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Cardiomyopathy

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-Using the C. elegans lem-2 Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy.

Ayaa AlKhaleefa, Frances L Snider, Henry J Duff, James D McGhee,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Arrhythmogenic right ventricular cardiomyopathy in the pediatric population.

Mitchell I Cohen, Melany B Atkins,

Review the current state of the art of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis and risk stratification in the pediatric population. ARVC is an inherited cardiomyopathy characterized by progressive myocyte loss and fibrofatty replacement of predominantly the right ventricle and high risk of ventricular arrhythmias and sudden cardiac death (SCD). ... Read more >>

Curr Opin Cardiol (Current opinion in cardiology)
[2022, 37(1):99-108]

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LIM Domain-Wide Comprehensive Virtual Mutagenesis Provides Structural Rationale for Cardiomyopathy Mutations in CSRP3

Pankaj Kumar Chauhan, Sowdhamini,

Cardiomyopathies are a severe and chronic cardiovascular burden worldwide, affecting a large cohort in the general population. Cysteine and glycine-rich protein 3 (CSRP3) is one of key proteins implicated in dominant dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). In this study, we device a rapid in-silico screening protocol that creates ... Read more >>

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Reply to letter to editor by McCullough.

Amandeep Goyal, Pankaj Bansal,

Ann Med (Annals of medicine)
[2021, 53(1):335-336]

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Regarding: "Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019".

Peter A McCullough,

Ann Med (Annals of medicine)
[2021, 53(1):286]

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Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report.

Rahul Banerjee, Mimi Lo, Liviu Klein, Mandar Aras, Aaron C Logan,

<h4>Introduction</h4>For young adult patients with acute leukemia, both the efficacy and cardiotoxicity of anthracycline-based regimens have been documented. We report the case of a patient with severe cardiomyopathy, mechanically supported by a left ventricular assist device (LVAD), who subsequently developed Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph + ALL). To our knowledge, this ... Read more >>

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2021, :10781552211062148]

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Myocardial Strain and Association With Clinical Outcomes in Danon Disease: A Model for Monitoring Progression of Genetic Cardiomyopathies.

Quan M Bui, Kimberly N Hong, Megan Kraushaar, Gary S Ma, Michela Brambatti, Andrew M Kahn, Carol Elias Battiha, Kylie Boynton, Garrett Storm, Luisa Mestroni, Matthew R G Taylor, Anthony N DeMaria, Eric A Adler,

Background Myocardial strain can identify subclinical left ventricular dysfunction in various cardiac diseases, but its association with clinical outcomes in genetic cardiomyopathies remains unknown. Herein, we assessed myocardial strain in patients with Danon disease (DD), a rare X-linked autophagic disorder that causes severe cardiac manifestations. Methods and Results Echocardiographic images ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e022544]

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Imaging-Based Risk Stratification for Recurrence Risk in Women with a History of Peripartum Cardiomyopathy.

Marwan Ma'ayeh, Jeremy A Slivnick, Monique E McKiever, Zachary D Garrett, Woobeen Lim, Michael Cackovic, Kara M Rood, Elisa A Bradley,

 Peripartum cardiomyopathy (PPCM) affects 1:1,000 U.S. pregnancies, and while many recover from the disease, the risk of recurrence in subsequent pregnancy (SSP) is high. This study aims to evaluate the utility of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) to predict the risk of recurrence of PPCM ... Read more >>

Am J Perinatol (American journal of perinatology)
[2021, :]

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Impact of Comorbidities on Atrial Fibrillation and Sudden Cardiac Death in Hypertrophic Cardiomyopathy.

Aadhavi Sridharan, Martin S Maron, Richard T Carrick, Christopher A Madias, Dou Huang, Craig Cooper, Jennifer Drummond, Barry J Maron, Ethan J Rowin,

<h4>Background</h4>The impact of comorbid disease states on the development of atrial and ventricular arrhythmias in patients with hypertrophic cardiomyopathy (HCM) remains unresolved.<h4>Objective</h4>Evaluate the association of comorbidities linked to arrhythmias in other cardiovascular diseases (e.g., obesity, systemic hypertension, diabetes, obstructive sleep apnea, renal disorders, tobacco and alcohol use) to atrial fibrillation ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, :]

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Cutting through the Fat: Relationship Between Comorbidities and Arrhythmias in Hypertrophic Cardiomyopathy.

Alan Sugrue, David Lin,

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, :]

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Pediatric AML patients with acute-onset cardiomyopathy in the setting of Streptococcus viridans bacteremia after anthracyclines.

