Full Text Journal Articles about
Cerebellar Hemorrhage

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Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress.

Mayson H Alkhatib, Shaza A Alyamani, Faiza Abdu,

Methotrexate (MTX), a chemotherapeutic agent, has limited clinical applications due to its pulmonary and neurotoxicity. The antineoplastic activity of MTX-NE COCO, which is MTX formulated in coconut oil nanoemulsion (NE), was evaluated in A549 non-small cell lung cancer cells while its adverse side effects on the oxidative stress of the ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):422-430]

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Compression analysis of the gray and white matter of the spinal cord.

Norihiro Nishida, Fei Jiang, Junji Ohgi, Akihiro Tanaka, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Takashi Sakai, Itsuo Sakuramoto, Xian Chen,

The spinal cord is composed of gray matter and white matter. It is well known that the properties of these two tissues differ considerably. Spinal diseases often present with symptoms that are caused by spinal cord compression. Understanding the mechanical properties of gray and white matter would allow us to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1344-1349]

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Remote ischemic conditioning approach for the treatment of ischemic stroke.

Seyed Mohammad Seyedsaadat, David F Kallmes, Waleed Brinjikji,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1033-1034]

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Neuropathology of Congenital Heart Disease in an Inpatient Autopsy Cohort 2000-2017.

Leigh A Rettenmaier, Patricia A Kirby, Benjamin E Reinking, Angela N Viaene, Marco M Hefti,

Background As a result of medical and surgical advancements in the management of congenital heart disease (CHD), survival rates have improved substantially, which has allowed the focus of CHD management to shift toward neurodevelopmental outcomes. Previous studies of the neuropathology occurring in CHD focused on cases preceding 1995 and reported ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(7):e013575]

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Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age.

Aicha B C Dijkshoorn, Elise Turk, Lisa M Hortensius, Niek E van der Aa, Freek E Hoebeek, Floris Groenendaal, Manon J N L Benders, Jeroen Dudink,

The cerebellum is connected to numerous regions of the contralateral side of the cerebrum. Motor and cognitive deficits following neonatal cerebellar hemorrhages (CbH) in extremely preterm neonates may be related to remote cortical alterations, following disrupted cerebello-cerebral connectivity as was previously shown within six CbH infants. In this retrospective case ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5283]

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Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage.

Dominik Reisinger, Johannes Gojo, Gregor Kasprian, Christine Haberler, Andreas Peyrl, Amedeo A Azizi, Lisa Mayr, Monika Chocholous, Marcel Kool, Thomas Czech, Irene Slavc,

BACKGROUND:Primary intratumoral hemorrhage as a presenting sign is rare in children with medulloblastomas but may result in severe complications. Given the distinct properties of molecular medulloblastoma subgroups, the impact on neurosurgical practice has still to be defined. OBJECTIVE:To investigate both clinical and radiological presentation of intratumoral hemorrhage in medulloblastoma patients ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):478-484]

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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury.

Xin Chen, Yan Chai, Shao-Bo Wang, Jia-Chong Wang, Shu-Yuan Yue, Rong-Cai Jiang, Jian-Ning Zhang,

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid insufficiency. Critical illness-related corticosteroid insufficiency can easily occur after traumatic brain injury, but few studies have examined this occurrence. A multicenter, prospective, cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1259-1265]

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Superficial siderosis associated with the long-term recurrence of pilocytic astrocytoma in an elderly person: A case report.

Kenji Yoshiki, Yasuo Sasagawa, Masashi Kinoshita, Takuya Furuta, Sho Tamai, Hemragul Sabit, Shingo Tanaka, Mitsutoshi Nakada,

BACKGROUND:Superficial siderosis is an irreversible disease in the central nervous system caused by the deposition of hemosiderin in the subpial tissue due to persistent bleeding in the subarachnoid space. The main symptoms include sensorineural hearing loss, cerebellar ataxia, and pyramidal tract disorder. Superficial siderosis is mainly idiopathic, but bleeding factors ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Advanced Imaging Techniques in Diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES).

Nasim Sheikh-Bahaei, Jay Acharya, Anandh Rajamohan, Paul E Kim,

Diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES) in some circumstances can be challenging and structural imaging may not be sufficient to distinguish it from other differential diagnostic considerations. Advanced imaging techniques, such as MR spectroscopy or positron emission tomography (PET) can provide additional information to determine the diagnosis. Other techniques, ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:165]

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Ultrasound of acquired posterior fossa abnormalities in the newborn.

