Full Text Journal Articles about
Chemotherapy

Advertisement

Find full text journal articles






DMSO reduces the cytotoxicity of anticancer ruthenium complex KP1019 in yeast.

Jonathan Davis, Anne Cetto, Mary Campbell, Seth Scoggins, Laura Stultz, Pamela Hanson,

Low solubility in aqueous solutions is a significant limitation of the otherwise promising anticancer ruthenium complex KP1019. In laboratory studies, this challenge is often overcome by using DMSO to help drive the drug into solution. Since DMSO was previously shown to alter the bioactivity of platinum-based chemotherapeutics, here we examine ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

View full text PDF listing >>



Some effects of a chrysin bromide-derivative on GABA-A receptors and on Caenorhabditis elegans.

José Téllez-Arreola, Alejandro Valdez-Calderón, Simplicio González-Montiel, Ataúlfo Martinez-Torres, Adan Hernandez,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

View full text PDF listing >>



Advertisement

Research advances on how metformin improves memory impairment in "chemobrain".

Ahmad Alhowail, Sridevi Chigurupati,

Cognitive impairment caused by chemotherapy, referred to as "chemobrain," is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):15-19]

Cited: 0 times

View full text PDF listing >>



Clinical and prognostic characteristics of 95 cases of Langerhans cell histiocytosis in children: a single-institute experience from 2013 to 2020.

Xue Tang, Ju Gao, Zhi-Gui Ma, Xia Guo, Qiang Li, Zhi Wan, Jing-Jing Sun,

<h4>Background</h4>This study aimed to understand the clinical characteristics and outcomes of children with Langerhans cell histiocytosis (LCH) in China.<h4>Methods</h4>We conducted a retrospective study of 95 paediatric patients with LCH in West China Second University Hospital of Sichuan University between July 2013 and August 2020.<h4>Results</h4>The onset age of multisystem LCH (MS-LCH) ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1537-1546]

Cited: 0 times

View full text PDF listing >>



Acute leukemia in pregnancy: a single institutional experience with 21 cases at 10 years and a review of the literature.

Dengqin Zhu, Doudou Tang, Xiaoshan Chai, Guangsen Zhang, Yewei Wang,

<h4>Introduction</h4>Acute leukemia (AL) occurring in pregnancy is extremely rare, and its treatment is a clinical dilemma.<h4>Methods</h4>We retrospectively reviewed the medical records of our hospital from 2010 to 2019.<h4>Results</h4>Twenty-one patients were diagnosed with AL during pregnancy. Of whom, eighteen had acute myeloid leukemia, and 3 had acute lymphoblastic leukemia. Six, eight ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):567-575]

Cited: 0 times

View full text PDF listing >>



A five-year retrospective study of treatment outcomes using the L-asparaginase-based regimen as a first-line chemotherapy protocol for patients diagnosed with extranodal NK/T-cell lymphoma, nasal-type, in Thailand.

Pongthep Vittayawacharin, Archrob Khuhapinant,

<h4>Objective</h4>To assess clinical outcomes of newly diagnosed extranodal NK/T-cell lymphoma nasal-type (ENKTL) patients treated with L-asparaginase-containing chemotherapy as first-line chemotherapy.<h4>Materials and methods</h4>We retrospectively reviewed data of new ENKTL patients in Siriraj Hospital, Thailand during 2012-2016.<h4>Results</h4>Among 27 patients, 16 were men and 11 were women, and their median age was 52 ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):75-82]

Cited: 0 times

View full text PDF listing >>



Safety and efficacy of different doses of anthracyclines combined with arsenic trioxide and all-trans retinoic acid in the treatment of de novo acute promyelocytic leukemia.

Yaxue Wu, Peng Ke, Haixia Zhou, Depei Wu, Suning Chen, Huiying Qiu, Yue Han, Caixia Li, Xiao Ma, Aining Sun, Xiaowen Tang, Xiaohui Hu,

<h4>Objectives</h4>The purpose of this study was to evaluate the efficacy and safety of different doses of anthracyclines combined with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for induction in newly diagnosed acute promyelocytic leukemia (APL).<h4>Methods</h4>One hundred and forty patients were included between January 2011 and December 2017. Seventy patients ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):271-276]

Cited: 0 times

View full text PDF listing >>



Impact and feasibility of a pharmacist-delivered pharmacotherapy rotation on pediatric resident education.

