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Childhood Optic Neuritis

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First Clinical Experience with Anti-myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis.

Jan Heckmann, Margarita Todorova, Stefanie Müller, Philip Julian Broser, Veit Sturm,

BACKGROUND:Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been consistently found in a range of demyelinating disorders. In this context, MOG-IgG-associated optic neuritis (ON) has been suggested as a new subset of optic neuropathy. However, clinical manifestations and distinctive characteristics have only rarely been described. PATIENTS AND METHODS:A retrospective case series ... Read more >>

Klin Monbl Augenheilkd (Klinische Monatsblatter fur Augenheilkunde)
[2020, :]

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Medical management of acute loss of vision in tuberculous meningitis: A case report.

Maryam Amour, Sarah Shali Matuja, Jerome H Chin,

Blindness and vision impairment are unpredictable complications of tuberculous meningitis (TBM) that are often unrecognized in the acute stages of illness due to inability to assess vision in patients with depressed levels of consciousness or confusion. We present a patient with definite TBM confirmed by positive Xpert MTB/RIF assay of ... Read more >>

J Clin Tuberc Other Mycobact Dis (Journal of clinical tuberculosis and other mycobacterial diseases)
[2020, 19:100145]

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Dramatic efficacy of ofatumumab in refractory pediatric-onset AQP4-IgG neuromyelitis optica spectrum disorder.

Elisabeth Maillart, Florence Renaldo, Caroline Papeix, Kumaran Deiva, Julie Bonheur, Teresa Kwon, Odile Boespflug-Tanguy, David Germanaud, Romain Marignier,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Ocular side effects of antirheumatic medications: a qualitative review.

Clara M Castillejo Becerra, Yue Ding, Beatrice Kenol, Andrew Hendershot, Alexa Simon Meara,

Topic:This paper reviews the ocular side effects of medications used in the treatment of rheumatological conditions. Clinical relevance:Rheumatic diseases are inflammatory conditions that may affect the skin, blood vessels, joints, muscles and internal organs. Immunosuppressive agents are often used as treatment and while powerful, they carry side effects and toxicities ... Read more >>

BMJ Open Ophthalmol (BMJ open ophthalmology)
[2020, 5(1):e000331]

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Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss.

Christopher Le, Adam Jacob, Devarajan Iyengar, John Dedousis, Antonios Tsompanidis,

Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage IV small cell lymphocytic lymphoma, who presented to the emergency room ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2020, 2020:3752409]

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Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium.

Michael Enders, Thorsten Heider, Andreas Ludwig, Stefanie Kuerten,

Calcium ions are vital for maintaining the physiological and biochemical processes inside cells. The central nervous system (CNS) is particularly dependent on calcium homeostasis and its dysregulation has been associated with several neurodegenerative disorders including Parkinson's disease (PD), Alzheimer's disease (AD) and Huntington's disease (HD), as well as with multiple ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases.

Jun Yang, Qinqing Li,

Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn2+. Mn2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to describe ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:143]

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Acute disseminated encephalomyelitis (ADEM) associated with mosquito-borne diseases: Chikungunya virus X yellow fever immunization.

Karolyna Carvalho, Ana Luiza Biancardi, Giovanna Provenzano, Haroldo Moraes,

Acute disseminated encephalomyelitis (ADEM) is a demyelinating autoimmune neuropathic condition characterized by extensive bilateral and confluent lesions in the cerebral white matter and cerebellum. The basal ganglia and gray matter may also be involved. In most cases, the symptoms are preceded by viral infection or vaccination. In this report, we ... Read more >>

Rev. Soc. Bras. Med. Trop. (Revista da Sociedade Brasileira de Medicina Tropical)
[2020, 53:e20190160]

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Multiphasic acute disseminated encephalomyelitis and differential with early onset multiple sclerosis.

Arla Cinderella Stokes Brackett, Otto Jesus Hernández-Fustes, Carlos Arteaga Rodríguez, Olga Judith Hernandez Fustes,

Multiple sclerosis is considered the most frequent demyelinating disorder of the Central Nervous System (CNS) among young adults, yet is very rare before 10 years old. Acute disseminated encephalomyelitis is a monophasic, polysymptomatic disorder that involves the CNS white matter with demyelinating lesions, which usually occurs after systemic viral infections. ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):61-63]

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Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children.

In Jeong Lyu, Kyung-Ah Park, Sei Yeul Oh,

We investigated the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluated the associated risk factors. This cross-sectional study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced-depth image spectral-domain (SD) optical coherence ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2238]

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Simultaneous involvement of optic and abducens nerves by Lyme disease: Case report with review of the literature.

Iman Dabiri, Ahmet Z Burakgazi,

Ocular manifestations of Lyme disease (LD) remain a rare feature of the disease, but it may present a wide range of clinical presentations with different combinations. LD related optic neuritis or cranial nerve (CN) six palsy have been reported in the literature. However, this is the first case report of ... Read more >>

Neurol Int (Neurology international)
[2019, 11(3):8241]

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Cranio-Orbital and Orbitocranial Approaches to Orbital and Intracranial Disease: Eye-Opening Approaches for Neurosurgeons.

Hussam Abou-Al-Shaar, Khaled M Krisht, Michael A Cohen, Abdullah M Abunimer, Jayson A Neil, Michael Karsy, Gmaan Alzhrani, William T Couldwell,

Orbital approaches for targeting intracranial, orbital, and infratemporal disease have evolved over the years in an effort to discover safe, reliable, effective, and cosmetically satisfying surgical corridors. The surgical goals of these approaches balance important factors such as proximity of the lesion to the optic nerve, the degree of anticipated ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:1]

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Penicillin allergy: a practical approach to assessment and prescribing.