Monica Fumagalli, Alessandro Parodi, Luca Ramenghi, Catherine Limperopoulos, Sylke Steggerda, ,

Neonatal brain sonography is part of routine clinical practice in neonatal intensive care units, but ultrasound imaging of the posterior fossa has gained increasing attention since the burden of perinatal acquired posterior fossa abnormalities and their impact on motor and cognitive neurodevelopmental outcome have been recognized. Although magnetic resonance imaging ... Read more >>

Pediatr. Res. (Pediatric Research)
[2020, 87(Suppl 1):25-36]

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White Matter Disease and Outcomes of Mechanical Thrombectomy for Acute Ischemic Stroke.

E A Mistry, A M Mistry, T Mehta, N Arora, A K Starosciak, F D L R La Rosa, J E Siegler, S E Kasner, R Chitale, M Fusco, M Froehler, S Yaghi, M Schrag, P Khatri, ,

BACKGROUND AND PURPOSE:The increased severity of white matter disease is associated with worse outcomes and an increased rate of intracerebral hemorrhage in patients with ischemic stroke undergoing thrombolytic treatment. However, whether white matter disease is associated with outcomes in patients undergoing endovascular treatment remains unclear. MATERIALS AND METHODS:In this prespecified ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2020, :]

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Comparison of Traumatic Intracranial Hemorrhage Expansion and Outcomes Among Patients on Direct Oral Anticoagulants Versus Vitamin k Antagonists.

Samuel S Shin, Elisabeth B Marsh, Hasan Ali, Paul A Nyquist, Daniel F Hanley, Wendy C Ziai,

BACKGROUND:With increasing use of direct oral anticoagulants (DOACs) and availability of new reversal agents, the risk of traumatic intracranial hemorrhage (tICH) requires better understanding. We compared hemorrhage expansion rates, mortality, and morbidity following tICH in patients treated with vitamin k antagonists (VKA: warfarin) and DOACs (apixaban, rivaroxaban, dabigatran). METHODS:Retrospective chart ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, 32(2):407-418]

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Clinical and MRI Features of Posterior Reversible Encephalopathy Syndrome With Atypical Regions: A Descriptive Study With a Large Sample Size.

Kunhua Li, Yang Yang, Dajing Guo, Dong Sun, Chuanming Li,

Background: Accurate diagnosis and timely treatment for posterior reversible encephalopathy syndrome (PRES) with atypical regions are very important in clinical practice. However, until now, little has been known about the clinical and MRI manifestations of this disease. Therefore, the aim of this study is to investigate the clinical and MRI ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:194]

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White Matter Lesion Severity is Associated with Intraventricular Hemorrhage in Spontaneous Intracerebral Hemorrhage.

Vaibhav Vagal, Simone U Venema, Tyler P Behymer, Eva A Mistry, Padmini Sekar, Russell P Sawyer, Lee Gilkerson, Charles J Moomaw, Mary Haverbusch, Elisheva R Coleman, Matthew L Flaherty, Carson Van Sanford, Robert J Stanton, Christopher Anderson, Jonathan Rosand, Daniel Woo,

BACKGROUND:Intraventricular hemorrhage (IVH) and white matter lesion (WML) severity are associated with higher rates of death and disability in intracerebral hemorrhage (ICH). A prior report identified an increased risk of IVH with greater WML burden but did not control for location of ICH. We sought to determine whether a higher ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, :104661]

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Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL

Sung-Chun Tang, Chih-Hao Chen, Yu-Wen Cheng, Ya-Fang Chen, Jiann-Shing Jeng,

<title>Abstract</title> <p> Background Stroke remains the most cumbersome disease burden in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). This study aimed to investigate whether plasma biomarkers can reflect disease severity and predict stroke recurrence in CADASIL patients. Methods Sixty-three CADASIL ... Read more >>

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Microvascular decompression: is routine postoperative CT imaging necessary?

Gökce Hatipoglu Majernik, Shadi Al-Afif, Hans E Heissler, Luisa Cassini Ascencao, Joachim K Krauss,

BACKGROUND:Postoperative head CT imaging is routinely performed for detection of postoperative complications following intracranial procedures. However, it remains unclear whether with regard to radiation exposure, costs, and possibly lack of consequences this practice is truly justified in various operative procedures. The objective of this study was to analyze whether routine ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2020, :]

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High-dose atorvastatin improves vascular endothelial function in patients with leukoaraiosis.

Jianan Xue, Zhisheng Wu, Shujie Gong, Shengying Qin, Aiming Gu,

OBJECTIVE:Leukoaraiosis (LA), as an age-related white matter degeneration, is mainly caused by chronic ischemia. Our study aims to explore the efficacy of different doses of atorvastatin (ATV) in the vascular endothelial function in patients with LA. METHODS:Our study enrolled 402 LA patients who were then randomly included as control or ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(3):e23081]

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State-of-the-art neonatal cerebral ultrasound: technique and reporting.

