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Cerebral Aneurysms

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Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.

Jun-Mou Hong, Yi-Da Hu, Xiao-Qing Chai, Chao-Liang Tang,

Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in vascular endothelial cells, and its dynamic changes are closely related to the proliferation of endothelial cells, the recruitment of pericytes to blood vessels, and functional ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1807-1813]

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Remote ischemic conditioning approach for the treatment of ischemic stroke.

Seyed Mohammad Seyedsaadat, David F Kallmes, Waleed Brinjikji,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1033-1034]

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Combined Internal Maxillary Artery to Middle Cerebral Artery and In Situ Middle Cerebral to Middle Cerebral Artery Bypass for Complex Middle Cerebral Artery Aneurysm: 3-Dimensional Operative Video.

Timothy G White, Georgios Klironomos, David J Langer, Jeffrey Katz, Amir R Dehdashti,

Flow-replacement revascularization and/or flow augmentation surgery may be necessary for safe deconstruction of complex middle cerebral artery (MCA) aneurysms. Roughly 1% to 2% of all MCA aneurysms have angiographic features prohibiting standard microsurgical or endovascular management. Consent was obtained from the patient for the production of this video. No International Review ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E121-E122]

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Interleukin-6 Promotes Murine Estrogen Deficiency-Associated Cerebral Aneurysm Rupture.

Daisuke Wajima, Siham Hourani, William Dodd, Devan Patel, Chad Jones, Kartik Motwani, Hanain Z Fazal, Koji Hosaka, Brian L Hoh,

BACKGROUND:Estrogen deficiency is associated with cerebral aneurysm rupture, but the precise mechanism is unknown. OBJECTIVE:To test the hypothesis that IL-6 is required for the increase in aneurysm rupture rate observed in estrogen-deficient mice. METHODS:We analyzed IL-6 expression in human cerebral aneurysms. We induced cerebral aneurysms in estrogen-deficient female C57BL/6 mice ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):583-592]

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Flow Diversion of an Incompletely-Treated Fusiform Middle Cerebral Artery Aneurysm: 2-Dimensional Operative Video.

Thomas J Sorenson, Jon P Klein, Leonardo Rangel-Castilla, Giuseppe Lanzino,

Fusiform aneurysms involving the M2 branches of the middle cerebral artery are often dissecting, identified by a characteristic diseased adjacent segment, and location not at a branch point. Herein, we present the case of a 38-yr-old man with a symptomatic, dissecting M2 aneurysm that was previously incompletely treated with stent-assisted ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E125-E126]

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Recurrent Giant Anterior Cerebral Artery (ACA) Aneurysm With Previous Coiling, Attempted Clipping Then Direct ACA-to-ACA Bypass: 2-Dimensional Operative Video.

Benjamin K Hendricks, Robert F Spetzler,

Giant aneurysms are defined as lesions with a widest diameter of 2.5 cm or greater and account for 2% to 5% of all intracranial aneurysms. These lesions are challenging entities for microsurgical management with techniques such as direct aneurysmal neck clipping, aneurysm neck reconstructions, aneurysmotomy, and aneurysmectomy. This patient had ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E110]

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Commentary: Combined Internal Maxillary Artery to Middle Cerebral Artery and In Situ Middle Cerebral to Middle Cerebral Artery Bypass for Complex Middle Cerebral Artery Aneurysm: 3-Dimensional Operative Video.

Rose Fluss, Ralph Rahme,

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E123-E124]

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Clipping versus coiling in unruptured anterior cerebral circulation aneurysms.

Farrag Mohammad, Takashi Horiguchi, Katsuhiro Mizutani, Kazunari Yoshida,

Background:Unruptured intracranial aneurysms (UIAs) are not uncommon, especially in Japan. Treatment strategy for UIAs has evolved in the past decades in Western countries with the increased use of endovascular treatment as the primary option, but in Japan, clipping still has the upper hand.Methods:This study retrospectively included 200 patients treated by ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2020, 11:]

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Intracranial Aneurysms After Intravenous Thrombolysis in Patient with Atrial Myxoma: A Case Study.

Zhizhang Li, Xushen Xu, Liang Hu, Hongxian Sun, Yunhua Yue,

We administered intravenous thrombolytic therapy to a 51-year-old female patient with a 101-min stroke onset. The patient was unconscious during the manifestation of symptoms. Computed tomography angiography examination of the intracranial artery at the time of admission suggested that the left middle cerebral artery was occluded. The patient regained consciousness ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, :104796]

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Posterior Cerebral Artery Aneurysms: Parent Vessel Occlusion Being a Viable Option in the Era of Flowdivertors.

