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Central Sleep Apnea Syndromes

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TECPR2 Mutation Associated Respiratory Dysregulation: More than Central Apnea.

Pallavi P Patwari, Lisa F Wolfe, Girish D Sharma, Elizabeth Berry-Kravis,

None:Children with rare genetic diseases that cause respiratory dysregulation are at particularly high mortality risk due development of respiratory failure. The Tectonin beta-propeller containing protein 2 (TECPR2) mutations are proposed to cause autophagy defect affecting axonal integrity and development of progressive neurodegenerative and neuromuscular disease. Published TECPR2 mutation cases have ... Read more >>

J Clin Sleep Med (Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine)
[2020, :]

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Elevated Central and Mixed Apnea Index after Upper Airway Stimulation.

Jena Patel, Kelly Daniels, Lauren Bogdan, Colin Huntley, Maurits Boon,

OBJECTIVE:Upper airway stimulation (UAS) is used to treat patients with moderate to severe obstructive sleep apnea (OSA). The aim of this study is to report the incidence and potential predictors of elevated central and mixed apnea index (CMAI) after UAS. STUDY DESIGN:Retrospective chart review of patients undergoing UAS. SETTING:Tertiary care ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2020, :194599820912740]

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Effect of 12 weeks continuous positive airway pressure on day and night arterial stiffness and blood pressure in patients with type 2 diabetes and obstructive sleep apnea: A randomized controlled trial.

Christoffer Krogager, Anne Margareta Banghøj, Per L Poulsen, Martin G Kirkegaard, Birger Thorsteinsson, Lise Tarnow, Klavs W Hansen, Esben Laugesen,

The objective of this study was to evaluate the effect of continuous positive airway pressure treatment on pulse wave velocity and blood pressure in patients with type 2 diabetes and obstructive sleep apnea. A randomized controlled study was performed, including 72 patients with type 2 diabetes and newly diagnosed obstructive ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, :e12978]

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Injury and Apoptosis in the Palatopharyngeal Muscle in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome.

Jiaqi Dong, Xun Niu, Xiong Chen,

BACKGROUND This study aimed to elucidate the possible activity of the mitochondrial-mediated apoptotic pathway (MMAP) in obstructive sleep apnea-hypopnea syndrome (OSAHS). MATERIAL AND METHODS A control group, a mild OSAHS group, a moderate OSAHS group, and a severe OSAHS group were included. Masson staining, hematoxylin and eosin staining, and terminal ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919501]

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Non-contact diagnosis of obstructive sleep apnea using impulse-radio ultra-wideband radar.

Sun Kang, Dong-Kyu Kim, Yonggu Lee, Young-Hyo Lim, Hyun-Kyung Park, Sung Ho Cho, Seok Hyun Cho,

While full-night polysomnography is the gold standard for the diagnosis of obstructive sleep apnea, its limitations include a high cost and first-night effects. This study developed an algorithm for the detection of respiratory events based on impulse-radio ultra-wideband radar and verified its feasibility for the diagnosis of obstructive sleep apnea. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5261]

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Obstructive Sleep Apnea in Psychiatric Inpatients.

Maria Tanielian, Karl Doghramji, Kenneth Certa,

The aim of this study was to identify the prevalence of heightened risk for obstructive sleep apnea (OSA) and its clinical predictors in a heterogeneous diagnostic group of hospitalized psychiatric patients. Ninety-one consecutive psychiatric inpatients were administered the STOP-BANG and Epworth Sleepiness Scale (ESS) inventories. Medical and demographic information was ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2020, 208(3):190-193]

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Two cases of severe Purtscher-like retinopathy demonstrating recurrence and progression to neovascularization and vitreous hemorrhage.

Debora H Lee, Christopher K Hwang, Catherine A Cukras, Henry E Wiley, Farhan F Malik, Emily Y Chew, Tiarnan D Keenan,

Purpose:To report the clinical course of two cases with Purtscher-like retinopathy (PLR), associated with peritoneal dialysis (PD), demonstrating disease recurrence and progression to neovascularization and vitreous hemorrhage. Observations:Case 1 (45-year old woman) experienced acute bilateral vision loss. Medical history included hypertension, end-stage renal failure (ESRF), PD, and obstructive sleep apnea. ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2020, 18:100664]

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Prevalence and predictors of elevated central venous pressure and obstructive sleep apnea in patients with lower extremity chronic venous disease.

Raghu Kolluri, Riyaz Bashir, Todd Matros, Anne Albers, Brian C Fowler, Amanda Frederick, Anand Gupta, Nirav Patil, Paul Davis, Gary Ansel,

BACKGROUND:Chronic venous disease (CVD) is a common vascular disorder with manifestations ranging from asymptomatic spider veins to venous ulcers. Elevated right atrial pressure, otherwise called central venous pressure (CVP), can also result in edema and hyperpigmentation similar to chronic venous insufficiency. Obstructive sleep apnea (OSA) is a known risk factor ... Read more >>

J Vasc Surg Venous Lymphat Disord (Journal of vascular surgery. Venous and lymphatic disorders)
[2020, :]

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Five year follow-up of undiagnosed sleep apnea in patients undergoing coronary artery bypass graft surgery.

