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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Clinical observation and management of COVID-19 patients.

Taisheng Li, Hongzhou Lu, Wenhong Zhang,

Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormality of coagulation function and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):687-690]

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Cysteine redox state regulates human β2-adrenergic receptor binding and function.

Kalyn M Rambacher, Nader H Moniri,

Bronchoconstrictive airway disorders such as asthma are characterized by inflammation and increases in reactive oxygen species (ROS), which produce a highly oxidative environment. β2-adrenergic receptor (β2AR) agonists are a mainstay of clinical therapy for asthma and provide bronchorelaxation upon inhalation. We have previously shown that β2AR agonism generates intracellular ROS, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2934]

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Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure.

E Drizik, S Corbett, Y Zheng, R Vermeulen, Y Dai, W Hu, D Ren, H Duan, Y Niu, J Xu, W Fu, K Meliefste, B Zhou, Xiaohui Zhang, J Yang, Bryan Bassig, Hanqiao Liu, M Ye, Gang Liu, X Jia, T Meng, P Bin, J Zhang, D Silverman, A Spira, N Rothman, M E Lenburg, Q Lan,

BACKGROUND:Diesel engine exhaust (DEE) exposure causes lung cancer, but the molecular mechanisms by which this occurs are not well understood. OBJECTIVES:To assess transcriptomic alterations in nasal epithelium of DEE-exposed factory workers to better understand the cellular and molecular effects of DEE. METHODS:Nasal epithelial brushings were obtained from 41 diesel engine ... Read more >>

Environ Int (Environment international)
[2020, 137:105506]

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Cerebral Air Embolism and Cardiomyopathy Secondary to Large Bulla Rupture during a Pulmonary Function Test.

Ha Lee, Hyun Soo Lee, Dulk Hwan Moon, Sungsoo Lee,

Cerebral air embolism combined with cardiomyopathy secondary to pulmonary barotrauma is rare. Here, we report an unusual case of cerebral air embolism combined with transient cardiomyopathy secondary to large bulla rupture during a pulmonary function test after lung cancer surgery. The patient experienced loss of consciousness. Computed tomography and magnetic ... Read more >>

Korean J Thorac Cardiovasc Surg (The Korean journal of thoracic and cardiovascular surgery)
[2020, 53(1):34-37]

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Respiratory motion artefacts in Gd-EOB-DTPA (Primovist/Eovist) and Gd-DOTA (Dotarem)-enhanced dynamic phase liver MRI after intensified and standard pre-scan patient preparation: A bi-institutional analysis.

Christian Wybranski, Florian Siedek, Robert Damm, Angelos Gazis, Ortrud Wenzel, Stefan Haneder, Thorsten Persigehl, Susanne Steinhauser, Maciej Pech, Frank Fischbach, Katharina Fischbach,

OBJECTIVE:The objective of this study is to evaluate if intensified pre-scan patient preparation (IPPP) that comprises custom-made educational material on dynamic phase imaging and supervised pre-imaging breath-hold training in addition to standard informative conversation with verbal explanation of breath-hold commands (standard pre-scan patient preparation-SPPP) might reduce the incidence of gadoxetate ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230024]

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A case of a primary pulmonary meningioma mimicking a metastasis from a papillary thyroid carcinoma due to a size reduction after radioactive iodine therapy.

Ryo Fujikawa, Yoshifumi Arai, Yoshiro Otsuki, Toru Nakamura,

BACKGROUND:Primary pulmonary meningiomas (PPMs) are a rare mostly benign disease presenting as a solitary pulmonary nodule and are hardly distinguishable from a metastatic tumor because of a lack of specific radiological features. We described a case of a PPM initially diagnosed as a metastatic lung tumor from thyroid cancer with ... Read more >>

Surg Case Rep (Surgical case reports)
[2020, 6(1):57]

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Non-bacterial thrombotic endocarditis in the context of pulmonary adenocarcinoma: a case report.

Christoph C Kaufmann, Emil Wessely, Kurt Huber,

Background:Non-bacterial thrombotic endocarditis (NBTE) is a rare condition, usually observed in association with malignancy, lupus erythematosus, or antiphospholipid syndrome. Diagnosis of NBTE remains a challenge as patients are often asymptomatic up to their first thromboembolic event. While there is no randomized data available for the guidance of treatment in NBTE, ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(1):1-5]

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Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.

Ziyi Wang, Elianna A Bier, Aparna Swaminathan, Kishan Parikh, John Nouls, Mu He, Joseph G Mammarappallil, Sheng Luo, Bastiaan Driehuys, Sudarshan Rajagopal,

BACKGROUND:As an increasing number of patients exhibit concomitant cardiac and pulmonary disease, limitations of standard diagnostic criteria are more frequently encountered. Here, we apply noninvasive 129Xe magnetic resonance imaging (MRI) and spectroscopy to identify patterns of regional gas transfer impairment and haemodynamics that are uniquely associated with chronic obstructive pulmonary ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2019, 54(6):]

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A multi-vendor, multi-center study on reproducibility and comparability of fast strain-encoded cardiovascular magnetic resonance imaging.

