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Cardioembolic Stroke

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[Surgical considerations for two patients with cardioembolic stroke and mobile thrombus in the left atrium appendage].

Mayuko Sakuwa, Yuki Aozasa, Yutaka Suto, Hiroki Fukuda,

Two men (Case 1, 74 years old; Case 2, 65 years old) developed cardioembolic stroke due to self-interruption of anticoagulants for treating atrial fibrillation. They both had mobile thrombus in the left atrial appendage. In Case 1, a left atrial thrombectomy was scheduled on day 8, but infarction re-occurred on ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, :]

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Circular RNA expression profile in blood according to ischemic stroke etiology.

Aiora Ostolaza, Idoia Blanco-Luquin, Amaya Urdánoz-Casado, Idoya Rubio, Alberto Labarga, Beatriz Zandio, Miren Roldán, Judith Martínez-Cascales, Sergio Mayor, María Herrera, Nuria Aymerich, Jaime Gallego, Roberto Muñoz, Maite Mendioroz,

Background:The discovery of novel biomarkers of stroke etiology would be most helpful in management of acute ischemic stroke patients. Recently, circular RNAs (circRNAs) have been proposed as candidate biomarkers of neurological conditions due to its high stability. circRNAs function as sponges, sequestering miRNAs and are involved in most relevant biological ... Read more >>

Cell Biosci (Cell & Bioscience)
[2020, 10:34]

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Independent Prognostic Value of MRproANP (Midregional Proatrial Natriuretic Peptide) Levels in Patients With Stroke Is Unaltered Over Time.

Markus Arnold, Christos Nakas, Andreas Luft, Mirjam Christ-Crain, Alexander Leichtle, Mira Katan,

Background and Purpose- MRproANP (midregional proatrial natriuretic peptide) is known to be independently associated with cardioembolic stroke cause and to improve risk stratification for 90-day mortality when measured within 24 to 72 hours after symptom onset in patients with acute ischemic stroke. However, the optimal time point for assessment remains ... Read more >>

Stroke (Stroke)
[2020, :STROKEAHA120029333]

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Left Atrial Enlargement is Associated with Stroke Severity with Cardioembolic and Cryptogenic Subtypes in a Chinese Population.

Jie Xue, Xu-Shen Xu, Xiao-Qiong Zhu, Zhi-Zhang Li, Xiao-Guang Zhang, Yan-Ting Ma, Wen-Hao Yang, Ling-Yun Liu, Yun-Hua Yue,

BACKGROUND:Left atrial enlargement is associated with increased risk for stroke. However, few studies that evaluated the correlation between left atrial size and ischemic stroke severity. In this study, we aim to evaluate the association between left atrial size and stroke severity, especially with cardioembolic and cryptogenic stroke in the Chinese ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, :104767]

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Cilostazol uncovers covert atrial fibrillation in non-cardioembolic stroke.

Junya Aoki, Yasuyuki Iguchi, Takao Urabe, Hiroshi Yamagami, Kenichi Todo, Shigeru Fujimoto, Koji Idomari, Nobuyuki Kaneko, Takeshi Iwanaga, Tadashi Terasaki, Ryota Tanaka, Nobuaki Yamamoto, Akira Tsujino, Koichi Nomura, Koji Abe, Masaaki Uno, Yasushi Okada, Hideki Matsuoka, Sen Yamagata, Yasumasa Yamamoto, Toshiro Yonehara, Takeshi Inoue, Yoshiki Yagita, Kazumi Kimura, ,

BACKGROUND:We hypothesized that administration of cilostazol may clarify the occult atrial fibrillation (AF) during hospitalization in mild stroke patients, who has no history of AF. METHODS:From our prospective non-cardioembolic stroke study, randomized to dual antiplatelet therapy using cilostazol and aspirin or aspirin alone trial (ADS), data on the presence or ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 413:116796]

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Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study.

