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The C. elegans pseudogene sspt-16 (F55A3.7) is required to safeguard germ cells against reprogramming.

Andreas Ofenbauer, Clara Maria Kraus, Baris Tursun,

We recently identified FAcilitates Chromatin Transcription (FACT) as a reprogramming barrier of transcription factor (TF) mediated conversion of germ cells into neurons in <i>C. elegans</i>. FACT is a conserved heterodimer consisting of SPT16 and SSRP1 in mammals. Duplication events during evolution in <i>C. elegans</i> generated two SSRP1 homologs named HMG-3 ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Genetic Mapping of a new Hippo allele, HpoN.1.2, in Drosophila melanogaster.

Jamie L Siders, Kayla L Bieser, Danielle R Hamill, Erika C Acosta, Olivia K Alexander, Humza I Ali, Micah J Anderson, Hayden R Arrasmith, Mustafa Azam, Nikki J Beeman, Hassan Beydoun, Lauren J Bishop, Morgan D Blair, Brianna Bletch, Heather R Bline, Jennifer C Brown, Kelly M Burns, Karina C Calagua, Lexie Chafin, William Ah Christy, Carlyn Ciamacco, Hannah Cizauskas, Caitlyn M Colwell, Abigail R Courtright, Lucero Diaz Alavez, Rayne Is Ecret, Fatima Edriss, Taylor G Ellerbrock, Madison M Ellis, Erica M Extine, Eric Feldman, Luke J Fickenworth, Caroline M Goeller, Alexis S Grogg, Yailine Hernandez, Abigail Hershner, Megan M Jauss, Leyre Jimenez Garcia, Katey E Franks, Ethan T Kazubski, Emily R Landis, Jon Langub, Tia N Lassek, Triet C Le, Julia M Lee, Daniel P Levine, Phoebe J Lightfoot, Natasha Love, Ali Maalhagh-Fard, Colin Maguire, Brynna E McGinnis, Bhargavi V Mehta, Veronica Melendrez, Zimri E Mena, Seth Mendell, Petra Montiel-Garcia, Autumn S Murry, Riley A Newland, Ryan M Nobles, Neha Patel, Yashodhara Patil, Cassidy L Pfister, Victoria Ramage, Mya R Ray, Joseph Rodrigues, Victoria C Rodriquez, Yara Romero, Alexandra M Scott, Nicholas Shaba, Samantha Sieg, Kayla Silva, Sahiba Singh, Aleksandria J Spargo, Savanna J Spitnale, Nicole Sweeden, Logan Tague, Breanna M Tavernini, Kathleen Tran, Liselle Tungol, Kylie A Vestal, Amber Wetherbee, Kayla M Wright, Anthony T Yeager, Rehab Zahid, Jacob D Kagey,

Genetic screens provide a mechanism to identify genes involved with different cellular and organismal processes. Using a Flp/FRT screen in the <i>Drosophila</i> eye we identified mutations that result in alterations and de-regulation of cell growth and division. From this screen a group of undergraduate researchers part of the Fly-CURE consortium ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila.

Pooja Kr, Jonathan Lee, Nathan T Mortimer,

In nature, <i>Drosophila melanogaster</i> larvae are infected by parasitoid wasps and mount a cellular immune response to this infection. Several conserved signaling pathways have been implicated in coordinating this response, however our understanding of the integration and regulation of these pathways is incomplete. Members of the S1A serine protease family ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).

Hanwen Zhang, Shuya Liu, Lian Tang, Jianhua Ge, Xiaobo Lu,

Long non-coding RNA (LncRNA) contributes to the occurrence and development of osteosarcoma (OS), although the underlying mechanism is not clear. In the present study, we showed that lncRNA MRPL23-AS1 was remarkably increased in OS tissues and cell lines. Stable knockdown of MRPL23-AS1 evidently attenuated cell viability and invasive ability, meanwhile ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):162-171]

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Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.

Qizhi Li, Jiang Liang, Shuai Zhang, Ning An, Lingfeng Xu, Changhong Ye,

Differentiated thyroid carcinoma (DTC) is one of the most common malignant tumors. Increasing evidence indicates that centromere protein K(CENPK) may play a key role in promoting carcinogenesis. The expression, biological functions, and clinical significance of CENPK in DTC are still unclear. The CENPK expression in the DTC specimen was confirmed ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1299-1310]

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Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation.

Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang, Zhiyong Yuan,

<h4>Context</h4>Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain.<h4>Objective</h4>We investigated the potential beneficial effects of tanshinone IIA in a colitis-associated colorectal tumorigenesis mouse model and its underlying mechanisms.<h4>Materials and methods</h4>Male C57BL/6 ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):89-96]

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Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest.