Jennifer Erley, Victoria Zieschang, Tomas Lapinskas, Aylin Demir, Stephanie Wiesemann, Markus Haass, Nael F Osman, Orlando P Simonetti, Yingmin Liu, Amit R Patel, Victor Mor-Avi, Orhan Unal, Kevin M Johnson, Burkert Pieske, Jochen Hansmann, Jeanette Schulz-Menger, Sebastian Kelle,

Myocardial strain is a convenient parameter to quantify left ventricular (LV) function. Fast strain-encoding (fSENC) enables the acquisition of cardiovascular magnetic resonance images for strain-measurement within a few heartbeats during free-breathing. It is necessary to analyze inter-vendor agreement of techniques to determine strain, such as fSENC, in order to compare existing studies ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2020, :]

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Quantification of gas exchange-related upward motion of the liver during prolonged breathholding-potential reduction of motion artifacts in abdominal MRI.

Rachita Khot, Melissa McGettigan, James T Patrie, Sebastian Feuerlein,

OBJECTIVE:To test the hypothesis that there is a measureable upward motion of the diaphragm during prolonged breath-holds that could have a detrimental effect on image quality in liver MRI and to identify factor that potentially influence the magnitude of this motion. METHODS:15 healthy volunteers underwent MRI examination using prolonged breath-holds ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1106):20190549]

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Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium.

Jonathan Fix, Isabella Annesi-Maesano, Isabelle Baldi, Mathilde Boulanger, Soo Cheng, Sandra Cortes, Jean-Charles Dalphin, Mohamed Aqiel Dalvie, Bruno Degano, Jeroen Douwes, Wijnand Eduard, Grethe Elholm, Catterina Ferreccio, Anne-Helen Harding, Mohamed Jeebhay, Kevin M Kelly, Hans Kromhout, Ewan MacFarlane, Cara Nichole Maesano, Diane Catherine Mitchell, Hussein Mwanga, Saloshni Naidoo, Beyene Negatu, Dorothy Ngajilo, Karl-Christian Nordby, Christine G Parks, Marc B Schenker, Aesun Shin, Torben Sisgaard, Malcolm Sim, Thibaud Soumagne, Peter Thorne, Keun-Young Yoo, Jane A Hoppin,

Purpose: Respiratory hazards of farming have been identified for centuries, with little focus on gender differences. We used data from the AGRICOH consortium, a collective of prospective cohorts of agricultural workers, to assess respiratory disease prevalence among adults in 18 cohorts representing over 200,000 farmers, farm workers, and their spouses ... Read more >>

J Agromedicine (Journal of agromedicine)
[2020, :1-12]

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Practical laboratory considerations amidst the COVID-19 outbreak: early experience from Singapore.

Shaun S Tan, Benedict Yan, Sharon Saw, Chun Kiat Lee, Ai Teng Chong, Roland Jureen, Sunil Sethi,

The coronavirus disease 2019 (COVID-19) is a zoonotic viral infection originating from Wuhan, China in December 2019. The World Health Organization has classified this pandemic as a global health emergency due to its virulent nature of transmission, which may lead to acute respiratory distress syndrome. Singapore's health ministry has responded ... Read more >>

J. Clin. Pathol. (Journal of clinical pathology)
[2020, :]

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Preliminary application of 3.0 T magnetic resonance chemical exchange saturation transfer imaging in brain metastasis of lung cancer.

Yonggui Yang, Xiaobo Qu, Yihui Huang, Khan Afsar, Gen Yan, Gang Guo, Shaoyin Duan,

BACKGROUND:Lung cancer brain metastases are very common and one of the common causes of treatment failure. We aimed to examine the clinical use of chemical exchange saturation transfer (CEST) technology in the evaluation of brain metastases for lung cancer diagnosis and prognosis. METHODS:We included26 cases of lung cancer brain metastases, ... Read more >>

BMC Med Imaging (BMC medical imaging)
[2020, 20(1):4]

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Mechanisms underlying the stimulatory effect of inhaled sulfur dioxide on vagal bronchopulmonary C-fibres.

An-Hsuan Lin, Chun-Chun Hsu, You Shuei Lin, Ruei-Lung Lin, Lu-Yuan Lee,

KEY POINTS:Brief inhalation of SO2 of concentration >500 p.p.m. triggered a pronounced stimulatory effect on vagal bronchopulmonary C-fibres in anaesthetized rats. This stimulatory effect was drastically diminished by a pretreatment with NaHCO3 that raised the baseline arterial pH, suggesting a possible involvement of acidification of airway fluid and/or tissue generated by ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2020, 598(5):1093-1108]

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Revisiting the dangers of the coronavirus in the ophthalmology practice.

Ivan Seah, Xinyi Su, Gopal Lingam,

Eye (Lond) (Eye (London, England))
[0, :1-3]

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Small-Molecule Inhibition of Bacterial Biofilm.