Vivek Singh, Rajendra Vishnu Phadke, Vivek Agarwal, Sanjay Behari, Zafar Neyaz, Gaurav Chauhan,

Background and Purpose:The purpose of this study is to evaluate posterior cerebral artery (PCA) aneurysms along with the efficacy, safety, procedural, and clinical outcome of the endovascular management of these aneurysms. We studied different techniques of endovascular treatment such as selective aneurysmal coiling, parent artery occlusion, and stent-assisted coiling in ... Read more >>

Neurol India (Neurology India)
[2020, :]

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Clinically Applicable Deep Learning for Intracranial Aneurysm Detection in Computed Tomography Angiography Images: A Comprehensive Multicohort Study

Zhao SHI, Chong Chang Miao, Cheng Wei Pan, Xue Chai, Xiu Li Li, Shuang Xia, Yan Gu, Yong Gang Zhang, Bin Hu, Wen Da Xu, Chang Sheng Zhou, Song Luo, Hao Wang, Li Mao, Kong Ming Liang, Yi Zhou Yu, Guang Ming Lu, Long Jiang Zhang,

Intracranial aneurysm is a common life-threatening disease. CTA is recommended as a standard diagnosis tool, while the interpretation is time-consuming and challenging. We presented a novel deep-learning-based framework trained on 1,177 DSA verified bone-removal CTA cases. The framework had excellent tolerance to the influence of occult cases of CTA-negative but ... Read more >>

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The clinical characteristics and treatment considerations for intracranial aneurysms associated with middle cerebral artery anomalies: a systematic review

Jinlu Yu, Kun Hou, Guichen Li, Hongping Liu, Kan Xu,

<title>Abstract</title> <p> <bold>Background:</bold> As a result of its low occurrence, most of the studies on intracranial aneurysms associated with MCA anomalies were presented as case reports or small case series. In this study, a systematic review on this specific entity was conducted.<bold>Methods:</bold> A PubMed search of the published ... Read more >>

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Clinical usefulness of early serial measurements of C-reactive protein as outcome predictors in patients with subarachnoid hemorrhage.

Sangkil Lee, Yong Oh Kim, Jeong-Am Ryu,

BACKGROUND:The purpose of this study was to evaluate the role of C-reactive protein (CRP) in predicting neurological outcomes of patients with subarachnoid hemorrhage (SAH). METHODS:In this retrospective, observational study of adult patients with SAH treated between January 2012 and June 2017. Initial CRP levels collected within 24 h from the onset ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):112]

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Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial.

Ardalan H Zolnourian, Stephen Franklin, Ian Galea, Diederik Oliver Bulters,

INTRODUCTION:Subarachnoid haemorrhage (SAH) from a ruptured cerebral aneurysm carries high morbidity and mortality. Despite huge advances in techniques to secure the aneurysm, there has been little progress in the treatment of the deleterious effects of the haemorrhage.Sulforaphane is an Nrf2 inducer with anti-oxidant and anti-inflammatory properties. It has been shown ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e028514]

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Quantitative Susceptibility Mapping and Vessel Wall Imaging as Screening Tools to Detect Microbleed in Sentinel Headache.

Daizo Ishii, Daichi Nakagawa, Mario Zanaty, Jorge A Roa, Sami Al Kasab, Amir Shaban, Joseph S Hudson, Carlos Osorno-Cruz, Stefano Byer, Lauren Allan, James C Torner, Issam A Awad, Timothy J Carroll, Edgar A Samaniego, David M Hasan,

BACKGROUND:MR-quantitative susceptibility mapping (QSM) can identify microbleeds (MBs) in intracranial aneurysm (IA) wall associated with sentinel headache (SH) preceding subarachnoid hemorrhage. However, its use is limited, due to associated skull base bonny and air artifact. MR-vessel wall imaging (VWI) is not limited by such artifact and therefore could be an ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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[Isolated atrial septal aneurysm: Exceptional cause of digital ischemia - a case report].

O Zahdi, S El Bouhali, I El Hamraoui, M Hormat-Allah, H El Bhali, Y Sefiani, A El Mesnaoui, B Lekehal,

An atrial septal aneurysm (ASA) is a rare but well recognized entity characterized by saccular deformity of the atrial septum that bulges into the right or left atrium. Diagnosis can be established using transthoracic and transesophageal echocardiography. Although this abnormality is considered clinically benign, it has been independently associated with ... Read more >>

Ann Cardiol Angeiol (Paris) (Annales de cardiologie et d'angeiologie)
[2020, :]

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Acute Tentorial Subdural Hematoma Caused by Rupture of the Posterior Cerebral Artery after Minor Trauma-A Case Report.

Urszula Maria Ciochon, Erik Gudmann Steuble Brandt, Trine Stavngaard,

Acute subdural hematoma (aSDH) is a common pathology encountered after head trauma. Only a minority of aSDHs have an arterial source. In this article, we report a case of aSDH originating from a traumatic pseudoaneurysm of the distal segment of posterior cerebral artery (PCA), diagnosed several days after the initial ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(3):]

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Association of zinc administration with growth suppression of intracranial aneurysms via induction of A20.

Kosuke Hayashi, Hiroharu Kataoka, Manabu Minami, Taichi Ikedo, Takeshi Miyata, Kampei Shimizu, Manabu Nagata, Tao Yang, Yu Yamamoto, Masayuki Yokode, Susumu Miyamoto,

OBJECTIVE:Zinc is an essential micronutrient with multiple biological effects, including antiinflammation. Previously, the authors demonstrated that the pathogenesis of intracranial aneurysms (IAs) is strongly related to chronic inflammation. In this study, the authors investigated whether administration of zinc inhibits the growth of IAs in a rat model. METHODS:The authors analyzed ... Read more >>

J. Neurosurg. (Journal of neurosurgery)
[2020, :1-7]

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A3-A3 Bypass for Giant Anterior Cerebral Artery Aneurysm: 2-Dimensional Operative Video.

