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Some effects of a chrysin bromide-derivative on GABA-A receptors and on Caenorhabditis elegans.

José Téllez-Arreola, Alejandro Valdez-Calderón, Simplicio González-Montiel, Ataúlfo Martinez-Torres, Adan Hernandez,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities.

Ahmed M Shawky, Nashwa A Ibrahim, Mohammed A S Abourehab, Ashraf N Abdalla, Ahmed M Gouda,

In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and one normal (MRC-5) cell lines. The results of the MTT assay revealed potent cytotoxic ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):15-33]

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Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms.

Samir Mehndiratta, Mei-Chuan Chen, Yuh-Hsuan Chao, Cheng-Hsin Lee, Jing-Ping Liou, Mei-Jung Lai, Hsueh-Yun Lee,

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitution at C3 of quinoline is favoured for HDAC6 selectivity. Two ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):74-84]

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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells.

Shuaishuai Huang, Gulimire Tuergong, Hangjie Zhu, Xue Wang, Guobin Weng, Yu Ren,

Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemotherapy treatments. Norcantharidin (NCTD), a therapeutic compound derived from medicinal plants, has been shown to trigger apoptosis, as well as antimetastatic and antioxidant activities in several tumor cells. However, NCTD's mechanism of ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2021, 71(2):267-278]

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Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines.

Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R Marshall, Elisabetta Orlandini,

Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):34-47]

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Toxicity Effects of Anthracycline-Converted Herceptin and Azo-Functionalized Fe₃O₄ Nanoparticles on the Heart of Patients with Breast Cancer Based on Echocardiography.

Li Liu, Tingting Shen, Hongfang Liu, Gen Zhang, Yongfu Shao, Aliberti Antonino, Khoufi Ines, Meriem Djezzar,

The multifunctional nano-carrier system can simultaneously achieve multiple functions such as diagnostic imaging, targeted delivery of anti-tumor drugs, and combined therapy. Application potential Fe₃O₄ magnetic nanoparticles have the characteristics of low toxicity, superparamagnetism and good photothermal properties. Therefore, a multifunctional magnetic nanocarrier with both magnetic targeting and photothermal properties can ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):878-885]

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The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Mateusz Winder, Weronika Bulska-Będkowska, Jerzy Chudek,

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect. This review discusses two species of edible fungi, used for centuries in ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2021, 71(1):1-16]

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Application of Novel Hollow Carbon Nanosphere Drug-Loading System in Chemotherapy of Esophageal Squamous Cell Carcinoma.

Yi Chen, Min Xiang, Zhong Wang, Marcel Thieme, Charles Joenathan,

With the continuous improvement of carbon nanotube synthesis and purification technology and the continuous improvement of carbon nanotube dispersion technology, carbon nanotubes have played an increasingly important role in the treatment of malignant tumours. One of the hot spots. Compared with other carbon nanotube materials, the carbon nanosphere drug loading ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):814-823]

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Compare the Effects of Magnolol on Gastric Cancer Cells Through c-Jun N-Terminal Kinase Signaling Pathway and Gold Magnetic.

Yu Chen, Xiuyun He, Dagang Feng, Shijie Li, Bilel Romdhani, Sabrine Aroua,

This article explores the effects and mechanisms of magnolol on the proliferation of gastric cancer cells as well as the apoptosis. First, 0 (control group), 20, 40, and 80 /x mol/L magnolol were observed on SGC-7901 cells for 24, 48, and 72 h. We use MTT method to measure the ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):943-948]

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Limiting tumor cells comprehensively at micro and macro levels to improve the therapeutic effect of chemotherapy.

Binghua Wang, Lulu Sun, Jing Zhao, Jingyi An, Yajie Jin, Xinwei Yang, Haixia Li, Hongling Zhang, Zhenzhong Zhang, A Youmei,

Clinical data shows that antitumor treatments are often ineffective if tumor cells have metastasized. To gain an effective antitumor therapeutic effect, in this report, the tumor cell was limited to the primary site and simultaneously ablated by chemotherapy. Considering the extremely complicated process of cancer metastasis, we seek to comprehensively ... Read more >>

Nanotechnology (Nanotechnology)
[2021, 32(1):015301]

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Treatment of Primary Central Nervous System Germinomas With Short-course Induction Chemotherapy Followed by Low-dose Radiotherapy Without a Tumor Bed Boost: Prognostic Impact of Human Chorionic Gonadotropin.

Yung-Chih Chou, Yao-Yu Wu, Sheng-Ping Hung, Ngan-Ming Tsang, Ping-Ching Pai, Tang-Her Jaing, Chien-Yu Lin, Cheng-En Hsieh, Kang-Hsing Fan, Wei-Heng Kao, Chen-Kan Tseng,

OBJECTIVE:To investigate the clinical utility of short-course induction chemotherapy followed by low-dose radiotherapy without a tumor bed boost in patients with primary central nervous system (CNS) germinomas. METHODS:We retrospectively reviewed the clinical records of patients with primary CNS germinomas who received short-course induction chemotherapy (2 cycles of cisplatin 20 mg/m plus ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, :]

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Is there a seasonal variation of survival after systemic chemotherapy for metastatic castration-resistant prostate cancer in a rural part of North Norway?