Anirban Ghosh, Narayansaswamy Jayaraman, Dipankar Chatterji,

Antibiotic resistance is a massive and serious threat to human welfare and healthcare. Apart from being genetically resistant to antibiotics, the other important mechanism by which bacteria can evade antibiotics is multidrug tolerance. Here cells enter into a transiently nongrowing phase, and as a result, latent infection remains inside the ... Read more >>

ACS Omega (ACS omega)
[2020, 5(7):3108-3115]

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A case report on transient global ventricular wall thickening secondary to acute myocarditis: Focus on the unique role of cardiac MRI.

Tiantian Xu, Hongjie Hu,

INTRODUCTION:Transient left ventricular wall thickening is known to develop in the acute phase of myocarditis, with several reports documenting this unusual mode of myocarditis. Diagnosing myocarditis can be challenging because symptoms, clinical exam findings, electrocardiogram results, biomarkers, and echocardiogram results are often non-specific. Therefore, cardiac magnetic resonance imaging has become ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(8):e19223]

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A probabilistic approach for economic evaluation of occupational health and safety interventions: a case study of silica exposure reduction interventions in the construction sector.

Amirabbas Mofidi, Emile Tompa, Seyed Bagher Mortazavi, Akbar Esfahanipour, Paul A Demers,

BACKGROUND:Construction workers are at a high risk of exposure to various types of hazardous substances such as crystalline silica. Though multiple studies indicate the evidence regarding the effectiveness of different silica exposure reduction interventions in the construction sector, the decisions for selecting a specific silica exposure reduction intervention are best ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):210]

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European Headache Federation recommendations for neurologists managing giant cell arteritis.

S P Mollan, K Paemeleire, J Versijpt, R Luqmani, A J Sinclair,

BACKGROUND AND AIM:Giant cell arteritis (GCA) remains a medical emergency because of the risk of sudden irreversible sight loss and rarely stroke along with other complications. Because headache is one of the cardinal symptoms of cranial GCA, neurologists need to be up to date with the advances in investigation and ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):28]

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Cardiac Myxoma with Cerebral Metastases and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Case Report and Review.

Jared A Maas, Manuel Menes, Vitaly Siomin,

Background  Cardiac myxomas, the most common primary cardiac tumors, are generally benign neoplasms. Primary cardiac lymphoma is a rare cardiac malignancy with a very poor prognosis. Here we present a case of a cardiac myxoma with cerebral metastases and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) arising within the cerebral metastases. ... Read more >>

J Neurol Surg Rep (Journal of neurological surgery reports)
[2020, 81(1):e1-e6]

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The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.

Ernst R Werner, Markus A Keller, Sabrina Sailer, Katharina Lackner, Jakob Koch, Martin Hermann, Stefan Coassin, Georg Golderer, Gabriele Werner-Felmayer, Raphael A Zoeller, Nicolas Hulo, Johannes Berger, Katrin Watschinger,

A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer's and chronic obstructive pulmonary disease. Plasmalogens contain a characteristic 1-O-alk-1'-enyl ether (vinyl ether) double ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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High-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report.

Aisling B Mc Glacken-Byrne, David Prentice, Danial Roshandel, Michael R Brown, Philip Tuch, Kyle S-Y Yau, Padma Sivadorai, Mark R Davis, Nigel G Laing, Fred K Chen,

BACKGROUND:Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-smooth muscle actin (α-SMA). Previous reports attributed MSMDS-related congenital mydriasis to the absence of iris sphincter muscle. Similarly, it has been hypothesized that abnormal ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2020, 20(1):68]

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A Probabilistic Approach for Economic Evaluation of Occupational Health and Safety Interventions: A Case Study of Silica Exposure Reduction Interventions in the Construction Sector

SeyedBagher Mortazavi, Amirabbas Mofidi, Emile Tompa, Akbar Esfahanipour, Paul Demers,

<title>Abstract</title> <p> Background: Construction workers are at a high risk of exposure to various types of hazardous substances such as crystalline silica. Though multiple studies indicate the evidence regarding the effectiveness of different silica exposure reduction interventions in the construction sector, the decisions for selecting a specific silica ... Read more >>

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Bioinformatics analysis on differentially expressed genes of alveolar macrophage in IPF.

Huaibin Wang, Miaomiao Wang, Kun Xiao, Xu Zhang, Peng Wang, Shuyu Xiao, Huisheng Qi, Lijun Meng, Xiujun Zhang, Fuhai Shen,

Objective: This study aimed to explore the differentially expressed genes (DEGs) of pulmonary macrophages in human idiopathic pulmonary fibrosis (IPF) by bioinformatics, and elaborate on IPF on the gene level. Methods: The gene expression profile GSE49072 was downloaded from the gene expression omnibus (GEO) database. Genes of alveolar macrophages between ... Read more >>

Exp. Lung Res. (Experimental lung research)
[2019, 45(9-10):288-296]

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