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Socheongryongtang suppresses COPD-related changes in the pulmonary system through both cytokines and chemokines in a LPS COPD model.

Soon-Young Lee, Seung-Sik Cho, Chun-Sik Bae, Min-Suk Bae, Dae-Hun Park,

Context: Socheongryongtang is a traditional Korean medical prescription used to treat pulmonary diseases.Objective: This study investigated the therapeutic mechanism of socheongryongtang for pulmonary diseases.Materials and methods: Seventy BALB/c mice were used: control, 0.8 mg/kg/study LPS intranasal instillation, 1 mg/kg/day Spiriva oral administration for five days, two socheongryongtang groups (150 or 1500 mg/kg/day orally treatment ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):538-544]

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Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress.

Qingning Duan, Yin Jia, Yan Qin, Yingji Jin, Haozhong Hu, Jiebin Chen,

Acute lung injury (ALI) is a life-threatening disorder related to serious pulmonary inflammation. Narciclasine exhibits strong anti-inflammation activity and attenuates the reactive oxygen species (ROS) production. The present study aims to investigate the underlying mechanism related to the effect of narciclasine on the pathogenesis of neonatal acute lung injury (ALI). ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):801-810]

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The role of TRPV1 channels in atherosclerosis.

Chenyang Zhang, Lifang Ye, Qinggang Zhang, Fei Wu, Lihong Wang,

Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):141-150]

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The protective effects of bexarotene against advanced glycation end-product (AGE)-induced degradation of articular extracellular matrix (ECM).

Zhuqing Zha, Qingmin Han, Shaochuan Huo,

Osteoarthritis (OA) is a common debilitating disease primarily characterised by excessive loss of the articular ECM, which is composed of up to 95% type II collagen. Among the factors that contribute to the pathogenesis of OA, the natural process of aging is regarded as the most significant risk factor. AGEs, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):1-7]

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Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway.

Rong Tang, Xiangcheng Xiao, Yang Lu, Huihui Li, Qiaoling Zhou, Patrick Kwadwo Nuro-Gyina, Xia Li,

Transforming growth factor-β1 (TGF-β1) is a crucial factor implicated in the development of renal inflammation and tubulointerstitial fibrosis (TIF). The cytokine interleukin 22 (IL-22) was previously reported to involve in the pathogenesis of chronic inflammatory diseases, however recent studies showed that IL-22 could reduced inflammatory responses and tissue damage. In ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):381-390]

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Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord.

Ju-Young Oh, Tae-Yeon Hwang, Jae-Hwan Jang, Ji-Yeun Park, Yeonhee Ryu, HyeJung Lee, Hi-Joon Park,

Despite numerous efforts to overcome neuropathic pain, various pharmacological drugs often fail to meet the needs and have many side effects. Muscovite is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect, but the efficacy of muscovite for neuropathic pain has not been investigated. Here, we assessed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(11):2162-2168]

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Setting the stage: The initial immune response to blood-stage parasites.

Allison N Bucşan, Kim C Williamson,

Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which ... Read more >>

Virulence (Virulence)
[2020, 11(1):88-103]

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Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles.

Bahman Emami, Farzaneh Shakeri, Zahra Gholamnezhad, Saeideh Saadat, Marzie Boskabady, Vahab Azmounfar, Hamed Sadatfaraji, Mohammad Hossein Boskabady,

Context: Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation.Objective: The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not examined so far, thus, this study was designed to assess the relaxant effect of curcumin on rat ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):257-264]

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Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis.

Bing Tian, Ming Tian, Shu-Ming Huang,

ABSRACTContext: Rhizoma Corydalis (RC) is the dried tubers of Corydalis yanhusuo (Y. H. Chou and Chun C. Hsu) W. T. Wang ex Z. Y. Su and C. Y. Wu (Papaveraceae). Traditionally, RC is used to alleviate pain such as headache, abdominal pain, and epigastric pain. Modern medicine shows that it ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):265-275]

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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

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Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis.

Javad Seyyedi, Shahab Alizadeh,

BACKGROUND:This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. METHODS:PubMed, Scopus, and Google scholar were systematically searched to identify related studies published ... Read more >>

Obes Surg (Obesity surgery)
[2020, 30(9):3549-3560]

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A new clinical prognostic nomogram for liver cancer based on immune score.