Shuai Yuan, Ang Lin, Qi-Qiang He, Stephen Burgess, Susanna C Larsson,

BACKGROUND:The causal role of interleukins (ILs) for cardiovascular disease has not been fully elucidated. We conducted a Mendelian randomization study to investigate the associations of circulating ILs with coronary artery disease (CAD), atrial fibrillation (AF), and ischemic stroke. METHODS AND RESULTS:Single-nucleotide polymorphisms associated with IL-1β, IL-1 receptor antagonist (IL-1ra), IL-2 ... Read more >>

Int. J. Cardiol. (International Journal of Cardiology)
[2020, :]

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Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after stroke.

Benjamin Hotter, Sarah Hoffmann, Lena Ulm, Joan Montaner, Alejandro Bustamante, Christian Meisel, Andreas Meisel,

OBJECTIVE:Prognosis of stroke is negatively affected by complications, in particular stroke-associated pneumonia (SAP). We hypothesized that inflammatory and stress biomarkers predict SAP during hospitalization and outcome 3 months after stroke. METHODS:We pooled the clinical data of 2 acute stroke studies with identical assessment: the STRoke Adverse outcome is associated WIth ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Efficacy and Safety of Mono Antiplatelet Treatment for Cardioembolic and Undetermined Etiological Stroke after Receiving Successful Mechanical Thrombectomy

Yueqi Zhu, Jiangshan Deng, Guangchen He, Haitao Lu, Liming Wei, Minghua Li, Yuehua Li, Yuwu Zhao,

<title>Abstract</title> <p> Background Periprocedural antithrombotic medication after mechanical thrombectomy (MT) for acute intracranial large vessel occlusion (LVO) is still controversial. Recent studies have indicated that majority of stroke with undetermined etiology (SUE), as defined by the TOAST classification, showed strong overlap with cardioembolic stroke (CE). We intended to ... Read more >>

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Development of a predictive scale for cardioembolic stroke using extracted thrombi and angiographic findings.

Bomi Kim, Yeon Mee Kim, Sung-Chul Jin, Jun-Won Lee, Byung In Lee, Sung Eun Kim, Kyong Jin Shin, JinSe Park, Kang Min Park, Si Eun Kim, Seongho Park, Sam Yeol Ha,

We analyzed the histopathological findings of the clots obtained from patients with acute ischemic stroke by mechanical thrombectomy. We then developed a clinical scoring system for predicting pathogenic causes in patients with undetermined ischemic stroke using these histopathological and the angiographic findings during endovascular treatment. Only cases with the occlusion ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 73:224-230]

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The Atrium and Embolic Stroke: Myopathy Not Atrial Fibrillation as the Requisite Determinant?

Jithin K Sajeev, Jonathan M Kalman, Helen Dewey, Jennifer C Cooke, Andrew W Teh,

Atrial fibrillation (AF) is well-recognized in the pathophysiology of left atrial thrombogenesis and resultant cardioembolic stroke. Subclinical AF is believed to account for a significant proportion of embolic stroke. However, recent randomized control trials failed to demonstrate a significant benefit for oral anticoagulation, in an unselected population with embolic stroke ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(3):251-261]

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Medical Management for Secondary Stroke Prevention.

Anthony S Kim,

PURPOSE OF REVIEW:This article reviews the evidence base and recommendations for medical management for secondary stroke prevention. RECENT FINDINGS:Recent developments for secondary stroke prevention include evidence to support the use of short-term dual antiplatelet therapy after minor stroke and transient ischemic attack, direct oral anticoagulants for nonvalvular atrial fibrillation, reversal ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2020, 26(2):435-456]

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Safety and Efficacy of Prasugrel in Elderly/Low Body Weight Japanese Patients with Ischemic Stroke: Randomized PRASTRO-II.

Kazuo Kitagawa, Kazunori Toyoda, Takanari Kitazono, Masakatsu Nishikawa, Shinsuke Nanto, Yasuo Ikeda, Kenji Abe, Akira Ogawa,

INTRODUCTION:The safety of prasugrel in elderly and/or low body weight Japanese patients with ischemic stroke who have a relatively high bleeding risk with antiplatelet therapy remains unknown. OBJECTIVE:We aimed to investigate the safety and efficacy of long-term prasugrel monotherapy for stroke prevention compared with clopidogrel in elderly and/or low body ... Read more >>

Cerebrovasc. Dis. (Cerebrovascular diseases (Basel, Switzerland))
[2020, :1-8]

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Normal Systolic Blood Pressure at Presentation With Acute Ischemic Stroke Predicts Cardioembolic Etiology.