Kazuhiro Sabet, Arun Panigrahi, Jo Chung, Yoni Dayan,

We reviewed three very similar cases of acute-onset heart failure in children with acute myeloid leukemia who received anthracyclines during their treatment. All three children were diagnosed with recent Streptococcus viridans bacteremia and had persistent tachycardia prior to acute-onset heart failure with near-complete resolution within weeks. We hypothesize their heart ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29450]

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Mitral annular calcification in hypertrophic cardiomyopathy.

Daniele Massera, Yuhe Xia, Boyangzi Li, Katherine Riedy, Daniel G Swistel, Mark V Sherrid,

<h4>Background</h4>Changes in mitral valve anatomy contribute to left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM). Mitral annular calcification (MAC) is common among patients with HCM but its implications are currently unknown.<h4>Methods</h4>We tested the hypothesis that echocardiographic MAC would be associated with anterior displacement of the mitral valve and ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, :]

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Reversible Takotsubo cardiomyopathy with non-revascularized concomitant severe coronary artery disease.

Yumiko V Taguchi, Tasneem Z Naqvi,

Takotsubo cardiomyopathy is a transient cardiac condition commonly triggered by a stressor, presenting with clinical features mimicking acute coronary syndromes. We report an unusual case of Takotsubo cardiomyopathy in a man with severe three-vessel coronary artery disease awaiting coronary bypass surgery who developed rapid spontaneous recovery of cardiac function before ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, :]

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Comprehensive analysis of miRNA-mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse.

Jiahe Wu, Jianlei Cao, Yongzhen Fan, Chenze Li, Xiaorong Hu,

<h4>Background</h4>Chronic chagasic cardiomyopathy (CCC) is the leading cause of heart failure in Latin America and often causes severe inflammation and fibrosis in the heart. Studies on myocardial function and its molecular mechanisms in patients with Chronic chagasic cardiomyopathy are very limited. In order to understand the development and progression of ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):283]

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Lipid Droplet-Associated Proteins in Cardiomyopathy.

Weiwei Huang, Fei Gao, Yuting Zhang, Tianhui Chen, Chen Xu,

The heart requires a high rate of fatty-acid oxidation (FAO) to meet its energy needs. Neutral lipids are the main source of energy for the heart and are stored in lipid droplets (LDs), which are cytosolic organelles that primarily serve to store neutral lipids and regulate cellular lipid metabolism. LD-associated ... Read more >>

Ann Nutr Metab (Annals of nutrition & metabolism)
[2021, :1-13]

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Myocardial early systolic lengthening predicts mid-term outcomes in patients with hypertrophic cardiomyopathy.

Ozkan Candan, Cetin Gecmen, Muzaffer Kahyaoğlu, Zeki Şimsek, Mehmet Çelik, Cevat Kirma,

In this study, we investigated whether early systolic lengthening (ESL) which reflects subclinical ischemia and other echocardiographic and clinic parameters predict primary outcome [appropriate ICD shock, cardiovascular mortality and ventricular tachycardia (VT) or fibrillation] in patients with hypertrophic cardiomyopathy (HCM). 202 Patients with HCM (68% male, mean age 48 ± 13.9 years) were ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2021, :]

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A homozygous CAP2 pathogenic variant in a neonate presenting with rapidly progressive cardiomyopathy and nemaline rods.

Sharavana Gurunathan, Jessica Sebastian, Jennifer Baker, Hoda Z Abdel-Hamid, Shawn C West, Brian Feingold, Vivek Peche, Miguel Reyes-Múgica, Suneeta Madan-Khetarpal, Jeffrey Field,

Nemaline Myopathy (NM) is a disorder of skeletal muscles caused by mutations in sarcomere proteins and characterized by accumulation of microscopic rod or thread-like structures (nemaline bodies) in skeletal muscles. Patients diagnosed with both NM and infantile cardiomyopathy are very rare. A male infant presented, within the first few hours ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, :]

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Berberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-κB signalling in rats.

Huiqi Chen, Qian Liu, Xiangqi Liu, Jinlan Jin,

<h4>Context</h4>Berberine (Ber) can increase the survival rate of septic mice and inhibit inflammation, but whether it has a protective effect on septic cardiomyopathy (SCM) is unclear.<h4>Objective</h4>To investigate whether Ber ameliorates SCM in a rat model and its potential mechanism.<h4>Materials and methods</h4>Male SD rats were randomly divided into three groups: control ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):121-128]

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Retrospective evaluation of notched and fragmented QRS complex in dogs with naturally occurring myxomatous mitral valve disease.

