Full Text Journal Articles about
Chemoresistance

Advertisement

Find full text journal articles






Overexpression of secretory clusterin (sCLU) induces chemotherapy resistance in human gastric cancer cells by targeting miR-195-5p.

Lihua Mu, Fengxia Yang, Dong Guo, Ping Li, Maoshen Zhang,

Recent focus has turned to secretory clusterin (sCLU) as a key contributor to chemoresistance of anticancer agents, but the role of sCLU on chemotherapy drug response to gastric cancer cells is not fully understood. Previous research found that sCLU was overexpressed in the induced multidrug-resistant MGC-803/5-FU cell line, suggesting that ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):472-483]

Cited: 0 times

View full text PDF listing >>



Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer.

Wangkai Xie, Man Chu, Gendi Song, Ziyi Zuo, Zheng Han, Chenbin Chen, Yuyun Li, Zhi-Wei Wang,

Pancreatic cancer is one of the most common causes of cancer death in the world due to the lack of early symptoms, metastasis occurrence and chemoresistance. Therefore, early diagnosis by detection of biomarkers, blockade of metastasis, and overcoming chemoresistance are the effective strategies to improve the survival of pancreatic cancer ... Read more >>

Semin Cancer Biol (Seminars in cancer biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

HIF1α promotes tumor chemoresistance via recruiting GDF15-producing TAMs in colorectal cancer.

Hongtu Zheng, Shan Yu, Congcong Zhu, Tianan Guo, Fangqi Liu, Ye Xu,

Chemoresistance is a tremendous challenge to efficacy of systemic chemotherapy which is the preferred treatment for the advanced CRC patients. More tumor-associated macrophages (TAMs) are recruited into the CRC tumor under chemotherapy, which are highly implicated in the chemoresistance development, but the underlying molecular mechanism is unclear. Here, we present ... Read more >>

Exp Cell Res (Experimental cell research)
[2020, :112394]

Cited: 0 times

View full text PDF listing >>



Nestin +/CD31 + Cells in the Hypoxic Perivascular Niche Regulate Glioblastoma Chemoresistance by Upregulating JAG1 and DLL4.

Zong-Qing Zheng, Jin-Tao Chen, Ming-Cheng Zheng, Li-Juan Yang, Jun-Ming Wang, Quan-Li Liu, Lu-Fei Chen, Zu-Cheng Ye, Jin-Ming Lin, Zhi-Xiong Lin,

BACKGROUND:Failure of glioblastoma (GBM) therapy is often ascribed to different types of glioblastoma stem-like cells (GSLCs) niche, in particularly, a hypoxic perivascular niche (HPVN) is involved in GBM progression. However, the responsible cells for HPVN remained unclear. METHODS:Immunostaining was performed to determine the cells that are responsible for HPVN. A ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Epigenetic Modifications of c-MYC: Role in Cancer Cell Reprogramming, Progression and Chemoresistance.

Homa Fatma, Santosh K Maurya, Hifzur R Siddique,

Both genetic and epigenetic mechanisms intimately regulate cancer development and chemoresistance. Different genetic alterations are observed in multiple genes, and most are irreversible. Aside from genetic alterations, epigenetic alterations play a crucial role in cancer. The reversible nature of epigenetic modifications makes them an attractive target for cancer prevention and ... Read more >>

Semin Cancer Biol (Seminars in cancer biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Knockdown of PDIA6 Inhibits Cell Proliferation and Enhances the Chemosensitivity in Gastric Cancer Cells.

Chao Yan, Xiaolei Song, Su Wang, Jinhai Wang, Lu Li,

Background:Protein disulfide isomerase A6 (PDIA6), a member of the disulfide isomerase (PDI) family, has been reported to be closely associated with progression of various cancers. However, the specific effects of PDIA6 on gastric cancer (GC) remain unclear. In this study, we investigated the expression pattern and biological functions of PDIA6 ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:11051-11062]

Cited: 0 times

View full text PDF listing >>



MicroRNA-7 Regulates Migration and Chemoresistance in Non-Hodgkin Lymphoma Cells Through Regulation of KLF4 and YY1.