Margaret Moores, Vignan Yogendrakumar, Olena Bereznyakova, Walid Alesefir, Hailey Pettem, Grant Stotts, Dar Dowlatshahi, Michel Shamy,

Background Early insight into the possible etiology of ischemic stroke allows for early initiation of mechanism-specific secondary stroke prevention. Initial systolic blood pressure during acute ischemic stroke may relate to stroke etiology. We sought to determine whether normotension at presentation with acute ischemic stroke predicts cardioembolic etiology. Methods and Results ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(1):e014399]

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Risk Factors Associated With Outcomes of Non-cardioembolic Ischemic Stroke In Patients Stratified By Essen Stroke Risk Score

Haibin Dai, Yanting Ping, Qianqian Yang, Yuwen Huang, Huimin Xu,

<title>Abstract</title> <p> Background: Identifying risk factors of cardiovascular events is crucial for stroke prevention and they can be used as predictive factors of stroke outcomes.In this study, it is to evaluate the risk factors that predict outcomes of acute non-cardioembolic ischemic stroke in patients stratified by Essen Stroke ... Read more >>

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Embolic Stroke of Undetermined Source and Sleep Disorders.

Laavanya Dharmakulaseelan, Nathan Chan-Smyth, Sandra E Black, Richard H Swartz, Brian J Murray, Mark I Boulos,

Background and Purpose- Compared with other causes of ischemic stroke, the mechanism of action of embolic stroke of undetermined source (ESUS) remains unclear, with previous literature suggesting that ESUS may be due to an undetected cardioembolic source. This study aimed to improve our understanding of the pathophysiology of ESUS through ... Read more >>

Stroke (Stroke)
[2020, 51(4):1294-1296]

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Limitations of transoesophageal echocardiogram in acute ischaemic stroke.

Zachary P Rosol, Kathleen F Kopecky, Bailey R Minehart, Kristen M Tecson, Anupama Vasudevan, Peter A McCullough, Paul A Grayburn, Jeffrey M Schussler,

ObjectiveThe role of transoesophageal echocardiography (TOE) in identifying ischaemic stroke aetiology is debated. In 2018, the American Heart Association/American Stroke Association (AHA/ASA) issued class IIa recommendation for echocardiography, with the qualifying statement of use in cases where it will alter management. Hence, we sought to determine the rate at which ... Read more >>

Open Heart (Open Heart)
[2020, 7(1):]

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Assessment of the manifestations of atrial fibrillation in patients with acute cerebral stroke - a single-center study based on 998 patients.

Paweł Warmus, Natalia Niedziela, Maciej Huć, Krzysztof Wierzbicki, Monika Adamczyk-Sowa,

Aim of the Study: Cardioembolic stroke accounts for approximately 15-25% of ischemic strokes and is characterized by a poor prognosis. Atrial fibrillation (AF) is more commonly diagnosed in the elderly.The aim of the study was the assessment of the manifestations of AF in patients hospitalized due to cerebral stroke, with ... Read more >>

Neurol. Res. (Neurological research)
[2020, :1-6]

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Effects of Gamma-Glutamyl Transferase on Stroke Occurrence Mediated by Atrial Fibrillation.

Wookjin Yang, Dong Wan Kang, Seung Hoon Lee,

BACKGROUND AND PURPOSE:Gamma-glutamyl transferase (GGT) is reported to be associated with stroke independently of the conventional risk factors. However, the underlying mechanism remains to be identified. This study focused on atrial fibrillation (AF), which also reportedly has a close association with GGT. METHODS:Acute ischemic stroke patients who were admitted to ... Read more >>

J Clin Neurol (Journal of clinical neurology (Seoul, Korea))
[2020, 16(1):60-65]

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Influence of oral anticoagulation on stroke severity and outcomes: A propensity score matching case-control study.