Joseph M LaRochelle, Aryn C Karpinski, Bonnie Desselle, Sheila W Chauvin,

Pharmacotherapy training for pediatric residents is an important part of their overall education. Limited data exist describing formal engagement of clinical pharmacists in residency training. The objective of this study was to evaluate a novel pharmacotherapy rotation for learner gains and program feasibility. We designed a novel pharmacotherapy rotation (PTR) ... Read more >>

Med Educ Online (Medical education online)
[2021, 26(1):1955645]

Cited: 0 times

View full text PDF listing >>



Characteristics of 18F-FDG and 18F-FDOPA PET in an 8-year-old neutered male Yorkshire Terrier dog with glioma: long-term chemotherapy using hydroxyurea plus imatinib with prednisolone and immunoreactivity for PDGFR-β and LAT1.

Taesik Yun, Yoonhoi Koo, Sanggu Kim, Wonguk Lee, Hakhyun Kim, Dongwoo Chang, Soochong Kim, Mhan-Pyo Yang, Byeong-Teck Kang,

An 8-year-old neutered male Yorkshire Terrier dog presented with head pressing, vestibular ataxia, neck tenderness, and no oculocephalic reflex. A demarcated lesion in the pons was identified on MRI. The patient was tentatively diagnosed with a glioma and was treated with hydroxyurea plus imatinib and prednisolone. After 30 days of ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):163-171]

Cited: 0 times

View full text PDF listing >>



Patient vital signs in relation to ICU admission in treatment of acute leukemia: a retrospective chart review.

Katharine McLaughlin, Amanda Stojcevski, Abdulkadir Hussein, Devinder Moudgil, Indryas Woldie, Caroline Hamm,

<h4>Objectives</h4>The objective of the current study was to investigate the relationship between changes in vital signs and intensive care unit (ICU) admission. Windsor Regional Hospital treats 15-20 new patients a year with acute leukemia. These patients are at increased risk of neutropenic fevers and admission to the ICU following induction ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):637-647]

Cited: 0 times

View full text PDF listing >>



Effect of Superparamagnetic [email protected]γ-Fe₂O₃ Combined with Carmustine on Cervical Cancer.

Shu Wen, Weiping Xing, Lingxue Gao, Shuping Zhao,

This study aimed to investigate the effects of [email protected]<i>γ</i>-Fe₂O₃ nanomagnetic fluid thermotherapy combined with the chemotherapy drug carmustine on cervical cancer cells under a certain intensity of alternating magnetic field. And the role of Mir-590-3P in the development and progression of cervical cancer. The optimal thermotherapy concentration of <i>γ</i>-Fe₂O₃ nanomaterials ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(12):6196-6204]

Cited: 0 times

View full text PDF listing >>



Genetic features and efficacy of decitabine-based chemotherapy in elderly patients with acute myeloid leukemia.

Bianhong Wang, Wei Guan, Na Lv, Ting Li, Fan Yu, Yuehua Huang, Yanying Wang, Lihong Li, Li Yu,

<h4>Objectives</h4>The outcome of elderly acute myeloid leukemia (AML) patients is poor, which was traditionally attributed to patient- and leukemia-related factors. However, studies about the genetic features of these elderly patients have not been integrated and the genetic mechanism of their poor outcome is less known.<h4>Methods</h4>Here, we used next generation sequencing ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):371-379]

Cited: 0 times

View full text PDF listing >>



Efficacy and safety of cladribine addition to induction treatment of newly diagnosed acute myeloid leukemia: a systematic review and meta-analysis.

Qianying Pan, Juan Li,

<h4>Objectives</h4>Compared with the 3 + 7 regimen, the cladribine-containing regimen has led to improvements in the rate of complete remission (CR) in the treatment of newly diagnosed acute myeloid leukemia (AML) patients. We conducted a systematic review and meta-analysis to investigate the overall efficacy and safety of cladribine-containing regimens in the induction ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):577-587]

Cited: 0 times

View full text PDF listing >>



Efficacy and safety of consolidation therapy with intermediate and high dose cytarabine in acute myeloid leukemia patients.

