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Carcinoma

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The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming.

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun,

We recently identified FAcilitates Chromatin Transcription (FACT) as a reprogramming barrier of transcription factor (TF) mediated conversion of germ cells into neurons in <i>C. elegans</i>. FACT is a conserved heterodimer consisting of SPT16 and SSRP1 in mammals. Duplication events during evolution in <i>C. elegans</i> generated two SSRP1 homologs named HMG-3 ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Testing the Anti-inflammatory Effects of Curcuminoids in Patients with Colorectal Cancer.

Tannaz Jamialahmadi, Paul C Guest, Aida Tasbandi, Muhammed Majeed, Amirhossein Sahebkar,

Colorectal cancer is the third most common cancer and accounts for the second highest number of cancer-related deaths worldwide. Natural products such as the turmeric-derived curcuminoids are known to have protective effects against several kinds of cancers by acting as antioxidant and anti-inflammatory agents. Here, we present a protocol for ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:319-330]

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Testing the Effect of Curcumin on Proliferative Capacity of Colorectal Cancer Cells.

Tannaz Jamialahmadi, Paul C Guest, Amir R Afshari, Muhammed Majeed, Amirhossein Sahebkar,

This chapter presents a protocol for studying the effects of curcumin in a colorectal cell line and a mouse model of colitis-associated colon carcinogenesis. The protocol using the CT26 cell line incorporates cell proliferation, migration, invasion, spheroid formation, cell cycle, polymerase chain reaction (PCR), and western blot analyses. For the ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:287-298]

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MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.

Mehmet Taha Yildiz, Lütfi Tutar, Nazlı Irmak Giritlioğlu, Banu Bayram, Yusuf Tutar,

Breast cancer has five major immune types; luminal A, luminal B, HER2, Basal-like, and normal-like. Cells produce a family of protein called heat shock proteins (Hsps) in response to exposure to thermal and other proteotoxic stresses play essential roles in cancer metabolism and this large family shows a diverse set ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2257:293-310]

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A pan-cancer analysis revealed the role of the SLC16 family in cancer.

Jun Li, Jiaheng Xie, Dan Wu, Liang Chen, Zetian Gong, Rui Wu, Yiming Hu, Jiangning Zhao, Yetao Xu,

Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In recent years, the tumor ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):528-540]

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Targeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non-small-cell lung cancer.

Songbai Zheng, Xiaodan Wang, Ying Fu, Beibei Li, Jianhua Xu, Haifang Wang, Zhen Huang, Hui Xu, Yurong Qiu, Yaozhou Shi, Kui Li,

The knowledge of genetic variation in Chinese patients with non-small-cell lung cancer (NSCLC) is still limited. We aimed to profile this genetic variation in 206 Chinese patients with NSCLC using next-generation sequencing. Tumor tissues or whole-blood samples were collected and subjected to whole-exome targeted next-generation sequencing, which included 565 tumor-associated genes, for somatic gene mutation screening ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):791-802]

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Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression.

Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li,

Renal cell carcinoma (RCC) is a highly aggressive cancer leading to high economic and social burden, and has increasing annual cases. Curcumin is a traditional Chinese medicine widely used as anti-inflammatory, anti-viral and anti-cancer agent, thus can be applicable in RCC therapy. The work assessed the effects of RCC treatment ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5017-5027]

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Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.

Qizhi Li, Jiang Liang, Shuai Zhang, Ning An, Lingfeng Xu, Changhong Ye,

Differentiated thyroid carcinoma (DTC) is one of the most common malignant tumors. Increasing evidence indicates that centromere protein K(CENPK) may play a key role in promoting carcinogenesis. The expression, biological functions, and clinical significance of CENPK in DTC are still unclear. The CENPK expression in the DTC specimen was confirmed ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1299-1310]

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Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.

Jian Chen, Luke Zhou, Jie Yang, Hui Xie, Lin Liu, Youwei Li,

Hepatocellular carcinoma (HCC) is a serious malignant tumor of the liver. It has been reported that serine/threonine kinase 39 (STK39) participates in tumorigenesis. However, the role of STK39 in HCC remains unknown. In this study, the qRT-PCR and western blot assay demonstrated that STK39 expression was enhanced in HCC patients ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6529-6537]

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Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.

Hao Xu, Chen Xiong, Yuan Chen, Chi Zhang, Dousheng Bai,

Rad51, a DNA-repair-related gene, has been reported to be involved in multiple cancers. However, its link with immune infiltration in liver cancer still unknown. Therefore, more research into the roles and activities of Rad51 in hepatocellular carcinoma (HCC) is required. The International Cancer Genome Consortium (ICGC) was used to identify ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2664-2675]

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Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma.

Rui Zhang, Wei-Jia Mo, Lan-Shan Huang, Ji-Tian Chen, Wei-Zi Wu, Wei-Ying He, Zhen-Bo Feng,

Synaptojanin 2 (SYNJ2) regulates cell proliferation and apoptosis via dephosphorylating plasma membrane phosphoinositides. Aim of this study is to first seek the full-scale expression levels and potential emerging roles of SYNJ2 in hepatocellular carcinoma (HCC). We systematically analyzed SYNJ2 mRNA expression and protein levels in HCC tissues based on large-scale data ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):855-874]

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Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.

Liang Chen, Zhonghua Yang, Yuan Cao, Yiming Hu, Wei Bao, Dan Wu, Li Hu, Jiaheng Xie, Hongzhu Yu,

Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer. Many patients with hepatocellular carcinoma are diagnosed at an advanced stage because the early symptoms are not obvious. For advanced hepatocellular carcinoma, immunotherapy and targeted therapy seem to be a promising direction. Finding a new prognostic marker for hepatocellular ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):541-554]

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Absent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma.