J Rodríguez-Pardo, A Plaza Herráiz, L Lobato-Pérez, M Ramírez-Torres, I De Lorenzo, M Alonso de Leciñana, E Díez-Tejedor, B Fuentes,

BACKGROUND:Oral anticoagulants (OAC) such as vitamin K antagonists (VKA) and direct-acting OACs (DOAC) remain the mainstay for prevention of cardioembolic stroke. The influence of previous OAC treatment on stroke severity and outcomes is not well stablished. We compared patients with incident cardioembolic strokes according to pre-stroke treatment. METHODS:Retrospective observational study ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, 410:116685]

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Early Anticoagulation for Minor Non-Cardioembolic Stroke and Transient Ischemic Attack: Too Early to Call.

Prachi Mehndiratta, Seemant Chaturvedi,

Stroke (Stroke)
[2020, 51(4):1051-1052]

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The role of statins in cardioembolic stroke.

Bruno Kusznir Vitturi, Rubens José Gagliardi,

BACKGROUND:Statin therapy has become one of the most important advances in stroke secondary prevention. Nevertheless, statin therapy in patients with cardioembolic stroke has not been supported by clinical evidence yet. This study aimed to investigate the effect of statins on the neurological outcomes after a cardioembolic stroke. METHODS:We conducted a ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 72:174-179]

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Stroke Rate, Subtype, and Cardiovascular Risk Factors in Nonarteritic Anterior Ischemic Optic Neuropathy: A Population-Based Study.

Robert C Foster, M Tariq Bhatti, Olivia M Crum, Elizabeth R Lesser, David O Hodge, James P Klaas, John J Chen,

BACKGROUND:Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in adults and is associated with vascular risk factors. Owing to the overlapping risk factor profiles between NAION and cerebral stroke, previous studies have produced conflicting results with regard to NAION as an independent risk factor ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2020, :]

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Associations Between Features of Nonstenosing Carotid Plaque on Computed Tomographic Angiography and Ischemic Stroke Subtypes.

Ashley Knight-Greenfield, Joel Jose Quitlong Nario, Amar Vora, Hediyeh Baradaran, Alex Merkler, Babak B Navi, Hooman Kamel, Ajay Gupta,

Background Thromboembolism from nonstenosing carotid plaques may be an underrecognized cause of embolic strokes of undetermined source (ESUS). We evaluated the association between features of nonstenosing atherosclerotic plaque on computed tomographic angiography and ESUS. Methods and Results We identified consecutive acute ischemic stroke patients from 2011 to 2015 who had ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(24):e014818]

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Association of Small Dense Low-Density Lipoprotein Cholesterol with Stroke Risk, Severity and Prognosis.

Peiyang Zhou, Jincheng Liu, Lingyun Wang, Wenmin Feng, Zhihua Cao, Pu Wang, Guangzhi Liu, Chenglin Sun, Yan Shen, Lijun Wang, Jiahuan Xu, Peng Meng, Ziwei Li, Wang-Yang Xu, Xifa Lan,

AIM:To investigate the association of small dense low-density lipoprotein cholesterol (sdLDL-C) and acute ischemic stroke (AIS) in terms of risk, severity, and outcomes. Prediction models were established to screen high-risk patients and predict prognosis of AIS patients. METHODS:We enrolled in this study 355 AIS patients and 171 non-AIS controls. AIS ... Read more >>

J. Atheroscler. Thromb. (Journal of atherosclerosis and thrombosis)
[2020, :]

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Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported With Left Ventricular Assist Devices.

Jonathan Grinstein, A Reshad Garan, Adam Oesterle, Justin Fried, Teruhiko Imamura, Xingchen Mai, Sara Kalantari, Gabriel Sayer, Gene H Kim, Nitasha Sarswat, Jayant Raikhelkar, Sirtaz Adatya, Valluvan Jeevanandam, Erin Flatley, Joshua Moss, Nir Uriel,

Ventricular arrhythmias are common following left ventricular assist device implantation (LVAD), and the effects of ventricular tachycardia (VT) ablation on thrombosis and embolic events are unknown. We aimed to assess LVAD thrombosis, stroke, and embolic event rates after VT ablation. Left ventricular assist device implantation patients from two academic centers ... Read more >>

ASAIO J. (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, :]

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