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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

MicroPubl Biol (microPublication. Biology)
[2020, 2020:]

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Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication. Biology)
[2020, 2020:]

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ImageJ/Fiji ROI 1-click tools for rapid manual image annotations and measurements.

Laurent Thomas, Jochen Gehrig,

MicroPubl Biol (microPublication. Biology)
[2020, 2020:]

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Interspecific comparison of sensitivity to paralytic compounds.

Vivian Vy Le, Bryan Sanchez, Ray Hong,

MicroPubl Biol (microPublication. Biology)
[2019, 2019:]

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Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication. Biology)
[2019, 2019:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans: Integration.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication. Biology)
[2019, 2019:]

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Resolving a contradiction: full gene deletion of kqt-3 by CRISPR does not lead to pharyngeal pumping defects.

Rosemary Bauer, Benjamin Nebenfuehr, Andy Golden,

MicroPubl Biol (microPublication. Biology)
[2019, 2019:]

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A C. elegans model for the rare human channelopathy, Timothy syndrome type 1.

Ross Lagoy, Heesun Kim, Craig Mello, Dirk Albrecht,

MicroPubl Biol (microPublication. Biology)
[2018, 2018:]

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How visiting nurses detect symptoms of disease progression in patients with chronic heart failure.

Chinatsu Taniguchi, Ayako Okada, Natsuko Seto, Yasuko Shimizu,

Purpose: Chronic heart failure patients are often rehospitalized because they fail to seek appropriate, timely care. However, both patients and nurses experience difficulties in detecting signs of heart failure exacerbation. We aimed to qualitatively investigate how visiting nurses detect symptoms of disease progression in chronic heart failure patients in their ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1735768]

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Yangxinkang tablet protects against cardiac dysfunction and remodelling after myocardial infarction in rats through inhibition of AMPK/mTOR-mediated autophagy.

Pei-Hua Ren, Zhi-Min Zhang, Peng Wang, Han-Ping Zhu, Zhen-Qiu Li,

Context: Acute myocardial infarction (AMI) is defined as myocardial necrosis. Clinicians use the traditional Chinese patent medicine Yangxinkang Tablet (YXK) to treat chronic heart failure.Objective: To explore the effects of YXK on heart injury following AMI and the underlying mechanisms.Materials and methods: The AMI model was produced in Wistar rats ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):321-327]

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Maternal hypothermia from environmental exposure in the third trimester.

Margot Rosenthal, Vanessa Poliquin, Adelicia Yu,

A primigravida at 32 weeks gestation developed hypothermia after prolonged exposure to the elements at -30.0°C. Her core temperature dropped to 29.8°C with associated foetal bradycardia. Passive rewarming was undertaken with forced warm air blankets and warmed IV fluids. The foetal heart rate normalised once normothermia was achieved. Serial foetal ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1710894]

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The CaMKII phosphorylation site Thr1604 in the CaV1.2 channel is involved in pathological myocardial hypertrophy in rats.

Jingyuan Li, Siqi Wang, Jie Zhang, Yan Liu, Xi Zheng, Fan Ding, Xuefei Sun, Meimi Zhao, Liying Hao,

Residue Thr1604 in the CaV1.2 channel is a Ca2+/calmodulin dependent protein kinase II (CaMKII) phosphorylation site, and its phosphorylation status maintains the basic activity of the channel. However, the role of CaV1.2 phosphorylation at Thr1604 in myocardial hypertrophy is incompletely understood. Isoproterenol (ISO) was used to induce cardiomyocyte hypertrophy, and ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):151-162]

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Serial evaluation of cardiac biomarker NT-proBNP with speckle tracking echocardiography in a 6-year-old Golden Retriever dog with subaortic stenosis and dilated cardiomyopathy.

Woong-Bin Ro, Min-Hee Kang, Hee-Myung Park,

Vet Q (The veterinary quarterly)
[2020, 40(1):77-82]

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Transplantation of adipose tissue lacking PAI-1 improves glucose tolerance and attenuates cardiac metabolic abnormalities in high-fat diet-induced obesity.

Sijing Liu, Yi Li, Xin Fan, Kai Li, Chunrong Xu, Liping Zhang, Mao Luo, Liqun Wang, Rong Li, Jianbo Wu,

Adipose tissue is an important metabolic organ, and transplantation of white adipose tissue plays crucial roles in glucose homoeostasis and energy metabolism. However, how adipose tissue affects glucose utilization is poorly understood. PAI-1-knockout (PAI-1KO) mice were previously shown to be resistant to a high-fat diet and obesity. We used microPET/CT ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):170-178]

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Qiliqiangxin improves cardiac function and attenuates cardiac remodelling in doxorubicin-induced heart failure rats.

