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Cerebral Amyloid Angiopathy

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Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage.

Lieke Jäkel, H Bea Kuiperij, Lara P Gerding, Emma E M Custers, Emma van den Berg, Wilmar M T Jolink, Floris H B M Schreuder, Benno Küsters, Catharina J M Klijn, Marcel M Verbeek,

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β (Aβ) protein in the cerebral vasculature and poses a major risk factor for the development of intracerebral haemorrhages (ICH). However, only a minority of patients with CAA develops ICH (CAA-ICH), and to date it is unclear which ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):99]

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White Matter Atrophy in Cerebral Amyloid Angiopathy.

Panagiotis Fotiadis, Yael D Reijmer, Susanne J Van Veluw, Sergi Martinez-Ramirez, Fikret Isik Karahanoglu, Elif Gokcal, Kristin M Schwab, , Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Steven M Greenberg, M Edip Gurol,

OBJECTIVE:We postulated that Cerebral Amyloid Angiopathy (CAA) is associated with white matter atrophy (WMA) and that WMA can be related to cognitive changes in CAA. METHODS:White matter volume expressed as percent of intracranial volume (pWMV) of prospectively enrolled non-demented patients diagnosed with probable CAA was compared to age-matched healthy controls ... Read more >>

Neurology (Neurology)
[2020, :]

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Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy-Related Inflammation.

Robert W Regenhardt, Jesse M Thon, Alvin S Das, Olga R Thon, Andreas Charidimou, Anand Viswanathan, M Edip Gurol, Bart K Chwalisz, Matthew P Frosch, Tracey A Cho, Steven M Greenberg,

Importance:Cerebral amyloid angiopathy-related inflammation (CAA-ri), a distinct subtype of cerebral amyloid angiopathy, is characterized by an autoimmune reaction to cerebrovascular β-amyloid deposits. Outcomes and response to immunosuppressive therapy for CAA-ri are poorly understood. Objective:To identify clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of CAA-ri. Design, ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, :]

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The severity of microstrokes depends on local vascular topology and baseline perfusion

Franca Schmid, Giulia Conti, Patrick Jenny, Bruno Weber,

Cortical microinfarcts are caused by blood flow disturbances and are linked to pathologies like cerebral amyloid angiopathy and dementia. Despite their relevance for disease progression, microinfarcts often remain undetected and the smallest scale of disturbance has not yet been identified. We employ blood flow simulations in realistic microvascular networks from ... Read more >>

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Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study.

José Rafael Romero, Serkalem Demissie, Alexa Beiser, Jayandra J Himali, Charles DeCarli, Daniel Levy, Sudha Seshadri,

OBJECTIVE:Cerebral microbleeds (CMBs) are associated with higher risk of stroke and dementia, predating clinical diagnosis by several years. CMB are considered markers of cerebral small vessel disease (CSVD): hypertensive (deep CMB) and cerebral amyloid angiopathy (lobar CMB). We related plasma β-Amyloid (40, 42 and their ratio), clusterin, and tau levels ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, :]

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Clinical and radiological evolution of cerebral amyloid angiopathy-related inflammation in the context of anti-PD-1 immunotherapy.

Arian Lasocki, Damien Kee,

Immune-related adverse events (irAEs) are a frequent complication of immunotherapy, but neurological irAEs are rare and varied. Here, we present a case of cerebral amyloid angiopathy-related inflammation (CAA-ri) attributable to nivolumab monotherapy, which has not been previously reported. The context of immunotherapy and availability of serial imaging also provide unique ... Read more >>

Melanoma Res. (Melanoma research)
[2020, :]

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Amyloid-β plaques may be reduced in advanced stages of cerebral amyloid angiopathy in the elderly.

Koichi Okamoto, Masakuni Amari, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatama,

We examined 29 cases in which cerebral amyloid angiopathy (CAA) was detected among routine aged autopsies. Most cases with severe CAA had many amyloid-β (Aβ) plaques in the occipital cortex. Nonetheless, two cases had few Aβ plaques with many small vessels and capillaries with CAA. In the two cases, severe ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2020, :]

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Aβ peptide and fibrinogen weave a web of destruction in cerebral amyloid angiopathy.

Woosuk S Hur, Matthew J Flick,

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, :]

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ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes.