Jeroen Dudink, Sylke Jeanne Steggerda, Sandra Horsch, ,

In the past three decades, cerebral ultrasound (CUS) has become a trusted technique to study the neonatal brain. It is a relatively cheap, non-invasive, bedside neuroimaging method available in nearly every hospital. Traditionally, CUS was used to detect major abnormalities, such as intraventricular hemorrhage (IVH), periventricular hemorrhagic infarction, post-hemorrhagic ventricular ... Read more >>

Pediatr. Res. (Pediatric Research)
[2020, 87(Suppl 1):3-12]

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Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome.

Kangping Song, Xiaojie Liu, Qiuyue Zheng, Lingling Zhang, Hongying Zhang, Hailong Yu, Yan Zhu, Li-An Huang, Yingzhu Chen,

Although many studies have focused on functional impairment after intracerebral hemorrhage, little is known about the relationship between secondary injuries to distal regions and neurological function. Our study aimed to evaluate the secondary injuries after intracerebral hemorrhage and explore their relationship to neurological functional outcome. Twenty-one patients with hemorrhages in ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(5):4283-4298]

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Pazopanib-induced posterior reversible encephalopathy syndrome with possible syndrome of inappropriate secretion of antidiuretic hormone: an incidental or pathophysiological association?

Jonathan Wong So, Bérenger Largeau, Frédérique Beau-Salinas, Stephan Ehrmann, Christophe Magni, Jérôme Meunier,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1166-1168]

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Cranial ultrasound by neonatologists.

Paul Govaert, Charles C Roehr, Pierre Gressens,

Pediatr. Res. (Pediatric Research)
[2020, 87(Suppl 1):1-2]

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Predictors of localization, outcome, and etiology of spontaneous intracerebral hemorrhages: focus on cerebral amyloid angiopathy.

Bernadett Fakan, Zita Reisz, Denes Zadori, Laszlo Vecsei, Peter Klivenyi, Levente Szalardy,

Despite its clinical relevance, cerebral amyloid angiopathy (CAA) is underdiagnosed worldwide. This retrospective study aimed to assess the incidence, etiology, predictors, and outcome of intracerebral hemorrhages (ICHs) in this region, with special focus on possible underlying CAA. Database screening of acute cares with intracranial hemorrhage diagnosis within 01/07/2014-01/07/2018 were conducted ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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Diffusion Basis Spectrum Imaging with Deep Neural Network Differentiates Distinct Histology in Pediatric Brain Tumors

Zezhong Ye, Komal Srinivasa, Joshua Lin, Jeffrey Viox, Chunyu Song, Anthony Wu, Peng Sun, Sheng-Kwei Song, Sonika Dahiya, Joshua Rubin,

Abstract High-grade pediatric brain tumors constitute the highest mortality of cancer-death in children. While conventional MRI has been widely adopted for examining pediatric high-grade brain tumor clinically, accurate neuroimaging detection and differentiation of tumor histopathology for improved diagnosis, surgical planning, and treatment evaluation, remains an unmet need in the clinical ... Read more >>

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Ultrafast Brain Magnetic Resonance Imaging in Acute Neurological Emergencies: Diagnostic Accuracy and Impact on Patient Management.

Philipp M Kazmierczak, Max Dührsen, Robert Forbrig, Maximilian Patzig, Matthias Klein, Andreas Pomschar, Wolfgang G Kunz, Daniel Puhr-Westerheide, Jens Ricke, Olga Solyanik, Clemens C Cyran,

OBJECTIVES:The aim of this study was to investigate diagnostic accuracy and impact on patient management of an ultrafast (4:33 minutes/5 sequences) brain magnetic resonance imaging (MRI) protocol for the detection of intracranial pathologies in acute neurological emergencies. MATERIALS AND METHODS:Four hundred forty-nine consecutive emergency patients with acute nontraumatic neurological symptoms ... Read more >>

Invest Radiol (Investigative radiology)
[2020, 55(3):181-189]

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Retrosigmoid Clip Anterior Inferior Cerebellar Artery Aneurysm: 2-Dimensional Operative Video.

Benjamin K Hendricks, Robert F Spetzler,

Aneurysms of the anterior inferior cerebellar artery (AICA) are rare and require a considerate approach to facilitate successful and safe clipping. Surgical approaches vary and are dependent on the relation of the aneurysm to the internal acoustic meatus. An anterior approach should be considered for lesions medial to the meatus. ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E111]

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