Benjamin K Hendricks, Robert F Spetzler,

Large fusiform anterior cerebral artery aneurysms often require revascularization to allow for the treatment of the aneurysm and preservation of distal perfusion. The A3-A3 side-to-side anastomosis maintains ipsilateral distal perfusion. The inflow to the fusiform segment can then be clip occluded to treat the diseased vessel segment. This procedure is ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, :]

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Pterional Craniotomy for Anterior Temporal Artery to Middle Cerebral Artery Bypass: 2-Dimensional Operative Video.

Benjamin K Hendricks, Robert F Spetzler,

Broad-based aneurysms of the middle cerebral artery M1 bifurcation usually involve aneurysmal inclusion of an M2 vessel wall within the neck. This necessitates a consideration of performing a bypass to preserve the patency of distal perfusion. The patient in this video is a 17-yr-old man who presented after experiencing a ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, :]

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Safety and efficacy of different therapeutic strategies in the endovascular treatment of anterior cerebral artery aneurysms with different features: A single centre experience.

Bin Yuan, Xiao-Ming Zhou, Jie-Mei Fan, Shu-Juan Chen, Zong-Qi You, Wei-Dong Xu, Li-Li Wen, Jin-Long Deng, Qi Wu, Xin Zhang,

BACKGROUND:Outcomes of endovascular treatment of anterior cerebral artery (ACA) aneurysms are still not well-characterized. OBJECTIVE:The study aimed to review the clinical effect, procedure-related complications and follow-up outcomes and to evaluate the safety and efficacy of endovascular treatment of ACA aneurysms in our center experience. METHODS:From August 2014 to August 2018, ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 193:105786]

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Rapid formation and rupture of an infectious basilar artery aneurysm from meningitis following suprasellar region meningioma removal: a case report.

Xu Wang, Ge Chen, Mingchu Li, Jiantao Liang, Hongchuan Guo, Gang Song, Yuhai Bao,

BACKGROUND:Infectious basilar artery (BA) aneurysm has been occasionally reported to be generated from meningitis following transcranial operation. However, infectious BA aneurysm formed by intracranial infection after endoscopic endonasal operation has never been reported. CASE PRESENTATION:A 53-year-old man who was diagnosed with suprasellar region meningioma received tumor removal via endoscopic endonasal ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):94]

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Recanalization of Embolized Endovascular Intracranial Aneurysms and Changes in the Blood Viscosity: A Pilot Study.

Rafał Morga, Marek Moskała, Tadeusz Popiela, Marek Rajzer, Aleksander Wilk, Michał Kłosiński, Tomasz Muszyński, Mariusz Trystuła,

BACKGROUND The purpose of our research was to evaluate the relationships between blood viscosity and recanalization of coiled intracranial aneurysms. MATERIAL AND METHODS The study included consecutives patients treated endovascularly by a team of experienced neurosurgeons and neuroradiologists due to brain aneurysm. A total of 50 patients (the average age ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919059]

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Sphenoparietal sinus transposition technique: optimization of the surgical corridor with preservation of prominent bridging veins between the brain and the cranial base during aneurysm clipping via the pterional approach.

Takeya Niibo, Katsumi Takizawa, Jurou Sakurai, Seizi Takebayashi, Hiroyasu Koizumi, Toru Kobayashi, Rina Kobayashi, Kouta Kuris, Syusuke Gotou, Ryousuke Tsuchiya, Hiroyasu Kamiyama,

OBJECTIVE:The sylvian bridging veins between the brain and the dura on the inner surface of the sphenoid wing can restrict brain retraction for widening of the lateral retrocarotid space during clipping surgery for internal carotid artery (ICA)-posterior communicating artery (PCoA) and basilar apex (BX) aneurysms. In such cases, the authors ... Read more >>

J. Neurosurg. (Journal of neurosurgery)
[2020, :1-7]

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Stroke rate after endovascular aortic interventions in the Society for Vascular Surgery Vascular Quality Initiative.

Nicholas J Swerdlow, Patric Liang, Chun Li, Kirsten Dansey, Thomas F X O'Donnell, Livia E V M de Guerre, Rens R B Varkevisser, Virendra I Patel, Grace J Wang, Marc L Schermerhorn, ,

OBJECTIVE:The stroke rate after endovascular aneurysm repair (EVAR), particularly complex EVAR such as fenestrated EVAR (FEVAR) and chimney EVAR (chEVAR), is not well defined. Whereas stroke is a well-established risk of thoracic endovascular aortic repair (TEVAR), the impact of procedural characteristics on stroke remains unclear. Therefore, we characterized the risk ... Read more >>

J. Vasc. Surg. (Journal of vascular surgery)
[2020, :]

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