Keying Liu, Biyun Xue, Guiqin Bai, Wentao Zhang,

Diacylglycerol kinase zeta (DGKZ) participates in cancer progression. Here, the current work aims to identify the functional role of DGKZ in cervical cancer (CC). DGKZ expression in cervical cancer tissues and paired adjacent normal cervical tissues was assessed using Immunohistochemistry assay. SiHa and HeLa cells were transfected with lentivirus plasmids ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1517-1529]

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Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses.

Jun Cao, Chi Zhang, Guo-Qing Jiang, Sheng-Jie Jin, Qian Wang, Ao-Qing Wang, Dou-Sheng Bai,

Macrophage differentiation is associated with tumorigenesis, including the tumorigenesis of hepatocellular carcinoma (HCC). Herein, we explored the value of macrophage differentiation-associated genes (MDGs) in the prognosis of HCC using data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) databases. We performed multivariate Cox regression analyses ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):296-309]

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Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer.

Hongjun Guan, Changpeng Sun, Yinfeng Gu, Jinjin Li, Jie Ji, Yongxian Zhu,

Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. Circular RNA (circRNA) circ_0003028 was reported to be upregulated in NSCLC. This study is designed to explore the role and mechanism of circ_0003028 on NSCLC progression. In this work, circ_0003028, microRNA-1298-5p (miR-1298-5p), and glutamic oxaloacetic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2326-2340]

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Long noncoding RNA MST1P2 promotes cervical cancer progression by sponging with microRNA miR-133b.

Rongrong Xu, Xiaoyue Zhang, Yan Xu, Junqin Wang, Zhihui Li, Xiaoming Cui,

Long noncoding RNA (lnc RNA) is aberrant expressed in many kinds of tumors and may be concerned with the occurrence and progression of tumors. Lnc RNA MST1P2 is increased in cervical cancer (CC), but its mechanism in CC has not been clarified. In this study, RT-qPCR was employed to analyze ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1851-1860]

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Long non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway.

Shuo Yan, Jichong Xu, Bingyan Liu, Lin Ma, Hao Feng, Huaqiao Tan, Chun Fang,

Long non-coding RNA breast cancer antiestrogen resistance 4 (lncRNA BCAR4) is an independent factor on the survival prognosis of patients with multiple cancers. However, the role of lncRNA BCAR4 in esophageal squamous cell cancer (ESCC) remains unknown. Here, we unraveled that lncRNA BCAR4 was upregulated in ESCC and predicted poor ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):682-696]

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MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2).

Huang Jinghua, Zhou Qinghua, Chen Chenchen, Chen Lili, Xu Xiao, Wang Yunfei, An Zhengzhe, Lin Changxiu, Han Hui,

MicroRNAs (miRNAs) dysregulation contributes to tumorigenesis, and it is reported that abnormal miR-92a-3p expression participates in multiple cancers' occurrence and progression. This study focuses on miR-92a-3p's functions and regulatory mechanism in breast cancer (BC). The current study proved miR-92a-3p expression was enhanced in BC tissues and cells, and its high ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2033-2044]

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MicroRNA miR-425 promotes tumor progression by inhibiting Dickkopf-related protein-3 in gastric cancer.

Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao, Bozhen Xie,

Gastric cancer is a prevalent yet heterogeneous disease which ranks as the fifth most common cancer in the world. Dietary habit, genetic background, <i>Helicobacter Pylori</i> infections were the risk factors of gastric cancer. MicroRNA miR-425 is highly expressed in gastric cancer, but little attention has been devoted to the mechanism ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2045-2054]

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Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.

Xianliao Zhang, Zhengbo Hu, Wenhu Li, Zhongxun Liu, Jie Li, Zhaozhen Wang, Vidmi Taolam Martin, Bing Yan, Bo Yu,

Circular RNAs (circRNAs) are a type of non-coding RNAs generated from back splicing to enhance or inhibit the progression of multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found to be highly expressed in OS cell lines, the role and specific mechanism of circ_0102049 in OS remains unclear. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2022-2032]

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Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis.

Dexiang Zhou, Xiaofeng Lin, Peng Wang, Yong Yang, Jiantao Zheng, Dong Zhou,

The biological modulatory roles of many circular RNAs (circRNAs) have been validated in glioma. The current study was designed to research the functional mechanism of circ_0001162 in glioma progression. The quantitative real-time polymerase chain reaction (qRT-PCR) was used for assaying the levels of circ_0001162 and microRNA-936 (miR-936). Cell proliferation and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2106-2118]

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Long non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p.