Mario Morales-Martinez, Gabriel G Vega, Natividad Neri, M J Nambo, Isabel Alvarado, Ivonne Cuadra, M A Duran-Padilla, Sara Huerta-Yepez, Mario I Vega,

The discovery and description of the role of microRNAs has become very important, specifically due to their participation in the regulation of proteins and transcription factors involved in the development of cancer. microRNA-7 (miR-7) has been described as a negative regulator of several proteins involved in cancer, such as YY1 ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:588893]

Cited: 0 times

View full text PDF listing >>



Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma.

Linhe Gan, Hao Shen, Xinduo Li, Zhipeng Han, Yingying Jing, Xue Yang, Mengchao Wu, Yong Xia,

Intrahepatic cholangiocarcinoma (ICC) is a type of cancer that is difficult to cure; chemoresistance of cholangiocarcinoma cells affect the prognosis of patients who cannot be treated with surgery. The mechanism underlying this chemoresistance remains unknown. Mesenchymal stem cells (MSCs) are known to be important components of the tumor microenvironment. In the present ... Read more >>

Oncol Rep (Oncology reports)
[2020, :]

Cited: 0 times

View full text PDF listing >>



miR-1260b Activates Wnt Signaling by Targeting Secreted Frizzled-Related Protein 1 to Regulate Taxane Resistance in Lung Adenocarcinoma.

Jin Ren, Deqiang Wang, Hanpeng Huang, Xiaoqin Li, Xiufen Zhuang, Jian Li,

Objectives: MicroRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis; however, their association with tumor chemoresistance is not fully understood. In this study we aimed to investigate the molecular mechanisms involved in resistance to taxane-based chemotherapy in lung adenocarcinoma (LAD). Methods: We established paclitaxel-resistant A549 cells (A549/PTX) and docetaxel-resistant H1299 ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:557327]

Cited: 0 times

View full text PDF listing >>



Exploring role of 5hmC as potential marker of chemoresistance.

Suhas S Kharat, Shyam K Sharan,

Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified ... Read more >>

Mol Cell Oncol (Molecular & cellular oncology)
[2020, 7(6):1827904]

Cited: 0 times

View full text PDF listing >>



Molecular mechanisms of breast cancer chemoresistance by immune checkpoints.

Narges Dastmalchi, Reza Safaralizadeh, Amir Baghbanzadeh, Khalil Hajiasgharzadeh, Elmira Roshani Asl, Mohammad Amini, Behzad Baradaran,

Progression of resistance to chemotherapy in breast cancer (BC) has been recognized as a main factor in decreasing the survival of patients with this malignancy. Recent investigations have described the involvement of immune checkpoint molecules in the progress of drug resistance in breast carcinoma patients. In the present study, the ... Read more >>

Life Sci (Life sciences)
[2020, 263:118604]

Cited: 0 times

View full text PDF listing >>



The Roles of ceRNAs-Mediated Autophagy in Cancer Chemoresistance and Metastasis.

Huilin Zhang, Bingjian Lu,

Chemoresistance and metastasis are the main causes of treatment failure and unfavorable outcome in cancers. There is a pressing need to reveal their mechanisms and to discover novel therapy targets. Autophagy is composed of a cascade of steps controlled by different autophagy-related genes (ATGs). Accumulating evidence suggests that dysregulated autophagy ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

Cited: 0 times

View full text PDF listing >>



EGFR/PPARδ/HSP90 pathway mediates cancer cell metabolism and chemoresistance.

Qian Gou, Wenbo Zhang, Ying Xu, Jianhua Jin, Qian Liu, Yongzhong Hou, Juanjuan Shi,

Epidermal growth factor receptor (EGFR) induces peroxisome-proliferator-activated receptor-δ (PPARδ)-Y108 phosphorylation, while it is unclear the effect of phosphorylation of PPARδ on cancer cell metabolism. Here we found that EGF treatment increased its protein stability by inhibiting its lysosomal dependent degradation, which was reduced by gefitinib (EGFR inhibitor) treatment. PPARδ-Y108 phosphorylation ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro.