Radu Andrei Baisan, Cătălina Andreea Turcu, Eusebiu Ionuț Condurachi, Vasile Vulpe,

Myxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs. The association of QRS notching (nQRS) or fragmentation (fQRS) with disease severity is currently unknown. The study objective was to assess the prevalence of nQRS and fQRS in dogs with MMVD and its severity according to ACVIM ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):301-307]

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Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats.

Mahmoud E Youssef, Mona F El-Azab, Marwa A Abdel-Dayem, Galal Yahya, Ibtesam S Alanazi, Sameh Saber,

Diabetes is a clinical condition that is associated with insulin deficiency and hyperglycemia. Cardiomyopathy, retinopathy, neuropathy, and nephropathy are well known complications of the elevated blood glucose. Diabetic cardiomyopathy is a clinical disorder that is associated with systolic and diastolic dysfunction along with cardiac fibrosis, inflammation, and elevated oxidative stress. ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Unraveling the genetic substrate and phenotypic variability of hypertrophic cardiomyopathy: A role for desmosome gene variants?

Paloma Jordà, Gavin Y Oudit, Rafik Tadros,

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Substrate Characterization and Outcome of Catheter Ablation of Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy and Isolated Epicardial Scar.

Ioan Liuba, Daniele Muser, Anwar Chahal, Cory Tschabrunn, Pasquale Santangeli, Ling Kuo, David S Frankel, David J Callans, Fermin Garcia, Gregory E Supple, Robert D Schaller, Sanjay Dixit, David Lin, Saman Nazarian, Ramanan Kumareswaran, Jeffrey Arkles, Michael P Riley, Matthew C Hyman, Katie Walsh, Gustavo Guandalini, Martin Arceluz, Naga Venkata K Pothineni, Erica S Zado, Francis Marchlinski,

<h4>Background</h4>The substrate for ventricular tachycardia (VT) in left ventricular (LV) nonischemic cardiomyopathy may be epicardial. We assessed the prevalence, location, endocardial electrograms, and VT ablation outcomes in LV nonischemic cardiomyopathy with isolated epicardial substrate.<h4>Methods</h4>Forty-seven of 531 (9%) patients with LV nonischemic cardiomyopathy and VT demonstrated normal endocardial (>1.5 mV)/abnormal epicardial ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2021, :CIRCEP121010279]

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Microvolt QRS Alternans in Hypertrophic Cardiomyopathy: A Novel Risk Marker of Late Ventricular Arrhythmias.

Praloy Chakraborty, Adrian M Suszko, Karthik Viswanathan, Kimia Sheikholeslami, Danna Spears, Arnon Adler, Anna Woo, Harry Rakowski, Vijay S Chauhan,

Background Unlike T-wave alternans (TWA), the relation between QRS alternans (QRSA) and ventricular arrhythmia (VA) risk has not been evaluated in hypertrophic cardiomyopathy (HCM). We assessed microvolt QRSA/TWA in relation to HCM risk factors and late VA outcomes in HCM. Methods and Results Prospectively enrolled patients with HCM (n=130) with ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e022036]

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Loeys-Dietz Cardiomyopathy? Long-Term Follow-Up After Onset of Acute Decompensated Heart Failure.

Takashi Yokota, Hiroaki Koiwa, Shouji Matsushima, Shingo Tsujinaga, Masanao Naya, Hiroko Morisaki, Takayuki Morisaki,

Loeys-Dietz syndrome (LDS) is an inherited connective tissue disorder the phenotype of which resembles Marfan syndrome (MFS). LDS frequently affects the cardiovascular system leading to aortic aneurysm or dissection, but unlike MFS, primary cardiomyopathy is very rare in LDS, and thus the detailed clinical course of LDS-associated cardiomyopathy is unknown. ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Suspected primary hyperreninism in a cat with malignant renal sarcoma and global renin-angiotensin-aldosterone system upregulation.

Jeremy Evans, Jessica Ward, Oliver Domenig, Jonathan P Mochel, Kate Creevy,

A 14-year-old male castrated domestic medium-hair cat with diabetes mellitus was evaluated for vomiting, diarrhea, and anorexia. Two weeks before presentation, the cat had been diagnosed with congestive heart failure and started on furosemide. Initial diagnostic testing identified hypokalemia, systemic hypertension, and hypertrophic cardiomyopathy phenotype, and plasma aldosterone concentration was moderately ... Read more >>

J Vet Intern Med (Journal of veterinary internal medicine)
[2021, :]

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