Carsten Nieder, Astrid Dalhaug, Ellinor Haukland,

The winter darkness or polar night induces endocrine and metabolic mechanisms, which might reduce the efficacy of cancer treatment and thus contribute to shorter survival. Moreover, season-and weather-related treatment delays and irregularities might also cause reduced efficacy of anti-cancer drugs. Therefore, this study evaluated the prognostic impact of timing of ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1742520]

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Salvage systemic therapy for advanced gastric and oesophago-gastric junction adenocarcinoma.

Yoko Tomita, Max Moldovan, Rachael Chang Lee, Amy Hc Hsieh, Amanda Townsend, Timothy Price,

BACKGROUND:Salvage systemic therapy has become the new standard of care in patients with advanced gastric and oesophago-gastric junction (OGJ) adenocarcinoma, following disease progression on first-line fluoropyrimidine and platinum-containing chemotherapy. Pharmacological agents proven to be effective in this setting include both chemotherapy and biological therapy, however, the consensus on the best ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 11:CD012078]

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The stage-specific roles of radiotherapy and chemotherapy in nodular lymphocyte predominant Hodgkin lymphoma patients: a propensity score-matched analysis of the SEER database.

Shijie Wang, Mingfang Jia, Jianglong Han, Rui Zhang, Kejie Huang, Yunfeng Qiao, Ping Chen, Zhenming Fu,

BACKGROUND:The stage-specific roles of radiotherapy (RT) alone, chemotherapy alone, and combined RT and chemotherapy (CRT) for patients with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) have not been adequately evaluated. METHODS:We analyzed patients with all stages of NLPHL enrolled in the Surveillance, Epidemiology, and End Results (SEER) registry from January 2000 ... Read more >>

Cancer Med (Cancer medicine)
[2020, :]

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ATAS Acupuncture Reduces Chemotherapy Induced Fatigue in Breast Cancer Through Regulating ADROA1 Expression: A Randomized Sham-Controlled Pilot Trial.

Yun-Fen Li, De-Quan Liu, Jian-Yun Nie, De-Dian Chen, Mei Yan, Zhen Zuo, Liang-Xian Liu, Wei-Yu Wang, Mian-Sheng Zhu, Wen-Hui Li,

Objective:To investigate the feasibility and effectiveness of ATAS acupuncture (Acupoints-Time-Space Acupuncture) as a non-pharmacological intervention to prevent or relieve chemotherapy-induced fatigue in breast cancer patients undergoing taxane chemotherapy. Methods:A pilot study in Kunming center with the aim of evaluating 40 patients randomized to 3 groups: ATAS, sham and non-acupuncture with ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:11743-11754]

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Phase I feasibility study of Magnetic Resonance guided High Intensity Focused Ultrasound-induced hyperthermia, Lyso-Thermosensitive Liposomal Doxorubicin and cyclophosphamide in de novo stage IV breast cancer patients: study protocol of the i-GO study.

Josanne S de Maar, Britt B M Suelmann, Manon N G J A Braat, P J van Diest, H H B Vaessen, Arjen J Witkamp, S C Linn, Chrit T W Moonen, Elsken van der Wall, Roel Deckers,

INTRODUCTION:In breast cancer, local tumour control is thought to be optimised by administering higher local levels of cytotoxic chemotherapy, in particular doxorubicin. However, systemic administration of higher dosages of doxorubicin is hampered by its toxic side effects. In this study, we aim to increase doxorubicin deposition in the primary breast ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e040162]

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Intraoperative Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients with Locally Advanced Colon Cancer: A Prospective Parallel Phase II Study.

Ina Macaione, Lucio Mandalà, Antonella Campisi, Elena Roz, Sebastiano Mercadante, Dario Piazza, Pietro Mezzatesta, Vittorio Gebbia,

.Background: Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) showed promising results in patients with colorectal carcinoma at high risk of recurrence but still without clinically and radiologically evident signs of peritoneal spread. This study aims to analyze the feasibility of this proactive, early phase, multimodality approach. Methods: A mono-institutional, prospective, parallel, two-stage ... Read more >>

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Lack of National Adoption of Evidence-Based Treatment for Resectable Gastric Adenocarcinoma.

Tiffany C Lee, Koffi Wima, Mackenzie C Morris, Michael E Johnston, Shimul A Shah, Syed A Ahmad, Sameer H Patel, Gregory C Wilson,

BACKGROUND:Level 1 evidence for multimodal treatment of resectable gastric adenocarcinoma from the Intergroup 0116 (2001) and MAGIC (2006) trials demonstrated survival benefit of adjuvant chemoradiation (CRT) and perioperative chemotherapy, respectively. We evaluated the adoption of evidence-based treatment in the post-MAGIC era and its impact on survival. METHODS:A total of 7058 ... Read more >>

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2020, :]

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WT1 overexpression predicted good outcomes in adult B-cell acute lymphoblastic leukemia patients receiving chemotherapy.