Kittisak Tangchitpianvit, Ekarat Rattarittamrong, Chatree Chai-Adisaksopha, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Adisak Tantiworawit, Lalita Norasetthada,

<h4>Objectives</h4>The primary objective was to compare the efficacy of intermediate-dose cytarabine (IDAC) and high-dose cytarabine (HiDAC) as consolidation chemotherapy for acute myeloid leukemia (AML) in terms of a one-year-relapse-free survival rate (RFS). The secondary objectives were one-year-overall survival rate (OS) and adverse effects.<h4>Methods</h4>This was a retrospective study conducted at Chiang ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):355-364]

Cited: 0 times

View full text PDF listing >>



The effect of the detection of minimal residual disease for the prognosis and the choice of post-remission therapy of intermediate-risk acute myeloid leukemia without FLT3-ITD, NPM1 and biallelic CEBPA mutations.

Wen-Shuai Zheng, Ya-Lei Hu, Li-Xun Guan, Bo Peng, Shen-Yu Wang,

<h4>Background</h4>Intermediate-risk acute myeloid leukemia (IR-AML) without FLT3-ITD, NPM1 and biallelic CEBPA mutations (here referred to as NPM1<sup>mut-neg</sup>CEBPA<sup>dm-neg</sup>FLT3-ITD<sup>neg</sup> AML) is a clinically heterogeneous disease. The optimal post-remission therapy (PRT) is unclear for patients with NPM1<sup>mut-neg</sup>CEBPA<sup>dm-neg</sup>FLT3-ITD<sup>neg</sup> AML who achieved first complete response (CR1). This study aims to explore clinical and molecular factors ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):179-185]

Cited: 0 times

View full text PDF listing >>



T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges.

Omaima Ahmed, Yara Felimban, Abeer Almehdar,

Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present first before the diagnosis of A-T made. The chromosomalin stability in A-T increases the toxicity to radio-chemotherapeutic agents, ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):348-354]

Cited: 0 times

View full text PDF listing >>



Simulating drug penetration during hyperthermic intraperitoneal chemotherapy.

Daan R Löke, Roxan F C P A Helderman, Nicolaas A P Franken, Arlene L Oei, Pieter J Tanis, Johannes Crezee, H Petra Kok,

Hyperthermic intraperitoneal chemotherapy (HIPEC) is administered to treat residual microscopic disease after debulking cytoreductive surgery. During HIPEC, a limited number of catheters are used to administer and drain fluid containing chemotherapy (41-43 °C), yielding heterogeneities in the peritoneum. Large heterogeneities may lead to undertreated areas, increasing the risk of recurrences. Aiming ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):145-161]

Cited: 0 times

View full text PDF listing >>



Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2'-5'-oligoadenylate synthetase 2 axis in acute myeloid leukemia.

Hong Zhou, Xiaofeng Jia, Fan Yang, Pengfei Shi,

Acute myeloid leukemia (AML) represents a hematopoietic cancer with an invasive property. Chemoresistance blunts the therapeutic effect of chemotherapeutics in AML. Long noncoding RNAs (lncRNAs) have been implicated in chemotherapy resistance in AML. Transcriptome sequencing in the current study was applied to clarify the differentially expressed lncRNAs between peripheral blood ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6403-6417]

Cited: 0 times

View full text PDF listing >>



Stimuli-responsive drug delivery systems for head and neck cancer therapy.

Jingou Liang, Bina Yang, Xuedong Zhou, Qi Han, Jing Zou, Lei Cheng,

Head and neck cancer (HNC) is among the most common malignancy that has a profound impact on human health and life quality. The treatment for HNC, especially for the advanced cancer is stage-dependent and in need of combined therapies. Various forms of adjuvant treatments such as chemotherapy, phototherapy, hyperthermia, gene ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):272-284]

Cited: 1 time

View full text PDF listing >>



Clinical importance of serum secreted clusterin in predicting invasive breast cancer and treatment responses.

