence of a small, circular, single-stranded Gemykibivirus (GkV) genome from the respiratory tract of an elderly woman with severe acute respiratory distress syndrome. Our results suggest that further studies on whether GkVs infect humans and cause respiratory disease are needed. ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(5):861-864]

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Survey on Chlamydiaceae in cloacal swabs from Swiss turkeys demonstrates absence of Chlamydia psittaci and low occurrence of Chlamydia gallinacean.

Barbara Renate Vogler, Michal Trinkler, Hanna Marti, Nicole Borel, Theresa Pesch, Barbara Prähauser, Richard Hoop, Prisca Mattmann, Sarah Albini,

In Switzerland, domestic turkey meat is a niche product. Turkeys are fattened on mixed family-based farms scattered across the country, with most providing access to an uncovered outdoor pasture for the birds. Swiss fattening turkeys may therefore get infected with Chlamydiaceae via wild birds or their faeces, potentially shedding these ... Read more >>

PLoS ONE (PloS one)
[2019, 14(12):e0226091]

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Multi-peptide ELISAs overcome cross-reactivity and inadequate sensitivity of conventional Chlamydia pneumoniae serology.

Kh Shamsur Rahman, Bernhard Kaltenboeck,

Cross-reactivity of classical chlamydial antigens compromises Chlamydia (C.) pneumoniae serology. By testing with 185 human antisera, we expanded 18 previously discovered C. pneumoniae-specific B-cell epitopes to 48 peptide antigens from 12 C. pneumoniae immunodominant proteins. For specific detection of antibodies against C. pneumoniae, we developed novel ELISAs with strongly reactive individual ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15078]

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[Human Psittacosis: A Case Report].

Ana Cipriano, Ana Machado, Fábio Videira Santos, Miguel Araújo Abreu, Rui Sarmento Castro,

Psittacosis is a rare disease caused by Chlamydophila psittaci, an intracellular bacteria transmitted by contaminated birds. The clinical and radiological presentations are nonspecific. We describe a case of a 42-year-old woman, with known exposure to birds, who presented to the emergency department with one-week evolution of myalgia, polyarthritis, and respiratory ... Read more >>

Acta Med Port (Acta medica portuguesa)
[2019, 32(2):161-164]

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Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues.

Sankhya Bommana, Adam Polkinghorne,

Chlamydia are a genus of successful obligate intracellular pathogens spread across humans, wildlife, and domesticated animals. The most common species reported in livestock in this genus are Chlamydia abortus, Chlamydia psittaci, Chlamydia suis, and Chlamydia pecorum. Chlamydial infections trigger a series of inflammatory disease-related sequelae including arthritis, conjunctivitis, pneumonia, and ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:113]

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Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia.

Michael Steurer, Marco Montillo, Lydia Scarfò, Francesca R Mauro, Johannes Andel, Sophie Wildner, Livio Trentin, Ann Janssens, Sonja Burgstaller, Anna Frömming, Thomas Dümmler, Kai Riecke, Matthias Baumann, Diana Beyer, Stéphanie Vauléon, Paolo Ghia, Robin Foà, Federico Caligaris-Cappio, Marco Gobbi,

Olaptesed pegol (NOX-A12) is a pegylated structured L-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine tightly regulating the life cycle of chronic lymphocytic leukemia cells. The resulting inhibition of CXCR4 and CXCR7 signaling reduces the protective activity of the bone marrow and lymph node microenvironment. CXCL12 inhibition mobilizes chronic lymphocytic ... Read more >>

Haematologica (Haematologica)
[2019, 104(10):2053-2060]

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Respiratory Disorders.

Karen Hardy, Osama Naga,

This chapter provides the reader with a concise outline of the topics required for general pediatric board examination, respiratory component. Basic diagnostic testing is reviewed. Common upper airway problems, lower airway issues, and parenchymal diseases are covered. Congenital malformations and common diseases of the lung are reviewed. The physiology of ... Read more >>

(Pediatric Board Study Guide)
[0, :291-312]

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Psittacosis Outbreak among Workers at Chicken Slaughter Plants, Virginia and Georgia, USA, 2018.

Kelly A Shaw, Christine M Szablewski, Stephanie Kellner, Laura Kornegay, Patricia Bair, Skyler Brennan, Audrey Kunkes, Meredith Davis, Olivia L McGovern, Jonas Winchell, Miwako Kobayashi, Nancy Burton, Marie A de Perio, Julie Gabel, Cherie Drenzek, Julia Murphy, Caroline Holsinger, Laurie Forlano,

During August-October, 2018, an outbreak of severe respiratory illness was reported among poultry slaughter plant workers in Virginia and Georgia, USA. A multiorganizational team investigated the cause and extent of illness, determined that the illness was psittacosis, and evaluated and recommended controls for health hazards in the workplace to prevent ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2019, 25(11):2143-2145]

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Technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries.