Xutao Sun, Guozhen Chen, Ying Xie, Deyou Jiang, Jieru Han, Fei Chen, Yunjia Song,

Context: Therapeutic doxorubicin administration is restricted as this anticancer drug may be cardiotoxic. The traditional Chinese medicine qiliqiangxin has been approved for clinical treatment of chronic heart failure.Objective: To explore the protective effects and molecular mechanisms of qiliqiangxin on doxorubicin-induced congestive heart failure (CHF) in rats.Materials and methods: A CHF ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):417-426]

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Apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation response.

Wei Quan, Shanbo Ma, Yanrong Zhu, Qing Shao, Jixing Hou, Xiaoqiang Li,

Context: Traditionally, Clematis tangutica Korsh. (Ranunculaceae) is used as a Tibetan herb for treating indigestion and blood stasis in China. Recently, a flavonoid glycoside, apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside (APG), was isolated from the whole plant of C. tangutica.Objective: To investigate the cardioprotective effects of APG against myocardial ischaemia/reperfusion injury (MI/RI) and the possible ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):80-88]

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Consulting with a folk deity before making decisions: spiritual practices in parents facing end-of-life decisions for their child on life support with brain stem dysfunction.

Shih-Chun Lin, Mei-Chih Huang,

Background: Adolescents with brain stem dysfunction may undergo many invasive treatments, and parents are often faced with making the decision to withdraw treatment. However, in the face of their child's death, the spiritual practices of parents dealing with end-of-life decision-making remain under investigated.Purpose: This study explores the spiritual practices in ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1756686]

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The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes.

Onur Argan, Kübra Çıkrıkçı, Aybike Baltacı, Nahit Gencer,

Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention. In this study, we aimed to determine the in vitro effects of 35 frequently used cardiac drugs on human carbonic anhydrase I (hCA I) and II (hCA II). ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1359-1362]

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The protective effects of different compatibility proportions of the couplet medicines for Astragali Radix and Angelica sinensis Radix on myocardial infarction injury.

Lu Chen, Min Song, Lusha Zhang, Chunxiao Li, Zhirui Fang, Joel Wake Coffie, Liyuan Zhang, Lulu Ma, Leyu Fang, Qianyi Wang, Wenjie Yang, Fanggang Li, Xiumei Gao, Hong Wang,

Context: Astragali Radix (AR) and Angelica sinensis Radix (ASR) combinations are used to treat cardiovascular disorders.Objectives: This study investigates the protective effects of different compatibility proportions of AR and ASR on cardiac dysfunction in a C57BL/6 mouse model of myocardial infarction (MI).Materials and methods: MI mice were induced by ligation ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):165-175]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Combined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3β1/Nrf-2 pathway.

Ming Zhang, Ning-Wei Zhu, Wei-Cheng Ma, Meng-Jia Chen, Lei Zheng,

The present study sought to investigate the effect of non-mitogenic acidic fibroblast growth factor (NM-aFGF) loaded PEGylated nanoliposomes (NM-aFGF-PEG-lips) combined with the ultrasound-targeted microbubble destruction (UTMD) technique on modulating diabetic cardiomyopathy (DCM)and the mechanism involved. Animal studies showed that the diabetes mellitus (DM) group exhibited typical myocardial structural and functional ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):938-952]

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The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency.

Tina Jenewein, Scott A Kanner, Daniel Bauer, Brigitte Hertel, Henry M Colecraft, Anna Moroni, Gerhard Thiel, Silke Kauferstein,

The congenital long QT syndrome (LQTS) is a cardiac disorder characterized by a prolonged QT interval on the electrocardiogram and an increased susceptibility to ventricular arrhythmias and sudden cardiac death. A frequent cause for LQTS is mutations in the KCNH2 gene (also known as the human ether-a-go-go-related gene or hERG), ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):163-174]

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The quest to identify the mechanism underlying adrenergic regulation of cardiac Ca2+ channels.

Daniel Roybal, Jessica A Hennessey, Steven O Marx,

Activation of protein kinase A by cyclic AMP results in a multi-fold upregulation of CaV1.2 currents in the heart, as originally reported in the 1970's and 1980's. Despite considerable interest and much investment, the molecular mechanisms responsible for this signature modulation remained stubbornly elusive for over 40 years. A key manifestation ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):123-131]

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Ketofol performance to reduce postoperative emergence agitation in children undergoing adenotonsillectomy.

Idress Ali, Murad Alahdal, Haifa Xia, Arafa S El Moughrabi, Huang Shiqian, Shanglong Yao,

Background: Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adenotonsillectomy.Methods: A total of 60 children aged 3-15 ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1688450]

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Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis.

Bing Tian, Ming Tian, Shu-Ming Huang,

ABSRACTContext: Rhizoma Corydalis (RC) is the dried tubers of Corydalis yanhusuo (Y. H. Chou and Chun C. Hsu) W. T. Wang ex Z. Y. Su and C. Y. Wu (Papaveraceae). Traditionally, RC is used to alleviate pain such as headache, abdominal pain, and epigastric pain. Modern medicine shows that it ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):265-275]

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