Abby Keable, Ronan O'Neill, Matthew MacGregor Sharp, Maureen Gatherer, Ho Ming Yuen, David Annandale Johnston, Roy Oliver Weller, Roxana Octavia Carare,

The accumulation of amyloid-β (Aβ) in the walls of capillaries and arteries as cerebral amyloid angiopathy (CAA) is part of the small vessel disease spectrum, related to a failure of elimination of Aβ from the brain. Aβ is eliminated along basement membranes in walls of cerebral capillaries and arteries (Intramural ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(12):]

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Cerebral amyloid angiopathy-linked β-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen.

Steven A Cajamarca, Erin H Norris, Louise van der Weerd, Sidney Strickland, Hyung Jin Ahn,

Cerebral amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathology is unclear. Hereditary cerebral amyloid angiopathy (HCAA) is a rare familial form of CAA in ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(25):14482-14492]

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Alzheimer's Disease: The Link Between Amyloid-β and Neurovascular Dysfunction.

Ernesto Solis, Kevin N Hascup, Erin R Hascup,

While prevailing evidence supports that the amyloid cascade hypothesis is a key component of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular system is also a major contributor to disease progression. Vascular dysfunction and reduced cerebral blood flow (CBF) occur prior to the accumulation and aggregation of ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, :]

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Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia.

Rosana Ottakandathil Babu, Vincent Chi Hang Lui, Yan Chen, Rachel Sze Wan Yiu, Yongqin Ye, Ben Niu, Zhongluan Wu, Ruizhong Zhang, Michelle On Na Yu, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Huimin Xia, Michael Qi Zhang, Bin Wang, Urban Lendahl, Paul Kwong Hang Tam,

BACKGROUND AND AIMS:Biliary atresia (BA) is a poorly understood deadly liver disease, often diagnosed late, is incurable and frequently requires liver transplantation. In this study, we aim to investigate the underlying pathomechanisms and molecular signatures associated with BA. METHODS:We combine organoid and transcriptomic analysis to gain new insights into BA ... Read more >>

J. Hepatol. (Journal of hepatology)
[2020, :]

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Arrival blood pressure in hypertensive and non-hypertensive spontaneous intracerebral hemorrhage.

Michael E Reznik, Nasir Fakhri, Scott Moody, Kayleigh Murray, Samantha Costa, Shadi Yaghi, Matthew Schrag, Tracy E Madsen, Tina M Burton, Shawna Cutting, Ali Mahta, Linda C Wendell, Bradford B Thompson, Shyam S Rao, Christoph Stretz, Karen L Furie, Brian Mac Grory,

BACKGROUND AND PURPOSE:Hypertension is a known risk factor for intracerebral hemorrhage (ICH), but it is unclear whether blood pressure (BP) at hospital arrival can be used to distinguish hypertensive ICH from non-hypertensive etiologies. PATIENTS AND METHODS:We performed a single-center cohort study using data from consecutive ICH patients over 12 months. ICH ... Read more >>

J. Neurol. Sci. (Journal of the Neurological Sciences)
[2020, 416:117000]

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Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease.

Raluca Stefanescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Luminita Paduraru, Bogdan-Ionel Tamba,

Alzheimer's disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal toxicity. They are prone to aggregation, yielding oligomers and ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(6):]

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[Clinico-radiological spectrum of cerebral small vessel diseases].

E Ouin, E Jouvent,

Cerebral small vessel diseases are frequent and can be seen through all ages. Although the most frequent forms related to age and hypertension or to cerebral amyloid angiopathy are mainly observed in subjects over 50 years of age, rarer forms may affect young people, sometimes even children. Some familial or ... Read more >>

Rev Med Interne (La Revue de medecine interne)
[2020, :]

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Mapping of Microvascular Architecture in the Brain of an Alzheimer’s Disease Mouse Model using MRI

Suk-Ki Chang, JeongYeong Kim, DongKyu Lee, Chang Hyun Yoo, Seokha Jin, Hak Young Rhee, Chang-Woo Ryu, Jong Kil Lee, HyungJoon Cho, Geon-Ho Jahng,

Abstract Purpose Growing evidence suggests that alterations of the cerebral microvasculature play a critical role in the pathogenesis of Alzheimer’s disease (AD). The objective of this study was to characterize and evaluate the cerebral microvascular architecture in the AD transgenic (Tg) mice model compared with non-Tg mice using brain microvascular ... Read more >>

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Amyloid Depositions and Small Vessel Disease in Patients with Cerebral Amyloid Angiopathy: a Case Series.

