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Pyrogallol induces oxidative stress defects in the fission yeast S. pombe.

Nafees Ahamad, Simmi Anjum, Shakil Ahmed,

Apart from the beneficial roles of pyrogallol in industries, it also tends to produce free radicals that trigger apoptosis in human cells. In this study, we checked the toxic effect of pyrogallol in fission yeast <i>S. pombe</i> cells. We observed that the wild type and <i>wat1/pop3</i> delete cells were unable ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers.

Nawaf A Alsaif, Mohammed S Taghour, Mohammed M Alanazi, Ahmad J Obaidullah, Abdulrahman A Al-Mehizia, Manal M Alanazi, Saleh Aldawas, Alaa Elwan, Hazem Elkady,

Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-<i>a</i>:3',4'-<i>c</i>]quinoxaline derivatives have been successfully designed and synthesised. The synthesised derivatives were biologically investigated for their cytotoxic activities against HepG2 and MCF-7. Also, the tested compounds were further examined <i>in vitro</i> for their VEGFR-2 inhibitory activity. The most promising derivative <b>23j</b> was further investigated ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1093-1114]

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LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer.

Juan Luo, Huifei Xiang,

Extensive studies showed the vital function of long noncoding RNAs (lncRNAs) in the pathological and physiological progression of tumors. Previous evidence has indicated that lncRNA MYLK Antisense RNA 1 (<i>MYLK-AS1</i>) acts as an oncogene to facilitate the progression of several tumors. Nevertheless, little is known about its biological role in ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3101-3112]

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High expression of CD56 may be associated with favorable overall survival in intermediate-risk acute myeloid leukemia.

Cunte Chen, Chi Leong Chio, Hui Zeng, Yangqiu Li,

<h4>Objectives</h4>Previous study (<i>Br. J. Haematol.</i> 2017; 176:498) reported that CD56 positive is associated with poor prognosis of patients with intermediate-risk acute myeloid leukemia (IR-AML). However, our data were inconsistent with the finding<i>.</i> Thus, in this study, we provided the different results to discuss.<h4>Methods</h4>A total of 262 bone marrow transcriptomic data ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):210-214]

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Novel natural inhibitors targeting B-RAF(V600E) by computational study.

Bo Wu, Zhiyun Zhang, Gaojing Dou, Xiaye Lv, Junliang Ge, Hongyu Wang, Haoqun Xie, Dong Zhu,

The aim of this research was to screen the ZINC15 database to select lead compounds and drug candidates which can inhibit B-RAF (V600E). In order to identify drugs potentially inhibited B-RAF (V600E), numerous modules of Discovery Studio 4.5 were employed. Structure-based screening using LibDock was carried out followed by ADME ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2970-2983]

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Invited Perspective: Prioritizing Chemical Testing and Evaluation Using Validated in Vitro Assays Relevant to Key Characteristics.

Kathryn Z Guyton, Mary K Schubauer-Berigan,

Environ Health Perspect (Environmental health perspectives)
[2021, 129(7):71303]

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Safety and efficacy of different doses of anthracyclines combined with arsenic trioxide and all-trans retinoic acid in the treatment of de novo acute promyelocytic leukemia.

Yaxue Wu, Peng Ke, Haixia Zhou, Depei Wu, Suning Chen, Huiying Qiu, Yue Han, Caixia Li, Xiao Ma, Aining Sun, Xiaowen Tang, Xiaohui Hu,

<h4>Objectives</h4>The purpose of this study was to evaluate the efficacy and safety of different doses of anthracyclines combined with arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) for induction in newly diagnosed acute promyelocytic leukemia (APL).<h4>Methods</h4>One hundred and forty patients were included between January 2011 and December 2017. Seventy patients ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):271-276]

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Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia.

Run-Qing Lu, Li-Xin Wu, Jing Zhang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai, Hao Jiang, Ying-Jun Chang, Guo-Rui Ruan, Xiao-Jun Huang,

<h4>Objectives</h4>Ras-related dexamethasone-induced 1 (<i>RASD1</i>) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, <i>RASD1</i>, as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL.<h4>Methods</h4>The ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):9-15]

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The effect of the detection of minimal residual disease for the prognosis and the choice of post-remission therapy of intermediate-risk acute myeloid leukemia without FLT3-ITD, NPM1 and biallelic CEBPA mutations.

