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Castor Bean and Jequirity Bean Poisoning

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Biological Toxins as the Potential Tools for Bioterrorism.

Edyta Janik, Michal Ceremuga, Joanna Saluk-Bijak, Michal Bijak,

Biological toxins are a heterogeneous group produced by living organisms. One dictionary defines them as "Chemicals produced by living organisms that have toxic properties for another organism". Toxins are very attractive to terrorists for use in acts of bioterrorism. The first reason is that many biological toxins can be obtained ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(5):]

Cited: 5 times

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Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication.

Adva Mechaly, Ron Alcalay, Tal Noy-Porat, Eyal Epstein, Yoav Gal, Ohad Mazor,

Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent. To date, there is no effective post-exposure treatment for abrin poisoning and passive immunization ... Read more >>

Toxins (Basel) (Toxins)
[2018, 10(2):]

Cited: 1 time

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Abrus Precatorius Poisoning and Central Pontine Myelinolysis.

Sumantra Sarkar, Kaushambi Basu, Jayati Das, Supratim Datta,

Accidental poisoning with Abrus precatorius (AP) can rarely produce neurological complication due to its toxic principle "Abrin". The authors report such a case in a 2-year old child, who subsequently developed central pontine myelinolysis, an association, to the best of the author's knowledge, has never been reported in literature. ... Read more >>

J Pediatr Neurosci (Journal of pediatric neurosciences)
[2017, 12(4):353-355]

Cited: 0 times

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Abrin Toxicity and Bioavailability after Temperature and pH Treatment.

Christina C Tam, Thomas D Henderson, Larry H Stanker, Xiaohua He, Luisa W Cheng,

Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and ... Read more >>

Toxins (Basel) (Toxins)
[2017, 9(10):]

Cited: 3 times

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Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine.

Letizia Polito, Massimo Bortolotti, Stefania Maiello, Maria Giulia Battelli, Andrea Bolognesi,

Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2016, 21(11):]

Cited: 10 times

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The medicinal plants of Myanmar.

Robert A DeFilipps, Gary A Krupnick,

A comprehensive compilation is provided of the medicinal plants of the Southeast Asian country of Myanmar (formerly Burma). This contribution, containing 123 families, 367 genera, and 472 species, was compiled from earlier treatments, monographs, books, and pamphlets, with some medicinal uses and preparations translated from Burmese to English. The entry ... Read more >>

PhytoKeys (PhytoKeys)
[2018, (102):1-341]

Cited: 1 time

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A Monoclonal-Monoclonal Antibody Based Capture ELISA for Abrin.

Christina C Tam, Luisa W Cheng, Xiaohua He, Paul Merrill, David Hodge, Larry H Stanker,

Abrin, one of the most highly potent toxins in the world, is derived from the plant, Abrus precatorius. Because of its high toxicity, it poses potential bioterror risks. Therefore, a need exists for new reagents and technologies that would be able to rapidly detect abrin contamination as well as lead ... Read more >>

Toxins (Basel) (Toxins)
[2017, 9(10):]

Cited: 2 times

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Simultaneous detection of ricin and abrin DNA by real-time PCR (qPCR).

Eva Felder, Ilona Mossbrugger, Mirko Lange, Roman Wölfel,

Ricin and abrin are two of the most potent plant toxins known and may be easily obtained in high yield from the seeds using rather simple technology. As a result, both toxins are potent and available toxins for criminal or terrorist acts. However, as the production of highly purified ricin ... Read more >>

Toxins (Basel) (Toxins)
[2012, 4(9):633-642]

Cited: 9 times

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Rapid method using two microbial enzymes for detection of L-abrine in food as a marker for the toxic protein abrin.

Anthony G Dodge, Kelvin Carrasquillo, Luis Rivera, Lei Xu, Lawrence P Wackett, Michael J Sadowsky,

Abrin is a toxic protein produced by the ornamental plant Abrus precatorius, and it is of concern as a biothreat agent. The small coextracting molecule N-methyl-l-tryptophan (l-abrine) is specific to members of the genus Abrus and thus can be used as a marker for the presence or ingestion of abrin. ... Read more >>

Appl. Environ. Microbiol. (Applied and environmental microbiology)
[2015, 81(5):1610-1615]

Cited: 0 times

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Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects.

Artem V Domashevskiy, Dixie J Goss,

Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and must adapt to the requirements of the host translational systems. Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome inactivating protein (RIP) and is an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin (S/R) ... Read more >>

Toxins (Basel) (Toxins)
[2015, 7(2):274-298]

Cited: 8 times

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Transcriptomic profile of host response in mouse brain after exposure to plant toxin abrin.

A S Bala Bhaskar, Nimesh Gupta, P V Lakshmana Rao,

Abrin toxin is a plant glycoprotein, which is similar in structure and properties to ricin and is obtained from the seeds of Abrus precatorius (jequirity bean). Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 μg/kg, and has caused death after accidental and intentional poisoning. Abrin is ... Read more >>

Toxicology (Toxicology)
[2012, 299(1):33-43]

Cited: 5 times

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Ribosome-inactivating proteins: potent poisons and molecular tools.