Misha Devchand, Jason A Trubiano,

Penicillin allergies are not always lifelong Approximately 50% are lost over five years: A reaction to penicillin during a childhood infection is unlikely to be a true allergy: Only 1–2% of patients with a confirmed penicillin allergy have an allergy to cephalosporins In patients with a low risk of severe ... Read more >>

Aust Prescr (Australian prescriber)
[2019, 42(6):192-199]

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Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent.

Ismail Ibrahim Ismail, John K John, Mohamed Ibrahim, Jasem Yousef Al-Hashel,

Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2020, 12(1):50-55]

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Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.

Dengpan Song, Dingkang Xu, Qiang Gao, Peizhu Hu, Fuyou Guo,

Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis of the lower limbs and incontinence. The initial MRI of the spinal cord revealed expansion and abnormal ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:99]

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Transitional B cells involved in autoimmunity and their impact on neuroimmunological diseases.

Yang Zhou, Ying Zhang, Jinming Han, Mengge Yang, Jie Zhu, Tao Jin,

Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in healthy individuals, the frequency of CD24hiCD38hi TrB cells in circulation may be altered in individuals with ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):131]

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Visual impairment in children with a brain tumor: a prospective nationwide multicenter study using standard visual testing and optical coherence tomography (CCISS study).

M A Nuijts, M H Degeling, I Stegeman, A Y N Schouten-van Meeteren, S M Imhof,

BACKGROUND:Children with a brain tumor have a high risk of impaired vision. Up to now, visual acuity measurement, visual field testing and orthoptic testing are the most informative diagnostic investigations for the assessment of visual function. Evaluating vision in children can be challenging given the challenges in cooperation, concentration and ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2019, 19(1):220]

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Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor-related adverse reactions in the nervous system.

Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu Huang, Liying Cui, Yuzhou Guan, Li Zhang,

Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%-12% and 80% of nervous system adverse reactions occur within the first four months of application. ICIs can cause diseases of various parts of the nervous system including central nervous system diseases such as ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(2):481-487]

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Normal measurements of the optic nerve, optic nerve sheath and optic chiasm in the adult population.

Sanele S Mncube, Matthew D Goodier,

Background:Imaging assessment of the anterior visual pathway structures, particularly the optic nerves (ON), requires knowledge of normal dimensions. Several studies suggesting techniques and normal ranges have been performed, but most suffer from various methodological flaws. This study is the first to be performed in a South African population. Objectives:The aim ... Read more >>

SA J Radiol (SA journal of radiology)
[2019, 23(1):1772]

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Understanding Childhood Neuroimmune Diseases of the Central Nervous System.

Sara Matricardi, Giovanni Farello, Salvatore Savasta, Alberto Verrotti,

Immune-mediated diseases of the central nervous system (CNS) in childhood are a heterogeneous group of rare conditions sharing the inflammatory involvement of the CNS. This review highlights the growing knowledge of childhood neuroimmune diseases that primarily affect the CNS, outlining the clinical and diagnostic features, the pathobiological mechanisms and genetics, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:511]

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"Disability Grief": A patient's allegorical expression of her disability.

Abdorreza Naser Moghadasi,

Iran J Neurol (Iranian journal of neurology)
[2019, 18(4):190-191]

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Systemic sarcoidosis presenting as optic nerve head granuloma.

Srikanta Kumar Padhy, Vinod Kumar,

Indian J Ophthalmol (Indian journal of ophthalmology)
[2019, 67(10):1714-1715]

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Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair.

Davide Marangon, Marta Boccazzi, Davide Lecca, Marta Fumagalli,

: Myelin is an essential structure that protects axons, provides metabolic support to neurons and allows fast nerve transmission. Several neurological diseases, such as multiple sclerosis, are characterized by myelin damage, which is responsible of severe functional impairment. Myelin repair requires the timely recruitment of adult oligodendrocyte precursor cells (OPCs) ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Pediatric autoimmune encephalitis: Recognition and diagnosis.

Marienke A A M de Bruijn, Arlette L Bruijstens, Anna E M Bastiaansen, Agnes van Sonderen, Marco W J Schreurs, Peter A E Sillevis Smitt, Rogier Q Hintzen, Rinze F Neuteboom, Maarten J Titulaer, ,

OBJECTIVE:The aims of this study were (1) to describe the incidence of autoimmune encephalitis (AIE) and acute disseminated encephalomyelitis (ADEM) in children, (2) to validate the currently used clinical criteria to diagnose AIE, and (3) to describe pitfalls in the diagnosis of pediatric autoimmune (AI) and inflammatory neurologic disorders. METHODS:This ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Dimethyl Fumarate Was Ineffective but Not Harmful for a Patient with Myelin Oligodendrocyte Glycoprotein Antibody Disease.

Yoko Warabi, Toshiyuki Takahashi, Eiji Isozaki,

We treated a myelin oligodendrocyte glycoprotein (MOG) antibody disease patient who had been prescribed dimethyl fumarate because she was thought to have been suffering from multiple sclerosis (MS). Mild optic neuritis relapsed at one year and four months after the administration of dimethyl fumarate. Therefore, dimethyl fumarate was ineffective for ... Read more >>

Cureus (Cureus)
[2019, 11(10):e6040]

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