Wen-Shuai Zheng, Ya-Lei Hu, Li-Xun Guan, Bo Peng, Shen-Yu Wang,

<h4>Background</h4>Intermediate-risk acute myeloid leukemia (IR-AML) without FLT3-ITD, NPM1 and biallelic CEBPA mutations (here referred to as NPM1<sup>mut-neg</sup>CEBPA<sup>dm-neg</sup>FLT3-ITD<sup>neg</sup> AML) is a clinically heterogeneous disease. The optimal post-remission therapy (PRT) is unclear for patients with NPM1<sup>mut-neg</sup>CEBPA<sup>dm-neg</sup>FLT3-ITD<sup>neg</sup> AML who achieved first complete response (CR1). This study aims to explore clinical and molecular factors ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):179-185]

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Achievements and memories of Dr. Takashi Sugimura.

Keiji Wakabayashi,

Genes Environ (Genes and environment : the official journal of the Japanese Environmental Mutagen Society)
[2021, 43(1):31]

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Food security, obesity, and meat-derived carcinogen exposure in US adults.

Luke Dolan, Kristen Shea Smith, Michael Brett Marlin, Leonard N Bell, Eugene Blythe, Michael W Greene, Andrew Dandridge Frugé,

Risk for colorectal cancer (CRC) is increased in adults with poor diet quality, low socioeconomic status, and increased body mass index (BMI). Cooked meats contain high contents of mutagenic compounds related to CRC risk. To explore differences in meat-based carcinogen exposure, a 99-item Qualtrics survey was issued to 1648 US ... Read more >>

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2021, 155:112412]

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Global Analysis of Protein Expression in A549 Cells After Prolonged Nicotine Exposure by Using Label-free Quantification.

Sasikarn Komkleow, Churat Weeraphan, Daranee Chokchaichamnankit, Papada Chaisuriya, Chris Verathamjamras, Theetat Ruangjaroon, Jisnuson Svasti, Polkit Sangvanich, Chantragan Srisomsap,

<h4>Background/aim</h4>Lung cancer is the leading cause of cancer death worldwide. Cigarette smoke is the most important risk factor for cancer development. Growing evidence indicates that prolonged nicotine exposure is a potential factor associated with tumorigenesis. Here, the effect of prolonged nicotine exposure on A549 cells was investigated, using label-free quantitative ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(8):3833-3842]

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Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors.

Bethsaida Cardona, Ruthann A Rudel,

<h4>Background</h4>Established breast cancer risk factors, such as hormone replacement therapy and reproductive history, are thought to act by increasing estrogen and progesterone (P4) activity.<h4>Objective</h4>We aimed to use <i>in vitro</i> screening data to identify chemicals that increase the synthesis of estradiol (E2) or P4 and evaluate potential risks.<h4>Method</h4>Using data from a ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2021, 129(7):77003]

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Less Carcinogenic Chlorinated Estrogens Applicable to Hormone Replacement Therapy.

Yoshinori Okamoto, Hideto Jinno, Shinji Itoh, Shinya Shibutani,

Human estrogens prescribed for hormone replacement therapy (HRT) are known to be potent carcinogens. To find safer estrogens, several chlorinated estrogens were synthesized and their carcinogenic potential were determined. A pellet containing either 2-chloro-17β-estradiol (2-ClE<sub>2</sub>) or 4-chloro-17β-estradiol (4-ClE<sub>2</sub>) was implanted subcutaneously for 52 weeks into August Copenhagen Irish (ACI) rats, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(13):]

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Proteases, Protease Inhibitors and Radiation Carcinogenesis.

Ann R Kennedy,

<h4>Purpose</h4>The purpose of the studies described in this mini review article was to identify non-toxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.<h4>Conclusions</h4>1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, :1-39]

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Comparison of the Potential Ecological and Human Health Risks of Heavy Metals from Sewage Sludge and Livestock Manure for Agricultural Use.

Baoling Duan, Qiang Feng,

Sewage sludge and livestock (chicken, swine and cattle) manure samples were collected from the Yanmenguan Cattle Herbivorous Livestock Area to compare the potential ecological and human health risks caused by heavy metals contained in them. In this study, the Class II level of Quality Control of Imported Organic Fertilizers is ... Read more >>

Toxics (Toxics)
[2021, 9(7):]

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Influence of Bisphenol Compounds at Nanomolar Concentrations on Chromosome Damage Induced by Metabolically Activated Carcinogens in HepG2 Cells.

Hang Yu, Meiqi Song, Keqi Hu, Yujian Wang, Ruifang Fan, Zongying Yang, Hansruedi Glatt, Albert Braeuning, Yungang Liu,

Bisphenol (BP) compounds are endocrine-disrupting organic pollutants. BPs may increase the messenger RNA (mRNA) transcripts of nuclear receptors (NRs) regulating the expression of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes. Their impact on the genotoxicity of metabolically activated carcinogens, however, remains unknown. In this study, effects of the bisphenols A, F, S, ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, 55(14):10001-10011]

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Assessment of toxicity and potential health risk from persistent pesticides and heavy metals along the Delhi stretch of river Yamuna.