Alexandra M Hogan, Sammra Ibrahim, Melanie J Moylan, David J McCormack, Ann-Marie Openshaw, Francesca Cormack, Alex Shipolini,

BACKGROUND:We aimed to study prospectively the nature and effect of sleep apnea-hypopnea syndrome (SAHS) in patients undergoing coronary artery bypass graft (CABG) surgery over five years of follow-up. METHODS:Patients undergoing CABG surgery (n=145) were assessed longitudinally (baseline, and 1- year, 5-years post-surgery) using the 'STOP-BANG' screen of sleep apnoea risk. ... Read more >>

J Cardiovasc Surg (Torino) (The Journal of cardiovascular surgery)
[2020, :]

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Central sleep apnea alters neuronal excitability and increases the randomness in sleep-wake transitions.

Hila Dvir, Shu Guo, S Havlin, Ni Xin, Tai Jun, Daqing Li, Xu Zhifei, Rui Kang, Ronny P Bartsch,

OBJECTIVE:While most studies on Central Sleep Apnea (CSA) have focused on breathing and metabolic disorders, the neuronal dysfunction that causes CSA remains largely unknown. Here, we investigate the underlying neuronal mechanism of CSA by studying the sleep-wake dynamics as derived from hypnograms. METHODS:We analyze sleep data of seven groups of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

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Continuous professional development: elevating sleep andbreathing disorder education in Europe.

Sophia E Schiza, Winfried Randerath, Manuel Sánchez-de-la-Torre, Andrea Aliverti, MariaR Bonsignore, Anita K Simonds, Pierantonio Laveneziana,

The @EuroRespSoc launches a new sleep and breathing disorders continuous professional development programme http://bit.ly/30PU01P. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(1):190336]

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White matter tract-specific alterations in male patients with untreated obstructive sleep apnea are associated with worse cognitive function.

Dae Lim Koo, Hye Ryun Kim, Hosung Kim, Joon-Kyung Seong, Eun Yeon Joo,

STUDY OBJECTIVES:Neurocognitive impairment is one of the daytime symptoms of obstructive sleep apnea (OSA). We proposed to use tract-specific statistical analysis (TSSA) to investigate whether there are fiber tract abnormalities in OSA, which may be undiscovered using voxel-based approaches, and whether such tract-specific disruptions in brain connectivity are associated with ... Read more >>

Sleep (Sleep)
[2020, 43(3):]

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Sleep Disorders in Four Patients With Myotonic Dystrophy Type 1.

Yuka Urata, Masayuki Nakamura, Nari Shiokawa, Aiko Yasuniwa, Nagisa Takamori, Kensuke Imamura, Takehiro Hayashi, Takanori Ishizuka, Motofumi Kasugai, Akira Sano,

Sleep disturbances such as excessive daytime sleepiness, central and obstructive sleep apneas, restless legs syndrome, and rapid eye movement sleep dysregulation are prominent in patients with myotonic dystrophy type 1 (DM1). Mild intellectual deficits presented in many patients with DM1. In addition, psychosocial issues caused by neuropsychiatric symptoms are a ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:12]

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Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes - Possible Link.

Anna Brzecka, Natalia Madetko, Vladimir N Nikolenko, Ghulam M Ashraf, Maria Ejma, Jerzy Leszek, Cyryl Daroszewski, Karolina Sarul, Liudmila M Mikhaleva, Siva G Somasundaram, Cecil E Kirkland, Sergey O Bachurin, Gjumrakch Aliev,

There is increasing number of the patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral neuropathy and nocturia, or associated other sleep ... Read more >>

Curr Neuropharmacol (Current neuropharmacology)
[2020, :]

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Prolonged Sleep Apnea in Two Patients with a History of Opium Abuse -A Case Report.

Hadi Asadpour, Seyede Maryam Naghibi, Sadegh Rahimi, Amir Sharafkhaneh, Lahya Afshari Saleh, Fariborz Rezaee Talab, Mahnaz Amini, Faezeh Nikzad,

Introduction:Obstructive sleep apnea (OSA) is a highly prevalent sleep-disordered breathing (SDB).Case Report:Two 53- and 51-year-old male cases with daytime sleepiness and opium abuse and severe sleep apnea and long respiratory events duration (200 and 275 seconds respectively) noted in polysomnography were reported at Ebn-e-Sina and Razavi hospitals, in Mashhad, Iran. ... Read more >>

Iran J Otorhinolaryngol (Iranian journal of otorhinolaryngology)
[2020, 32(109):127-131]

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Psychomotor Performance in Patients with Obstructive Sleep Apnea Syndrome.

Linda Lusic Kalcina, Ivana Pavlinac Dodig, Renata Pecotic, Maja Valic, Zoran Dogas,

Purpose:Determinants of obstructive sleep apnea (OSA) are hypoxemia and hypercapnia, as well as (micro) arousals from sleep, resulting in chronic sleep fragmentation, sleep deprivation, and excessive daytime sleepiness (EDS). All of the above-mentioned factors might contribute to psychomotor impairment seen in OSA patients. Additionally, this study aimed to assess the ... Read more >>

Nat Sci Sleep (Nature and science of sleep)
[2020, 12:183-195]

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Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice.