Wenliang Zhou, Yuan Zhang, Shixi Zhang, Zongguo Yang,

Identifying biomarkers for hepatocellular carcinoma (HCC) survival is of great importance for the early detection, monitoring, and predicting for prognosis. This study aimed to investigate the candidate biomarkers for predicting overall survival (OS) in HCC patients. Using RTCGAToolbox, top 50 upregulated differential expressed genes (DEGs) were identified. The least absolute ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2750-2762]

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MicroRNA miR-509-3p inhibit metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.

Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo, Gang Zhao,

Our study seeks to obtain data which help to assess the impacts and related mechanisms of microRNA miR-509-3p in hepatocellular carcinoma (HCC). We found that the expression of miR-509-3p was down-regulated and Twist was up-regulated in HCC tissues and cell lines (HepG2, HCCLM3, Bel7402, and SMMC7721) compared with the adjacent ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2263-2273]

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Leptin expression is substantially correlated with prognosis of urinary bladder carcinoma.

Mohamad Nidal Khabaz, Imtiaz Ahmad Qureshi, Jaudah Ahmad Al-Maghrabi,

This study examined leptin expression in cases of bladder cancer and its diagnostic and prognostic usefulness in bladder malignancies.A set of 128 urinary bladder cancer cases and 24 normal specimens of bladders were employed for an immunohistochemical investigation of leptin expression in tissue microarrays.Leptin was up-regulated during transformation and was ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1949798]

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Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP).

Chengwu Tang, Wenming Feng, Ying Bao, Huimin Du,

The long non-coding RNAs (lncRNAs) participate in modulating numerous important cancer phenotypes via formation of RNA-protein complex. TINCR (terminal differentiation-induced lncRNA) modulates cancer cell behavior in many human malignancies, such as hepatocellular carcinoma (HCC). Herein, we proposed to investigate the underlying mechanism by which TINCR regulates HCC progression via formation ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2119-2131]

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MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3).

Ruiguang Zhang, Chunxia Guo, Ting Liu, Wenting Li, Xiliu Chen,

Hepatocellular carcinoma (HCC) represents a type of lethal cancer in the world and its treatment options produce limited and unsatisfactory effectiveness. MicroRNAs (miRNAs) that play critical roles in tumorigenesis have shown promising clinical therapeutic potential. Here, we reported that miRNA-495 (miR-495) plays important roles in inhibiting HCC cell growth via ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6902-6912]

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Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1.

Weifang Song, Zhang Wenhui, Yao Ruiqiang, Xinli Hu, Ting Shi, Meijiao Wang, Haijuan Zhang,

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults, ranking the second leading cause of cancer-related death. To date, the underlying mechanisms of HCC pathogenesis are still unclear. Recently, more and more studies have reported that long noncoding RNAs (lncRNAs) are involved in the occurrence and development ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1599-1610]

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A genomic instability-derived risk index predicts clinical outcome and immunotherapy response for clear cell renal cell carcinoma.

Sha Wu, Xiaoning Li,

This study aims to originate agenomic instability-derived risk index (GIRI) for prognostic analysis of clear cell renal cell carcinoma (ccRCC) and explore the mutation characteristics, immune characteristics, and immunotherapy response defined by GIRI. Differentially expressed genome instability-associated genes were obtained from the genomic unstable (GU) group and the genomic stable ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1642-1662]

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Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis.

Yujuan Wang, Huafeng Zong, Haicheng Zhou,

Circular RNAs (circRNAs) feature prominently in regulating the progression of tumors, including papillary thyroid carcinoma (PTC). This work is designated to delve into the role of circ_0062389 in PTC. Generally, quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect circ_0062389, miR-1179 and high mobility group box 1 (HMGB1) mRNA ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1484-1494]

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Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.

Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan, Lu Wang,

RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1202-1211]

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An epithelial-mesenchymal transition-related long non-coding RNA signature to predict overall survival and immune microenvironment in kidney renal clear cell carcinoma.

You-Peng Zhang, Yong-Biao Cheng, Sen Li, Ning Zhao, Zhao-Hui Zhu,

Kidney renal clear cell carcinoma (ccRCC) is a malignant tumor originating from renal tubular epithelium, lncRNAs can regulate the occurrence and development of EMT by targeting EMT transcription factors. We constructed a new survival signature based on EMT-related differentially expressed lncRNAs obtained from the Cancer Genome Atlas (TCGA-KIRC). We first ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):555-564]

Cited: 2 times

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Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism.

Hailan Bao, Qi Muge,

<h4>Context</h4>Myristicin is a natural active compound that has inflammatory, antimicrobial and anti-proliferative properties. Yet, its effect on hepatic carcinoma has not been investigated.<h4>Objective</h4>To explore the role and related molecular mechanism of myristicin in hepatic carcinoma <i>in vitro</i>.<h4>Materials and methods</h4>Human hepatic carcinoma cell lines (Huh-7 and HCCLM3 cells) were treated with different ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1126-1132]

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The underlying molecular mechanism and identification of transcription factor markers for laryngeal squamous cell carcinoma.

Bin-Yu Mo, Guo-Sheng Li, Su-Ning Huang, Wei-Ying He, Li-Yuan Xie, Zhu-Xin Wei, Ya-Si Su, Yue Liang, Li Yang, Cheng Ye, Wen-Bin Dai, Lin Ruan,

The screening and treatment of laryngeal squamous cell carcinoma (LSCC) still perplexes clinicians, making it necessary to explore new markers. To this end, this research examined the underlying molecular mechanism of LSCC based on high-throughput datasets (<i>n</i> = 249) from multiple databases. It also identified transcription factors (TFs) independently associated with ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):208-224]

Cited: 1 time

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