Yun Jeong Hong, Si Baek Lee, Seong Hoon Kim, Dong Woo Ryu, Yongbang Kim, Jeong Wook Park,

Dement Neurocogn Disord (Dementia and neurocognitive disorders)
[2020, 19(2):74-76]

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Cerebral amyloid angiopathy: a cross-sectional study in a single center in Northeastern Brazil.

Marx Lima de Barros-Araújo, Irapuá Ferreira Ricarte, Edward Montalverne Filho, Guilherme Marconi Guimarães Martins Holanda, Ícaro Araújo de Sousa, Matheus Rodrigues Corrêa, Matheus Rocha de Seixas Nogueira, Pedro Jorge Luz Alves Cronemberger,

BACKGROUND:Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder caused by progressive deposition of β-amyloid peptides in the walls of small and medium-sized cortical and leptomeningeal vessels. Until today, the prevalence of CAA is unknown in our region. OBJECTIVE:This study aims to analyze the prevalence of this entity in a specific ... Read more >>

Arq Neuropsiquiatr (Arquivos de neuro-psiquiatria)
[2020, 78(5):277-281]

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Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.

Joel W Blanchard, Michael Bula, Jose Davila-Velderrain, Leyla Anne Akay, Lena Zhu, Alexander Frank, Matheus B Victor, Julia Maeve Bonner, Hansruedi Mathys, Yuan-Ta Lin, Tak Ko, David A Bennett, Hugh P Cam, Manolis Kellis, Li-Huei Tsai,

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein (APOE4) is the strongest risk factor for CAA, yet the mechanisms underlying this genetic susceptibility are unknown. Here we developed ... Read more >>

Nat. Med. (Nature medicine)
[2020, 26(6):952-963]

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Correction to: Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy.

Bernadett Fakan, Zita Reisz, Denes Zadori, Laszlo Vecsei, Peter Klivenyi, Levente Szalardy,

The original version of this article unfortunately contained a mistake. ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, 127(6):973-975]

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Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target.

Karan Govindpani, Chitra Vinnakota, Henry J Waldvogel, Richard L Faull, Andrea Kwakowsky,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1030-1032]

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Intracranial High-Grade Stenosis and Hyperhomocysteinemia Presenting as Cortical Subarachnoid Hemorrhage Concomitant with Acute Ischemic Stroke in a Young Man.

Weiwei Qin, Weizheng Xie, Mingrong Xia, Robert Chunhua Zhao, Jiewen Zhang,

BACKGROUND Cortical subarachnoid hemorrhage (cSAH) is a rare clinical presentation with different causes, but rarely happens along with acute ischemic stroke. Intracranial high-grade stenosis originated from brain has been regarded as an unusual cause of cSAH, especially in young adults. CASE REPORT A case of 33-year-old male presented with mild ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e920606]

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Interhemispheric distribution of amyloid and small vessel disease burden in cerebral amyloid angiopathy-related intracerebral hemorrhage.

M Planton, J Pariente, F Nemmi, J-F Albucher, L Calviere, A Viguier, J-M Olivot, A-S Salabert, P Payoux, P Peran, N Raposo,

BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating presentation of cerebral amyloid angiopathy (CAA), but the mechanisms leading from vascular amyloid deposition to ICH are not well known. Whether amyloid burden and magnetic resonance imaging (MRI) markers of small vessel disease (SVD) are increased in the ICH-affected hemisphere compared to ... Read more >>

Eur. J. Neurol. (European journal of neurology)
[2020, :]

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Cerebral amyloid angiopathy with focal presentation-about 3 cases.

Antoine Garnier-Crussard, Amélie Taki, Marc Bonnefoy, Jean-Yves Bar, Pierre Krolak-Salmon, François Cotton, Thomas Gilbert,

Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. In vivo diagnosis of CAA is guided by the modified Boston criteria, with the presence of multiple intracerebral hemorrhage or cerebral microbleeds (CMB), or single hemorrhage and ... Read more >>

Neuroradiology (Neuroradiology)
[2020, :]

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Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer's Disease.

Hector Rosas-Hernandez, Elvis Cuevas, James B Raymick, Bonnie L Robinson, Sumit Sarkar,

Alzheimer's disease (AD) pathology is characterized by amyloid plaques containing amyloid beta (Aβ) peptides, neurofibrillary tangles containing hyperphosphorylated tau protein, and neuronal loss. In addition, Aβ deposition in brain microvessels, known as cerebral amyloid angiopathy (CAA), increases blood-brain barrier (BBB) permeability and induces vascular dysfunction which aggravates AD pathology. The ... Read more >>

Neuroscience (Neuroscience)
[2020, 440:48-55]

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