Matthew J Walsh, Jennifer E Dodd, Guillaume M Hautbergue,

Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of atomic structures and molecular mechanism has revealed these proteins to be a diverse group subdivided into two classes. RIPs have been shown to exhibit RNA ... Read more >>

Virulence (Virulence)
[2013, 4(8):774-784]

Cited: 34 times

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A recombinant chimeric protein containing B chains of ricin and abrin is an effective vaccine candidate.

Junhong Wang, Shan Gao, Tao Zhang, Lin Kang, Wuchun Cao, Na Xu, Wensen Liu, Jinglin Wang,

Both ricin toxin (RT) and abrin toxin (AT) are 2 important toxin agents as potantial bioweapons. A dual subunit vaccine against RT and AT exposure is a promising option for developing prophylactic vaccination. In this study, we constructed a dual vaccine with RT B chain and AT B chain named ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2014, 10(4):938-944]

Cited: 2 times

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Attempted suicide, by mail order: Abrus precatorius.

David H Jang, Robert S Hoffman, Lewis S Nelson,

Abrus precatorius is cultivated in many subtropical areas. The seeds exist in a variety of colors such as black, orange, and most commonly, glossy red. A black band is found at the end of the seed. The plant contains multiple pods which typically contain three to five Abrus seeds. The ... Read more >>

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[2010, 6(4):427-430]

Cited: 11 times

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Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin.

Rudolph C Johnson, Yingtao Zhou, Ram Jain, Sharon W Lemire, Shannon Fox, Pat Sabourin, John R Barr,

Abrin is a toxic protein found in the jequirity seed. L-Abrine (N-methyl-tryptophan) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. Analysis of L-abrine was added to an existing method for quantifying ricinine as a marker for ricin exposure in human urine ... Read more >>

J Anal Toxicol (Journal of analytical toxicology)
[2009, 33(2):77-84]

Cited: 9 times

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Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius).

Vaibhav Sahni, Satish K Agarwal, Narinder P Singh, Sunandan Sikdar,

INTRODUCTION:Castor and jequirity beans are uncommon causes of poisoning. The more common but less severe castor poisoning is well described, but jequirity bean (Abrus Precatorius) poisoning is rare. The toxicity is attributed to toxalbumins (ricin and abrin) that act by inhibiting protein synthesis. Their use as agents of biological warfare, ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2007, 45(1):77-79]

Cited: 9 times

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Abrin poisoning.

Kirsten J Dickers, Sally M Bradberry, Paul Rice, Gareth D Griffiths, J Allister Vale,

Abrin is a toxic protein obtained from the seeds of Abrus precatorius (jequirity bean), which is similar in structure and properties to ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentional poisoning. Abrin can be extracted from ... Read more >>

Toxicol Rev (Toxicological reviews)
[2003, 22(3):137-142]

Cited: 39 times

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Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Bharat B Aggarwal, Sahdeo Prasad, Simone Reuter, Ramaswamy Kannappan, Vivek R Yadev, Byoungduck Park, Ji Hye Kim, Subash C Gupta, Kanokkarn Phromnoi, Chitra Sundaram, Seema Prasad, Madan M Chaturvedi, Bokyung Sung,

Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and other chronic diseases. Extensive research within last three decades has confirmed ... Read more >>

Curr Drug Targets (Current drug targets)
[2011, 12(11):1595-1653]

Cited: 62 times

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Pathogenesis of bacterial colitis.

M F Heyworth,

Gut (Gut)
[1995, 36(1):154-155]

Cited: 0 times

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Medicinal plants--old and new.

Morton,

The historic role of plants in healing declined early in the twentieth century with the ascendency of synthetic drugs, even though a number of basic medical tools, such as opium, strychnine, and cocaine, are of botanical origin. In recent years, interest in natural products has been restored dramatically by the ... Read more >>

Bull Med Libr Assoc (Bulletin of the Medical Library Association)
[1968, 56(2):161-167]

Cited: 0 times

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Questions and Comments.

Br Med J (British medical journal)
[1950, 2(4693):1403-1404]

Cited: 0 times

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Paul Ehrlich, born March 14, 1854.

H DALE,

Br Med J (British medical journal)
[1954, 1(4863):659-663]

Cited: 3 times

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Section I: Alphabetical index to diseases and nature of injury, P-Q.

Bull World Health Org Suppl (Bulletin of the World Health Organization. Supplement)
[1949, 1(Index):315-374]

Cited: 0 times

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Remarks ON POISONING BY FUNGI: AMANITA PHALLOIDES.

C B Plowright,

Br Med J (British medical journal)
[1905, 2(2332):541-542]

Cited: 0 times

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Goulstonian Lectures on the Chemical Pathology of Diphtheria, Compared with that of Anthrax, Infective Endocarditis, and Tetanus.

S Martin,

Br Med J (British medical journal)
[1892, 1(1632):755-759]

Cited: 0 times

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