Suzanna C Francis, Arun Parajuli, Otilia Mardh, Jane Falconer, Aura Andreasen, Emma Harding-Esch, ,

OBJECTIVES:This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care for populations at risk for specific curable sexually transmitted infections (STIs) (chlamydia, gonorrhoea, syphilis, trichomoniasis, and Mycoplasma genitalium infections). ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):64]

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Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.

Olga M Sigalova, Andrei V Chaplin, Olga O Bochkareva, Pavel V Shelyakin, Vsevolod A Filaretov, Evgeny E Akkuratov, Valentina Burskaia, Mikhail S Gelfand,

BACKGROUND:Chlamydia are ancient intracellular pathogens with reduced, though strikingly conserved genome. Despite their parasitic lifestyle and isolated intracellular environment, these bacteria managed to avoid accumulation of deleterious mutations leading to subsequent genome degradation characteristic for many parasitic bacteria. RESULTS:We report pan-genomic analysis of sixteen species from genus Chlamydia including identification ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):710]

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In Vitro Activity of Omadacycline against Chlamydia pneumoniae.

Stephan A Kohlhoff, Natalia Huerta, Margaret R Hammerschlag,

The in vitro activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of Chlamydia pneumoniae The minimum inhibitory concentration at which 90% of the isolates of C. pneumoniae were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 to 0.5 μg/ml). ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(2):]

Cited: 3 times

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A Bird's-Eye View of Chronic Unilateral Conjunctivitis: Remember about Chlamydia psittaci.

Stien Vandendriessche, Joanna Rybarczyk, Pieter-Paul Schauwvlieghe, Geraldine Accou, Anne-Marie Van den Abeele, Daisy Vanrompay,

Chlamydia psittaci causes psittacosis in humans, mainly in people in contact with birds in either the setting of occupational or companion bird exposure. Infection is associated with a range of clinical manifestations from asymptomatic infection to severe atypical pneumonia and systemic disease. C. psittaci has also been associated with ocular ... Read more >>

Microorganisms (Microorganisms)
[2019, 7(5):]

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Evaluation of a PCR-electrospray ionization mass spectrometry platform for detection and identification of fungal pathogens directly from prospectively collected bronchoalveolar lavage specimens.

Bei Jia, Robert Lovari, Heather Miller, David Metzgar, Christian Massire, Heather Carolan, Donna Toleno, Franco D'Alessio, Richard Rothman, Lawrence B Blyn, Sean X Zhang,

The incidence of invasive fungal infections is on the rise worldwide due to the growth of the immunocompromised population. We report here the use of a diagnostic assay that utilizes a universal extraction method, broad spectrum PCR amplification and analysis via electrospray ionization mass spectrometry (PCR/ESI-MS) to detect and identify ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2020, 97(1):114988]

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Evaluation of Viruses Associated With Acute Respiratory Infections in Long-Term Care Facilities Using a Novel Method: Wisconsin, 2016‒2019.

Mary M Checovich, Shari Barlow, Peter Shult, Erik Reisdorf, Jonathan L Temte,

Residents of long-term care facilities (LCTFs) have high morbidity and mortality associated with acute respiratory infections (ARIs). Limited information exists on the virology of ARI in LTCFs, where virological testing is reactive. We report on findings of a surveillance feasibility substudy from a larger prospective trial of introducing rapid influenza ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, 21(1):29-33]

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[Psittacosis - a forgotten diagnosis in Sweden?]

Ulrika Marking, Berit Hammas, Malin Grabbe, Christian Giske,

Psittacosis, parrot fever, is an infectious disease caused by Chlamydophila psittaci, a common pathogen among birds. The clinical course ranges from a mild flu-like illness to severe disease that requires intensive care in humans. We report three cases of severe pneumonia where C. psittaci was unexpectedly detected during routine validation ... Read more >>

Lakartidningen (Lakartidningen)
[2018, 115:]

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[Laboratory diagnosis of rare diseases].

Elvar Theodorsson,

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower ... Read more >>

Lakartidningen (Lakartidningen)
[2018, 115:]

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Age distribution and seasonality in acute eosinophilic pneumonia: analysis using a national inpatient database.