Jianfei Xu, Shanglong Liu, Xiaopeng Yang, Shougen Cao, Yanbing Zhou,

BACKGROUND:Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor microenvironment and are considered to contribute to chemoresistance. PSCs can participate in malignant behaviors of pancreatic carcinoma (PC) by secreting hepatocyte growth factor (HGF). The objective of this research was to explore the potential molecular mechanism of HGF on ... Read more >>

Life Sci (Life sciences)
[2020, 263:118523]

Cited: 0 times

View full text PDF listing >>



circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.

Wei Gao, Huina Guo, Min Niu, Xiwang Zheng, Yuliang Zhang, Xuting Xue, Yunfeng Bo, Xiaoya Guan, Zhongxun Li, Yujia Guo, Long He, Yu Zhang, Li Li, Jimin Cao, Yongyan Wu,

BACKGROUND:Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs) play critical roles in cancer progression and chemoresistance. However, the function and mechanism of circRNA in autophagy regulation of LSCC remain unclear. METHODS:The autophagy-suppressive circRNA circPARD3 was identified via ... Read more >>

Mol Cancer (Molecular cancer)
[2020, 19(1):166]

Cited: 0 times

View full text PDF listing >>



Connexin 43 confers chemoresistance through activating PI3K

Kevin Pridham, Farah Shah, Kevin Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina Grek, Gautam Ghatnekar, Robin Varghese, Deborah Kelly, Robert Gourdie, Zhi Sheng,

ABSTRACT Circumventing chemoresistance is crucial for effectively treating glioblastoma due to limited therapeutic options. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to the frontline chemotherapy temozolomide; however, targeting Cx43 is difficult because mechanisms underlying Cx43-mediated chemoresistance remain elusive. Here we show that Cx43, but not other connexins, ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells.

Chencheng Dai, Pengfei Xu, Siyu Liu, Sujuan Xu, Juan Xu, Ziyi Fu, Jian Cao, Mingming Lv, Juan Zhou, Guangquan Liu, Huilin Zhang, Xuemei Jia,

PURPOSE:The long noncoding RNA (lncRNA) ZEB1-AS1 is reported overexpressed in sensitive ovarian cancer cells A2780 compared with paclitaxel (PTX)-and cisplatin (DDP)- resistant. However, the function and mechanism of ZEB1-AS1 in EOC cells still unknown. METHODS:We used quantitative real-time PCR (qPCR) to detect ZEB1-AS1 expression in A2780 and A2780/R cells. A ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet,

Abstract Colon adenocarcinoma is characterized by an infiltration of tumor-associated macrophages (TAMs). TAMs are associated with a chemoresistance to 5-Fluorouracil (5-FU), but the mechanisms involved are still poorly understood. In the present study, we found that macrophages specifically overexpress dihydropyrimidine dehydrogenase (DPD) in hypoxia, leading to a macrophage-induced chemoresistance to ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Protein Disulfide Isomerase 4 Drives Docetaxel Resistance in Prostate Cancer.

Subo Qian, Shun Zhang, Yu Wu, Yu Ding, , Xinyan Li,

BACKGROUND:Protein disulfide isomerase 4 (PDIA4) has been reported to be closely associated with chemoresistance in several types of malignancies. But the pathogenic mechanisms of PDIA4 involved in docetaxel (DTX) resistance in prostate cancer (PCa) are still unknown. Hence, this study was conducted to evaluate the potential effect of PDIA4 on ... Read more >>

Chemotherapy (Chemotherapy)
[2020, :1-9]

Cited: 0 times

View full text PDF listing >>



Regulating mitochondrial pH with light and implications for chemoresistance.