Shujuan Wang, Chong Wang, Tao Li, Weiqiong Wang, Qianqian Hao, Xinsheng Xie, Dingming Wan, Zhongxing Jiang, Yanfang Liu,

Objectives: The prognostic role of WT1 in acute lymphoblastic leukemia (ALL) is still controversial. No study has focused on the prognostic role of WT1 expression in adult B-ALL patients receiving chemotherapy only.Methods: Using TaqMan-based real time quantitative PCR (RQ-PCR), we detected the WT1 transcript levels of 162 de-novo adult B-ALL ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):118-124]

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First Line Systemic Treatment for MALT Lymphoma-Do We Still Need Chemotherapy? Real World Data from the Medical University Vienna.

Barbara Kiesewetter, Ingrid Simonitsch-Klupp, Marius E Mayerhoefer, Werner Dolak, Julius Lukas, Markus Raderer,

There is no clear therapeutic algorithm for mucosa-associated lymphoid tissue (MALT) lymphoma beyond Helicobacter pylori eradication and while chemotherapy-based regimens are standard for MALT lymphoma patients in need of systemic treatment, it appears of interest to also investigate chemotherapy-free strategies. We have retrospectively assessed MALT lymphoma patients undergoing upfront systemic ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(12):]

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Subtotal gastrectomy combined with chemotherapy: An effective therapy for patients with circumscribed Borrmann type IV gastric cancer

Hai-Bo Huang, Zi-Ming Gao, An-Qi Sun, Wei-Tian Liang, Kai Li,

BACKGROUND Although Borrmann type IV (B-4) gastric cancer has a higher mortality rate and presents distant metastasis easily, especially peritoneal metastasis, when diagnosed, some B-4 patients were found to have no distant metastasis by preoperative detection and underwent curative surgery, which was defined as circumscribed B-4 in our study. In ... Read more >>

World J Gastrointest Oncol (World journal of gastrointestinal oncology)
[2020, 12(11):1325-1335]

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Enhanced nursing self-awareness and pharmacotherapy knowledge-base: peer-teaching and nursing/pharmacy interprofessional education.

Brecon Powell, Kim D Jardine, Michelle Steed, Jennifer Adams, Barb Mason,

Peer-teaching and interprofessional education can help students define individual healthcare roles, establish improved interprofessional relationships, and improve overall knowledge-base. Peer-teaching was provided by student pharmacists completing Advanced Pharmacy Practice Experiences (APPEs) for nine weeks to undergraduate student nurses. 4 student pharmacists and 25 student nurses participated in this study. Knowledge-base ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1814551]

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A Phase II Study of Fulvestrant 500 mg as Maintenance Therapy in HR-Positive, HER2-Negative Patients with Advanced Breast Cancer After First-Line Chemotherapy.

Fei Xu, Qiufan Zheng, Wen Xia, Quchang Ouyang, Danmei Pang, Zhongyu Yuan, Yanxia Shi, Roujun Peng, Qianyi Lu, Shusen Wang,

LESSONS LEARNED:Fulvestrant 500-mg maintenance therapy showed a CBR of 76% and median PFS of 16.1 months in patients who achieved objective responses or disease control after first-line chemotherapy. Adverse events with fulvestrant maintenance therapy were consistent with the known safety profile of the drug. BACKGROUND:Evidence for maintenance hormonal therapy after ... Read more >>

Oncologist (The oncologist)
[2020, :]

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Retrospective Observational Study of ALK-Inhibitor Therapy Sequencing and Outcomes in Patients with ALK-Positive Non-small Cell Lung Cancer.

David M Waterhouse, Janet L Espirito, Marc D Chioda, Bismark Baidoo, Jack Mardekian, Nicholas J Robert, Elizabeth T Masters,

BACKGROUND:Data are sparse concerning the sequential use of multiple anaplastic lymphoma kinase (ALK) inhibitors for ALK-positive locally advanced or metastatic non-small cell lung cancer (NSCLC). OBJECTIVE:This study investigated sequencing and outcomes among patients receiving multiple ALK inhibitors. PATIENTS AND METHODS:This was a retrospective observational cohort study of adult patients with ... Read more >>

Drugs Real World Outcomes (Drugs - real world outcomes)
[2020, 7(4):261-269]

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Oligometastatic Pancreatic Cancer to the Liver in the Era of Neoadjuvant Chemotherapy: Which Role for Conversion Surgery? A Systematic Review and Meta-Analysis.

Ottavia De Simoni, Marco Scarpa, Marco Tonello, Pierluigi Pilati, Francesca Tolin, Ylenia Spolverato, Mario Gruppo,

Background: the improved survival rates achieved using new polychemotherapy regimens in patients with metastatic pancreatic cancer (mPDAC) have suggested a potential role for surgery following a favorable response to initial chemotherapy (IC). The purpose of this systematic review is to summarize the available evidence on the role of surgery following ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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