Qinyan Shen, Guinv Hu, JinZhong Wu, Liting Lv,

BACKGROUND:Increased attention is being paid to the relationship between the immune status of the tumor microenvironment and tumor prognosis. The application of immune scoring in evaluating the clinical prognosis of liver cancer patients has not yet been explored. This study sought to clarify the association between immune score and prognosis ... Read more >>

PLoS ONE (PloS one)
[2020, 15(7):e0236622]

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The renoprotective effect of curcumin against cisplatin-induced acute kidney injury in mice: involvement of miR-181a/PTEN axis.

Si-Jia Huang, Jing Huang, Yun-Bo Yan, Jiao Qiu, Rui-Qiao Tan, Yu Liu, Qing Tian, Li Guan, Shuai-Shuai Niu, Yanxiang Zhang, Zhijiang Xi, Ying Xiang, Quan Gong,

Background: Nephrotoxicity, especially acute kidney injury (AKI), is the main dose-limiting toxicity of cisplatin. Although recent studies showed that curcumin prevented cisplatin-induced AKI effectively, further studies to understand the mechanism are required.Methods: We established an AKI mouse model. Male C57BL/6 mice were assigned to three groups: saline group (control), cisplatin ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):350-357]

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The Complexity of Targeting Chemokines to Promote a Tumor Immune Response.

Marianne Strazza, Adam Mor,

Immunotherapeutic treatment strategies greatly extend patient survival following malignant disease across a wide range of tumor types, including even those with metastatic disease. While diverse in approach, adoptive cell therapy, introduction of T cells that express chimeric antigen receptors, and checkpoint inhibitors all aim to re-invigorate the immune system to ... Read more >>

Inflammation (Inflammation)
[2020, 43(4):1201-1208]

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MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice.

Shu Fang, Jie Feng, Hongbin Zhang, Ping Li, Yudan Zhang, Yanmei Zeng, Yingying Cai, Xiaochun Lin, Yaoming Xue, Meiping Guan,

MiR-455 has been verified a key regulator of brown adipose tissue and adipose tissue-specific overexpression of miR-455 (ap2-miR-455) mice could combat high-fat-diet-induced obesity. This study is to verify overexpression of miR-455 could ameliorate the lipid accumulation and metabolism in the liver of db/db diabetic mice and explore the potential mechanisms. ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):179-188]

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Monocyte chemotactic protein-1-induced protein 1 contributes to neuronal injury following hypoxic-ischemia in the neonatal mouse brain.

Radheya Y Naik, Dawson Foster, Phillip Bray, Yingzi Chang, Byung Hee Han,

Neuroinflammation has been implicated in neurodegenerative diseases and acute brain injuries such as stroke. Monocyte chemotactic protein-1-induced protein-1 (Mcpip1) is a multifunction protein known to have pro-apoptotic or anti-apoptotic actions depending on the nature of experimental settings. However, its role in brain damage after asphyxia in the developing brain has ... Read more >>

Neuroreport (Neuroreport)
[2020, 31(11):833-839]

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Embryo-Derived Chemokine CXCL12 Enhances Pregnancy Outcome via Improvement of Endometrial Receptivity

Hwa Seon Koo, Min-Ji Yoon, Seon-Hwa Hong, Jungho Ahn, Hwijae Cha, Danbi Lee, Hwang Kwon, Dong Hee Choi, Kyung-Ah Lee, Jung-Jae Ko, YOUN-JUNG KANG,

Abstract Background: Successful pregnancy inevitably depends on the implantation of a competent embryo into a receptive endometrium. Although a remarkable improvement of assisted reproductive technology (ART) has been achieved over the last few decades, there are still a number of infertile women experiencing frequent ART failure after repeated attempts due ... Read more >>

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Identification of candidate host serum and saliva biomarkers for a better diagnosis of active and latent tuberculosis infection.

Olivia Estévez, Luis Anibarro, Elina Garet, Ángeles Pallares, Alberto Pena, Carlos Villaverde, Víctor Del Campo, África González-Fernández,

In our work, we aim to identify new candidate host biomarkers to discriminate between active TB patients (n = 28), latent infection (LTBI; n = 27) and uninfected (NoTBI; n = 42) individuals. For that, active TB patients and their contacts were recruited that donated serum and saliva samples. A ... Read more >>

PLoS ONE (PloS one)
[2020, 15(7):e0235859]

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Impact of Latent Tuberculosis Infection on Neurocognitive Functioning and Inflammation in HIV-Infected and Uninfected South Indians.