Koshi Ota, Yusuke Sasabuchi, Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi, Hideo Yasunaga,

BACKGROUND:Acute eosinophilic pneumonia (AEP) is a rare inflammatory lung disease. Previous studies have shown that most patients with AEP are aged 20 to 40 years, whereas several case studies have included older patients with AEP. These studies also suggested that AEP is more prevalent in summer, but they were limited due ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2019, 19(1):38]

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Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infection.

Sai Qiao, Hong Zhang, Xiaoyu Zha, Wenhao Niu, Juyou Liang, Gaoju Pang, Yingying Tang, Tengli Liu, Huili Zhao, Yue Wang, Hong Bai,

Chlamydia is an obligate intracellular bacteria, which can infect cervix, urethra, conjunctiva, joints, lungs and so on. Neutrophils are important in host protection against microbial invasion during the early phase of infection. Here, to investigate the mechanism of IL-17A in recruiting neutrophils during Chlamydia muridarum (Cm) lung infection, we introduced ... Read more >>

Microb. Pathog. (Microbial pathogenesis)
[2019, 129:106-111]

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Prebiotics and probiotics in atopic dermatitis.

Emilia Rusu, Georgiana Enache, Raluca Cursaru, Alexandra Alexescu, Raluca Radu, Oana Onila, Teodora Cavallioti, Florin Rusu, Mihaela Posea, Mariana Jinga, Gabriela Radulian,

Recent years have brought additional data on the benefits of prebiotics and probiotics treatment in patients with atopic dermatitis. This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. The terms used for the search were 'prebiotic', 'probiotic', 'atopic dermatitis', 'Severity Scoring of Atopic ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2019, 18(2):926-931]

Cited: 1 time

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Immunogenicity And Safety Of The 13-Valent Pneumococcal Conjugate Vaccine In Patients With Monoclonal Gammopathy Of Undetermined Significance - Relationship With Selected Immune And Clinical Parameters.

Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Ewelina Grywalska, Agnieszka Stelmach-Gołdyś, Artur Kowalik, Stanisław Góźdź, Jacek Roliński,

Purpose:Patients with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of developing infections. Streptococcus pneumoniae vaccinations are recommended for immunocompromised patients, including patients with lymphoproliferative disorders such as MGUS. The objective of the study was to assess the immune response to the 13-valent pneumococcal conjugate vaccine (PCV13) in ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2019, 14:1741-1749]

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Flow-based regenerable chemiluminescence receptor assay for the detection of tetracyclines.

Verena K Meyer, Claire V Chatelle, Wilfried Weber, Reinhard Niessner, Michael Seidel,

For the first time, a flow-based regenerable chemiluminescence receptor assay is established that is eminently suited as screening method for the detection of widely used tetracyclines (TCs) in environmental and food samples. The complex functionality and high reactivity of TCs complicate the creation of immunogens which is currently the bottleneck ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2020, 412(14):3467-3476]

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Macrolide Allergic Reactions.

Kristy M Shaeer, Elias B Chahine, Sheeba Varghese Gupta, Jonathan C Cho,

Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2019, 7(3):]

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A snapshot of pneumonia research activity and collaboration patterns (2001-2015): a global bibliometric analysis.

José M Ramos-Rincón, Héctor Pinargote-Celorio, Isabel Belinchón-Romero, Gregorio González-Alcaide,

BACKGROUND:This article describes a bibliometric review of the scientific production, geographical distribution, collaboration, impact, and subject area focus of pneumonia research indexed on the Web of Science over a 15-year period. METHODS:We searched the Web of Science database using the Medical Subject Heading (MeSH) of "Pneumonia" from January 1, 2001 ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2019, 19(1):184]

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Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective.

Marisa Di Pietro, Simone Filardo, Silvio Romano, Rosa Sessa,

Research in Chlamydia trachomatis and Chlamydia pneumoniae has gained new traction due to recent advances in molecular biology, namely the widespread use of the metagenomic analysis and the development of a stable genomic transformation system, resulting in a better understanding of Chlamydia pathogenesis. C. trachomatis, the leading cause of bacterial ... Read more >>

Microorganisms (Microorganisms)
[2019, 7(5):]

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Treatment of Neonatal Chlamydial Conjunctivitis: A Systematic Review and Meta-analysis.

Andrew Zikic, Holger Schünemann, Teodora Wi, Ornella Lincetto, Nathalie Broutet, Nancy Santesso,

Background:With the continued high prevalence of chlamydia worldwide and high risk of transfer from mothers to their infant during delivery, a need for safe and effective therapies for infants who acquire a chlamydial infection remains. We conducted a systematic review and meta-analysis of antibiotic treatments, including oral erythromycin, azithromycin, and ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2018, 7(3):e107-e115]

Cited: 1 time

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