Qing-Feng Chen, Lei Chang, Qun Su, Ying Zhao, Bin Kong,

Enhanced serum secreted clusterin (sCLU) protein was associated with progression, poor prognosis and chemotherapy sensitivity evaluation in malignant patients. However, the clinical significance of serum sCLU protein levels in patients with invasive breast cancer (IBC) is unknown. In this study, the serum sCLU protein in 2648 patients with IBC was ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):278-285]

Cited: 0 times

View full text PDF listing >>



MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel.

Jie Yan, Litong Shi, Shan Lin, Yi Li,

Development of chemoresistance remains a major challenge in treating patients suffering from esophageal squamous cell carcinoma (ESCC), despite treatment advances. MicroRNAs (miRNAs) have been shown to play critical roles in the regulation of ESCC cell chemoresistance. Here, we aimed to investigate the role of miR-624 in ESCC and its molecular ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5334-5347]

Cited: 0 times

View full text PDF listing >>



The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.

Yujie Xie, Xiaoshun Shi, Ying Chen, Bomeng Wu, Xiaolin Gong, Weicheng Lu, Wanli Lin,

<h4>Background</h4>The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy. However, in-depth studies of immune subtypes (ISs), immune landscape and tumour microenvironment of oesophageal cancer (ESCA) and their clinical implications are less reported.<h4>Methods</h4>We first ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):626-638]

Cited: 0 times

View full text PDF listing >>



A 10-year cohort study of 175 primary gastrointestinal lymphoma cases in Thailand: clinical features and outcomes in the immunochemotherapy era.

Weerapat Owattanapanich, Theera Ruchutrakool, Tawatchai Pongpruttipan, Monthira Maneerattanaporn,

<h4>Background</h4>Primary gastrointestinal lymphoma (PGIL), an uncommon subtype of lymphoma, accounts for 1%-4% of gastrointestinal cancers. This study, therefore, aimed to investigate the current 10-year epidemiology and outcomes of PGIL.<h4>Methods</h4>This retrospective study involved a hospital-based chart review to analyze the epidemiology, clinical features, predisposing factors, and clinical outcomes of patients diagnosed ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):249-255]

Cited: 0 times

View full text PDF listing >>



Allogeneic hematopoietic cell transplantation using fludarabine plus myeloablative busulfan and melphalan confers promising survival in high-risk hematopoietic neoplasms: a single-center retrospective analysis.

Taro Edahiro, Takakazu Kawase, Hisao Nagoshi, Keita Fujino, Kayo Toishigawa, Takahiko Miyama, Tatsuji Mino, Tetsumi Yoshida, Takehiko Morioka, Yuji Hirata, Mitsunori Noma, Teruhisa Fujii, Masatoshi Nishizawa, Noriyasu Fukushima, Tatsuo Ichinohe,

<h4>Objectives</h4>Optimal selection of pretransplant conditioning is crucially vital for improving survival and quality-of-life of patients who receive allogeneic hematopoietic cell transplantation (allo-HCT), particularly in those with high-risk diseases. In this study, we evaluated the efficacy and safety of recently-developed reduced-toxicity myeloablative regimen that combines fludarabine, intravenous busulfan, and melphalan (FBM).<h4>Methods</h4>We ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):186-198]

Cited: 0 times

View full text PDF listing >>



Feasibility of six cycles of lenalidomide-based triplet induction before stem cell collection for newly diagnosed transplant-eligible multiple myeloma.

Satoshi Yoshihara, Kyoko Yoshihara, Yoshifumi Shimizu, Takehito Imado, Hiroyuki Takatsuka, Hiroyuki Kawamoto, Mahito Misawa, Hideki Ifuku, Yokiko Ohe, Masaya Okada, Yoshihiro Fujimori,

<h4>Objectives</h4>Achieving a deep response with induction therapy has a major impact on outcomes following autologous stem cell transplantation. Although longer and intensified induction therapy may provide better disease control, longer exposure to lenalidomide negatively affects stem cell yield. We examined the feasibility of 6 cycles of lenalidomide-based triplet induction therapy ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):388-392]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.375 s