Hongyan Wang, Xin Di, Yingjie Bi, Shidong Sun, Tao Wang,

Although long non-coding RNA (LncRNA) LINC00649 is reported to be closely associated with acute myeloid leukemia (AML), prostate cancer and colorectal cancer, its role in regulating other types of cancer, such as gastric cancer (GC), has not been studied. This study analyzed the expression status of LINC00649 in GC tissues ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1791-1802]

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A signature of 13 autophagy‑related gene pairs predicts prognosis in hepatocellular carcinoma.

Jie Cao, Lili Wu, Xin Lei, Keqing Shi, Liang Shi,

Growing evidences suggest that autophagy plays a momentous part in the tumorigenesis and development of hepatocellular carcinoma (HCC). However, there are not many researches to predict the prognosis of HCC using autophagy-related genes. Therefore, based on the clinical information and RNA-Seq data of The Cancer Genome Atlas data portal (TCGA), ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):697-707]

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Long intergenic non-protein coding RNA 960 regulates cancer cell viability, migration and invasion through modulating miR-146a-5p/interleukin 1 receptor associated kinase 1 axis in pancreatic ductal adenocarcinoma.

Yaoxing Huang, Qingqing Yan, Danchun Yu, Xiaojuan Sun, Shuman Jiang, Weidong Li, Lin Jia,

Long non-coding RNAs (lncRNAs) are considered as crucial regulatory factors in cancer biology. However, the biological function of long intergenic non-protein coding RNA 960 (LINC00960) in the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) is still unknown. The goal of this study is to investigate the role of LINC00960 in PDAC. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):369-381]

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Novel insights into clear cell renal cell carcinoma prognosis by comprehensive characterization of aberrant alternative splicing signature: a study based on large-scale sequencing data.

Dong Zhang, Wenjie Zhang, Rui Sun, Zhongxian Huang,

Clear cell renal cell carcinoma (ccRCC) is the most common type with poor prognosis in kidney tumor. Growing evidence has indicated that aberrant alternative splicing (AS) events are efficacious signatures for tumor prognosis prediction and therapeutic targets. However, the detailed roles of AS events in ccRCC are largely unknown. In ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1091-1110]

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Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression.

Qiao Gu, Wenjie Hou, Lijuan Shi, Huan Liu, Zonghao Zhu, Wenfeng Ye,

Countless studies have demonstrated that Circular RNAs (circRNAs) exert vital effects in regulating tumorigenesis of various cancers. CircRNA ZNF609 (circ-ZNF609) has been reported as an oncogene in various human cancers. Nevertheless, its regulating effect in cervical cancer (CC) remains to be further explored. RT-qPCR was adopted to measure circ-ZNF609, miR-197-3p ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):927-936]

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Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma.

Jie Cao, Lili Wu, Xin Lei, Keqing Shi, Liang Shi, Yifen Shi,

Long non-coding RNAs (lncRNAs), as one common type of non-coding RNAs, play a critical role in the tumorigenesis and development of hepatocellular carcinoma (HCC). In the current study, we aimed to assess the correlation between lncRNAs expression levels and prognosis of HCC patients. A lncRNA-based signature was also developed to ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):673-681]

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Visfatin and global histone H3K9me levels in colon cancer.

Eman A Al Abdulsalam, Rowyda N Al Harithy,

<h4>Background</h4>Visfatin is considered to be a biomarker in various types of cancers, including colon cancer. Moreover, evidence for epigenetic mechanism must be reported for an association between visfatin level and colon cancer. Therefore, this study was designed to investigate the status of visfatin expression and the global histone three modifications ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):647-652]

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The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage.

Hao Guo, Wenlei Zhao, Aijie Wang, Mingzhuo Li, Heng Ma, Fang Wang, Qing Wang, Xinru Ba,

Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fat measurements in ccRCC ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):285-292]

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Community-driven research in the canadian arctic: dietary exposure to methylmercury and gastric health outcomes.

Emily V Walker, Safwat Girgis, Yan Yuan, Karen J Goodman,

Indigenous Arctic Canadians have a higher prevalence of gastric neoplasms relative to North Americans of European ancestry. We investigated the hypothesis that low-dose methylmercury exposure from eating fish/whale increases the risk of gastric cancer in Arctic communities. We used intermediate endpoints from an established model of gastric carcinogenesis: intestinal metaplasia, ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1889879]

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Protective Effects of Polyvinylpyrrolidone-Wrapped Fullerene Against Nitric Oxide/Peroxynitrite-Induced Cellular Injury in Human Skin Keratinocytes.

Yasukazu Saitoh, Asuka Tanaka, Sayuri Hyodo,

Excess ultraviolet (UV) exposure accelerates skin inflammation, melanogenesis, wrinkle formation, photoaging, and carcinogenesis through oxidative stress and deoxyribonucleic acid damage. These deleterious effects to skin are closely associated with UV-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced via nitric oxide (NO<sup>·</sup>) generation. RNS are known to be ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(9):4579-4585]

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