Musarrat Parween, A L Ramanathan, N Janardhana Raju,

The present study aims at the assessment of environmental quality of the most polluted stretch of river Yamuna along the megacity of Delhi. The study was conducted in order to examine toxicity and health hazards associated with persistent pollutants present in the fluvial ecosystem. Eighty four sediment and 56 vegetable ... Read more >>

Environ Res (Environmental research)
[2021, :111780]

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Source apportionment and risk assessment for polycyclic aromatic hydrocarbons in soils at a typical coking plant.

Qifan Zhang, Jing Meng, Guijin Su, Zhelun Liu, Bin Shi, Tieyu Wang,

Polycyclic aromatic hydrocarbons (PAHs) are widely present in the environment. The coking industry is an important industrial source of PAHs. Coke production in China accounts for 67.44% of total global coke production. Tangshan, a coastal city on the Bohai Rim, contains the largest cluster of coking plants in China. Extremely ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 222:112509]

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Deep Neural Network for the Determination of Transformed foci in Bhas 42 Cell Transformation Assay

Minami Masumoto, Ittetsu Fukuda, Suguru Furihata, Takahiro Arai, Tatsuto Kageyama, Kiyomi Ohmori, Shinichi Sirakawa, Junji Fukuda,

Bhas 42 cell transformation assay (CTA) has been used to estimate the carcinogenic potential of chemicals by exposing Bhas 42 cells to carcinogenic stimuli to form colonies, referred to as transformed foci, on the confluent monolayer. Transformed foci are classified and quantified by trained experts using morphological criteria. Although the ... Read more >>

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N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity.

F Oesch, N Honarvar, E Fabian, F I Berger, Robert Landsiedel,

Several N-vinyl compounds are produced in high volumes and are widely employed in the production of copolymers and polymers used in chemical, pharmaceutical, cosmetic and food industry. Hence, information on their genotoxicity and carcinogenicity is requisite. This review presents hitherto available information on the carcinogenicity and genotoxicity of N-vinyl compounds ... Read more >>

Arch Toxicol (Archives of toxicology)
[2021, :]

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Asbestos Exposure Level and the Carcinogenic Risk Due to Corrugated Asbestos-Cement Slate Roofs in Korea.

Eun-Soo Lee, Young-Ki Kim,

Asbestos-cement slate roofs are one of the most common environmental causes of asbestos exposure. However, few studies have examined residential asbestos-cement slate-related exposure and its effects on human health. This study was performed to evaluate cumulative asbestos exposure levels and to calculate the Excess Lifetime Cancer Risk (ELCR) of residents ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(13):]

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Microorganisms: crucial players of smokeless tobacco for several health attributes.

Akanksha Vishwakarma, Digvijay Verma,

Global consumption of smokeless tobacco (SLT) reached 300 million users worldwide majorly from middle-income countries. More than 4000 chemical compounds represent it as one of the noxious consumable products by humans. Besides toxicants/carcinogens, the heavy microbial load on smokeless tobacco further keeps human health at higher risk. Several of these ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2021, :]

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Development of Korean CARcinogen EXposure: An Initiative of the Occupational Carcinogen Surveillance System in Korea.

Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Inah Kim, Donguk Park,

<h4>Objective</h4>To prevent occupational cancers, carcinogen exposure surveillance systems have been developed in many countries. This study aimed to develop a carcinogen exposure database specific to South Korea.<h4>Methods</h4>Twenty known human carcinogens were selected for this study. The International Standard Classification of Industry was used for a classification scheme of industries. Three ... Read more >>

Ann Work Expo Health (Annals of work exposures and health)
[2021, 65(5):528-538]

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Levels and health risk assessment of heavy metals in dried fish consumed in Bangladesh.

Md Refat Jahan Rakib, Y N Jolly, Christian Ebere Enyoh, Mayeen Uddin Khandaker, M Belal Hossain, Shirin Akther, Abdullah Alsubaie, Abdulraheem S A Almalki, D A Bradley,

As a cheap source of high-quality protein, healthy fats and essential nutrients, dried fish is a common item in the daily diet of the Bangladesh populace. In this study, ten types of widely consumed dried fish (H. neherius, T. lepturu, P.chinensis, P. affinis, A. mola, P. microdon, I. megaloptera, C. ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14642]

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