Han Guo, Xiang-Shan Yuan, Ji-Chuan Zhou, Hui Chen, Shan-Qun Li, Wei-Min Qu, Zhi-Li Huang,

Hypoglossal motor neurons (HMNs) innervate tongue muscles and play key roles in a variety of physiological functions, including swallowing, mastication, suckling, vocalization, and respiration. Dysfunction of HMNs is associated with several diseases, such as obstructive sleep apnea (OSA) and sudden infant death syndrome. OSA is a serious breathing disorder associated ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2020, :]

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Palatopharyngoplasty Resolves Concentric Collapse in Patients Ineligible for Upper Airway Stimulation.

Stanley Yung-Chuan Liu, Michael J Hutz, Sasikarn Poomkonsarn, Corissa P Chang, Michael Awad, Robson Capasso,

OBJECTIVE:To determine if a modified tissue-preserving palatopharyngoplasty could convert retropalatal concentric collapse to anteroposterior or lateral patterns of collapse on drug-induced sleep endoscopy (DISE) in patients who are not candidates for upper airway stimulation due to complete circumferential collapse at the velum. METHODS:A prospective, nonconsecutive, single-blinded cohort study was performed ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Physiological and geometrical effects in the upper airways with and without mandibular advance device for sleep apnea treatment.

Adela Martínez, Alfonso López Muñiz, Eduardo Soudah, Juan Calvo, Alberto Álvarez Suárez, Juan Cobo, Teresa Cobo,

Sleep apnea is a sleep disorder that occurs when the breathing of a person is interrupted during the sleep. This interruption occurs because of the patient has narrowed airways and the upper airways muscles relax, closes in and blocks the airway. Therefore, any forces or reaction originated by the air ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5322]

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Risk of alzheimer's disease in obstructive sleep apnea patients with or without treatment: Real-world evidence.

Ming-Shao Tsai, Hsueh-Yu Li, Chung-Guei Huang, Robert Y L Wang, Li-Pang Chuang, Ning-Hung Chen, Chi-Hung Liu, Yao-Hsu Yang, Chia-Yen Liu, Cheng-Ming Hsu, Wen-Nuan Cheng, Li-Ang Lee,

OBJECTIVE:To assess the risk of Alzheimer's disease (AD) in patients with obstructive sleep apnea (OSA) with or without treatment based on real-world evidence. STUDY DESIGN:Retrospective cohort study. METHODS:Patients newly diagnosed with OSA during 1997-2012 were identified using the National Health Insurance Research Database of Taiwan. Patients without OSA were randomly ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Post-Concussion Syndrome and Sleep Apnea: A Retrospective Study.

Alexandra Santos, Hannah Walsh, Neda Anssari, Ivone Ferreira, Maria Carmela Tartaglia,

BACKGROUND:Concussion symptoms typically resolve within 7-10 days, but 10%-25% of patients do not fully recover. They can develop post-concussion syndrome (PCS), which includes sleep abnormalities such as obstructive sleep apnea. It is unclear how specific sleep problems manifest in PCS and how it relates to cognition and symptomology. METHODS:A retrospective ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Brain Awareness Week, CoVID-19 infection and Neurological Sciences.

Antonio Federico,

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Sleep Apnea Detection with Polysomnography and Depth Sensors.

Martin Schätz, Aleš Procházka, Jiří Kuchyňka, Oldřich Vyšata,

This paper is devoted to proving two goals, to show that various depth sensors can be used to record breathing rate with the same accuracy as contact sensors used in polysomnography (PSG), in addition to proving that breathing signals from depth sensors have the same sensitivity to breathing changes as ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(5):]

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Risk factors of obstructive sleep apnea syndrome in children.

Zhifei Xu, Yunxiao Wu, Jun Tai, Guoshuang Feng, Wentong Ge, Li Zheng, Zhe Zhou, Xin Ni,

BACKGROUND:The known risk factors of childhood OSAS include tonsillar and adenoidhypertrophy, obesity, craniofacial anomalies, neuromuscular disorders and African-American (AA) ancestry. Whether other factors such as allergic rhinitis (AR), premature, environmental tobacco smoking (ETS) are associated with OSAS are inconsistent in different studies. Our study enrolled children of a broad age ... Read more >>

J Otolaryngol Head Neck Surg (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale)
[2020, 49(1):11]

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Vagus Nerve Stimulator (VNS)-induced Severe Obstructive Sleep Apnea Which Resolved After the VNS Was Turned Off.

Puja Gurung, Yash Nene, Manjamalai Sivaraman,

We present a young 21-year-old male with drug-resistant epilepsy who developed vagus nerve stimulator (VNS)-induced severe obstructive sleep apnea (OSA). Severe OSA resolved after the VNS was turned off. ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6901]

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