Stephanie LaVergne, Anya Umlauf, Allen McCutchan, Robert Heaton, Constance Benson, Nagalingeswaran Kumarasamy, Ajay R Bharti,

BACKGROUND:HIV-associated neurocognitive disorder persists in some people living with HIV despite optimal antiretroviral therapy. Latent tuberculosis infection (LTBI) may cause systemic inflammation and immune activation that may impair brain function. We assessed cognition and biomarkers of inflammation in both HIV+ and HIV- South Indians with and without LTBI. METHODS:Adults (≥18 ... Read more >>

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(4):430-436]

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The kidney, COVID-19, and the chemokine network: an intriguing trio.

Gianluigi Taverna, Simona Di Francesco, Elena Monica Borroni, Daniel Yiu, Elena Toniato, Samantha Milanesi, Maurizio Chiriva-Internati, Robert S Bresalier, Matteo Zanoni, Paolo Vota, Davide Maffei, Matteo Justich, Fabio Grizzi,

On December 30th 2019, some patients with pneumonia of unknown etiology were reported in the Program for Monitoring Emerging Diseases (ProMED), a program run by the International Society for Infectious Diseases (ISID), hypothesized to be related to subjects who had had contact with the seafood market in Wuhan, China. Chinese ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2020, :]

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Molecular Identification and Dual Functions of Two Different CXC Chemokines in Nile Tilapia (Oreochromis niloticus) against Streptococcus agalactiae and Flavobacterium columnare.

Chatsirin Nakharuthai, Prapansak Srisapoome,

Two CXC chemokines in Nile tilapia (On-CXC1 and On-CXC2) were identified at both the genomic and proteomic levels. A southern blot analysis and comparison searching in Ensembl confirmed the typical structure of the CXC chemokine genes and provided evidence for unusual mechanisms used to generate the two different CXC chemokine ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(7):]

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Thymus and activation-regulated chemokine (TARC) in patients with psoriasis: Increased serum TARC levels in patients with generalized pustular psoriasis.

Yurika Kawasaki, Masahiro Kamata, Teruo Shimizu, Mayumi Nagata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada,

Thymus and activation-regulated chemokine (TARC) is designated as a T-helper 2-type chemokine and its expression is upregulated in patients with atopic dermatitis. Previous studies reported that serum TARC levels in patients with psoriasis vulgaris (PsV) were comparable with those in healthy controls. However, the association of clinical severity of psoriasis ... Read more >>

J. Dermatol. (The Journal of dermatology)
[2020, :]

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Multiple Roles for Chemokines in Neutrophil Biology.

Arianna Capucetti, Francesca Albano, Raffaella Bonecchi,

Chemokines are recognized as the most critical mediators for selective neutrophil recruitment during inflammatory conditions. Furthermore, they are considered fundamental regulators of neutrophil mobilization from the bone marrow (BM) to the bloodstream and for their homing back at the end of their life for apoptosis and clearance. However, chemokines are ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1259]

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Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development

Rishika Chaudhary, Robert A. H. Scott, Graham Wallace, Martin Berry, Ann Logan, Richard J. Blanch,

Purpose Proliferative vitreoretinopathy (PVR) occurs in 5%–10% of rhegmatogenous retinal detachment cases and is the principle cause for failure of retinal reattachment surgery. Although there are a number of surgical adjunctive agents available for preventing the development of PVR, all have limited efficacy. Discovering predictive molecular biomarkers to determine the ... Read more >>

Transl Vis Sci Technol (Translational vision science & technology)
[0, 9(3):]

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TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P.

Rui Yamaguchi, Misa Haraguchi, Reona Yamaguchi, Arisa Sakamoto, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchi,

The chemokine fractalkine is synthesized as a membrane-bound protein, but studies have shown that serum levels of soluble fractalkine are elevated in inflammatory and autoimmune diseases. Patients with autoimmune diseases also have increased serum levels of neuropeptide substance P (SP). The shedding activity of the ADAM family is induced by ... Read more >>

Cytokine (Cytokine)
[2020, 134:155180]

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