Tinghan Zhao, Zhaoxiong Wan, Karthik Sambath, Shupei Yu, Mehrun Nahar Uddin, Yuanwei Zhang, Kevin D Belfield,

Chemoresistance is one of the major challenges for cancer treatment, more recently ascribed to defective mitochondrial outer membrane permeabilization (MOMP), significantly diminishing chemotherapeutic agent-induced apoptosis. A boron-dipyrromethene (BODIPY) chromophore-based triarylsulfonium photoacid generator (BD-PAG) was used to target mitochondria with the aim to regulate mitochondrial pH and further depolarize the mitochondrial ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2020, :]

Cited: 0 times

View full text PDF listing >>



Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway.

Hong Liao, Dan Zhu, Mingzhu Bai, Huifen Chen, Shihuan Yan, Jing Yu, Huiting Zhu, Wenxin Zheng, Guorong Fan,

Background:Chemoresistance reduces the 5-year survival rate of endometrial cancer patient, which is the current major obstacle for cancer therapy. Increasing evidence state that Nrf2 contributes to chemoresistance in several kinds of cancer. However, its role in endometrial cancer cells remains unclarified. Methods:Immunohistochemistry staining was used to detect the expression of ... Read more >>

Cancer Cell Int (Cancer cell international)
[2020, 20:480]

Cited: 0 times

View full text PDF listing >>



MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3.

Ming Cheng, Ping-Guo Duan, Zhi-Zeng Gao, Min Dai,

Metastasis and chemoresistance indicate poor prognosis in patients with osteosarcoma (OS). In the present study, the expression level of microRNA(miR)‑487b‑3p in OS specimens and cell lines was found to be decreased, and the expression level of miR‑487b‑3p was associated with overall survival in patients with OS. The inhibition of miR‑487b‑3p ... Read more >>

Oncol Rep (Oncology reports)
[2020, 44(6):2691-2700]

Cited: 0 times

View full text PDF listing >>



Chemokine CXCL-2 Regulates Resistance to Platinum in Epithelial Ovarian Cancer by Mediating ATR/CHK1 Signaling Pathway

Sipei Nie, Yicong Wan, Hui Wang, Jinhui Liu, Jing Yang, Rui Sun, Huangyang Meng, Xiaolin Ma, Yi Jiang, Wenjun Cheng,

Abstract Backgrounds: Platinum-resistance remains a challenge to recurrence and metastasis of epithelial ovarian cancer (EOC) and the mechanisms are unidentified. Tumor microenvironment (TME) and chemokine might play a key role in tumor chemoresistance. This study is designed to reveal the important role of CXCL-2 in causing EOC platinum-resistance. Materials and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Long noncoding RNA LINC01189 is associated with HCV-hepatocellular carcinoma and regulates cancer cell proliferation and chemoresistance through hsa-miR-155-5p.

Ying Yao, Fang Shu, Fang Wang, Xiaoqiang Wang, Zhengshe Guo, Haili Wang, Lu Li, Haigang Lv,

INTRODUCTION AND OBJECTIVES:Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) may be closely associated with Hepatitis C virus (HCV) infection and the development of hepatocellular carcinoma (HCC). In this study, we investigated the expression and functions of a lncRNA, LINC01189, in HCV-associated HCC. PATIENTS OR MATERIALS AND METHODS:LINC01189 expression ... Read more >>

Ann Hepatol (Annals of hepatology)
[2020, :100269]

Cited: 0 times

View full text PDF listing >>



ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.

Zhi-Hui Zhang, Qian Hong, Zhi-Cheng Zhang, Wei-Yang Xing, Shen Xu, Qi-Xing Tian, Qing-Lin Ye, Hua Wang, De-Xin Yu, Dong-Dong Xie, De-Xiang Xu,

Several epidemiological studies reported that chronic arsenic exposure increased risk of prostate cancer. This study aimed to investigate whether chronic NaAsO2 exposure elevates stemness and chemoresistance in prostate cancer cells. DU145 (wild-type p53) and PC-3 (p53-null) cells were exposed to NaAsO2 (2 μmol/L) for 30 generations. IC50s to docetaxel and ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2020, 208:111436]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1273 s